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Mysoline

Mysoline is a barbiturate. It controls seizures or fits by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.

Other names for this medication:
Primidone

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Also known as: Primidone

Description

{name} is an anticonvulsant medicine that is used to control seizures.

Dosage

This section provides information on the proper use of a number of products that contain barbiturate. It may not be specific to Mysoline. Please read with care.

For patients taking the extended-release capsule or tablet form of this medicine:

These capsules or tablets are to be swallowed whole. Do not break, crush, or chew before swallowing.

For patients using the rectal suppository form of this medicine:

To insert the suppository: First remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum. Wash your hands with soap and water.

Use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. If too much is used, it may become habit-forming (causing mental or physical dependence).

If you think this medicine is not working properly after you have taken it for a few weeks, do not increase the dose. To do so may increase the chance of your becoming dependent on the medicine. Instead, check with your doctor.

If you are taking this medicine for epilepsy, it must be taken every day in regularly spaced doses as ordered by your doctor in order for it to control your seizures. This is necessary to keep a constant amount of medicine in the blood. To help keep the amount constant, do not miss any doses.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For amobarbital For oral dosage form (tablets or capsules): For trouble in sleeping: Adults—65 to 200 milligrams (mg) at bedtime. Children—Dose must be determined by your doctor. For daytime sedation: Adults—50 to 300 mg, taken in smaller doses during the day. Children—Dose is based on body weight or size and must be determined by your doctor. The usual dose is 2 mg per kilogram (kg) (0.9 mg per pound) of body weight taken three times a day. For sedation before surgery: Adults—200 mg taken one to two hours before surgery. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 2 to 6 mg per kg (0.9 to 2.7 mg per pound) of body weight, taken before surgery. However, the dose is usually not more than 100 mg. For sedation during labor: Adults—200 to 400 mg every one to three hours if needed. However, the total dose is usually not more than 1000 mg. For injection dosage form: For trouble in sleeping: Adults—65 to 200 mg, injected into a muscle or vein. Children up to 6 years of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 2 to 3 mg per kg (0.9 to 1.4 mg per pound) of body weight, injected into a muscle. Children 6 years of age and over—Dose is based on body weight and must be determined by your doctor. The usual dose is 2 to 3 mg per kg (0.9 to 1.4 mg per pound) of body weight, injected into a muscle, or 65 to 500 mg injected into a vein. For daytime sedation: Adults—30 to 50 mg two or three times a day, injected into a muscle or vein For sedation before surgery: Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 3 to 5 mg per kg (1.4 to 2.3 mg per pound) of body weight or 65 to 500 mg per dose, injected into a vein. For control of seizures: Adults and children 6 years of age and over—65 to 500 mg per dose, injected into a vein. Children up to 6 years of age—Dose is based on body weight or size and must be determined by your doctor. The usual dose is 3 to 5 mg per kg (1.4 to 2.3 mg per pound) of body weight, injected into a muscle or vein.

For aprobarbital For oral dosage form (elixir): For trouble in sleeping: Adults—40 to 160 milligrams (mg) at bedtime. Children—Dose must be determined by your doctor. For daytime sedation: Adults—40 mg three times a day. Children—Dose must be determined by your doctor.

For butabarbital For oral dosage forms (elixir or tablets): For trouble in sleeping: Adults—50 to 100 milligrams (mg) at bedtime. Children—Dose must be determined by your doctor. For daytime sedation: Adults—15 to 30 mg three or four times a day. Children—Dose is based on body weight or size and must be determined by your doctor. The usual dose is 2 mg per kilogram (kg) (0.9 mg per pound) of body weight three times a day. For sedation before surgery: Adults—50 to 100 mg sixty to ninety minutes before surgery. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 2 to 6 mg per kg (0.9 to 2.7 mg per pound) of body weight. However, the dose is usually not more than 100 mg.

For mephobarbital For oral dosage form (tablets): For daytime sedation: Adults—32 to 100 milligrams (mg) three or four times a day. Children—16 to 32 mg three or four times a day. For control of seizures: Adults—200 to 600 mg a day, taken in smaller doses during the day. Children 5 years of age and over—32 to 64 mg three or four times a day. Children up to 5 years of age—16 to 32 mg three or four times a day.

For metharbital For oral dosage form (tablets): For control of seizures: Adults—At first, 100 milligrams (mg) one to three times a day. Your doctor may increase your dose if needed. However, the dose is usually not more than 800 mg a day. Children—50 mg one to three times a day.

For pentobarbital For oral dosage forms (elixir or capsules): For trouble in sleeping: Adults—100 milligrams (mg) at bedtime. Children—Dose must be determined by your doctor. For daytime sedation: Adults—20 mg three or four times a day. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 2 to 6 mg per kilogram (kg) (0.9 to 2.7 mg per pound) of body weight per day. For sedation before surgery: Adults—100 mg before surgery. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 2 to 6 mg per kilogram (0.9 to 2.7 mg per pound) of body weight, taken before surgery. However, the dose is usually not more than 100 mg. For injection dosage form: For trouble in sleeping: Adults—150 to 200 mg, injected into a muscle. Or, 100 mg injected into a vein, with additional small doses given if needed. However, the dose is usually not more than 500 mg. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 2 to 6 mg per kg (0.9 to 2.7 mg per pound) of body weight, injected into a muscle. Or, 50 mg injected into a vein, with additional small doses given if needed. For sedation before surgery: Adults—150 to 200 mg, injected into a muscle. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 2 to 6 mg per kg (0.9 to 2.7 mg per pound) of body weight, injected into a muscle. However, the dose is usually not more than 100 mg. For control of seizures: Adults—At first, 100 mg injected into a vein. Additional small doses may be given if needed. However, the dose is usually not more than 500 mg. Children—At first, 50 mg injected into a muscle or vein. Additional small doses may be given if needed. For rectal dosage form (suppositories): For trouble in sleeping: Adults—120 to 200 mg inserted into the rectum at bedtime. Children 12 to 14 years of age—60 or 120 mg inserted into the rectum at bedtime. Children 5 to 12 years of age—60 mg inserted into the rectum at bedtime. Children 1 to 4 years of age—30 or 60 mg inserted into the rectum at bedtime. Children 2 months to 1 year of age—30 mg inserted into the rectum at bedtime. Children up to 2 months of age—Dose must be determined by your doctor. For daytime sedation: Adults—30 mg inserted into the rectum two to four times a day. Children—Dose is based on body weight or size and must be determined by your doctor. The usual dose is 2 mg per kg (0.9 mg per pound) of body weight, inserted into the rectum three times a day. For sedation before surgery: Children 12 to 14 years of age—60 or 120 mg inserted into the rectum. Children 5 to 12 years of age—60 mg inserted into the rectum. Children 1 to 4 years of age—30 or 60 mg inserted into the rectum. Children 2 months to 1 year of age—30 mg inserted into the rectum. Children up to 2 months of age—Dose must be determined by your doctor.

For phenobarbital For oral dosage forms (elixir, capsules, or tablets): For trouble in sleeping: Adults—100 to 320 milligrams (mg) at bedtime. Children—Dose must be determined by your doctor. For daytime sedation: Adults—30 to 120 mg a day, taken in smaller doses two or three times during the day. Children—Dose is based on body weight or size and must be determined by your doctor. The usual dose is 2 mg per kilogram (kg) (0.9 mg per pound) of body weight three times a day. For sedation before surgery: Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 3 mg per kg (0.45 to 1.4 mg per pound) of body weight. For control of seizures: Adults—60 to 250 mg a day. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 6 mg per kg (0.45 to 2.7 mg per pound) of body weight a day. For injection dosage form: For trouble in sleeping: Adults—100 to 325 mg, injected into a muscle or vein, or under the skin. Children—Dose must be determined by your doctor. For daytime sedation: Adults—30 to 120 mg a day, injected into a muscle or a vein, or under the skin, in smaller doses two or three times during the day. Children—Dose must be determined by your doctor. For sedation before surgery: Adults—130 to 200 mg, injected into a muscle sixty to ninety minutes before surgery. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 3 mg per kg (0.45 to 1.4 mg per pound) of body weight, injected into a muscle or vein sixty to ninety minutes before surgery. For control of seizures: Adults—100 to 320 mg injected into a vein. The dose may be repeated if needed, but is usually not more than 600 mg a day. However, higher doses may be needed for certain types of continuing seizures. Children—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 10 to 20 mg per kg (4.5 to 9 mg per pound) of body weight, injected into a vein. Later, 1 to 6 mg per kg (0.45 to 2.7 mg per pound) of body weight a day, injected into a vein. Higher doses may be needed for certain types of continuing seizures.

For secobarbital For oral dosage form (capsules): For trouble in sleeping: Adults—100 milligrams (mg) at bedtime. Children—Dose must be determined by your doctor. For daytime sedation: Adults—30 to 50 mg three or four times a day. Children—Dose is based on body weight or size and must be determined by your doctor. The usual dose is 2 mg per kilogram (kg) (0.9 mg per pound) of body weight three times a day. For sedation before surgery: Adults—200 to 300 mg one or two hours before surgery. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 2 to 6 mg per kg (0.9 to 2.7 mg per pound) of body weight one or two hours before surgery. However, the dose is usually not more than 100 mg. For injection dosage form: For trouble in sleeping: Adults—100 to 200 mg injected into a muscle, or 50 to 250 mg injected into a vein. Children—Dose is based on body weight or size and must be determined by your doctor. The usual dose is 3 to 5 mg per kg (1.4 to 2.3 mg per pound) of body weight, injected into a muscle. However, the dose is usually not more than 100 mg. For sedation before dental procedures: Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 1.1 to 2.2 mg per kg (0.5 to 1 mg per pound) of body weight, injected into a muscle ten to fifteen minutes before the procedure. Children—Dose must be determined by your dentist. For sedation before a nerve block: Adults—100 to 150 mg, injected into a vein. For sedation before surgery: Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 4 to 5 mg per kg (1.8 to 2.3 mg per pound) of body weight, injected into a muscle. For seizures from tetanus: Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 5.5 mg per kg (2.5 mg per pound) of body weight, injected into a muscle or vein. Dose may be repeated every three to four hours if needed. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 3 to 5 mg per kg (1.4 to 2.3 mg per pound) of body weight, injected into a muscle or vein.

For secobarbital and amobarbital combination For oral dosage form (capsules): For trouble in sleeping: Adults—1 capsule at bedtime. Children—Dose must be determined by your doctor. For sedation before surgery: Adults—1 capsule taken one hour before surgery. Children—Dose must be determined by your doctor.

Overdose

If you overdose Generic Mysoline and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Mysoline overdosage: uncontrolled eye movement, troublesome breathing, and confusion.

Storage

Store at room temperature, approximately 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Mysoline are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Mysoline if you are allergic to Mysoline or phenobarbital, or if you have:

porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Tell your doctor if you have ever had:

depression; a mood disorder; or suicidal thoughts or actions.

Some people have thoughts about suicide while taking Mysoline. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of primidone on the baby. Be sure to tell the doctor who delivers your baby about your Mysoline use. Both you and the baby may need to receive medications to prevent excessive bleeding during delivery and just after birth.

Stop breast-feeding if you notice unusual drowsiness in the nursing baby. Talk with your doctor about how best to feed your baby while taking Mysoline.

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An expeditious synthetic route to a carboranyl-substituted tetrabenzoporphyrin is reported. To investigate the intraobserver and interobserver variability of computed tomography-based volume measurements of nasopharyngeal carcinoma. This information is important for furthering our understanding of the burden of sport and active recreation injury and setting priorities for treatment and rehabilitation. Control of varicella-zoster infection on renal and other specialist units. Situation after 7 years of 43 children and adolescents hospitalized for mental disorders in 1969. Laboratory and field evaluation of biodegradable polyesters for sustained release of isometamidium and ethidium. Ultrasonographic imaging, cystoscopy, and biopsy should be considered to allow observation and follow-up of leiomyomas. An increased left ventricular stiffness during exercise is an early manifestation of hypertensive heart disease. MR cholangiography in children and young adults with biliary disease. Similarly, placing a gap between the short helix formed by loop-loop pairing and the adjacent acceptor stems also diminished complex formation.

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The recognition and management of cardiac and circulatory emergencies during anesthesia. Its half-time was 1.58 min which is practically identical to the fast phase of calcium influx previously found to be 1.54 min. The authors describe a case of complex regional pain syndrome type 1, emphasising the rarity of this clinical situation in association with a Parkinsonian Syndrome. Here we examine the antiretroviral activity of TRIM5alpha orthologs from humans, apes, Old World monkeys, and New World monkeys. The data reveal significant deficits in the primary care treatment of postmenopausal osteoporosis. We are continually expanding our knowledge of JCA and establishing our understanding on an ever-increasing knowledge base encompassing immunology, immunogenetics, physiology, psychology and sociology. Template-assembled triple-helical peptide molecules: mimicry of collagen by molecular architecture and integrin what does allopurinol 100 mg look like -specific cell adhesion. International Conference on Medico-Ecological Problems of Reproductive Health of Workers (Moscow, December 9-10, 1998). The two minor clades contain the sterol and lipid glycosyltransferases and each show more homology to non-plant sequences.

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Telomerase activity was detected in the pure pancreatic juice of the patient, who was diagnosed with a malignant IPMT. Mixed infections in children with Mycoplasma pneumoniae pneumonia. Recently, valve upgrade and/or endoscopic third ventriculostomy, which have the merit of no additional shunting, were introduced for the treatment of slit ventricle syndrome, because lumboperitoneal shunting entails various complications including development of Chiari malformation, shunt malfunction, and infection. Here it is shown that the endogenous VHL complex in rat liver also includes Rbx1, an evolutionarily conserved protein that contains a RING-H2 fingerlike motif and that interacts with Cullins. Fourteen patients received cisplatin, 5-fluorouracil, folinic acid, and mitomycin C with the protocol unchanged, and oral etoposide 50 mg on Days 1-21 without growth factors (1 cycle every 28 days can i drink alcohol and take lipitor ). Living organisms have regular patterns and routines that involve obtaining food and carrying out life history stages such as breeding, migrating, molting, and hibernating.

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The hypothesis that BDV is associated with human illness is controversial. The causal relationship between IST and hypertension and/or hostile personality type remains speculative. The information for this paper was derived from five years of experience that the Mallinckrodt Institute has accumulated through its own technical group plus information gained through discussions with other groups in the therapy field. Using the most recent values of these markers provides a better estimate of the risk of AIDS or death, compared to the more common method of analysis, where baseline values of the markers are used. Even if current treatment programs were carried out at or near perfect levels, we predict that significant residual mother-to-child transmission (7.9 percent) would remain.

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Randomized, comparative studies of this technique as an alternative to hysteroscopic ablation or resection may be warranted. We found that cadherin engagement induced tyrosine phosphorylation of p190RhoGAP and increased its binding to p120RasGAP. RELMA V.5 and LOINC V.2.34 offer the opportunity to start thinking again about LOINC mapping even in non-English languages, since mapping tenormin 50 mg tablets effort is acceptable and mapping results equal those of previous manual mapping reports. Here, we report that next to its trafficking roles, stargazin may also act as a positive allosteric modulator of AMPA receptor ion channel function. Our experience for the development and assessment of AF and CHF dog models may help researchers who are in search for animal model for assessing the safety and efficacy of a device-based therapy. Bovine immunodeficiency virus tat gene: cloning of two distinct cDNAs and identification, characterization, and immunolocalization of the tat gene products. Urine samples were simultaneously obtained during the clinical stage of the disease and in healthy ewes. The availability of an easy-to-use, reliable tonometer for IOP measurements in mice will allow more extensive use of the mouse as a model for glaucoma. Incarcerated individuals represent a vulnerable population when it comes to TB exposure, development of disease, and poor treatment outcomes. For practical emergency management of a new outbreak of rabies, the ring-like application of oral vaccination is not a favourable strategy at all.

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BID and QHS dosing were equally effective in improving symptoms of bipolar disorder, as measured with the YMRS, HAM-D(21), MADRS, and CGI-BP. Limbal relaxing incisions and opposite clear corneal incisions were the main surgical techniques in use during last decade. Relationships of ligand binding, redox properties, and protonation in Coprinus cinereus peroxidase. The chemical and structural variations of xylans produced by different plants, and the concentration of xylan in various plant resources are summarized. Subjects who displayed either low or very high firing rates exhibited poor performance, while those who displayed intermediate firing rates exhibited relatively valtrex dosage herpes simplex keratitis good performance.

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They were also asked about diseases for which they regularly consult doctors, and about subjective symptoms. From the files of the Committee for the Study of Maternal Mortality. Virtual congresses and a newsgroup on hand surgery seem to be worthwhile future goals. Norms for change are lacking for most psychometric instruments used for dementia diagnosis in the German-speaking area. The first one employs direct assembly of chromatin from sperm nuclei in CSF-arrested meiotic extracts, while the second is based on transition of sperm DNA through a replication step, followed by re-establishing of CSF arrest.

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However, few studies have evaluated this disease among ESRD patients. Dietary formulation with rendered spent hen meals on a total amino acid versus a digestible amino acid basis. Epidemiological study of the symptomatology of childhood depression in Madrid school-age population. Measurements of carotid-femoral (aortic) PWV may provide an easy and noninvasive technique to identify patients at increased risk of arterial disease. Our results demonstrate a central role for CAK in regulation of messenger RNA synthesis by either inhibition of RNA polymerase II-catalyzed transcription or stimulation of transcription through association with basal transcription repair factor IIH. IMG/M-HMP: a metagenome comparative analysis system for the Human Microbiome Project. Proponents of physician training expansion need to establish a body of evidence that having additional physicians will lead to improved health and well-being of patients and populations. Single and multiple mutations of IN at residues T66, S153, or M154 confer degrees of resistance to several inhibitors that prevent the enzyme from performing its normal strand transfer activity. This case report describes a 66-year-old woman who initially presented with features of hypopituitarism secondary to a giant intra-cavernous internal carotid aneurysm.

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Anabaena oscillarioides excretion products, some of which are exuded from heterocyst-vegetative cell junctions, are likely to be responsible for positive chemotactic responses. Moreover, HASH showed no cytotoxicity towards primary human fibroblasts and reduced the apoptosis rates of primary chondrocytes exposed to hydrogen peroxide in vitro. The anatomy of this part the rabbit eye differs in many respects from that found in primates. Renal expression of moduretic tablets fibrotic matrix proteins and of transforming growth factor-beta (TGF-beta) isoforms in TGF-beta transgenic mice. The physiometric parameters in children living in the areas having different levels of aerotechnogenic load. As the main products, the HO(2) radical and the Cl atom are active and may play important roles in the atmospheric oxidation processes. Pan American air sampling program December 1968, Pan American Health Organization and U.S. Transplant renal artery stenosis is a major complication that requires a therapeutic approach involving surgery or angioplasty.

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Hexagonal plate crystals with nearly horizontal end faces produce circumzenithal and circumhorizontal arcs. The purpose of this study was to determine, in the context of a hospital addiction unit, which benzodiazepines were abused and to look for correlations with the characteristics of detoxified patients. These findings further current understanding of TTP mechanism of action and its role in human health. A novel approach to visualize polyclonal virus-specific CD8 T cells in vivo. Drug-eluting stents do not increase the risk of ST, at least under appropriate anti-platelet therapy. VOCs were detected by different techniques on solid waste samples and the outlet air stream, before and after a biofilter. Careful operative techniques and sufficient personal experience can help avoid severe post-operative problems.

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