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Prograf (Tacrolimus)
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Prograf

Prograf belongs to a class of drugs known as topical calcineurin inhibitors (TCIs). This drug works by weakening the skin's defense (immune) system, thereby decreasing the allergic reaction and relieving the eczema.

Other names for this medication:
Acroli, Crolim, Cromus, Mustopic, Olmis, Pangraf, Protopic, Seegraf, Tacloran, Tacrel, Tacrim, Tacroderm, Tacrograf, Tacrokid, Tacrolimus, Tacromus, Tacrotor, Tacrovate, Tacroz, Tacstead, Talimus, Tarcel, Techlomus, Topgraf, Triplibact, Vingraf

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Also known as: Tacrolimus

Description

Tacrolimus injection is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Tacrolimus works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ.

Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is to be given only by or under the direct supervision of a doctor.

Dosage

Take Prograf exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

You may receive an injection of Prograf shortly after your transplant. The injection is given until you are ready to take the pill form of tacrolimus.

Take Prograf at the same time each day, with a full glass of water.

Swallow the capsule whole and do not crush, chew, break, or open it.

Mix Prograf oral granules with water right before you take them. Do not save this mixture for later use. Do not get the powder or mixture on your skin or in your eyes. If this happens, wash your skin with soap and water or rinse your eyes with water.

You may take Prograf with or without food, but take it the same way each time.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. All forms of tacrolimus are not equivalent and may not have the same dose or schedule. Avoid medication errors by using only the form and strength your doctor prescribes.

You will need frequent medical tests, and your blood pressure will need to be checked often.

Store at room temperature away from moisture and heat.

Detailed Prograf dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Prograf are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of tacrolimus injection in children with liver, kidney, or heart transplants.

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Furthermore, male patients and patients with concomitant hypertension were more likely to receive a higher dose of ACE inhibitor. The interaction of bradykinin and cholecystokinin preparations was investigated on the guinea-pig isolated gall bladder. Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion. During preincubation monocyte could affect lymphocytes susceptibility to apoptosis as an increase of number of apoptotic cells was observed after 72 hours in stimulated and resting cells. In addition, PLC-HDPs harbor a conserved active nuclear import signal that could also function as a protein transduction domain. The TNFR-KO mice had significantly less baseline sleep than the controls. The complexity of BCR signaling reactions may be required to allow the B cell to respond in a number of distinct ways to antigen (proliferation, survival, apoptosis, maturational arrest, etc.) depending on the maturation state of the B cell, the location in the body, the physical nature of the antigen, and the possible presence of the antigen in complex with antibody or complement components. In wild-type mice, blockade of PR induces a behavioral phenotype similar to that of the PRKO males, whereas progesterone exacerbates aggressive tendencies toward infants. This removes the need to invoke diploidy to explain assortment, thus resolving the question of subunit ploidy in favor of haploidy.

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PaCO2 and PtCO2 are similarly influenced by the changes in alveolar ventilation. In the present study, we have developed a method for assaying the binding reaction between fluorescent lectin and cells using a flow injection technique, which allows estimation of the amount of lectin bound to cells. The results suggest that national multidisciplinary summer surveillance program in the Aquitaine coast is required in order to provide alerts to the public, to better identify patients at risk for developing severe clinical symptoms, and hopefully to improve quality of health care. Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells. Real time near infrared spectroscopy was adopted to study the degree of vinyl double bond conversion and the photopolymerization rate. The polymorphism of a variable number tandem repeat (VNTR) region of the serotonin transporter gene consists of three alleles containing, respectively, 9 (STin2.9), 10 (STin2.10) and 12 (STin2.12) copies of a repetitive element. The presence of this isoenzyme cannot be used as a marker of neoplastic transformation. Testing the usefulness of the molecular coancestry information to assess genetic relationships in livestock using a set of Spanish sheep breeds. The benefit of screening for prostate cancer using prostate-specific antigen (PSA) testing and digital rectal examination (DRE) is uncertain and is under evaluation in a randomized prospective trial, the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Sequence analysis of genome segments S5 and S10 of Mal de Rio Cuarto virus (Fijivirus, Reoviridae).

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Indomethacin-associated bowel perforations: a study of possible risk factors. Determining the relationship between invasive and noninvasive blood pressure values. The occurrence of major complications does not predict a decreased quality of life. These findings suggest that the presence of functionally segregated thalamocortical projections is a conserved feature of brain organization among amniotes. All VRE strains were found to brand and generic name of lopressor be positive for the vanA genotype using the EVIGENE VRE Detection kit. The majority of the contaminants were identified as Staphylococcus epidermidis. These surgical procedures were performed to treat carcinoma of the prostate, breast, colon, stomach, and uterine cervix, respectively.

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Formation and characterization of phospholipid monolayers spontaneously assembled at interfaces between aqueous phases and thermotropic liquid crystals. Adhesion of acinetobacter venetianus to diesel fuel droplets studied with In situ electrochemical and molecular probes. A correlation between the histologic picture of lymphocyte infiltration of the tumor stroma, the presence of such a reaction, and a discussion of the significance of this phenomenon. Twenty-nine 2-year-old red deer (Cervus elaphus) stags weighing 106-131 kg each were used in this study. The catheter what are the side effects of prilosec 40 mg has two balloons to occlude the esophagus proximal and distal to the fistula. The entity was distinguished from teratoma by the presence of vertebral axis with limb buds. Interestingly, neutralization of TRAIL receptor 2 (TRAIL-R2), but not TRAIL-R1, impaired apoptosis in a caspase-10-dependent manner, indicating that caspase-10 enhances TRAIL-R2-induced cell death. Ninety sera from patients presenting with ectopic pregnancies, 187 sera from those with a variety of types of infertility, 33 sera from cases of PID where a fourfold rise in WIF titre occurred, and 90 sera from antenatal clinic attenders were tested.

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Minimum phototoxic dose reading at 72 hours underestimates the phototoxic effect of topical methoxsalen PUVA, and a change in the MPD assessment time should be considered. The authors present a series of 12 free-tissue transfers used in 11 patients to close large sternal defects in this subset of patients. In this study we investigated the regulation by IL-4 of IL-12 and IL-10 production. In this study, we have demonstrated that combining phthalimide pharmacophore with GABA has evolved compounds effective for the treatment of neuropathic pain. Fused tumor vaccine of UMR-106 cells and allogeneic DCs might induce specific anti-tumor effects on osteosarcoma. The fed-batch operation did does motrin help with sinus infection not improve the results obtained with batch operation.

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Reading impairment in the neuronal migration disorder of periventricular nodular heterotopia. In congenital obstructed hydronephrosis, the assessment of the differential renal function (DRF) is essential to provide a prognosis or to determine surgical treatment. Manometric diagnoses of conditions other than normal or achalasia are variable and have poor interobserver variability. It inhibits Kasumi-1 cells proliferation degradation of AML1-ETO protein expression, blocks the cells at G(0)/G(1) phase, and induces apoptosis and differentiation of the cells. Maximizing use of a surgical clinic for referrals of patients having back problems. The contribution of inflammatory mediators and nitric oxide to lipopolysaccharide-induced intussusception in mice. Each differentiating agent was active only at concentrations that inhibited cell cycling, suggesting that this property is also required for differentiation. Our objective was to determine the occurrence of different symptoms, signs and the recovery of symptoms during the course of acute bullous myringitis in children less than 2 years.

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Pathology and neurophysiology analysis for peripheral neuropathy of four patients with chemicals poisoning. As determined by immunoblotting and enzyme-linked immunosorbent assay, VEGF protein expression and secretion were similarly increased. Experimental Rat model for Corynebacterium renale-induced pyelonephritis. With this aim, 28 patients with suspected abdominal inflammatory mass were examined with power Doppler ultrasound before and after intravenous administration of the ultrasound contrast agent Levovist, with evaluation of vascularity within and/or around the inflammatory mass. These experiments suggest that some of the changes in sleep patterns which are observed under conditions simulating weightlessness may be adaptive. Inclusion of P32 in the internal organs during the effect of uninterrupted noise of low intensity.

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The role of either catecholamine in mediating the bronchomotor response to tyramine could not be ascertained.3. Forty-one highly probable patients with TBM whose ages ranged between 8 and 64 years and 14 of whom were females were included in this study. We identified and reviewed the imaging studies of patients who had increased FDG uptake on PET scans and whose CT scans showed no corresponding abnormalities suggestive of malignancy. Only one case was diagnosed on computed tomography performed for assessment of lumbar contusion. Prediction of posttraumatic adult respiratory distress syndrome by albumin excretion rate eight hours after admission. Transient and widespread astroglial activation in the brain after a i accidentally took 2 180 mg allegra striatal 6-OHDA-induced partial lesion of the nigrostriatal system. The ionization constants of N-methyl-N-(beta-aminoethyl) piperidine salts variously substitued to tertiary nitrogen.

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Crystal structure of Trematomus newnesi haemoglobin re-opens the root effect question. A crystal structure of I-AniI, a dual function intron-encoded protein, has shown that the protein has two pseudo-symmetric domains of equal size. Micro- and macroscale electrophoretic study of the constituent proteins of cerebral structures. Correcting for electron contamination at dose maximum in photon beams. The increases or decreases of EBA and DCF titers in other clinically ill birds that were treated with tetracycline varied, as normally occurs in cases of avian chlamydiosis. How the new PhRMA code on permissible pharmaceutical marketing practices affects your organization. After resection of the tumour the specimen was examined to identify blue-stained lymph nodes.

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