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Cytoxan (Cyclophosphamide)
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Cytoxan

Cytoxan is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast.

Other names for this medication:
Cyclomet, Cyclophosphamide, Cycloxan, Cycram, Cycrame, Cydoxan, Cyphos, Eldamide, Endoxan, Ledoxan, Neophos, Neosar, Oncomide, Oncophos, Oncoxan

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Also known as: Cyclophosphamide

Description

Cytoxan is an antineoplastic. It works by stopping or slowing the growth or spread of certain cancer cells. Generic name of Cytoxan is Cyclophosphamide. Cytoxan is also known as Cyclophosphamide, Cycloxan. Brand name of Cytoxan is Cytoxan.

Dosage

This section provides information on the proper use of a number of products that contain cyclophosphamide. It may not be specific to Cytoxan Lyophilized. Please read with care.

Take this medicine only as directed by your doctor. Do not take more or less of it, and do not take it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.

Cyclophosphamide is sometimes given together with certain other medicines. If you are using a combination of medicines, make sure that you take each one at the proper time and do not mix them. Ask your doctor to help you plan a way to remember to take your medicines at the right times.

While you are using cyclophosphamide, it is important that you drink extra fluids so that you will pass more urine. Also, empty your bladder frequently, including at least once during the night. This will help prevent kidney and bladder problems and keep your kidneys working well. Cyclophosphamide passes from the body in the urine. If too much of it appears in the urine or if the urine stays in the bladder too long, it can cause dangerous irritation. Follow your doctor's instructions carefully about how much fluid to drink every day. Some patients may have to drink up to 7 to 12 cups (3 quarts) of fluid a day.

Usually it is best to take cyclophosphamide first thing in the morning, to reduce the risk of bladder problems. However, your doctor may want you to take it with food in smaller doses over the day, to lessen stomach upset or help the medicine work better. Follow your doctor's instructions carefully about when to take cyclophosphamide.

Cyclophosphamide often causes nausea, vomiting, and loss of appetite. However, it is very important that you continue to use the medicine even if you begin to feel ill. Do not stop taking this medicine without first checking with your doctor. Ask your doctor for ways to lessen these effects.

If you vomit shortly after taking a dose of cyclophosphamide, check with your doctor. You will be told whether to take the dose again or to wait until the next scheduled dose.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For the treatment of cancer: Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 milligrams (mg) per kilogram (kg) of body weight per day. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 mg per kg of body weight per day.

Overdose

If you overdose Cytoxan and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Cytoxan dosage information

Side effects

The most common side effects associated with Cytoxan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Cytoxan if you are allergic to Cytoxan components or to other similar medicines. Do not take Cytoxan if you're pregnant or you plan to have a baby, or you are a nursing mother. Do not take Cytoxan if you are taking tumor necrosis factor (TNF)-blocking medicines (etanercept). Cytoxan may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Cytoxan may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Use Cytoxan with great care in case you want to undergo an operation (dental or any other). Cytoxan may decrease your body's ability to heal wounds. Cytoxan may increase your chance of developing a second cancer, sometimes even years after stopping treatment with Cytoxan. Cytoxan may cause infertility that is sometimes permanent. Be very careful receiving any vaccinations while you are using Cytoxan. The use of birth control is recommended while using Cytoxan. Lab tests, including complete blood cell counts, platelet counts, and urine tests, may be performed to monitor your progress or to check for side effects. Elderly people hould be very careful with Cytoxan because they may be more sensitive to its effects. Do not stop taking Cytoxan suddenly.

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Oxygen consumption and blood flow coupling in human motor cortex during intense finger tapping: implication for a role of lactate. Sex chromatin frequency and estrogenic activity in the newborn female. Effects of carbon and nitrogen sources on rhamnolipid biosurfactant production by Pseudomonas nitroreducens isolated from soil. Among them, 13 patients underwent posterior interface fusion (PLIF) and pedicle screw fixation. A report of two cases of calcifying odontogenic cyst in which the characteristic pathological finding of a peripheral band of intracystic calcification was demonstrated as a radiological sign on CT. Pluripotent stem cells, such as embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, hold great promise as a cell source for regenerative therapies to treat many major diseases characterized by an irreversible loss of functional tissues.

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A 22-year-old man with incessant ventricular tachycardia (VT) associated with pneumococcal meningitis without obvious heart disease manifesting as febrile sensation and severe headache visited our emergency department. Effect of hypotension on increase of CSF enzyme activity after cold injury in cats. Reversible synaptic depression in developing rat CA3 CA1 synapses explained by a novel cycle of AMPA silencing-unsilencing. Arachidonic acid, but not its metabolites, is essential for FcgammaR-stimulated intracellular killing of Staphylococcus aureus by human monocytes. Fire vulnerability was higher for trees with thin bark (young or recently debarked individuals) and decreased with increasing bark thickness until cork was 3-4 cm thick. The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation.

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Brain tissue around the hematoma in rats with cerebral hemorrhage was prepared for GLUT1 detection by immunohistochemistry. Syndactylization or amputation of toes for chronic, severe fungus infections. Marine caves of the Mediterranean Sea: a sponge biodiversity reservoir within a biodiversity hotspot. Multidrug resistance in Serratia marcescens and cloning of genes responsible for the resistance. Indication for the removal of an orbital foreign body has always to be decided upon individually taking into account the benefits and risks resulting from an operation. Blood samples were drawn from those animals as well as from 20 gilts synchronised in the above way and another 20 untreated gilts from a production unit during the various phases of treatment and cycle. These 4 patients had been treated medically more than 2 weeks before operation. We demonstrate that this modified vector efficiently delivers siRNA into multidrug-resistant human breast and oral cancer cells and suppresses MDR1 gene expression. Leucoderma on remitting lesions of leprosy in reaction--a case report.

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Snellen visual acuity, preoperative clinical condition, and postoperative clinical status were assessed. We suggest that this technique variation is applied to small and medium parastomal hernias, in case of patients with permanent left iliac anus, with the declared intent of minimal invasiveness. Evidence for the presence of 5alpha-hydroperoxycholest-6-en-3beta-ol (cholesterol 5alpha-hydroperoxide, Ch 5alpha-OOH) and 7alpha- and 7beta-hydroperoxycholest-5-en-3beta-ols (cholesterol 7-hydroperoxides: Ch 7alpha-OOH and Ch 7beta-OOH, respectively) in human erythrocyte membrane was found. The incidence and location of positive margins and the pathologic stage were noted according to the surgical approach. The considerable amount brought out to the environment poses a risk on the whole population. Arterial--alveolar CO2 gradient after cardiac resusciation in the dog. These data demonstrate that expression of PLP1 but not DMSO is necessary to prevent neuropathy, and suggest that the 35 amino acid PLP1-specific domain plays an important role in normal peripheral nerve function. One therapeutic strategy that inhibits metalloproteinses-tetracyclines or chemically transformed tetracyclines-cannot be considered a breakthrough with respect to either reduction of disease activity or prevention or retardation of cartilage injury in rheumatoid arthritis. Biological differences in a typical experiment are much greater than differences resulting from technical manipulations in labeling and hybridization. A subsequent modified PCR protocol for HIV proviral DNA was performed which included modified primers (SK145/SKCC1B) and altered thermal cycling parameters.

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In general, the spectrum of mutations that has been detected in the germline reflects that found in tumors, although there are some notable exceptions in certain tumor types. Substitution of amino acid residue S54 with E and not Q blocked partially the nuclear localization of the protein, implying that the phosphorylation at S54 is involved in the regulating mechanism of the cell cycle-dependent localization of Cdc6. The medical application of antibiotics dramatically reduced human infant mortality in the previous century. For example, folding mutants of CFTR form large inclusions which arise from the centrosome upon inhibition of proteasome activity. Alcohol degradation and bromsulphthalein metabolism in acute alcoholic liver disease. Thus, CRP can bind to cholesterol, and the interaction is mediated by the phosphorylcholine-binding site of CRP and the 3beta-hydroxyl group of cholesterol. We showed that a photographic assessment of pharyngeal dimensions was significantly associated with OSAS. We have therefore examined effects of IL-1 on islet glycolytic utilization of glucose and find that culture of islets with IL-1 in medium containing 5.5 mM glucose results in suppression of islet glucose utilization subsequently measured at glucose concentrations between 6 and 18 mM.

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The mechanisms by which dietary fibre exerts is laxative action are not fully understood. Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice. A case of exudative enteropathy with anomalies of intestinal lymphatic vessels: problems of diagnosis and treatment. In tissue processing only temperature and the duration of the dehydration and wax infiltration steps affected immunoreactivity. The increased fibrinolytic activity and the rise in soluble thrombomodulin were suppressed by the preadministration of tranexamic acid, resulting in remarkably improved pulmonary function during reperfusion. We investigated whether birth weight, infant growth, childhood cognition and adult height, as well as a range of lifestyle, socio-economic and educational factors, were associated with white blood cell telomere length at age 49-51 years. Retrospective analysis of patients with primary fallopian tube carcinoma treated at the University of Louisville. Effect of shipping and chromium supplementation on performance, immune response, and disease resistance of steers. Supramolecular architectures for the functionalization of solid surfaces. This abnormality in shape predisposes them to pooling and destruction in the spleen.

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This modelling approach extends the standard two-stage analysis used to combine results across different sub-groups or populations. Effect of induction chemotherapy on changes of laminin and syndecan expression in oral squamous cell carcinomas: a prospective, randomized, clinicopathologic and immunohistochemical study. Aggregate Health Status: a benchmark index for community health. Alteration of CCK-induced satiety in post-Nippostrongylus brasiliensis-infected rats. Using BSPY in treating PCHD displayed significant adjustment on disturbance of blood lipid spectrum and improvement on clinical manifestations. The aim of the stent insertion was to seal the fistula in order to prevent aspiration of esophageal content and subsequent pneumonitis. Synthesis and biological evaluation of the first dicarba-closo-dodecaborane (carborane) derivatives of retinoids are described. In an attempt to ensure a high degree of uniformity and quality, and to create a professional standardization amongst pathologists, digital imaging guidelines are proposed for use in general and academic practice. Dietary supplementation with NaCl was not associated with a change in urine calcium concentration. In the zebrafish embryo, a subset of mesodermal cells, the adaxial cells, delineates the prospective path of pioneering motor growth cones.

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Real-time chemical-shift scaling in high-resolution NMR spectroscopy. Koenig.) Smith Costaceae, Achyranthes aspera L., Amaranthus tristis Roxb., Blepharis maderaspatensis L., Merremia emerginata Hall.f., Aegle marmelos Corr., and Tabernaemontana heyneana Wall., used in the traditional Indian system of medicine as a cure for cancer. Passive gymnastics of the kidneys in the complex therapy of patients with pyelonephritis. The establishment of a new blood supply to ischemic tissues by the implantation of an arterial-venous pedicle. Although Phe ultimately proved to be the optimal N-terminal amino acid, several viable replacements for the Boc group were identified, two of which afforded analogues that were effective at enhancing the insulin-stimulated uptake of 2-deoxyglucose by L6 myocytes. A liberal transfusion practice was not significantly associated with postoperative complications, but pneumonia tended to be more common in the liberal group, which was more often admitted to the intensive care unit.

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It was shown that the peroxide compounds actively participated in the processes of levorin and mycoheptin inactivation as intermediate products of their transformation. Our results indicate that LCs and DETCs are synchronously and biphasically activated in the epidermis during the elicitation phase of contact hypersensitivity and suggest that different mechanisms may control early and late activation. PHE, developmental delay, and attention deficit disorder (ADHD) were the main outcome variables analyzed. Mean values of total Kt/Vurea remained unchanged (2.01 at the start, 1.83 at 3 years, 1.91 at 5 years) as a consequence of an increase in peritoneal Kt/Vurea. These sites have been suggested to play a role in chromosome instability observed in cancer. However, these data represent the most direct test currently possible of the specific role of the ER alpha protein on behavior and neuroendocrinology. This feature, along with ancillary findings, may prevent unnecessary surgery as well as painful FNA. Alternatively, it may be that none of these suggested mechanisms is of importance and that the endocrine changes are mediated instead by other mechanisms which remain, as yet, undiscovered or unconsidered.

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A cryptic DNA binding domain at the COOH terminus of TFIIIB70 affects formation, stability, and function of preinitiation complexes. Identifying whether the observed alterations are also present in ganglion retinal cells, and which of them underlies their degeneration process remains however an essential goal for therapeutic strategy. However, the binding of Ricinus communis agglutinin I (RCA) to sCJD and vCJD samples was significantly increased. Recent and contagious syphilis in blood donors (new Toulouse statistics). Interestingly, the application of 2-arachidonoylglycerol to the mouse ear evoked swelling, which was abolished by treatment with SR144528. delayed radiotherapy in a small cohort of patients with supratentorial low grade glioma.

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what is a high dose of cytoxan 2017-08-31

Our findings may partly explain the variable VWF levels and bleeding phenotype in type 1 VWD patients. We constructed a phantom with a lumbar vertebra that can be rotated within a CT scanner. Assessment of arteriovenous blood flow during retrograde cerebral perfusion. The evidence for cyproheptadine is less substantial, perhaps because the dose of cyproheptadine necessary to ensure blockade of brain 5-HT2 receptors is 20-30 mg, which is higher than that used in the cases reported to date (4-16 mg). The surgical management of pulmonary coccidioidomycosis in focalized lesions. Hepatic venous drainage was assisted by multiple large intrahepatic collaterals.

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Peripheral primitive neuroectodermal tumor: report of a case arising in the kidney. Precambrian age of the Boston basin: new evidence from microfossils. The consequences of public health of the acquisition and use of drugs of abuse have been can you take zyrtec with cold medicine well demonstrated. Neuropeptide restored initially, in patients with aphasias, relatively simple forms of speech and later--complicated ones. Arthroscopy of the knee: a needed adjunct to the management of meniscus disease. Primary glioblastomas (GBMs) are highly radioresistant, and in contrast to secondary GBMs, they bear wild-type (wt) p53 protein, which is stabilized in a proportion of these tumors. However, methods to assess insulin sensitivity and secretion are complicated and expensive to apply in epidemiological studies. Levels of antibody to conserved parts of Plasmodium falciparum merozoite surface protein 1 in Ghanaian children are not associated with protection from clinical malaria. The requested values of log P were obtained using three commercially available softwares.

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Variations in the expression of poly (ADP-ribose) polymerase (PARP) and special AT-rich sequence-binding protein-1 (SATB1) along with an increase in the phosphorylation of lamin B represent changes that might trigger passage towards a more aggressive phenotype. ArrayCyGHt can be accessed at http://genomics.catholic.ac.kr/arrayCGH/. To evaluate the impact of urinary diversion on disease status, complications, and subsequent treatment in patients with pelvic tumor recurrence after radical cystectomy for bladder cancer. In the control group a high number of premature failures occurred during cutting process and the mean (SD) bond strength recorded was 3.36 (4.17) MPa. Urinary hydroxyproline excretion was initially markedly increased and fell rapidly during therapy. Double and single-stranded oligonucleotides with several bases between CpGs underwent considerably more de novo methylation per CpG than sequences containing sequential uninterrupted methylatable sites.

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Arguing against these proposed laws, I first claim that their supporters fail to appreciate how personalized an abortion choice must be. Experience, brain, and behavior: the importance of a head start. Validated capillary electrophoresis method for the analysis of a range of acidic drugs and excipients. Mutational analysis, using a full-length rubella virus cDNA clone, of rubella virus E1 transmembrane and cytoplasmic domains required for virus release. Several studies in recent years have used fusion proteins between steroid receptors (estrogen, androgen, progesterone, etc.) and green fluorescent protein (GFP) that can serve as an alternative potent screening method to study intracellular dynamics of receptors in living cells. Treatment of acute severe asthma with inhaled albuterol delivered via jet nebulizer, metered dose inhaler with spacer, or dry powder.

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Quantifying liver cirrhosis by extracting significant features from MRI T2 image. Age-related decline in T cell function was also established by the reduced proliferative capacity of elderly T cells co-cultured with a reference monocyte cell line. Structure of a bacteriophytochrome and light-stimulated protomer swapping with a gene repressor. This is exemplified by the observation that after the burst of nitric oxide activity that coincides with peak primary parasitaemia, there follows a prolonged period of immunological tolerance during which nitrate levels remain low even at secondary challenge infection. Radioactive iodine uptake along with calcitriol dosing single-photon emission computed tomography (SPECT)-computed tomography imaging of KTC-3 xenografts after (99)Tc(m) administration confirmed NIS expression in vitro and in vivo, respectively, after virus treatment. We evaluated the chemotaxis of selected human leucocyte subsets induced by macrophages incubated with Mycobacterium tuberculosis (MT)-derived products in vitro. Utilization of radiometric analysis for measurement of activation of adenyl cyclase by sympathomimetic amines. Interference fringes are produced later by cross-correlating the two tape records in a digital computer.

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For children with frequent episodic and chronic asthma, preventive therapy with inhaled steroids is available and should be provided whenever flagyl dog dosage possible. Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), corneal compensated intraocular pressure (IOPcc) and central corneal thickness (CCT) were measured by ocular response analyser (ORA), preoperatively and 1 and 3 months postoperatively. Scores of factor 1 gave good discrimination, and this is further fine-tuned by employing Mahalanobis distance and spectral residuals as discriminating parameters. Establishment of a CMTM2 transgenic mouse model and the alteration of its serum testosterone level. Simultaneously, the antioxidant activities of the above samples were detected, such as lipid peroxidation inhibition activity in liver (LPIL), kidney (LPIK) and brain (LPIB) and the clearance rate of DPPH (CRD). The pilot study is intended to show whether prostaglandin E1 (PGE1) infusions are able to stop the gradual vision loss in dry age-related macular degeneration (AMD) and, further, to stabilize or improve visual acuity. Male pseudohermaphroditism with gynaecomastia due to testicular 17-ketosteroid reductase deficiency.

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We set up an in vitro model system to examine the effects of retinoic acid on human endometrial adenocarcinoma cells at three states of differentiation. faecalis strain and an isogenic biofilm-negative mutant to enter and survive within professional and nonprofessional phagocytes. The conditions and assumptions under which all resistances can be determined independently are discussed, and preliminary experiments are reported. Cloning and sequencing of the cDNA encoding lipase I from Trichosporon fermentans WU-C12. To the best of our knowledge, only one case of an isolated duplication in the distal segment of the TDR between chromosome 22-specific low-copy repeats B (LCR22-B) and D is nifedipine safe while breastfeeding (LCR22-D) has been published, but the present report is the first one with a detailed description of physical and developmental features in a patient carrying this kind of atypical 22q11.2 duplication. On the semiological value of hepatic scintiscanning with Au 198 in the diagnosis of echinococcal cysts of the liver.

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Following removal of a significant part of the dentate nucleus and most of the interpositus nucleus in the rat cerebellum degenerated cerebellopontine fibres are shown to end in three fairly restricted regions in the contralateral pontine gray: in the paramedian position, in the middle and in the lateral third. Fifteen mini-pigs were bled to a mean aortic blood pressure of 40 mm Hg and maintained at that level for three hours. Superoxide dismutase and glutathione peroxidase activities have been determined in newborns. EUS TCB was performed in patients presenting with obstructive jaundice who were suspected of having autoimmune pancreatitis based on their clinical, laboratory and imaging studies. Randomised controlled trials that compared leaving the visceral and/or parietal peritoneum unsutured at CS with suturing the peritoneum, in women undergoing elective or emergency CS. Only YAC 911D5 complemented the NP-C phenotype, as evidenced by cytological and biochemical analyses, whereas no complementation was obtained from the other two YACs within the interval or from a YAC derived from chromosome 7. Mimivirus has the largest known viral genome and encodes an unprecedented number of proteins, whereas the polydnavirus genome has an extremely low coding density and does not encode DNA-replication proteins.

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