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Cycloxan (Cyclophosphamide)
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Cycloxan

Cycloxan is a nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma. Cycloxan is a fine white crystalline powder. Odorless with a slightly bitter taste. Melting point 41-45°C. A 2% solution has pH of 4 to 6. Used medicinally as an antineoplastic agent.

Other names for this medication:
Cyclomet, Cyclophosphamide, Cycloxan, Cycram, Cycrame, Cydoxan, Cyphos, Eldamide, Endoxan, Ledoxan, Neophos, Neosar, Oncomide, Oncophos, Oncoxan

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Also known as: Cyclophosphamide

Description

Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Cyclophosphamide is also used for some kinds of kidney disease.

Cyclophosphamide interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by cyclophosphamide, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with cyclophosphamide, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain cyclophosphamide. It may not be specific to Cycloxan. Please read with care.

Take this medicine only as directed by your doctor. Do not take more or less of it, and do not take it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.

Cyclophosphamide is sometimes given together with certain other medicines. If you are using a combination of medicines, make sure that you take each one at the proper time and do not mix them. Ask your doctor to help you plan a way to remember to take your medicines at the right times.

While you are using cyclophosphamide, it is important that you drink extra fluids so that you will pass more urine. Also, empty your bladder frequently, including at least once during the night. This will help prevent kidney and bladder problems and keep your kidneys working well. Cyclophosphamide passes from the body in the urine. If too much of it appears in the urine or if the urine stays in the bladder too long, it can cause dangerous irritation. Follow your doctor's instructions carefully about how much fluid to drink every day. Some patients may have to drink up to 7 to 12 cups (3 quarts) of fluid a day.

Usually it is best to take cyclophosphamide first thing in the morning, to reduce the risk of bladder problems. However, your doctor may want you to take it with food in smaller doses over the day, to lessen stomach upset or help the medicine work better. Follow your doctor's instructions carefully about when to take cyclophosphamide.

Cyclophosphamide often causes nausea, vomiting, and loss of appetite. However, it is very important that you continue to use the medicine even if you begin to feel ill. Do not stop taking this medicine without first checking with your doctor. Ask your doctor for ways to lessen these effects.

If you vomit shortly after taking a dose of cyclophosphamide, check with your doctor. You will be told whether to take the dose again or to wait until the next scheduled dose.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For the treatment of cancer: Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 milligrams (mg) per kilogram (kg) of body weight per day. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 mg per kg of body weight per day.

Overdose

If you overdose Cycloxan and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature at or below 25 degrees C (77 degrees F) away from moisture and heat. This medicine can be stored at room temperatures of up to 30 degrees C (86 degrees F) for a short time. Protect from temperatures above 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Cycloxan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Cycloxan if you are allergic to Cycloxan components or to other similar medicines. Do not take Cycloxan if you're pregnant or you plan to have a baby, or you are a nursing mother. Do not take Cycloxan if you are taking tumor necrosis factor (TNF)-blocking medicines (etanercept). Cycloxan may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Cycloxan may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Use Cycloxan with great care in case you want to undergo an operation (dental or any other). Cycloxan may decrease your body's ability to heal wounds. Cycloxan may increase your chance of developing a second cancer, sometimes even years after stopping treatment with Cycloxan. Cycloxan may cause infertility that is sometimes permanent. Be very careful receiving any vaccinations while you are using Cycloxan. The use of birth control is recommended while using Cycloxan. Lab tests, including complete blood cell counts, platelet counts, and urine tests, may be performed to monitor your progress or to check for side effects. Elderly people hould be very careful with Cycloxan because they may be more sensitive to its effects. Do not stop taking Cycloxan suddenly.

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Catheterization in hepatic artery and interventional therapy through carotid artery is both feasible and safe. The aim of this study was to compare preoperative patient evaluation by a vascular physician with a standardized workup protocol prior to elective endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA), in terms of differences in patient medication and mortality. We conducted a systematic review of published literature in MEDLINE-PubMed to identify studies of cervical cancer susceptibility that used a twin study design. Use of a nylon tissue biopsy bag at the suction port during snare colonoscopic polypectomy refines our previously reported technique in which we used a 4-inch x 4-inch gauze pad. Effects of Azadirachta indica leaves on the seminal vesicles and ventral prostate in albino rats. We describe the basic characteristics of this lesion and a rare case of autopolypectomy.

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To perform a noncomparative open clinical study with oral itraconazole capsule (200 mg/day x 7 days) and consecutive usage 200 mg/day for the first 2 days of the following 2 months in patients with seborrhoeic dermatitis. Cydia pomonella granulovirus (CpGV) encodes for three inhibitor of apoptosis (IAP) proteins. An improved profiling approach (RAGE) was also described by utilizing restriction enzyme digestion and electrophoresis for quick and efficient kinase/phosphatase profiling. Thus, cAMP-induced nuclear accumulation of FGFR1 provides a signal that triggers molecular events leading to neuronal differentiation. Contrary to Bacillus subtilis which possesses clpC but not clpB, many Bacillus species were found to harbor both clpC and clpB. We conducted an observational study of 222 consecutive patients greater than 50 years of age who underwent surgical management of a hip fracture at one tertiary hospital. Improved surrogate biomarkers are needed for appropriate initiation of therapy and in order to monitor response.

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The results suggest that ISSR markers are useful in distinguishing the populations of A. The course of attention deficit hyperactivity disorder (ADHD) over the life span. Taken together, our preliminary results showed that AtPGIPs were spatially distributed and AtPGIP expression might take part in resistance to infection of S. Endowing RNase H-inactive antisense with catalytic activity: 2-5A-morphants. From a phagostimulant natural product to semisynthetic antifeedants against Spodoptera littoralis larvae: chemical transformations of the neoclerodane diterpenoid scutegalin B. Both groups terminated refractoriness and started reproducing simultaneously in December despite maintenance of the experimental group in darkness since September.

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In three cases, there was urodynamic evidence of outlet obstruction and symptoms resolved when the obstruction was surgically relieved. One of the inherent limitations of the traditional passive vibration absorber is that its vibration suppression is low if the mass ratio between the absorber mass and the mass of the primary structure is low. In the present study, peptides conferring erythromycin resistance were selected from in vivo expressed random peptide libraries to study structural features important for peptide activity. Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells. Mixed pulmonary fungal infection with Aspergillus fumigatus and Absidia corymbifera in a patient with relapsed acute myeloid leukaemia. Genetic diversity and relationships among the tribes of Meghalaya compared to other Indian and Continental populations. Phenolic compounds may have both beneficial and toxic effects on human health.

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Plasma serotonin level after 1 day of fluoxetine treatment: a biological predictor for antidepressant response?. When imaging studies demonstrate separate cystic lesions and do not reveal a bony defect in the lateral orbital wall, multiple lesions should be suspected. Molecular analysis of the 5 alpha-reductase type 2 gene in a patient with confirmed biochemical 5 alpha-reductase deficiency has resulted in the identification of a novel mutation, GAA to AAA, at codon 200. Oxidative stress related genes modify the effects of ambient air pollution or tobacco smoking on lung function decline. The authors have studied the ultrastructure of the lung in dogs following experimental hemorrhagic shock. The plasma clearance and volume of distribution of liposomal annamycin were decreased and a increase in plasma AUC in female as compared to male rabbits following a single intravenous bolus of liposomal annamycin was observed. These data obtained by the in vivo model of liver tumor development provide strong evidence for a link between dysregulation of the two critical checkpoints of the cell cycle as one of the possible mechanism(s) during tumor promotion by malachite green and metanil yellow. This study reports the qualitative exploratory component of a large mixed method sequential explanatory design. Increased expression of the peripheral-type benzodiazepine receptor-isoquinoline carboxamide binding protein mRNA in brain following portacaval anastomosis. The diagnoses were made by means of joint aspiration with bacteriologic study, arthrotomy, and clinical evaluation.

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Inactivating mutations in HNF1A and HNF4A cause the maturity-onset diabetes of youth (MODY)-3 and MODY1 forms of monogenic diabetes, respectively. Toll-like receptors (TLRs) are best known as initiators of the innate immune response to pathogens. These conditions are discussed with emphasis on aetiology, pathogenesis, diagnosis and treatment. The consensus is that more randomized controlled trials are needed to further study the benefits of routine screening and the efficacy of treating hyperhomocysteinemia. Here we highlight microfluidic, photochemical, localized removal, and backfilling techniques to locally pattern SAM substrates with biomolecules and also describe how these approaches have been applied in SAM-based screening systems. The bacterial LacI/GalR family repressors such as lactose operon repressor (LacI), purine nucleotide synthesis repressor (PurR), and trehalose operon repressor (TreR) consist of not only the N-terminal helix-turn-helix DNA-binding domain but also the C-terminal ligand-binding domain that is structurally homologous to periplasmic sugar-binding proteins. Endothelin-converting enzyme-1 (ECE-1) is a key enzyme in endothelin processing. Age-linked differences showed in practically all the parameters, especially in the platelet counts, fibrinogen and thrombelastograms. In order to identify general rules that shape codon-pair context and minimize mRNA decoding error, we have carried out a large scale comparative codon-pair context analysis of 119 fully sequenced genomes.

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Reduced bone morphogenetic protein receptor type 1A signaling in neural-crest-derived cells causes facial dysmorphism. High-risk and low-risk counties were then compared to identify significant sociodemographic and environmental differences. Comparative I-FABP gene expression was quantitated by use of a real-time reverse transcription-polymerase chain reaction assay. Breast surgeons are often the most advantaged by the contributions made by the breast physician to the multidisciplinary breast-care team with breast physicians particularly adding value to the service provided by breast surgeons. Production of Mucor pusillus acid protease in reconstituted whey. Programme for the 106th meeting of the British Neuropathological Society. These cues are maximally modified at frequencies related to the delay between direct and reflected signals, and therefore to the spatial location of the sound source.

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Compared with the vaccine prepared with virulent strains (Mahoney, MEF and Saukett) some distinct differences were found with regard to the interaction with glass vials (types 1 and 2) and antigenicity (type 3). The Lawson study design did not take into account modifying as well as initiating factors. Emic-etic issues in nursing research: an analysis of three studies. The plasmids of Chlamydia trachomatis and Chlamydophila pneumoniae (N16): accurate determination of copy number and the paradoxical effect of plasmid-curing agents. Influence of neutrophilokines on the synthesis of lymphokines in the process of the formation of immunity to plague.

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Altered behaviour in hamsters conceived and born in hypergravity. Caspase-1 (ICE - interleukin-1 converting enzyme), directly connected with apoptosis and responsible for the cleavage of IL-1b and IL-18, is also a member of the IL-1 family. Here, I discuss the regulation of the intestinal TJ barrier together with its implications for the pathogenesis of diseases. Effect of notoginsenoside R1 on the synthesis of components of the fibrinolytic system in cultured smooth muscle cells of human pulmonary artery. Contractile responses to phenylephrine, endothelin-l and U46619 were not affected by these treatments. Hepatovenous lactate dehydrogenase and alanine aminotransferase efflux as markers of liver integrity and biliary secretion of 2,4-dinitrophenyl-S-glutathione (DNP-GS) were determined photometrically. These data were then cross-referenced with data from international databases describing population size and age, gross domestic product (GDP), expenditure on healthcare and numbers of acute care beds. Random allocation to treatment to a single eye only of every subject. The minipress tablet dosage Redirect trial will provide robust information about the efficacy of an evidence-based complex educational intervention targeted at general practitioners on referral rates of young people with first episode psychosis to Early Intervention Services. To clarify the role of PKA in cisplatin resistance, we have performed a step-wise selection with a CHO RI alpha subunit mutant cell line, 10248, for further resistance to cisplatin.

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To explore the hypothalamic-pituitary-adrenal axis in PMR and GCA. Primary isolates and serial subcultures usually exhibited five- to tenfold population increases per passage. Acidic derivatives of the fungicide fenpiclonil: effect of adding a methyl group to the N-substituted chain on systemicity and fungicidal activity. This seems to be the first report of baboon syndrome due to streptococcal infection. The normalized mutual information (NMI) method was used for image registration. Optimizing organ functions in these patients before discharge from the ICU could result in reduced readmission rates. The Trp3 genotype was determined by means of sequencing the COL9A3 gene. Continuing efforts to find the best methods for identification of people with familial hypercholesterolemia are needed to ensure that this very treatable inherited condition is diagnosed early enough to prevent the development of atherosclerotic vascular disease. Plasma concentrations of beta-endorphin and adrenocorticotropic hormone in women with and without childbirth preparation.

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Young stroke mortality in fiji islands: an economic analysis of national human capital resource loss. Behavioral and audiological data were obtained from 40 subjects 61-81 years of age. Anthropometric measures as a predictor of cephalopelvic disproportion. With the RITA 3 study the interventional approach definitely comes top in comparison with a conservative approach for the treatment of unstable angina. Vascular endothelial growth factor is up-regulated in models of brain ischemia, but the underlying mechanisms in vivo remain unclear. Each enhancer contains DNase I-hypersensitive sites and appears to confer developmental specificity to Tsix expression. Attitudes that view these military buildup plans in a zero sum context whereby the positives of greater security and improved local economy can be attained only with corresponding negatives of environmental destruction are prevalent. An anterior mediastinal tumor and an intrathoracic disseminated lesion remained, and were treated by surgical resection combined with intrathoracic hyperthermic perfusion. The neurotrophic factors ciliary neurotrophic factor and brain-derived neurotrophic factor can prevent motor neuron cell death during development and after nerve lesion in neonatal rodents. A novel immunoassay format employing direct coating of small molecular hapten on microtiter plates is reported for the detection of atrazine and 2,4-dichlorophenoxyacetic (2,4-D).

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To examine the effect of intravenous gamma-globulin (IVIG) treatment on the results of ELISA based on serum and urine, levels of H. IFG with NGT exhibited significantly higher levels of HbA1c, true insulin and proinsulin. To evaluate the effect of CLA on myogenesis during inflammation, human primary muscle cells were grown in culture and exposed to varying concentrations of TNFalpha and the cis-9, trans-11 and trans-10, cis-12 CLA isomers. Oestrone has been found to depress the incorporation of tritiated thymidine, proline and histidine in human skin in vitro. The walls and floor of a room housing a Japanese quail colony were treated with a commercial disinfectant containing iodine complexed to organic molecules. Culture of two skin biopsies taken at two different observations of the woman, 3 weeks apart, allowed isolation of Scedosporium apiospermum. All the subjects were classified into four groups according to age.

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Cyclosporine a augments P-glycoprotein expression in the regenerating rat liver. In the preoperative diagnosis of thyroid cancer, several tissue- and/or tumor-specific mRNA have been described and in several cases, a higher sensitivity and specificity could be achieved using molecular techniques compared to conventional methods. Meeting the needs of unpartnered elders: a peer training program involving elders with myocardial infarction. Primary epithelial ovarian tumor samples were collected is generic propecia effective from 46 patients who underwent cytoreductive surgery. Chemerin can support peripheral blood NK cell migration through both DEC and ST cells. We analyzed data on 419,843 children (22,758 with a disability) younger than 18 years included in 14 annual editions of the National Health Interview Survey spanning the period 1979-2000.

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The Purification and Crystallization of Clostridium botulinum Type A Toxin. Taking advantage of the single nonessential SR protein-specific kinase Sky1p in Saccharomyces cerevisiae, we investigated RS domain interactions in vivo using the two-hybrid assay. Non-invasive ventilation for the treatment of hypercapnic respiratory failure in cystic fibrosis. Variations of Triple-H (hypervolemia, hypertension, hemodilution) therapy, used early after hemorrhage for prophylaxis of vasospasm, are associated with a decrease of nearly half in the incidence of delayed ischemia. In addition to peritoneal seedings, bloody ascites was present in mice inoculated with MKN28. Electrical impedance measurements with the CI24M cochlear implant for a child with Mondini dysplasia. Anaesthetic pre-registration house officers: a survey of doctors and medical students opinions. Sequence comparison revealed that, like metabotropic glutamate receptors, the extracellular domain of the two GABAB receptor splice variants possesses an identical region homologous to the bacterial periplasmic leucine-binding protein (LBP), but lacks the cysteine-rich region common to all other family 3 receptors. There was a significant correlation between serum LDH and NSE levels.

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