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Fasigyn (Tinidazole)
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Fasigyn

Fasigyn is indicated for the oral treatment of: Trichomonas vaginalis infections of the genitourinary tract in both female and male patients. When infection with Trichomonas vaginalis has been confirmed or is suspected, simultaneous treatment of the consort is recommended.

Other names for this medication:
Simplotan, Tindamax, Tinidazole

Similar Products:
Pamelor, Cycrin, Xeloda, Colcrys, Crestor, Aygestin, Motrin

Also known as: Tinidazole

Description

Fasigyn manufacturer is Pfizer. Fasigyn tablets contain active ingredient is Tinidazole, a 5-nitroimidazole anti-parasitic agent, which belongs to a drug class Amebicides, Antimalarials and gynecological Antiinfectives.

Dosage

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

Take Fasigyn with a glass of water during or after a meal. Swallow the tablets whole. It is best to take the medicine at the same time each day.

For bacterial infections, this medicine is not recommended for use in children less than 12 years as it has not been tested in this age group.

For protozoal infections, Fasigyn 500mg film-coated tablets can be used in children and has not been shown to cause any different side effects or more problems than it does in adults.

The dose and length of treatment depends upon the infection being treated. If you are on dialysis, your doctor may prescribe a different dose.

The doses most commonly used for the different infections are shown in the table below:

For treating the infection associated with stomach ulcers. The usual dose is 1 tablet (500mg) taken twice a day. Your doctor will probably prescribe two other medicines to be taken with Fasigyn 500mg film-coated tablets. Treatment with the three medicines together will usually be for 1 week.

For treating most bacterial infections. The usual dose is 4 tablets (2g) on the first day then 2 tablets (1g) once a day or 1 tablet (500mg) twice a day. The usual length of treatment is 5 to 6 days.

For treating bacterial vaginitis (a vaginal infection) and acute ulcerative gingivitis (a gum infection). The usual dose is 4 tablets (2g) given as a single dose. For vaginitis you may be given 4 tablets (2g) on two consecutive days.

For preventing bacterial infections after surgery. Usually 4 tablets (2g) are given as a single dose about 12 hours before surgery.

For treating protozoal infections. For treating intestinal amoebiasis (a stomach infection). Adult: The usual dose is 4 tablets (2g) once a day for 2 to 3 days. Child: The usual dose is 50 to 60mg/kg of body weight once a day for 3 days.

For treating amoebic involvement of the liver (a liver infection). Adult: The usual dose is 3 to 4 tablets (1.5 to 2g) once a day for 3 to 6 days. Child: The usual dose is 50 to 60mg/kg of body weight once a day for 5 days.

For treating giardiasis (an abdominal infection) and trichomoniasis (an infection of the sex organs in males and females). Adult: The usual dose is 4 tablets (2g) given as a single dose. Child: The usual dose is 50 to-75mg/kg of body weight given as a single dose.

Your doctor will calculate the dose required for a child and may repeat the dose once if the infection has not cleared up completely.

Overdose

If you take too much of this medicine tell your doctor or contact your nearest hospital casualty department immediately. Take any remaining tablets with you.

Storage

Keep all medicines out of the sight and reach of children.

Do not take this medicine after the expiry date stamped on the pack after EXP. The expiry date refers to the last day of that month.

Store below 25 C in a dry place. Store in the original package to protect from light and moisture.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Side effects

The most common side effects associated with Fasigyn are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Fasigyn if you are allergic to Tinidazole, to any antibiotic from the class Amebicides. Do not take Fasigyn if you are allergic to any of the other ingredients comprised in Fasigyn. Do not take Fasigyn if you have a history of severe allergic reactions associated with using antibiotics. Do not take Fasigyn you have a blood disorder or a history of blood disorders. Do not take Fasigyn if you have any disease of the brain, spinal cord or nerves. Do not take Fasigyn you have central nervous system (CNS) disease, including epilepsy. Do not take Fasigyn you are in the first 13 weeks of pregnancy, planning to have a baby, or you are breastfeeding. Do not drive or operate machinery if you feel dizzy or numb after taking Fasigyn. Do not consume alcohol while you are taking Fasigyn and for 3 days afterwards. Alcohol may cause an upset stomach, vomiting, stomach cramps, headaches, sweating, and flushing (redness of the face).

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Methylene Blue injected into rabbits resulted in increased glutamate, reduced glutathione and pyrrolid-2-one-5-carboxylate in erythrocytes. Urinary sodium excretion increased in all subjects from a mean value of 199 to 416 muEq/min. Immunological activities of a lymphocyte mitogen isolated from coenurus fluid of Taenia multiceps (Cestoda). This was a surprising finding, because unlike pure radial flow, this jittering radial flow should have generated sustained visual--vestibular conflicts--previously thought to always reduce/impair vection. Identification of critical steps governing the two-component alkanesulfonate monooxygenase catalytic mechanism. Water soluble CdTe nanocrystals covered with cationic thiol derivatives are efficiently transferred into a hydrophobic ionic liquid, in which they show enhanced photoluminescence. 5-FU decreased the number of peripheral and intestinal leukocytes, promoting an increase in T-cytotoxic cells and a decrease in T-helper and B cells. In five out of eight Dutch university hospitals, chart data of 459 patients treated before the guideline introduction were compared to data of 363 patients treated after the guideline introduction. When the form of the PSF is known, we propose an optimal method to infer 3D geometry from defocused images that involves computing orthogonal operators which are regularized via functional singular value decomposition. We report a case in which the patient developed ipsilateral phrenic nerve paralysis and acute respiratory failure following supraclavicular nerve block.

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The role of CT enteroclysis is gaining on importance in the diagnostics of small bowel diseases. Subjects had no history of speech therapy, were judged as having normal speech and resonance at the time of testing, and had no upper respiratory tract infections or allergies at the time of testing. These observations provide the first evidence of nonrandom coinfection of wild birds by influenza A viruses, suggesting that reassortment of these viruses in a natural population does not occur randomly. Prostaglandin (PG) D2 is a potent bronchoconstrictor mediator and is found, together with leukotriene (LT) D4, in bronchoalveolar lavage fluid during the early response to allergen challenge in asthmatic subjects. Commonalities between the Isaac and Oedipus myths: a speculation. After a formal practice session, members of the sample performed lateral (one-dimensional) tracking tasks in eight counterbalanced sessions, either with or without alcohol (0.836 g/kg), at 0900, 1300, 1800 and 0100 hours. To detect the platelet glycoprotein-specific antibodies in serum of thrombocytopenia patients and evaluate its diagnostic value for immune thrombocytopenia.

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Autonomic reactivity manifestations in patients with hypertension subjected to emotional stress. Isolation and identification of the major urinary metabolite of 4-(4-fluorophenoxy)benzaldehyde semicarbazone after oral dosing to rats. Dilatation of a recoarctation after initial surgical therapy is safe and successful whereas there is an ongoing debate whether native coarctation should be managed surgically or by catheter intervention. The results confirm a high rate of contact (poly)sensitization in patients with CVLU and local variability in allergen prevalence. Synaptic vesicles were isolated from adult bovine cortical gray matter by differential centrifugation and membrane filtration of a hypoosmotically lysed crude mitochondrial fraction. Plasma TBARS were augmented, while plasma GSH levels and the activities of erythrocyte CAT, SOD, GST and GPx decreased, in NDEA-treated rats. To study the regulation of complement activation in human coronary atherosclerotic lesions, we examined the spatial relationships between the major complement inhibitor, factor H, and the complement activation products C3d and C5b-9. This article describes a novel surgical model using vascular pressurization in a fresh cadaver to simulate an extracranial-to-intracranial bypass. Reduction in the dose of intravesical BCG can reduce the toxicity associated with the treatment of superficial bladder cancer without affecting the efficacy of therapy.

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The Veterans Affairs has been successful in providing access to treatment services for Iraq and Afghanistan Veterans with PTSD. We derived the most probable parameters (e.g., amino acid composition, peptide hydrophobic content, and net charge) from the antimicrobial peptide database by developing a database filtering technology (DFT). Spindle cell carcinoma of the breast: a case report and an immunohistochemical study including p53 and Ki-67 expression. Study of the hormone content and enzyme activity in patients with hypertensive disease at rest and in various types of stimulation revealed predominance of pressor humoral systems over depressor ones. Nicotine patches substantially increase quit rates among cigarette smokers, but their safety in patients with myocardial ischemia who are attempting to quit smoking is unknown. Little has been reported on the accuracy of frozen section diagnosis of the gallbladder. The sporadic reports of PPD conversion rates among dental care workers are not adequate to determine the magnitude of exposure to TB in educational dental settings. Our findings indicate that activity of orexinergic neurons is inhibited by propofol anesthesia, and the orexin signals in basal forebrain are involved in anesthesia-arousal regulation from propofol anesthesia. This global variable uniquely discriminates between the five categories of general health. Malignant pleural mesothelioma: surgical management in 285 patients.

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The purpose of this pilot study was to examine the changes in distress and body image, and fitness following exercise participation among 24 women who had been diagnosed with breast cancer within the previous 3 years. Atrial fibrillation after cardiac transplantation: experience in 498 consecutive cases. Endovascular therapy of renal artery stenosis: where do we stand today?. Sex education is intended to provide youth with the information and skills needed to make healthy and informed decisions about sex. Lymphography of the thyroid gland: is intraglandular dissemination of thyroid carcinoma possible?.

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Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection. In situ hybridization assays using digoxigenin-labeled riboprobes for the detection of EF-1 alpha mRNA in routinely formalin-fixed, paraffin-embedded tissue sections showed that EF-1 alpha is a suitable positive control in all types of cells. Catchment to Reef: water quality issues in the Great Barrier Reef Region--an overview of papers. In the present study, the autometallographic silver-enhancement technique, for tracing inorganic mercury bound to sulphide or selenide (AMG-Hg), was applied to tissue sections of dorsal root ganglia and dorsal nerve roots of the same rats used in the earlier study. Although exposure to real microgravity influenced the expression of a number of genes and proteins in the brain that have been shown to be involved in a wide spectrum of biological function, it is still unclear how the functional properties of brain were influenced by 3-month exposure to microgravity. Previous studies have suggested an important role of aberrant arachidonic acid metabolism, especially the cyclooxygenase (Cox) pathway, in oral carcinogenesis. Management of glioblastoma multiforme: with special reference to recurrence. Differences in self-assessed health by socioeconomic group amongst people with and without a history of cancer: an analysis using representative data from Scotland. Cocrystal dissociation and molecular demixing in the solid state.

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To provide a critical review of the role of tricyclic antidepressant (TCA) medications in children and adolescents. Fluoroscopic verification of needle placement, with contrast injection, greatly improves steroid delivery while reducing risks. There is evidence that use of anticoagulants is inadequate in primary and secondary prevention of stroke. Dentin bonding: SEM comparison of the dentin surface in primary and permanent teeth. The pam16-I61N mutation at ambient temperature caused synthetic lethal or sick phenotypes with genes involved in lipid metabolism, perixosome synthesis, histone deacetylation and mitochondrial protein import. Use of the pre-pro part of Staphylococcus hyicus lipase as a carrier for secretion of Escherichia coli outer membrane protein A (OmpA) prevents proteolytic degradation of OmpA by cell-associated protease(s) in two different gram-positive bacteria. Hemodialysis is the primary method of renal replacement therapy. We report a case of posttraumatic intestinal stenosis (PIS), an uncommon sequela of blunt abdominal trauma, in which injury to the mesentery and bowel wall results in later focal ischemic stricture of that segment. Furthermore, respondents pointed out that data quality is an issue and the three major data quality issues being faced are lack of data completeness, lack in consistency and lack in data accuracy.

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A case of heel reconstruction with a reverse sural artery flap in a hemophilia B patient. Animal behavior in response to inhibition of acetylcholinesterase (AChE) was tested in open field paradigms. New standards in the chemotherapy of metastatic hormone-refractory prostate cancer. 18Fluorodeoxyglucose-positron emission tomography in the management of patients with suspected pancreatic cancer. Surgical intervention involving splenectomy and short gastric vein ligation is mandatory and should be performed as soon as possible for such patients. In simulations, competitively successful genotypes were those that reflected plasticity appropriate to the season-length predictability. After 2 hours the wound outline is changed to a slit with the cut edges contracting in one or two areas. As full-thickness eyelid resections were avoided, the authors noted conservation of lid function and cosmetic aspect in all patients. Immune response and anti-microbial peptides expression in Malpighian tubules of Drosophila melanogaster is under developmental regulation.

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