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Glyburide (Glibenclamide)

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Glyburide is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
Aviglen, Betrol, Codica, Diabetrol, Diabnil, Duotrol, Dutrol, Glibenclamide, Glibet, Glibson, Glimsug, Glinil, Glitrac, Glucomin, Gluconil, Glunil, Glybovine, Glycurub, Iscept, Melitus, Monomet, Pionorm, Sugatrol, Sugronil, Triglycomet

Similar Products:
Avodart, Fosamax, Lexapro, Singulair, Artane, Flonase, Indocin

Also known as: Glibenclamide


This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.


Usual Adult Dose for Diabetes Type 2:

Standard Glyburide: -Initial dose: 2.5 mg to 5 mg orally once a day -Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses -Maximum dose: 20 mg/day Micronized Glyburide: -Initial dose: 1.5 mg to 3 mg orally once a day -Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses -Maximum dose: 12 mg/day Comments: -Administer with breakfast or the first main meal of the day -Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs -Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses. TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY: -Oral Antidiabetic Therapy: No exact dosage relationships exists between standard Glyburide, micronized Glyburide, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed. -Insulin: --If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day. --If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day. --If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting Glyburide at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Detailed Glyburide dosage information


In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Glyburide in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving Glyburide.

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pylori-inoculated gerbils were given fucoidan in drinking water. Earlier we indicated that neutrophilic invasion into cerebral parenchyma is an important step in rat cerebral ischemia-reperfusion injury and the production of chemotactic factors, cytokine-induced neutrophil chemoattractant (CINC) precede the neutrophilic invasion. The spectral density of current noise measured in zero voltage increases in proportion to the square of frequency at low frequencies and becomes constant at high frequencies. The difference between halothane and HFE on channel dynamics can be attributed to their distinctly different distributions within the lipid bilayer and consequently to the different interactions of the anesthetic and the nonanesthetic molecules with the channel-anchoring tryptophan residues. We used limiting dilution reactivation (frequency of cells reactivating gammaHV68 in vitro) and limiting dilution PCR (frequency of cells carrying gammaHV68 genome) assays to compare gammaHV68 latency in normal (C57BL/6) and B-cell-deficient (MuMT) mice. Report of a patient with hypoglossia-hypodactylia syndrome and a review of the literature.

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Baeocystin was detected in collections of Psilocybe, Conocybe, and Panaeolus from the U.S.A., Canada, Mexico, and Peru. Transcatheter arterial embolization is becoming the therapy of choice for controlling obstetric hemorrhage, affording the ability to control persistent bleeding from pelvic vessels while avoiding the morbidity of surgical exploration. The influence of early steroid withdrawal on body composition and bone mineral density in renal transplantation patients. Maternal serum hyaluronic acid concentrations increase as pregnancy progresses and serum levels increase significantly at term. Detailed functional analysis revealed that both serpins interfered with all three pathways of the human complement system at different stages of their activation. The cats were also checked for postmyelographic adverse effects for at least 3 h after their complete recovery from anaesthesia. The results of the plain radiograph, CT, and histopathological correlation are presented. The specific diagnosis of adrenal ganglioneuroma requires either biopsy or surgical removal for documentation. A historical account of advocacy efforts on behalf of abused and neglected children in the United States is presented, followed by an analysis of current advocacy efforts, highlighting the potential of court-appointed special advocates (CASAs).

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Relationships among patient age, diagnosis, hospital type, and clinical laboratory utilization. The type of oral dosage forms of roxithromycin altered its pharmacokinetics. These results suggest that oxygen-derived free radical-induced vasoconstriction in spontaneously hypertensive rat aorta is caused by TXA2 and PGH2 released in smooth muscle. Consequently, observation of the recurrent fractures in the majority of such cases can result in misdiagnosis of non-accidental injury in young children who have the syndrome. To compare the response to dimercaptopropanol (BAL) and calcium disodium ethylenediaminetetraacetic acid (EDTA) versus orally administered meso-2,3-dimercaptosuccinic acid (DMSA) and EDTA in children with lead poisoning pepcid complete and alcohol . ND was associated with low levels of education, extroversion, mastery, and self-esteem, high levels of neuroticism and dependency and a history of mood and alcohol use disorders. Periprosthetic fractures following total knee arthroplasty: a 6 months prospective study. In selected patients, surgical resection offers the possibility of cure, but effective palliation is often the principal goal of treatment. In one case the caudal collector entered a node, which was considered to be the sentinel node of the breast.

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This study examined the cognitive state of depressive patients during M-ECT. Participants performed deskwork for 2 hours while sitting on the seat pan of an office chair. The fact that eukaryotic chromosomes are linear poses a special problem for their maintenance: the natural ends of chromosomes must be distinguished from ends generated by chromosomal breakage and somehow, the chromosome ends must also be fully replicated to maintain their integrity. In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter. Disruption of a temporal discrimination under response-independent shock. A female infant, the recipient of a twin-twin transfusion syndrome was found, by ultrasound and computed tomography, to have both pulmonary arterial and intracerebral calcification. Risk factors of myocardial infarction and death in men aged 50 at entry.

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We speculate on the reasons why a formal dominance or subordination signal appears to be absent in bonobos. Association of a haplotype (196Phe/532Ser) in the interleukin-1-receptor-associated kinase (IRAK1) gene with low radial bone mineral density in two independent populations. Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells. Monitoring of the formation and dissociation of polyethylenimine/DNA complexes by two photon fluorescence correlation spectroscopy. Telocytes expressed CD34, c-kit and vimetin by immunohistochemistry. In the current study, we evaluated the strategy of using pol II promoters to drive the expression of siRNAs against HIV-1. Cloneless genomic DNA analysis: an efficient and simple methods for de novo genomic sequencing projects and gap filling. The aim of the work is to study the feasibility, tolerance and effectiveness of the destruction of porcine liver by HIFU.

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Pregnancy is possible after TCRE and which can complicate with difficulties of abortion, abnormal insertion of placenta, fetal growth restriction and abnormal third labor course etc. This cross-sectional study investigated mandibular developmental changes in untreated normal Taiwanese from the deciduous to permanent dentition. Thus, direct cellular coupling with glioma cells result in a phenotypic transformation of astrocytes that may contribute to the susceptibility of surrounding tissue to glioma invasion. Electron microscopy studies reveal that PkDBP knockout parasites are unable to form a junction with human erythrocytes. A urease-negative phenotype was observed among aminoglycoside-resistant ESBLKp. These data suggest that BMP-7 inhibits constitutive and IL-1 beta-induced MCP-1 expression in human mesangial cells partly by inhibiting c-Jun N-terminal kinase activity and subsequent AP-1 activity, and provide new insight into the therapeutic potential of BMP-7 in the inflammatory renal dramamine patches generic diseases.

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Improving the distal fixation of intramedullary nails in osteoporotic bone. The analysis of the dark current reveals the existence of a smooth but clear spatial dependence. Patients with choledochal cyst may have to be carefully followed up for more than 30 years even after diversion surgery. Reconstructions of segments of these dendrites show that the axon terminals synapse with both the dendritic spines and the dendritic shafts. Although the nucleus has a pre-eminent role in controlling chloroplast biogenesis, there is considerable evidence that the expression of nuclear genes encoding photosynthesis-related proteins is regulated by signals from plastids. Molecular pathways involved in the progression of mHRPC include the androgen receptor, angiogenesis, endothelin receptor, tyrosine kinases (SRC, MET, vascular endothelial growth factor receptor, RET), and the receptor activator of nuclear factor-kB-ligand. There is controversy concerning whether weight changes are associated with an increased risk of ischaemic heart disease (IHD). Prevalence of hemoglobin abnormalities in Kebili (Tunisian South).

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Comparison of aggregation behaviors of a phytosterol ethoxylate surfactant in protic and aprotic ionic liquids. By both methods, we conclude that Nrf2 directly protects airway epithelial cells from HOCl-induced toxicity. The interior of the protein consists of a water-filled cavity between the two beta-sheets. The syndrome is poorly understood by radiologists and is often misdiagnosed. Molecular typing of IberoAmerican Cryptococcus neoformans isolates. Toxoplasma gondii propagation in cell cultures and preservation at liquid nitrogen temperatures. Sapovirus (SaV) is an important pathogen that causes acute gastroenteritis in humans. The levitra medication side effects function(s) of ENs is not clear, but they may have a role in searching for DNA homology, synapsis, gene conversion and/or crossing over. Therefore we conclude, that an alteration of phospholipid metabolism with a diminished and/or altered synthesis of lung surfactant plays, at least in part, an important role in the pathogenesis of respiratory distress in sepsis and peritonitis.

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