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Terramycin

Terramycin is an antibiotic used to treat a wide variety of bacterial infections. The brand name drug Terramycin is no longer available in the U.S., but generic versions may still be available.

Other names for this medication:
Betacycline, Cotet, Dynoxytet, Ecomycin, Geomicina, Innolyre, Oxyteracin, Oxytetracycline, Tetracin

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Also known as: Oxytetracycline

Description

Terramycin is a product of the metabolism of Streptomyces rimosus and is one of the family of Terramycin antibiotics. A 1 percent solution in water is acidic (pH about 2.5). Its potency is affected in solutions more acid than pH 2 and it is rapidly destroyed by alkali hydroxides.

Terramycin diffuses readily through the placenta into the fetal circulation, into the pleural fluid and, under some circumstances, into the cerebrospinal fluid. It appears to be concentrated in the hepatic system and excreted in the bile, so that it appears in the feces, as well as in the urine, in a biologically active form.

Inert ingredients in the formulation are: glucosamine hydrochloride; hard gelatin capsules (which may contain Red 3, Yellow 10 and other inert ingredients); magnesium stearate; sodium lauryl sulfate; starch.

Dosage

The usual daily adult dose of Terramycin is 250 mg administered once every 24 hours or 300 mg given in divided doses at 8 to 12 hour intervals. For children above eight years of age the dose is determined by the child's body weight. Terramycin may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Terramycin should be used only if prescribed. Use during the last half of pregnancy, or during infancy and childhood up to the age of 8 years may cause permanent discoloration of the teeth (yellow-gray-brown). Tell your doctor if you are pregnant or plan to become pregnant before taking Terramycin. This drug passes into breast milk. Consult your doctor before breastfeeding.

Overdose

If you overdose Generic Tetracycline and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Terramycin overdosage: retching, diarrhoea, nausea.

Storage

Store Terramycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Keep away from heat, moisture, and light. Do not store in the bathroom. Keep Terramycin out of the reach of children and away from pets.

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The most common side effects associated with Terramycin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.

As with other antibiotic preparations, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, the antibiotic should be discontinued and appropriate therapy instituted.

In venereal diseases when coexistent syphilis is suspected, a dark field examination should be done before treatment is started and the blood serology repeated monthly for at least 4 months.

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

In long term therapy, periodic laboratory evaluation of organ systems, including hematopoietic, renal and hepatic studies should be performed.

All infections due to Group A beta-hemolytic streptococci should be treated for at least 10 days.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin.

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