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Conetrin (Nifedipine)
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Conetrin

Conetrin is a calcium-channel blocker. It affects the amount of calcium found in your heart and muscle cells. This relaxes your blood vessels, which can reduce the amount of work the heart has to do. This medicine is used to treat chest pain caused by angina.

Other names for this medication:
Afeditab, Antrolin, Bresben, Calchan, Calcigard, Cardalin, Chronadalate, Cisday, Conetrin, Cordaflex, Cordalat, Cordilat, Corinfar, Ficard, Jutadilat, Macorel, Nefelid, Nelapine, Nifed, Nifedalat, Nifedel, Nifedine, Nifedipine, Nifedipress, Nifelong, Nifensar, Nipidin, Tenif, Valni

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Also known as: Nifedipine

Description

Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Conetrin OROS. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Conetrin and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Conetrin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nifedipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require caution and an adjustment in the dose for patients receiving nifedipine.

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Stress-echocardiography with dobutamine in assessment of ischemic heart disease and non-coronarogenic myocardial diseases. Evidence for the site of Na-Ca antagonism in cardiac muscle of the frog, Rana pipiens. A multiple site, side binding model for the interaction of dystrophin with F-actin. Following purification, the majority of de novo DNA methyltransfearse activity was associated with Dnmt3b/Dnmt1 fractions. Some vaccination trials using irradiated metacercariae or isolated proteins have been shown to afford significant protection. Within-run and total coefficient variations of the three screening assays were analyzed for the evaluation of precision. T lymphoblasts (Jurkat cells) and immature myeloid cells (eg, Kcl22 cells) expressed high levels of the c-myb hematopoietic transcription factor.

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Specifically, we aimed to investigate conditioned reward in the absence of explicit reward anticipation. The assay procedure was validated using recombinant PI 3-kinase gamma with diC8PtdIns(4,5)P(2) as substrate and general receptor for phosphoinositides-1 (GRP1) PH domain as a PtdIns(3,4,5)P(3)-specific probe. Job latitude was positively associated with exercise in men and women. The residues were either held in dark or exposed to natural sunlight or germicidal UV light before being tested for mutagenicity using the Salmonella tester strain TA98 with and without metabolic activation (S9 mix). Associations of plasma isoflavone concentrations with other dietary behaviors suggest that these compounds may serve as biomarkers of health behaviors in populations with low soy consumption. This investigation demonstrates the well-known clinical effects of nitric oxide in improving pulmonary hemodynamics which were also associated with an increase in pulmonary blood flow, transpulmonary efficiency, and right ventricular contractility in the setting of monocrotaline pyrrole-induced pulmonary hypertension. A 61-year-old woman presented with vertigo and swallowing disturbance. However, this technique potentially introduces more radiation burden to patients as a result of the higher radiation exposure from CT.

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A multidisciplinary evaluation is desirable in the care of individuals with oral dyskinesia and in the selection of those who may benefit from a prosthodontic approach. Synthesis of new strands of mitochondrial and nuclear deoxyribonucleic acid by semiconservative replication. These long-term issues include reproductive effects, varying according to the time of life in which the individuals were exposed. Participants were visited in their own homes by two researchers on two occasions, one week apart and rated independently by each rater. General practitioners in the city and in the rural area go out together and make the emergency service better!. Corneal viscoelastic properties are not significantly influenced in the late postoperative period by 23-G TSV which is a minimal invasive vitreoretinal surgical technique. Furthermore, phage genomes have clearly been shaped by the acquisition of genes from their hosts.

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Partial cross-resistance to paclitaxel and docetaxel has been demonstrated in pre-clinical studies. In both animals there was no parasitism of keratinocytes or Langerhans cells. Acute pancreatitis: clinical and therapeutic study with somatostatin. Of these proteinases, matrix metalloproteinases (MMP) play significant roles in RA pathology, however recent studies show that a disintegrin and metalloproteinase (ADAM) families are another candidates. Electrically enhanced photodegradation of an azodye (acid orange II) using a Pt/TiO2 film electrode irradiating with an UV lamp. When mice with LPS-induced inflamed lungs were given a second intranasal LPS administration, IL-10 concentration recovered in the bronchoalveolar lavage fluids varied as a function of the time interval between the two LPS doses. This communication presents the complete genome sequence of FCCV. Low levels of serum 25(OH)D are associated with depressive symptoms, but no effect was found with vitamin D supplementation.

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Recently, the use of a resin replica of the mandibular dental arch was introduced to place the anterior maxillary segment correctly in the planned position and to obtain the correct occlusion. Effect of ethanol on DARPP-32 phosphorylation in transgenic mice that express human type VII adenylyl cyclase in brain. Antagonists of growth hormone releasing hormone (GHRH) as well as antagonists of bombesin/gastrin releasing peptide (BN/GRP) inhibit the growth of various malignancies (cancers) including prostate cancer. Ibutilide is an effective treatment for conversion of acute tachycardic atrial fibrillation/flutter in critically ill patients. We continue to monitor all aspects of the performance of the pipeline to ensure safe operating practices and recommend changes to the standards. Wolf attacks, however, are rare this century, but there are many anecdotal reports from previous times. Incidence of respiratory syncytial virus positivity in young Italian children referred to the emergency departments for lower respiratory tract infection over two consecutive epidemic seasons.

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Analytical chemists have increasingly turned their attention to drug discovery and drug analysis and to solve fundamental questions of biological significance in physiology and genetics. Postmenopausal survivors of breast cancer are at increased risk for clinical fractures. It was found that dose per unit ESD had a tendency to decrease with body mass index (BMI). Effects of ethanol and phenobarbital on the metabolism of propranolol by 9000 g rat liver supernatant. Furthermore, epibiosis modified the susceptibility of different algal genotypes to grazing. Molecular recognition in the HIV-1 capsid/cyclophilin A complex. Treatments based on direct heme-mimetics or other agonists of this pathway have enormous potential for linked antioxidant protection via heme oxygenase 1 and reduced foam cell formation via liver X receptor, a potent combination for treating atherosclerosis.

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Oestrous behaviour of Holstein cows during cooler and hotter tropical seasons. Thus, it is anticipated that this mouse model will be useful to investigate the pathogenic pathways linked to Alsin gene mutations. Using these methods we have identified two distinct regions of DAT that interact with multiple structurally related and diverse irreversible ligands, suggesting that these regions may be involved in the formation of ligand binding sites. Occurrence of Proteus mirabilis associated with two species of venezuelan oysters. In case of administration via an arteriovenous shunt, thrombosis of the shunt is the most frequent problem. Since prion diseases present metal dyshomeostasis and increased oxidative stress, we described the copper-binding site located in the human C-terminal domain of PrP-HuPrP(90-231), both in the wild-type protein and in the protein carrying the pathological mutation Q212P. Compounds S-1 and S-4 demonstrated in vivo androgenic and anabolic activity, whereas compounds S-2 and S-3 did not. The safety of ingested silver foil is indicated by absence of pathology in urine and unaltered levels of protein and albumin in the plasma.

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The urban poor living with life-limiting illnesses are a particularly vulnerable population. T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts. In particular, the clinical results of endotoxin removal with polymyxin B immobilized fiber are summarized in this article. The positive (IgM) seroprevalence for cytomegalovirus in children with intrahepatic cholestasis and extrahepatic cholestasis is high. Expression of hexokinase isoforms in the dorsal root ganglion of the adult rat and effect of experimental diabetes. We investigated the history of the relationship between reconstruction position and delayed emptying, reconstruction position and minor leakage, minor leakage and delayed emptying, reconstruction position and stomach mobility without leakage. The authors investigated the lymphocyte subset in 88 of the more than 750 patients listed in the tumor registry at their treatment center who had at least one carcinoma of the breast or colon and a second primary of the same or another site. bovis it has been identified in the tegument and in an excretion-secretion extract, consisting of several, non-glycosylated isoforms that are recognised by the sera of animals infected with S.

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Emergency thrombectomy in acute thrombosis of arteritis of the lower limbs. Human kallikrein 2 (hK2) mRNA in peripheral blood of patients with thyroid cancer: a novel molecular marker?. Normal expression of the Fanconi anemia proteins FAA and FAC and sensitivity to mitomycin C in two patients with Seckel syndrome. The contribution of the intestine, the liver and the rest of the body to maintaining the concentration of acetate in the circulation is examined. Role of time as a factor in the toxicity of chemical compounds in intermittent and continuous exposures. Construction lasix water pill of a standard reference for PET studies of methionine accumulation using a computerised brain atlas. Traditional analysis of saccade timing and dynamics was performed together with a quantitative analysis using the LATER model, enabling us to examine the underlying motor control processes. Isolation and characteristics of the lipid granules of Candida tropicalis yeasts.

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Five patients suffered from hand deformation manifesting rigidity, flexor tetanus, or malposition of the first, second and third interphalangeal joints of hands. Natural course of the remission of vertigo in patients with benign paroxysmal positional vertigo. The fungus was identified as Eupenicillium parvum by ITS analysis (ITS1 and ITS2 regions and the intervening 5.8S rDNA region). Codon usage and atenolol 50 mg para que sirve codon-pair context are important gene primary structure features that influence mRNA decoding fidelity. All the information suggested parallel evolution relationship among these traits. In relation to the date of introduction of new diagnostic methods (indirect as well direct) and to the change of treatment periods, the authors compared the clinical outcome of patients admitted prior and after 1984. Moreover, TRAIL co-treatment with bisindolylmaleimide XI or curcumin resulted in down-regulation of X-linked inhibitor of apoptosis protein. Both viability and fertility are important components in our populations.

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Exudative reaction, stages I-II, is the main problem encountered in the early postoperative period irrespective of a type of the implanted IOL. The method has been applied to the determination of DNA in mixed samples with satisfactory result. Evolution of the disease follows one of three broad clinical forms: subacute, slowly progressive or chronic. Both of these events were reported more frequently in women receiving HRT or estrogen. Complex cells in the visual cortex appear to provide a next level of abstraction in encoding information for stereopsis based on the activity of a group of simple-type subunits. A total of 8960 individuals from the 1970 British Cohort Study (BCS70) were studied. Polymorphism of the vitamin D receptor (VDR), collagen alpha I type I (Col I alpha I), and oestrogen receptor (ER) genes imipramine dosing have been shown to account for some of the heritability of bone mineral density (BMD) in adults. Efficiencies of induction of DNA double strand breaks in solution by photoabsorption at phosphorus and platinum.

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A key component of this technique was the calculation of the reference spectra for ordered helix, unordered helix, and sheet, turns, and unordered structures from a series of well-characterized reference proteins. We have previously reported BDF1 mice suspended by the tail in the antiorthostatic orientation for 4 days express high levels of resistance to virulent Listeria monocytogenesinfection. As a consequence, a growing demand for long-term care as well as hospital care can be expected and should be considered in future healthcare planning. Taking the complex diagnostic testing and heterogeneous clinical presentation of PML into account, an agreed case definition for PML is a prerequisite for a thorough assessment of PML. During malolactic fermentation (MLF), lactic acid bacteria influence wine aroma and claritin maximum dosage in 24 hours flavour by the production of volatile metabolites and the modification of aroma compounds derived from grapes and yeasts. Degradation of phenolic and chloroaromatic compounds by Coprinus spp. Because of their ability to efficiently multiply chirality, even on an industrial level, these catalysts promise to exert a general impact on molecular science and engineering.

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