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Combivent (Levosalbutamol)
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Combivent

Combivent is used to treat chronic obstructive pulmonary disease (COPD). Combivent is more popular than other beta agonist/anticholinergic combinations. There are currently no generic alternatives to Combivent.

Other names for this medication:
Levosalbutamol

Similar Products:
Compazine, Myambutol, Parlodel, Minocin, Anafranil, Imodium, Fasigyn, Vasotec, Diflucan, Alprostadil

Also known as: Levosalbutamol

Description

{name} Respimat contains a combination of albuterol and ipratropium. Albuterol and ipratropium are bronchodilators that relax muscles in the airways and increase air flow to the lungs.

{name} Respimat is used to prevent bronchospasm (tightening and narrowing of the airways) in people with chronic obstructive pulmonary disease (COPD) who are also using other medicines to control their condition.

Dosage

This section provides information on the proper use of a number of products that contain ipratropium and albuterol. It may not be specific to Combivent Respimat. Please read with care.

This medicine usually comes with patient directions or instructions. Read them carefully before using the medicine. If you do not understand the directions or you are not sure how to use the inhaler or nebulizer, ask your doctor to show you how to use it.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. Also, do not stop using this medicine without telling your doctor. To do so may cause your lung condition to become worse.

When you use the inhalation solution, make sure you use a jet nebulizer that is connected to an air compressor with a good air flow. Use a face mask or mouthpiece to inhale the medicine.

Keep the spray away from your eyes. This medicine may cause eye pain or discomfort, irritation, blurred vision, or start seeing halos or odd colors when you look at things. If it does come into contact with your eyes, check with your doctor right away.

To use the Combivent® inhaler:

Insert the metal canister firmly and fully into the clear end of the Combivent® Inhalation Aerosol mouthpiece. This mouthpiece should not be used with other inhaled medicines. Remove the cap and look at the mouthpiece to make sure it is clean. Shake the inhaler for at least 10 seconds and test spray it in the air 3 times before using it for the first time or if the inhaler has not been used for 24 hours. To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Put the mouthpiece just in front of your mouth with the canister upright. Open your mouth and breathe in slowly and deeply (like yawning), and at the same time firmly press down once on the top of the canister. Hold your breath for about 10 seconds, then breathe out slowly. If you are supposed to use more than one puff, wait 1 to 2 minutes before inhaling the second puff. Repeat these steps for the second puff, starting with shaking the inhaler. When you have finished all of your doses, rinse your mouth with water. Clean the inhaler mouthpiece every day with hot water. Dry it thoroughly before use.

To use the Combivent® Respimat® spray:

Insert the cartridge into the Combivent® Respimat® inhaler. Before using the inhaler, prime it by spraying the medicine towards the ground (away from your face), until an aerosol cloud is visible. Repeat 3 more times. The inhaler is now ready for use. If the inhaler is not used for more than 3 days, prime the inhaler once to prepare it for use. If it not used for more than 21 days, prime the inhaler 3 times. To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Open your mouth and breathe in slowly and deeply (like yawning), and at the same time firmly press down once the release button of the inhaler. Hold your breath for about 10 seconds, then breathe out slowly. After using the inhaler, clean the mouthpiece with a damp cloth or tissue at least once a week. This inhaler has a dose indicator window that shows how much medicine is left. When the pointer enters the red area of the scale, it is time that you need to refill your prescription. Throw away the inhaler 3 months from its first use or when the inhaler is locked (after 60 or 120 puffs).

Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For symptoms of chronic obstructive pulmonary disease (COPD): For inhalation aerosol dosage form (used with an inhaler): Adults—2 puffs four times a day and as needed. Do not use more than 12 puffs in any 24-hour period. Children—Use and dose must be determined by your doctor. For inhalation solution dosage form (used with a nebulizer): Adults—Use one 3 milliliter (mL) vial in the nebulizer four times a day. You may use 2 additional treatments per day if needed. Children—Use and dose must be determined by your doctor. For inhalation spray dosage form (used with an inhaler): Adults—One puff four times a day. You may take additional doses per day if needed. Do not use more than 6 puffs in any 24-hour period. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Combivent Respimat can be fatal. Overdose symptoms may include chest pain, fast or pounding heartbeats, tremors, dry mouth, extreme thirst, muscle weakness or limp feeling, severe headache, pounding in your neck or ears, or feeling like you might pass out.

Storage

Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Combivent Respimat dosage information

Side effects

The most common side effects associated with Combivent are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

If this medication gets in your eyes, rinse with water and seek medical attention.

Avoid driving or hazardous activity until you know how Combivent Respimat will affect you. Your vision or reactions could be impaired.

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Effects of different systemic contraceptives on blood fibrinolysis. For the quantitative evaluation of myocardial damage induced by isoprenaline (ISO) a method based on the uptake of 203Hg-labelled Mercurascan (MSC) in the heart was used. Ecstasy for intimacy: potentially fatal choices for adolescents and young adults: update for the clinical nurse specialist. Microscopically, the tumor consisted of sheets of both malignant spindle cells and poorly differentiated ductal carcinoma containing squamoid islands with gradual transition to the spindle cell component. High frequency of copy number alterations in myeloid leukaemia of Down syndrome.

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Autologous blood donation preceding coronary artery bypass graft operation in a hemodialysis patient. Predicted pulmonary artery pressure from these criteria were then compared with the pulmonary artery pressure measured during cardiac catheterization. Adherence is a general behaviour, which can explain why patients in the placebo arm of randomised clinical trials have a lower mortality rate when they are adherent. These results indicate a role for the local endocannabinoids in the regulation of glucose metabolism in human adipocytes and suggest a role in channeling excess energy fuels to adipose tissue in obese humans. These ARO-ir cells are sensitive to testosterone and its metabolites: Their number and size increase after exposure to these steroids.

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Sudden infant death syndrome: need for simple definition but detailed diagnostic criteria. We investigated the responses of single neurons in primary visual cortex (area V1) of awake monkeys to chromatic stimuli. These proteins play critical roles in various nuclear functions and the control of cell proliferation. Role of parathyroid hormone in calcium homeostasis and metabolism. Other causes of low zinc concentrations may be due to small bowel conditions that cause mucosal damage and thus decrease absorption. Genetic recombination through protoplast fusion in Streptomyces. Because jasmonates exert their cytotoxic effects independent of transcription, translation, and p53 expression, we hypothesized that these compounds may act directly on mitochondria. The increased species diversity found in halitosis samples suggests that halitosis may be the result of complex interactions between several bacterial species. We identified previously a region on chromosome 19p13.2 spanning the genes encoding the intercellular adhesion molecules (ICAM), ICAM1, ICAM4 and ICAM5 as a breast cancer susceptibility locus.

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Water-absorptive properties of selected solids in a lipophilic base. HIV-1 protease inhibitors herein investigated can fit the active site of Sap2, adopting very similar ligand-backbone conformations. The folding rates extracted using a simple kinetic model are close to those reported previously from laser-induced temperature-jump experiments that employ the change in tryptophan fluorescence as a probe. This retrospective study of 130 consecutive sternotomy wounds compares 41 bilateral pectoralis major muscle flaps with a modified anterior rectus fascia extension against 56 rectus abdominis muscle flaps alone in addressing the lower third of the sternum following dehiscence. Cross-resistance to photofrin-mediated photodynamic therapy and UV light and recovery from photodynamic therapy damage in Rif-8A mouse fibrosarcoma cells measured using viral capacity. Cloning and molecular characterization of Hev b 3, a spina-bifida-associated allergen from Hevea brasiliensis latex.

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Pregnancy loss in the antiphospholipid-antibody syndrome--a possible thrombogenic mechanism. In transmitted and in dark-and bright-field incident light and in the scanning electron beam the material reveals no indication of biological morphology. The Accelerating Effect of Calcium on the Fibrinogen-Fibrin Transformation. These results suggest that the expression of PrP(sc) in the CNS is associated with release of chemokines and, as shown previously, cytokines that attract and retain PrP-activated T cells and, quite likely, bystander activated T cells that have migrated from the periphery into the CNS. Post-hoc analysis was conducted on the data from a 3-year, randomized, double-blind, active-comparator, clinical trial of eldecalcitol versus alfacalcidol under vitamin D repletion conducted cleocin capsules 150mg in Japan. Associated with that, dramatic increases in abuse and overdose deaths from opioid use have been noted. This study compared the effects of PC in SHR and SHR-SP rats, under the hypothesis that PC may not be as effective in the SHR-SP, a strain genetically predisposed to stroke. We consider the capability of the ligament tissue to promote or to suppress calcification in connection with bone and cementum formation and the maintenance of the periodontal ligament space.

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Cutaneous metastases from gastric carcinoma: an unusual presentation. These results indicate that ICE plays an important role in UVB-induced apoptosis of SVHK cells. The purpose of this study was to demonstrate the initial results of the dynamic contrast-enhanced MRA in under four seconds in the assessment of anomalous pulmonary circulation. The site most bactrim dosing in hemodialysis likely served as a sun shrine rather than as a calendrical observing station. Under certain conditions, the recombinant protein was partially active in this prokaryotic organism. Interference in the mevalonate pathway and oxidative pathway provides effective protection of endothelial function. The historic development of these two most different views of obsession and their combination is explained.

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Method optimization for proteomic analysis of soybean leaf: Improvements in identification of new and low-abundance proteins. IL-10 attenuated the IFN-gamma-induced increase in electrical conductance and totally prevented the IFN-gamma-induced increase in mannitol and inulin fluxes. The childhood leukemia association possibly results from elevated intracellular iron in lymphoid cells increasing the vulnerability to DNA damage at a critical time window during lymphoid cell development. Furthermore, the extract was found to enhance radiation-induced G2/M phase arrest, induce Akt activation, and increase motility of Hep-2 cells. No signs of large organisms are apparent at either landing site. Specific features of the diagnosis and course of tuberculosis of peripheral lymph nodes in adults. Nitrogen-containing bisphosphonates effectively reduce the risk of SREs in patients with bone metastases from a variety of solid tumors and bone lesions from multiple myeloma.

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This was confirmed by reacting virus and IgG, separating virus and unbound IgG by centrifugation, and showing that virus was neutralized to essentially the same extent as virus that had been in constant contact with antibody. Glucocorticoid regulation of natural cytotoxicity: effects of cortisol on the phenotype and function of a cloned human natural killer cell line. Far more time was required for the induction of apoptosis in these two cell lines by vitamin K(2) than by GGO. Processing of chicken progastrin at post-Phe bonds by an aspartyl protease. Isolation of T antigen from solid hamster tumors induced by adenovirus type 31. A variety of systemic diseases may affect both the hand and eye, leading to profound sensory and functional deficits. The chemosensors were shown to be competent for detecting zinc pools in cultured rat pituitary (GH3) and hepatoma (H4IIE) cell lines. treatment of the animals with MBP-PC before the immunization was able to diminish the incidence and severity of the disease, reduce the histological alterations, abrogate the proliferative response against MBP and change the pattern of the humoral response to MBP. sustained after cardiac catheterization and angiography are probably due to the increase of growth -hormone secretion during the procedure.

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Bone resorption markers returned to the baseline level at 24 weeks after fracture, while values of bone formation marker were still higher compared to the baseline level at 24 weeks after fracture. Immunogenic neoplastic clones derived in vitro from an originally non-immunogenic BALB/c fibrosarcoma. The system can be web-based, takes seconds to input data and quickly converges to the correct diagnosis. We determined the need and sequence of retroperitoneal lymph node dissection and thoracotomy in patients with nonseminomatous testicular cancer, and with residual retroperitoneal and pulmonary masses after chemotherapy. The reduction in ovary weight revealed the possibility of the drug targeting the ovary. By utilizing transfection of living cells, as well as reconstituted in vitro systems, we identified a dual regulatory mechanism that combines human Sprouty2 and c-Cbl. The present study proved a weak correlation between the PWV and the pathologically verified degree of the aortic and systemic atherosclerosis. Once the hyphae were washed and resuspended in phosphate buffer, they were well buffered towards inhibitory concentrations of caproic acid. The intracellular cAMP level was reduced in transformants expressing the MST7(S212D T216E) allele.

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Wild-type (WT) or P-selectin deficient (P-sel-/-) platelets were isolated and labeled with the fluorochrome CFSE and administered to either WT or P-sel-/- mice placed on a normal diet (ND) or high cholesterol diet (HCD). In using GOALS, clinicians rate each of the four what drugs contain theophylline domains on a scale of 1, very much improved, to 7, very much worse. Conformational changes in Cry3A delta-endotoxin caused by three different alcohols (ethanol, butanol, and isopropanol) were studied using the methods of circular dichroism, scanning microcalorimetry, and electron miscroscopy. Cisplatin forms inter- and intrastrand crosslinked DNA adducts and its cytotoxicity is mediated by propagation of DNA damage recognition signals to downstream pathways involving ATR, p53, p73, and mitogen-activated protein kinases, ultimately resulting in apoptosis. This technique allowed grading of lung damage induced by COPD, whereas use of PFT and determination of BAL fluid cell populations failed to differentiate between remission 1 and remission 2. Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: importance for designing SARS vaccines. A significnat increase in shell thickness was evident for eggs laid on the second and subsequent days of the DLSM-regimen but nor for those laid during the first 24 hours. Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung. In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery. A comparative analysis and limitations of pseudo-isochromatic tests for color vision testing.

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Sperm protein phosphorylation was evaluated using indirect immunofluorescence with an antibody to phosphotyrosine (PY20). The acidic lipids, or protstaglandins, have been the more extensively investigated. Adult lean and high-fat diet-induced obese mice were orally treated with sodium tungstate. These extracts also were found to clarify suspensions of cell walls from nine different gram-positive bacteria, including Micrococcus lysodeikticus. We sought to examine in a clinical cohort the prognostic importance of ventricular ectopy immediately after exercise, when reactivation of parasympathetic activity occurs.

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Therefore, the new primers can be used as an easier and more sensitive tool for the identification of truffle species in any stage of their life cycle, including the mycorrhizal phase. We reviewed the pathologic specimens of culprit lesions obtained by directional coronary atherectomy in 27 patients indapamide dose adjustment in renal failure with MI, 29 patients with UA, and 16 patients with CSA. Several kinds of health consultation and rehabilitation for functional disorders aimed at stroke prevention and maintenance of cognitive function in an elderly population in Hokkaido county, Japan. Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics. Hence, understanding the molecular details of protein-protein interactions in the PKS megasynthases would be crucial for rational design of novel polyketides by domain swapping experiments involving engineered combinations of PKS catalytic domains. Herein, we investigate further the induced CME by means of a GFP-tagged clathrin light chain and a CME inhibitor, the hub domain of clathrin heavy chain.

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Zeolite-directed cascade reactions: cycliacyarylation versus decarboxyarylation of alpha,beta-unsaturated carboxylic acids. Lipid tubules: a paradigm for molecularly engineered structures. The fusion protein of GST-SjHSP40 was induced, purified and specifically recognized by anti-GST antibody. The authors present data from a patient registry and review publications retrieved by a selective literature search. Since the establishment of the guidelines for the treatment of venous ulcers by the Wound Healing Society in 2006, there has been an abundance of new literature, both in accord and discord with the guidelines. Measurement of the custom and conscience functions of the superego. While spontaneous thromboses of abdominal aortic aneurysms have been previously reported, we did not find any reports of a thrombosed thoracoabdominal aneurysm or a subsequent rupture of this type of aneurysm. This extra imaging time allowed coronary artery imaging with increased spatial resolution. Monotony is an inherent characteristic of transport industries, including rail, aviation and road transport, which can have adverse impact on safety, reliability and efficiency. A case arising from the attached lingual gingiva between the mandibular right permanent first molar and the second molar in a 67 year old Indian female is reported here.

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