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Combivent (Levosalbutamol)

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Combivent is used to treat chronic obstructive pulmonary disease (COPD). Combivent is more popular than other beta agonist/anticholinergic combinations. There are currently no generic alternatives to Combivent.

Other names for this medication:

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Also known as: Levosalbutamol


{name} Respimat contains a combination of albuterol and ipratropium. Albuterol and ipratropium are bronchodilators that relax muscles in the airways and increase air flow to the lungs.

{name} Respimat is used to prevent bronchospasm (tightening and narrowing of the airways) in people with chronic obstructive pulmonary disease (COPD) who are also using other medicines to control their condition.


This section provides information on the proper use of a number of products that contain ipratropium and albuterol. It may not be specific to Combivent Respimat. Please read with care.

This medicine usually comes with patient directions or instructions. Read them carefully before using the medicine. If you do not understand the directions or you are not sure how to use the inhaler or nebulizer, ask your doctor to show you how to use it.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. Also, do not stop using this medicine without telling your doctor. To do so may cause your lung condition to become worse.

When you use the inhalation solution, make sure you use a jet nebulizer that is connected to an air compressor with a good air flow. Use a face mask or mouthpiece to inhale the medicine.

Keep the spray away from your eyes. This medicine may cause eye pain or discomfort, irritation, blurred vision, or start seeing halos or odd colors when you look at things. If it does come into contact with your eyes, check with your doctor right away.

To use the Combivent® inhaler:

Insert the metal canister firmly and fully into the clear end of the Combivent® Inhalation Aerosol mouthpiece. This mouthpiece should not be used with other inhaled medicines. Remove the cap and look at the mouthpiece to make sure it is clean. Shake the inhaler for at least 10 seconds and test spray it in the air 3 times before using it for the first time or if the inhaler has not been used for 24 hours. To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Put the mouthpiece just in front of your mouth with the canister upright. Open your mouth and breathe in slowly and deeply (like yawning), and at the same time firmly press down once on the top of the canister. Hold your breath for about 10 seconds, then breathe out slowly. If you are supposed to use more than one puff, wait 1 to 2 minutes before inhaling the second puff. Repeat these steps for the second puff, starting with shaking the inhaler. When you have finished all of your doses, rinse your mouth with water. Clean the inhaler mouthpiece every day with hot water. Dry it thoroughly before use.

To use the Combivent® Respimat® spray:

Insert the cartridge into the Combivent® Respimat® inhaler. Before using the inhaler, prime it by spraying the medicine towards the ground (away from your face), until an aerosol cloud is visible. Repeat 3 more times. The inhaler is now ready for use. If the inhaler is not used for more than 3 days, prime the inhaler once to prepare it for use. If it not used for more than 21 days, prime the inhaler 3 times. To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Open your mouth and breathe in slowly and deeply (like yawning), and at the same time firmly press down once the release button of the inhaler. Hold your breath for about 10 seconds, then breathe out slowly. After using the inhaler, clean the mouthpiece with a damp cloth or tissue at least once a week. This inhaler has a dose indicator window that shows how much medicine is left. When the pointer enters the red area of the scale, it is time that you need to refill your prescription. Throw away the inhaler 3 months from its first use or when the inhaler is locked (after 60 or 120 puffs).

Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For symptoms of chronic obstructive pulmonary disease (COPD): For inhalation aerosol dosage form (used with an inhaler): Adults—2 puffs four times a day and as needed. Do not use more than 12 puffs in any 24-hour period. Children—Use and dose must be determined by your doctor. For inhalation solution dosage form (used with a nebulizer): Adults—Use one 3 milliliter (mL) vial in the nebulizer four times a day. You may use 2 additional treatments per day if needed. Children—Use and dose must be determined by your doctor. For inhalation spray dosage form (used with an inhaler): Adults—One puff four times a day. You may take additional doses per day if needed. Do not use more than 6 puffs in any 24-hour period. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Combivent Respimat can be fatal. Overdose symptoms may include chest pain, fast or pounding heartbeats, tremors, dry mouth, extreme thirst, muscle weakness or limp feeling, severe headache, pounding in your neck or ears, or feeling like you might pass out.


Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Combivent Respimat dosage information

Side effects

The most common side effects associated with Combivent are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


If this medication gets in your eyes, rinse with water and seek medical attention.

Avoid driving or hazardous activity until you know how Combivent Respimat will affect you. Your vision or reactions could be impaired.

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Water-absorptive properties of selected solids in a lipophilic base. HIV-1 protease inhibitors herein investigated can fit the active site of Sap2, adopting very similar ligand-backbone conformations. The folding rates extracted using a simple kinetic model are close to those reported previously from laser-induced temperature-jump experiments that employ the change in tryptophan fluorescence as a probe. This retrospective study of 130 consecutive sternotomy wounds compares 41 bilateral pectoralis major muscle flaps with a modified anterior rectus fascia extension against 56 rectus abdominis muscle flaps alone in addressing the lower third of the sternum following dehiscence. Cross-resistance to photofrin-mediated photodynamic therapy and UV light and recovery from photodynamic therapy damage in Rif-8A mouse fibrosarcoma cells measured using viral capacity. Cloning and molecular characterization of Hev b 3, a spina-bifida-associated allergen from Hevea brasiliensis latex.

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Method optimization for proteomic analysis of soybean leaf: Improvements in identification of new and low-abundance proteins. IL-10 attenuated the IFN-gamma-induced increase in electrical conductance and totally prevented the IFN-gamma-induced increase in mannitol and inulin fluxes. The childhood leukemia association possibly results from elevated intracellular iron in lymphoid cells increasing the vulnerability to DNA damage at a critical time window during lymphoid cell development. Furthermore, the extract was found to enhance radiation-induced G2/M phase arrest, induce Akt activation, and increase motility of Hep-2 cells. No signs of large organisms are apparent at either landing site. Specific features of the diagnosis and course of tuberculosis of peripheral lymph nodes in adults. Nitrogen-containing bisphosphonates effectively reduce the risk of SREs in patients with bone metastases from a variety of solid tumors and bone lesions from multiple myeloma.

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Wild-type (WT) or P-selectin deficient (P-sel-/-) platelets were isolated and labeled with the fluorochrome CFSE and administered to either WT or P-sel-/- mice placed on a normal diet (ND) or high cholesterol diet (HCD). In using GOALS, clinicians rate each of the four what drugs contain theophylline domains on a scale of 1, very much improved, to 7, very much worse. Conformational changes in Cry3A delta-endotoxin caused by three different alcohols (ethanol, butanol, and isopropanol) were studied using the methods of circular dichroism, scanning microcalorimetry, and electron miscroscopy. Cisplatin forms inter- and intrastrand crosslinked DNA adducts and its cytotoxicity is mediated by propagation of DNA damage recognition signals to downstream pathways involving ATR, p53, p73, and mitogen-activated protein kinases, ultimately resulting in apoptosis. This technique allowed grading of lung damage induced by COPD, whereas use of PFT and determination of BAL fluid cell populations failed to differentiate between remission 1 and remission 2. Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: importance for designing SARS vaccines. A significnat increase in shell thickness was evident for eggs laid on the second and subsequent days of the DLSM-regimen but nor for those laid during the first 24 hours. Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung. In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery. A comparative analysis and limitations of pseudo-isochromatic tests for color vision testing.

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Zeolite-directed cascade reactions: cycliacyarylation versus decarboxyarylation of alpha,beta-unsaturated carboxylic acids. Lipid tubules: a paradigm for molecularly engineered structures. The fusion protein of GST-SjHSP40 was induced, purified and specifically recognized by anti-GST antibody. The authors present data from a patient registry and review publications retrieved by a selective literature search. Since the establishment of the guidelines for the treatment of venous ulcers by the Wound Healing Society in 2006, there has been an abundance of new literature, both in accord and discord with the guidelines. Measurement of the custom and conscience functions of the superego. While spontaneous thromboses of abdominal aortic aneurysms have been previously reported, we did not find any reports of a thrombosed thoracoabdominal aneurysm or a subsequent rupture of this type of aneurysm. This extra imaging time allowed coronary artery imaging with increased spatial resolution. Monotony is an inherent characteristic of transport industries, including rail, aviation and road transport, which can have adverse impact on safety, reliability and efficiency. A case arising from the attached lingual gingiva between the mandibular right permanent first molar and the second molar in a 67 year old Indian female is reported here.

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