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Zofran (Ondansetron)

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Zofran is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

Other names for this medication:
Domar, Donrid, Doran, Emeset, Emtop, Lupisetron, Naucid, Omcet, Ondeo, Ondet, Ondon, Ontron, Onzil, Pantorex, Ranidom, Ranon, Tiron, Vomicare, Vomigo, Vomizen, Vorast, Xondmet, Zonda, Zondan, Zonde

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Cardizem, Naprosyn, Depakote, Mysoline, Eulexin, Clomid, Minipress, Fosamax

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Also known as: Ondansetron


{name} (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting.

{name} is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.

{name} may be used for purposes not listed in this medication guide.


Follow all directions on your prescription label. Do not take Zofran ODT in larger or smaller amounts or for longer than recommended.

Zofran ODT can be taken with or without food.

The first dose of ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully.

Take the Zofran ODT regular tablet with a full glass of water.

To take the orally disintegrating tablet (Zofran ODT):

Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet. Use dry hands to remove the tablet and place it in your mouth. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves.

To use Zofran ODT soluble film (strip) (Zuplenz):

Keep the strip in the foil pouch until you are ready to use the medicine. Using dry hands, remove the strip and place it on your tongue. It will begin to dissolve right away. Do not swallow the strip whole. Allow it to dissolve in your mouth without chewing. Swallow several times after the strip dissolves. If desired, you may drink liquid to help swallow the dissolved strip. Wash your hands after using Zuplenz.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Store at room temperature away from moisture, heat, and light. Store liquid medicine in an upright position.

Detailed Zofran ODT dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.


Store at temperature between 2 and 30 degrees C (36 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Zofran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


This medicine may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

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