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Sinequan

Sinequan is a tricyclic antidepressant. It is used in the treatment of insomnia (difficulty in sleeping). It is also used in patients intolerant of or unresponsive to alternative (other) treatment options for depression and anxiety disorders.

Other names for this medication:
Adapin, Doxedep, Doxepin, Doxure, Neuro, Noctaderm, Silenor, Spectra

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Also known as: Doxepin

Description

Doxepin is used to treat anxiety or depression. It is also used to treat insomnia (trouble with sleeping).

Doxepin is a tricyclic antidepressant (TCA). It works on the central nervous system (CNS) to increase levels of certain chemicals in the brain.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain doxepin. It may not be specific to Sinequan. Please read with care.

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

If you are using the Sinequan® oral liquid or capsule once a day, you may take it at bedtime.

To use the Sinequan® oral liquid:

Measure the dose with the calibrated dropper that comes with the medicine. Mix each dose with about one-half glass (4 ounces) of water, whole or skimmed milk, orange juice, grapefruit juice, tomato juice, prune juice, or pineapple juice. Do not mix this medicine with grape juice or carbonated beverages (soda pop). Mix the medicine just before taking the dose. Do not prepare it ahead of time.

To use the Silenor® tablet:

Do not take this medicine within 3 hours of a meal. It may not work as well, or it might make you sleepy the next day if you take it with or right after a meal. Take the tablet 30 minutes before going to bed, when you are ready to go to sleep. Do not take the medicine unless you can get a full night's sleep (7 to 8 hours). If you wake up too soon, you may feel drowsy from the medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules or solution): For depression or anxiety: Adults and children 12 years of age and older—At first, 75 milligrams (mg) once a day or in divided doses during the day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 150 mg per day. Children younger than 12 years of age—Use is not recommended. For oral dosage form (tablets): For insomnia: Adults—6 milligrams (mg) once a day. Older adults—At first, 3 mg once a day. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Sinequan and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Sinequan dosage information

Side effects

The most common side effects associated with Sinequan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Sinequan if you are allergic to Generic Sinequan components. Be careful with Generic Sinequan if you are pregnant, planning to become pregnant, or are breast-feeding. Do not take Generic Sinequan if you take clonidine, an H1 antagonist (eg, astemizole, terfenadine), or ibutilide, or you have taken a monoamine oxidase inhibitor (MAOI) (eg, furazolidone, phenelzine, isocarboxazid) within the past 14 days. Do not take Generic Sinequan if you have certain prostate problems (eg, asymptomatic prostatic hypertrophy), glaucoma, or trouble urinating. Be careful with Generic Sinequan if you have a history of heart problems, seizures (eg, epilepsy), overactive thyroid, prostate problems (eg, benign prostatic hypertrophy [BPH]), blood problems (eg, porphyria), other mental or mood problems, suicidal thoughts or attempts, or alcohol abuse. Be careful with Generic Sinequan if you take antiarrhythmics (eg, quinidine, propafenone, flecainide), antifungal medicines (eg, fluconazole, terbinafine), carbamazepine, cimetidine, mibefradil, phenothiazines (eg, chlorpromazine, thioridazine), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, sertraline) because they may increase the risk of Generic Sinequan 's side effects; anticoagulants (eg, warfarin), H1 antagonists (eg, astemizole, terfenadine), ibutilide, sulfonylureas (eg, tolazamide, glipizide), sympathomimetics (eg, phenylephrine, pseudoephedrine), or tramadol because the risk of their side effects may be increased by Generic Sinequan; clonidine, guanadrel, guanethidine, or guanfacine because their effectiveness may be decreased by Generic Sinequan; MAOIs (eg, furazolidone, phenelzine, isocarboxazid) because severe toxic effects may occur. Avoid alcohol. Be careful when you are driving or operating machinery. It can be dangerous to stop Generic Sinequan taking suddenly.

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To explore the involvement of mental health service users in the redesign of in-patient mental health services in six Trusts participating in a multi-regional NHS modernization programme. FSH first binds to the high-affinity hormone-binding subdomain of FSHR and reshapes the ligand conformation to form a sTyr-binding pocket. Revealing the glycation sites in synthetic neoglycoconjugates formed by conjugation of the antigenic monosaccharide hapten of Vibrio cholerae O1, serotype Ogawa with the BSA protein carrier using LC-ESI-QqTOF-MS/MS. One group was perfused with epirubicin 5 mg while another embolized with lipidol and polyvinyl (PVA). Eleven patients presenting with rhegmatogenous retinal detachments with causative inferior retinal breaks. Prevention of experimental atherosclerosis with pyridinolcarbamate. All responses are blocked by an inhibitor of arachidonic acid (AA) release, 4-bromophenacylbromide, and by inhibitors of lipoxygenases (nordihydroguaiaretic acid and AA-861) but not by indomethacin, a cyclooxygenase inhibitor. The tertiary structure of human I-FABP was calculated by using the distance geometry program DIANA based on 2519 distance constraints obtained from the NMR data. Cancer pain in the opioid-addicted patient: can we treat it right?.

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Photohemolysis sensitized by the furocoumarin imperatorin and its oxyfunctionalized derivatives. Tracheoesophageal puncture using a flexible gastroscope and a percutaneous endoscopic gastrostomy set. New approaches for optimizing transplant of sensitized patients. Chemotherapy patients were more likely to show cognitive decline than controls (OR 2.25). Use of statistics when examining lifetime studies in rodents to detect carcinogenicity. A study on the morphological characters of immortalized mandibular condylar chondrocyte. MxA appears to be a valuable parameter to demonstrate IFN-type I expression in imiquimod therapy.

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Sustained silver-releasing dressing in the treatment of diabetic foot ulcers. Coliphages do not yet fulfill enough of the criteria to be routinely employed. Tremor and other movement disorders after whiplash type injuries. Thin-layer chromatography assay of the branched-chain 2-oxo-acid dehydrogenase complex(es). Mortality due to neoplasms and violent causes in the first 15 years of life from 1958 through 1964 in Italy.

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The CD20 homolog Ms4a8a integrates pro- and anti-inflammatory signals in novel M2-like macrophages and is expressed in parasite infection. A mechanism-based fluorescence transfer assay for examining ketosynthase selectivity. Artery calcification occurring in atherosclerosis is connected with a high risk of cardiovascular events. Human combinatorial phage display antibody library consisting of 5.0 x 10(8) CFU was constructed. Patient satisfaction questionnaires may work as aid in detecting health care problems. Consumption of vegetables, fruits, and several micronutrients may inhibit precancerous lesions of the oral cavity.

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The burden of PI disease was low, but higher in ICUs with a high proportion of severe cases needing ventilation and ECMO treatment. Absence of antibody response to polysaccharide antigens may be a universal finding in patients with CVID, whereas preservation of T cell-dependent protein antibody response may be seen. In this article, we review current data on the prevalence of, risk factors for, and treatment of peripartum depression. Bipolar recording of potentials generated by excitable fibres in a volume conductor. Experience with 4 F catheters in cardiac catheterization is limited. Although the result that light shifted the peak of the agitated behavior might be generalizable to patients with milder forms of AD, the fact that agitation was not ameliorated might not be.

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Comparison of freeze-dried vaccines prepared from four different strains of BCG. As compared to hOSM, however, a 1000-fold higher concentrations of mOSM was required to stimulate proliferation of LIF-dependent murine DA1a cells, differentiation of M1 macrophage cells, and inhibition of ES cell differentiation. The secretion of lung lecithin to the surfactant fraction also appeared to be normal. Study 2 participants were 132 children and adolescents aged 7 to 18 years who met diagnostic criteria for an anxiety disorder, plus one or more of their parents. The corresponding treatment to various groups started from the 1st day after modeling. Malpighian epithelioma of the uterine cervix with early metastasis. Ventilation was assessed with the Oxylator ventilator, as well as the consecutive self-contained underwater breathing apparatus (SCUBA) regulators using an anaesthetic test lung: Poseidon Cyklon 5000, Poseidon XStream, Apeks TX 100, Spiro Arctic, Scubapro Air2 and Buddy AutoAir. melanogaster region containing a cluster of UBX sites that can also function as a repressor element. It was possible to conclude that light-cure MTA was similar to MTA at 60 days, but it did not stimulate mineralization. Bobath or orthopaedic treatment paired with spontaneous recovery resulted in improvements in impairment and functional levels for patient with stroke.

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To demonstrate the efficacy, safety, and appropriate mode of instillation of talc for sclerosis in treatment of malignant pleural effusions (MPEs). Functions of dietitians providing nutrition support to patients with inherited metabolic disorders. Both R and K judgments for studied words were associated with enhanced responses in left prefrontal and left parietal cortices relative to N judgments for unstudied words. The data obtained contribute to better understanding of cholelithiasis and planning of relevant preventive measures. No difference in assays sensitive to potential psychotic or anxiety states was observed between the 5-HT7 receptor knockout mice and wild type controls. Urodynamically controlled management of spinal cord injury in children. Experimental evidence suggests that tissue uptake and the elimination of thiamine are dose-dependent. We reviewed hospital records of infants admitted to the pediatric cardiac intensive care unit in our institution from January 1996 through April 1997.

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Fungi and aflatoxins associated with spices in the Sultanate of Oman. fastidiosa probably originated by LGT at a relatively recent time. Laparoscopic correction of laparoscopic fundoplication failures: 4 cases. Twelve single-nucleotide polymorphisms (SNPs) were genotyped in the Hong Kong cohort using TaqMan genotyping assay. In both cases the foreign body was a seed of a small Japanese apricot. We suggest that children who have a sibling with germ cell tumour should be carefully assessed for development of another germ cell tumour. A deletion of the homologous operon in Mycobacterium smegmatis is more susceptible to ethidium bromide, and drug zithromax antibiotic generic name resistance is restored by the intact operon from M. Two-dimensional proton chemical-shift imaging of human muscle metabolites.

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Condurango determination in condurango cortex and its preparations. Based on tissue culture studies, the mediator of apoptosis Bcl-2 has been suggested as a target of Brn3a regulation which could affect sensory viability in these mice. This article presents two different options that allow for successful and predictable reestablishing of anatomically correct contours and optimal proximal contacts in posterior teeth with proximal concavities. Four well-known cytoxan oral dosing effects of histamine have been considered (the contractions of an isolated guinea pig terminal ileum, dog gastric acid secretion, contractile frequency of an isolated guinea pig right atrium, blood pressure lowering effect in cats). Influence of percutaneous transluminal angioplasty on transcutaneous oxygen pressure in patients with peripheral arterial occlusive disease. In vitro, the anti-HLA antibodies were mitogenic to SMC and we showed that they activate a stress-induced signaling pathway implicating matrix metalloproteinases (MMP) and neutral sphingomyelinase 2 (nSMase-2). Due to the rural localisation, 6 of the 16 Furano cases were confirmed by biopsies, but the remaining 10 were carefully diagnosed with clinical and laboratory findings as they could not come up to general hospitals. These data suggest that speech and language deficits may be an important and under-recognized sequela of severe falciparum malaria. Thirty-one patients were treated with adjuvant radiation therapy to the vulva and 31 patients were observed after surgery.

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Maternofetal parvovirus B19 infection may result in fetal hydrops or abortion. We conclude that the level of neutrophil elastase in BAL fluid can be used to differentiate asymptomatic cigarette smokers who are at risk for pulmonary emphysema from those who are not. Changes in the extracellular concentration of inorganic phosphate (Pi) modulate cellular function in a physiologically relevant manner. Synthesis and pharmacological activities of C-terminal gastrin tetrapeptide analogues. Whereas any contribution of endothelial dysfunction or the geometric effect may be minimal. The cell-bound enzyme responsible for the synthesis was extracted by suspension of mycelia with 0.1 M phosphate buffer (pH 8.0), and the extract was purified. In the present paper a new methodological setup to objectify the parameters adhesiveness and adhesive strengths of Transdermal Delivery Systems is presented.

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C pneumoniae infection stimulated increased binding of nuclear proteins to the consensus DNA sequence for Egr-1, a key response element within the TF promoter, and increased the expression of Egr-1 protein. Prepared from certified water-soluble dyes and employed in color-coating tablets. More studies are necessary to evaluate the effectiveness of albendazole in the treatment of diffuse unilateral subacute neuroretinitis. Protocol biopsy-based studies have demonstrated a high and early prevalence of CAN lesions during the first year in patients with normal and stable renal function. The resonances are obtained for compression wavelengths much longer than the cavity size and thus have a low-frequency character. Additional dorsoventral asymmetry appears during retinal differentiation: the morphogenetic furrow (MF) initiates normally at the posterior tip of the disc, but fails to propagate into the ventral epithelium. Hypothalamic temperature during sleep is lower by approximately 0.5 degrees C and is characterized by widely varying, slow-frequency oscillations, compared to the higher, more precisely controlled temperature seen when the animal is awake. Recent advances in computer hardware and software technology have improved voice recognition systems used for radiology reporting. Dental implant failure rates for osseointegration are greater in the highly atro-phic maxilla. We assessed clinical implications of IKKalpha expression in oral carcinomas and epigenetic aberrations for the loss of expression.

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Skin tolerance and adherence of the transdermal system were evaluated at weeks 6 and 12 by qualified evaluators. These data provide evidence that the families described here represent a syndrome of familial CRC that is distinct from HNPCC. These data support the hypothesis that mGluR4a serves as a presynaptic heteroreceptor in the globus pallidus, where it may play an important role in regulating g-amino-n-butyric acid (GABA) release from striatopallidal terminals. We found increased levels of mRNA in both lungs of High-PEEP zyvox iv antibiotic cost rabbits (compared with both the Low-PEEP and untreated groups) for alpha1(III) and alpha2(IV) procollagen, fibronectin, basic fibroblast growth factor, and transforming growth factor-beta1. In contrast, pilocarpine, a muscarinic agonist, stimulated catecholamines more than cortisol. Two patients with erotomania and the results of their neuropsychologic testing were examined, and neurologic studies also were examined for one of the patients. Diabetic versus nondiabetic limb-threatening ischemia: outcome of percutaneous iliac intervention. We suggest that several uncharacterized glutaredoxin-like proteins present in the genomes of organisms lacking GSH, including archae, will also react with thioredoxin reductase and be related to the ancestors from which the GSH-dependent glutaredoxins have evolved by the acquisition of a GSH-binding site. A weak pulsed magnetic field affects adenine nucleotide oscillations, and related parameters in aggregating Dictyostelium discoideum amoebae. However, there continue to be deficiencies in the delivery of preventive care, and it is sometimes difficult to identify which interventions are effective--for lack of randomized clinical trials--and the theoretical basis of this approach is not always clear.

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Induction of fatty acid synthesis by pravastatin sodium in rat liver and primary hepatocytes. Magnetic resonance imaging of radiation-induced brain injury using targeted microparticles of iron oxide. The Authors conclude that groin hernia may be treated in a outpatient or day surgery regimen saving money. Closer proximity of mammary fat involved intensified biosynthesis of estrogens (as shown by aromatase level) and their conversion to catechol derivatives (as shown by CYP1B1 concentration) as well as accumulation of 8-OH-dG. Hyperoxia caused substantial photoreceptor death in both the C57BL/6-c2J and C57BL/6J strains. The correct insertion of the prosthesis as well as of the tubal patency may be controlled by instillation of a methylen blue solution. Large ensembles of consistent loop conformations, represented at atomic detail with idealized geometry, were generated for a large test set of protein loops of 2 to 12 residues long by a novel ab initio method called RAPPER that relies on fine-grained residue-specific phi/psi propensity tables for conformational sampling. In addition, we evaluated the effects of replacing carbamazepine by oxcarbazepine on these parameters, erythrocyte folate concentrations and serum vitamin B12 levels in 12 male patients with epilepsy.

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