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Klonopin (Clonazepam)

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Klonopin is one of the products that belong to the bensodiazepine group and have a strong sedative effect. It is widely used among people with severe panic attacks and anxiety caused by depression treatment. Thanks to its unique features, Klonopin helps to stop convulsions and epileptic seizures.

Other names for this medication:
Almac, Calmnir, Cleps, Clonark, Clonax, Clonaxyl, Clonazepam, Cloneepam, Clonopam, Clopam, Clotweet, Clozep, Cozil, Deptune, Dipwell, Ection, Eminaz, Epitril, Epizam, Escimax, Escitacalm, Escitapax, Escitrac, Estalonix, Jbcloz, Klopam, Lonipax, Lozep, Meloprax, Melzap, Nupam, Onapil, Ozepam, Prasilex, Revozip, Sezolep, Somnolex, Zeficar, Zepam, Zepamax, Zeptril

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Glucophage, Robaxin, Prilosec, Sovaldi, Aldara, Levaquin

Also known as: Clonazepam


{name} (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

{name} is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

{name} is also used to treat panic disorder (including agoraphobia) in adults.


Adults. The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding Klonopin to an existing anticonvulsant regimen.

Pediatric Patients. Klonopin is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

Geriatric Patients. There is no clinical trial experience with Klonopin in seizure disorder patients 65 years of age and older. In general, elderly patients should be started on low doses of Klonopin and observed closely.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.


Tablets should be kept at room temperature, between 15 C and 30 C (59 F and 86 F).

Side effects

The most common side effects associated with Klonopin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as seizures, mental/mood changes, shaking, stomach/muscle cramps) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

If you have several different types of seizure disorders, you may experience a worsening of seizures when you first start using Klonopin. Consult your doctor right away if this happens. Your doctor may need to add or adjust the dose of your other medications to control the seizures.

Tell your doctor if your condition persists or worsens.

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A past history of major depression or alcoholism has been associated with poorer smoking treatment outcomes. The effect of anaesthesia, hypotension, and epidural analgesia on blood loss in surgery for pelvic floor repair. Isoelectric focusing of human and guinea-pig C2: polymorphism of guinea-pig C2. Autopsy revealed second-degree and third-degree burns of the mammary regions. Protein variation in the eye lens nucleus of the mackerel scad (Decapterus pinnulatus). Characteristics that determine the anatomic site within the colorectum where carcinoma is most likely to occur would be useful in choosing optimal modalities for cancer screening and in the study of etiology. This article is intended to aid clinicians in reviewing potential metabolic diagnoses and to approaching metabolic evaluations in an economical, logical, and comprehensive manner. Addition of dexamethasone to HeLa cells transiently transfected with a chloramphenicol acetyl transferase (CAT) reporter plasmid containing the hormone response element and cotransfected with glucocorticoid receptor stimulated transcription 24-fold in an orientation- and position-independent manner. Analysis of clinical, haemodynamic, and echocardiographic data before and immediately after the procedure, the pregnancy outcome, and the fate of newborn babies.

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The surgical excision of spinal intradural vascular malformations. We identified three de novo point mutations in MPZ exon 3 in a sporadic DSS patient. Enterohemorrhagic Escherichia coli (EHEC) is known as an etiological agent of not only hemorrhagic colitis, but also hemolytic uremic syndrome (HUS) and other serious complications. Correct catheter positioning was verified by magnetic resonance imaging (MRI) in six patients. In this study we have analyzed the ability of src family tyrosine kinases and the CD45 tyrosine phosphatase in determining the phosphorylation state of the different ITAMs and the individual tyrosine residues of the TCR zeta chain. The purpose of this study was to investigate whether a 36-week complex exercise program helps to improve the risk factors for fall and hip fracture. The effects of a 20 min nap in the mid-afternoon on mood, performance and EEG activity.

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In fact, anecdotal observations suggest that muscle sympathetic activity may be inhibited. Loss of heterozygosity on chromosome arm 16q in breast cancer metastases. Their pathogenesis seems obscure and a few studies which have sought Epstein Barr virus (EBV) agree that this is generally not demonstrable. New oral anticoagulant in atrial fibrillation: are they comparable?. The transcription factors C-repeat binding factors/dehydration-responsive element binding proteins (CBFs/DREBs) control the expression of many stress-inducible genes in Arabidopsis. One must be cautious in extrapolating from a case report, but these findings strongly suggest a direct effect of VPA on spermatic structure and function. These data demonstrate that the immature fetus can survive a prolonged period of asphyxia, but paradoxically the capacity to survive exposes the fetus to profound hypotension and hypoperfusion. We now report that DA2B is caused by mutations in TNNI2 that are predicted to disrupt the carboxy-terminal domain of an isoform of troponin I (TnI) specific to the troponin-tropomyosin (Tc-Tm) complex of fast-twitch myofibers. Laparoscopic and classic cholecystectomy in patients with liver cirrhosis. Examples of work in several directions are presented here arranged by four levels of analysis.

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The effect of tremorigenic substances on the copper content in different areas of the rabbit brain. Study on the relationship between endogenous opioid peptides and fetal distress. Our results show that the GHR exon 3 genotype is in accord with the type of GHBP isoforms found in the serum. The collective evidence suggests that the selective activation of HTLV-I, in particular Tax expression, and/or the production of TNF-alpha in target spinal cord and peripheral nerves are causally related to apoptotic death of the oligodendrocytes and Schwann cells, a major pathogenetic pathway of HTLV-I induced myeloneuropathy in the WKAH rat. However, few studies have compared the relative importance of glycemic vs. Interferon-beta-induced activation of c-Jun NH2-terminal kinase mediates apoptosis through up-regulation of CD95 in CH31 B lymphoma cells. Point-spread function and modulation transfer function were also computed from the wavefront aberration. Mathematical models can be useful tools in exploring disease trends and health consequences of interventions in a population over time.

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For advanced-stage tumours, the role of adjuvant chemotherapy and/or biological agents must be defined more clearly. Transcutaneous immunization with a 40-kDa outer membrane protein of Porphyromonas gingivalis induces specific antibodies which inhibit coaggregation by P. Recent evidence indicates the presence of naturally occurring digitalis-like compounds in mammals. Site-selective modification of hyperreactive cysteines of ryanodine receptor complex by quinones. We integrate these features into an upright microscope, with no compromise to its capabilities (differential interference contrast microscopy, fluorescence microscopy, etc.). A conformational study of kiotorphin and its biologically active analogue. Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery: a systematic review and meta-analysis. Each underwent parallel testing of endocervical specimens by enzyme immunoassay (EIA) and ligase chain reaction (LCR), vulval swabs by LCR, and urine by LCR. Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway. With respect to the restabilization studies at high ionic strengths, new interesting results were obtained.

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The synthesis of 2-deoxy-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythrohexopyranosyl)-6-O-(3-deoxy-3-methylamino-alpha-D-xylopyranosyl)-D-streptamine (1), an analog of gentamicin A, from diideoxyneamine and methyl 3-methylamino-3-deoxy-beta-D-xylopyranoside is described. Despite the availability of newer topical treatments, classical topical treatments for chronic plaque psoriasis still have an important position for selected patient populations. Bronchoalveolar lavage fluid from 66 was analyzed for the level of cellular inflammation, cytokines, and soluble leptin. Randomised trials in ovarian cancer: trial design considerations. MRI may provide invaluable information in the diagnosis of EA infestation of the liver, either by disclosing the infiltrative pattern of infestation without significant effect to vascular structures, or by the signal characteristics. Cardiac involvement is an important cause of morbidity and mortality yet coronary involvement is very rarely documented.

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Comparison of biliary metabolites of androsterone glucuronide and androsterone sulphate in female rats. The effects of the testicular cytokines, interleukin-6 (IL-6) and interferon-gamma (IFN-gamma), on signal transducers and activators of transcription 3 and 1 (STAT-3 and STAT-1) and on c-fos gene expression in primary Sertoli cells are suggestive of their roles in differential function. Hence, we recommend complete surgical exploration of patients with umbilical detrol over counter drug adenomas. While most of the lower levels of gene expression data (pre)processing have been automated, our work can be seen as a step toward automating the higher level functional analysis of the data. The properties of incorporation of (14)C-leucine into protein by etioplasts from plants grown 6.5 days in darkness are similar to those of chloroplasts from plants of the same age that were illuminated for 12 hours. Proposal of analytical pathway for the treatment of poisonings--improvement of toxicological analysis in clinical laboratory and reconsideration of useful treatment for poisonings. Allocating medical resources: recommendations for a professional response. The possible mechanism of pleural effusion in CML, the cytological interpretive problem and the clinical significance of finding immature leucocytes in pleural fluid are also briefly discussed. Functional endoscopic sinus surgery (FESS) is the standard of care for the surgical management of sinonasal inflammatory disease.

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Doubling back over roads once traveled: creating a national organization for nurse-midwifery. Subcutaneous administration of Icatibant (0.3 or 1.5 mg/kg) significantly suppressed shortening of the large intestine and worsening of the general health. HIV-infected cells were found in the parenchyma, perivascular regions, and choroid plexus and found infiltrating the parenchyma from the meninges, suggesting multiple portals of entry into the brain. Pathology and clinical course of MALT lymphoma with plasmacytic differentiation. The reviewed studies have highlighted the importance of further research. The mode of action of penicillin in relation to its therapeutic use. Syntheses and characterization of two dioxygen-reactive dinuclear macrocyclic schiff-base copper(I) complexes. The activity of PGHS-2 promoter was potentiated by coexpression of protein kinase A and inhibited by coexpression of kinase A inhibitor. The monolithic column exhibited high column efficiency for thiourea, up to 135 000 plates per meter, and phenylmethanol, up to 102 000 plates per meter. Steroid-sensitive nephrotic syndrome: from childhood to adulthood.

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The detected I-PTH serum level abnormalities were not in any pattern related to the Ca and P serum levels. Angiotensin-II receptor blockers for hypertension and heart failure: quality of life and outcomes. The sequences of clomid drug form all hemX genes found, and of a 6.3 kbp hem gene cluster from P. For patients with hormone-sensitive breast cancer eligible for adjuvant hormonal therapy, it is important to know if the ovaries are (still) functional or not. The positive correlation was found between the length of mandibular ramus and posterior-anterior ratio. A 45-year-old man with a cholesteatoma experienced purulent meningitis.

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The aim of this study was to document the optimal spacing of two cannulae to form continuous strip lesions and maximal surface area by using water-cooled bipolar radiofrequency technology. The compleat angler: aggressive mimicry in an antennariid anglerfish. The adsorptive characteristics and eluting parameters of the process were studied by taking the content of depsides as index. A conserved histidine (H225) functions as the catalytic theolair residue for this enzymatic activity, and mutation of this residue abrogates genomic double-stranded RNA synthesis without affecting viroplasm formation. On the limits of generalizability: applying resource exchange theory to gay relationship processes. Pirenzepine (226 nmol/kg/h) shortened the phase III cycle, causing an early increase in plasma motilin concentrations.

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Mental health needs of women during pregnancy: the mental health nurse in obstetrics. Forty-two ASA I-II patients scheduled for elective knee arthroscopy under general anaesthesia were randomly assigned to a fresh gas flow consisting of oxygen in air or oxygen in nitrous oxide 1:2. Nursing management of patients receiving brachytherapy for early stage prostate cancer. The results of this study show that the application of discontinuous force results in less root resorption than does the application of continuous force. Awareness of such a possibility following talc pleurodesis may allow surgeons to avoid unnecessary mediastinal exploration, and its occurrence suggests that talc administration simultaneous with mechanical pleurodesis should be avoided. Congenital aneurysm of the coronary artery with myocardial infarction. Observational analytic design of a prospective cohort with internal comparison of the groups. The prone position was significantly superior to the supine position in terms of oxygenation. The purpose of this study was to investigate the characteristics of arachidonic acid-induced peripheral vascular disease in rats. The in situ coupling of the anti-BSA antibody as a model protein to the amine moiety of phosphatidylethanolamine (PE) in a lipid bilayer by the amine coupling method allowed us to design an antigen (BSA)-sensitive interface, in which the integrated current, rather than the frequency of channel event, can be used as an analytical signal.

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