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Singulair

Singulair is used to prevent wheezing, difficulty breathing, chest tightness, and coughing caused by asthma in adults and children 12 months of age and older. Singulair is in a class of medications called leukotriene receptor antagonists (LTRAs).

Other names for this medication:
Adomont, Aldbest, Allermax, Alvizy, Alzero, Ancer, Breathezy, Cetrite, Deriphyllin, Ebast, Emlucast, Fexoquin, Histakind, Kastzine, Lelet, Leomont, Levasma, Levocet, Levodel, Levoler, Levotin, Lewlet, Maast, Monhale, Montair, Montal, Montasame, Montelast, Monteleo, Montemac, Monten, Montina, Montlu, Montral, Novamont, Novolen, Nucez, Ontelio, Pulmokast, Reakst, Renea, Reokast, Romilast, Romlist, Sanmonte, Symkast, Xyvent, Xyzal

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Also known as: Montelukast

Description

{name} (montelukast) is a leukotriene (loo-koe-TRY-een) inhibitor. Leukotrienes are chemicals your body releases when you breathe in an allergen (such as pollen). These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms.

{name} is used to prevent asthma attacks in adults and children as young as 12 months old. {name} is also used to prevent exercise-induced bronchoconstriction (narrowing of the air passages in the lungs) in adults and children who are at least 6 years old.

{name} is also used to treat symptoms of year-round (perennial) allergies in adults and children who are at least 6 months old. It is also used to treat symptoms of seasonal allergies in adults and children who are at least 2 years old.

{name} is used for allergies, only after other treatments have failed.

If you already take {name} to prevent asthma or allergy symptoms, do not use an extra dose to treat exercise-induced bronchoconstriction.

Dosage

Usual Adult Dose of Singulair for Allergic Rhinitis:

-10 mg orally once a day Comments: -For asthma, efficacy has been demonstrated when this drug was administered in the EVENING without regard to time of food ingestion. -For allergic rhinitis, efficacy has been demonstrated for asthma when this drug was administered in the MORNING or EVENING without regard to time of food ingestion. -Patients with both asthma and allergic rhinitis should take only one dose daily in the evening. Uses: -Prophylaxis and chronic treatment of asthma -Relief of symptoms of seasonal allergic rhinitis and perennial allergic rhinitis

Usual Adult Dose of Singulair for Asthma -- Maintenance:

-10 mg orally once a day Comments: -For asthma, efficacy has been demonstrated when this drug was administered in the EVENING without regard to time of food ingestion. -For allergic rhinitis, efficacy has been demonstrated for asthma when this drug was administered in the MORNING or EVENING without regard to time of food ingestion. -Patients with both asthma and allergic rhinitis should take only one dose daily in the evening. Uses: -Prophylaxis and chronic treatment of asthma -Relief of symptoms of seasonal allergic rhinitis and perennial allergic rhinitis

Usual Adult Dose for Bronchospasm Prophylaxis:

-10 mg orally once a day at least 2 hours before exercise Comments: -An additional dose should not be taken within 24 hours of a previous dose. -Patients already taking this drug daily for another indication (including chronic asthma) should not take an additional dose to prevent EIB. -A rescue short-acting beta-agonist should be available at all times. -Daily administration for the chronic treatment of asthma has not been established to prevent acute episodes of EIB. Use: Prevention of exercise-induced bronchoconstriction (EIB)

Usual Pediatric Dose of Singulair for Asthma -- Maintenance:

Less than 12 months: Not approved. 12 to 23 months: -One sachet of 4 mg oral granules once a day 2 to 5 years: -4 mg chewable tablet or one sachet oral granules once a day 6 to 14 years: -5 mg chewable tablet orally once a day 15 years or older: -10 mg tablet orally once a day Comments: -Doses should be taken in the evening. -Efficacy has been demonstrated for asthma when this drug was administered in the evening without regard to time of food ingestion. Use: Prophylaxis and chronic treatment of asthma in pediatric patients 12 months of age and older

Usual Pediatric Dose of Singulair for Allergic Rhinitis:

Seasonal Allergic Rhinitis: Less than 2 years: Not approved. 2 to 5 years: -4 mg chewable tablet or one sachet of 4 mg oral granules once a day 6 to 14 years: -5 mg chewable tablet orally once a day 15 years or older: -10 mg tablet orally once a day Perennial Allergic Rhinitis: Less than 6 months: Not approved. 6 to 23 months: -One sachet of 4 mg oral granules once a day 2 to 5 years: -4 mg chewable tablet orally once a day 6 to 14 years: -5 mg chewable tablet orally once a day 15 years or older: -10 mg tablet orally once a day Comments: -Efficacy has been demonstrated for asthma when this drug was administered in the MORNING or EVENING without regard to time of food ingestion. -The time of administration may be individualized to suit patient needs. Uses: -Relief of symptoms of seasonal allergic rhinitis in patients 2 years of age and older -Relief of symptoms of perennial allergic rhinitis in patients 6 months of age and older

Usual Pediatric Dose for Bronchospasm Prophylaxis:

Less than 6 years: Not approved. 6 to 14 years: -5 mg chewable tablet orally once a day 15 years or older: -10 mg tablet orally once a day Comments: -Dose should be taken at least 2 hours before exercise. -An additional dose should not be taken within 24 hours of a previous dose. -Patients already taking this drug daily for another indication (including chronic asthma) should not take an additional dose to prevent EIB. -A rescue short-acting beta-agonist should be available at all times. -Daily administration for the chronic treatment of asthma has not been established to prevent acute episodes of EIB. Use: Prevention of exercise-induced bronchoconstriction (EIB) in patients 6 years of age and older

Detailed Singulair dosage information

Overdose

If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep this medicine in the original bottle. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Singulair are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid situations or activities that may trigger an asthma attack.

If your asthma symptoms get worse when you take aspirin, avoid taking aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

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Neurocognitive and clinical dysfunction in adult Chinese, nonpsychotic relatives of patients with schizophrenia: Findings from the Changsha study and evidence for schizotaxia. This study used data from a large, population-based cohort study to describe the incidence of minor surgical complications after CEA and examine associations between minor and major complications. MC3T3-E1 cells constitutively expressed type IA and type II BMP receptors. Expression studies of fusion proteins lacking the collagen and N-terminal domains produced in Escherichia coli affirmed that CL-L1 binds mannose weakly. Severe paroxysmal hypertension (pseudopheochromocytoma): understanding the cause and treatment. Nifedipine (10(-7) M), an antagonist of myocardial calcium uptake, prevented contracture and permitted nearly complete mechanical recovery without elevation in diastolic pressure. Gene expression has a stochastic component because of the single-molecule nature of the gene and the small number of copies of individual DNA-binding proteins in the cell.

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Curricular guidelines for residency training in developmental-behavioral pediatrics. There remains a debate about the definitional boundaries of hypsarrhythmia, and about the defining characteristics of NCSE. Convergence and divergence in the evolution of cat skulls: temporal and spatial patterns of morphological diversity. Application of ultrasound guidance for ilioinguinal or iliohypogastric nerve block in pediatric inguinal surgery. A significant rise in the frequency of neonatal pulmonary haemorrhage was observed in the year when intensive oxygen therapy by CPAP and IPPV ventilation was started. The aim of the present study was to review the experience of ERCP in children younger than 3 months in a national referral center. The labeled lectins showed good linearity, at least over a range of 20-1000 ng as the injected amount. Host eicosanoids have been shown to down-modulate macrophage functions. This is in part because of improved diagnostic modalities, but also changing pathology, an increased awareness of emerging comorbidities, such as childhood obesity, and other associated risk factors. Detection and treatment of depressive syndromes in a rural island clinic.

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Remote consultation for computerized tomography and magnetic resonance studies by means of teleradiology--experience at the Singapore General Hospital. Definition of ocular antigens in ciliary body and retinal ganglion cells by the marker antibody pANCA. Altogether, the results show that the HGF/MET signalling requirement for infection is mediated by its anti-apoptotic signal effects. The use of hepatitis B immunoglobulin prophylaxis with or without lamivudine has resulted in excellent survival and a low rate of graft reinfection in patients who undergo liver transplantation for decompensated HBV cirrhosis. The SENECA study, which sampled a cohort of community-dwelling persons born between 1913 and 1918 in 12 European countries in baseline (1988), follow up (1993), and final (1999) surveys, found a relatively high risk of malnutrition despite a low prevalence of actual malnourishment. Differential display polymerase chain reaction (PCR) was used to identify changes in gene expression in Arabidopsis elicited by a P6 transgene that causes a symptomatic phenotype. Implication of interfering antibody formation and apoptosis as two different mechanisms leading to variable duration of adenovirus-mediated transgene expression in immune-competent mice. Application of electrochemical breath test for detection of Helicobacter pylori in screening of Moscow students.

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Finally, in analysis 4, each region received its own set of orthotropic elastic properties. In spite of this xanax dosage orange qualified success, further analysis of both simulated and verification data is needed to establish the details of ice-age climate, especially the precipitation regimes, and to document the role of eddy fluxes in maintaining the heat, momentum, and moisture balances of the ice-age general circulation. Targeted deletion of the COUP-TFII gene results in embryonic lethality with defects in angiogenesis and heart development. These data suggest that AZ may not provide direct efficacy on the ear symptoms in OME patients with allergic rhinitis, but that there might be a possibility of its indirect efficacy in the patients in part by relieving the allergic rhinitis. High basal plasma levels of inflammatory molecules are associated with a higher risk of cardiovascular events. Self-association of Band 3, the human erythrocyte anion exchanger, in detergent solution.

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