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Cardem (Diltiazem)

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Cardem is a calcium channel blocker medication used to treat high blood pressure, angina, and certain heart arrhythmias. It may also be used in hyperthyroidism if beta blockers cannot be used. It is taken by mouth or injection into a vein. When given by injection, effects typically begin within a few minutes and last a few hours.

Other names for this medication:
Altiazem, Angizem, Cardem, Cardiorex, Cartia, Coriem, Dicard, Dilacor, Dilcardia, Dilcontin, Dilcor, Dilgard, Dilocor, Dilter, Diltia, Diltiaz, Diltiazem, Dilticard, Diltime, Diltp, Dilzem, Heartil, Icidil, Ionozem, Kaizem, Masdil, Onzem, Taztia, Tiamate, Tiazac

Similar Products:
Imitrex, Nolvadex, Prilosec, Estrace, Bactrim, Floxin, Phenergan

Also known as: Diltiazem


Diltiazem is used to control rapid heartbeats or abnormal heart rhythms. It belongs to a group of drugs called calcium channel blocking agents. Diltiazem affects the movement of calcium into the cells of the heart and blood vessels. As a result, the heart beats slower and the blood vessels relax, thus, increasing the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain diltiazem. It may not be specific to Cardem LA. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended-release tablet, extended-release capsule, or tablet whole. Do not open, crush, or chew it. It is best to take the extended-release capsule on an empty stomach.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain: For oral dosage form (extended-release capsules): Adults—At first, 120 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 milligrams (mg) once a day, either in the morning or evening. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 30 milligrams (mg) four times a day before meals and at bedtime. Your doctor may increase your dose if needed. Children—Use and dose must be determined by your doctor.

For high blood pressure: For oral dosage form (extended-release capsules): Adults—At first, 180 to 240 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 to 240 milligrams (mg) once a day, either in the morning or at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diltiazem can be fatal.

Overdose symptoms may include slow heartbeat, weakness, chest pain, shortness of breath, or fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Cardem CD dosage information

Side effects

The most common side effects associated with Cardem are:

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Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

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The changes could not be induced in control intestine either with hyperglycemia from glucose infusion or preincubation with glucose in vitro. DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit?. OTA increased pH significantly in PT, DT, CD as well as in the descending and ascending VR, whereas pH in RA remained unchanged. Scintigraphic imaging of macrophages involved in lung vasoreflex: rat model. Penetration of antibiotic into interstitial tissue fluid following parenteral administration of lysine cephalexin. The introduction of NPPV has been one of the most important advances in the management of patients at home with chronic respiratory failure. In a group of 1066 heroin addicts, who were seeking treatment for opioid agonist treatment, we looked for differences in historical, demographic, and clinical characteristics, between patients with different levels of awareness of illness (insight). Transfection of cells with a recombinant plasmid containing the p35 gene under the transcriptional control of a stress promoter (Drosophila hsp70) was also able to rescue cells from oxidative stress-induced cell death, demonstrating the direct involvement of P35. Up to now, there has been only a limited number of studies available dealing with low-field MR arthrography of the glenohumeral joint.

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Two cases of unexplained prolonged cholestatic jaundice in patients who underwent endoscopic retrograde cholangiography (ERC) for biliary obstruction due to choledocholithiasis are reported. Induction of systemic resistance of benzothiadiazole and humic Acid in soybean plants against fusarium wilt disease. The strength of the association increased with decreasing gestational age. Our objective was to investigate the association between the mitral valvular 3-dimensional geometric perturbations and chordae tendineae force redistribution in a porcine model of acute ischemic mitral regurgitation. Turkeys were inseminated at six different times of the day (1:00 p.m., 3:00 p.m., 5:00 p.m., 6:00 p.m., 9:00 p.m., and 12:00 a.m.) to determine the effect of time of day of insemination and the stage of egg formation on fertility. An inherited basis for congenital extrahepatic portosystemic shunts (EHPSS) has been demonstrated in several small dog breeds. Somatic dysfunction and its association with chronic low back pain, back-specific functioning, and general health: results from the OSTEOPATHIC Trial. Industry perspective: maximizing the benefit of improved detection with guided and monitored thermal ablation of small tumors. By using whole-cell patch-clamp recordings from sSC neurons in slice preparations obtained from mice that had received visual cortical lesions at 1 week prior to the recordings, we found cell type-dependent changes in the balance between excitation and inhibition.

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Specificity of antibodies was confirmed with Western-blot analysis. RNA molecules that bind tightly and specifically to a Rex fusion protein have been isolated from a conformationally constrained pool of random sequence RNAs. This system is well-known for its basic regulatory function in protein degradation, and controls a magnitude of key events. The care encounter: pondering caring, honest communication and control. Iridium-catalyzed intermolecular hydroamination of unactivated aliphatic alkenes with amides and sulfonamides.

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The study group included 263 patients who were suspected of having coronary artery disease. Use of videotaped feedback in training pharmacy students to take medication histories. Insulin receptor substrate p53 (IRSp53), a key player in cytoskeletal dynamics, is enriched in the postsynaptic density (PSD) fraction, but its significance in synaptic functions remains unclear. A substantial proportion of sphingomyelin, which normally contains only non-hydroxy fatty acids, also contains alpha-hydroxy fatty acids. There were no significant differences in morphologic presentation of cellular radiation damage.

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Thermodynamic interactions of a cis and trans benzanilide with Escherichia coli bacterial membranes. Only duration of mechanical ventilation has been identified as an independent risk factor for ventilator-associated pneumonia. (i) A discrepancy between the H-reflex amplitude, at an equal level of EMG activity, in two situations (e.g., walking and standing) may be taken as suggesting a different control of PAD interneurones in the two cases. The aim of this study was to produce and characterize nanoparticles (NPs), combining chondroitin sulfate (CS) and fucoidan (FC) with chitosan for therapeutic purposes. We examined the effects of picrotoxinin, pregnenolone sulfate (PS) and dehydroepiandrosterone sulfate (DHEAS) on gamma-aminobutyric acid (GABA) responses in Xenopus oocytes injected with wild type alpha1, beta2 and gamma2 GABA(A) receptor subunits and in oocytes injected with wild type alpha1 and beta2 subunits and a mutated gamma2 subunit that eliminates picrotoxin sensitivity. Morbidity and mortality associated with hyponatremia are primarily a result of brain edema, hypoxemia, and associated hormonal factors. maximum stimulating effects of fructose 1,6-diphosphate are observed at high pH.

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Understanding the etiology of seizures is the key to rational intervention. Reasons that may partially explain these findings are the high level of potential pathogen connectivity within the Caribbean as a result of its circulation patterns coupled to the large land-derived pollutants and pathogens input into this Mediterranean sea, together with the surface water warming effects which stress corals and enhance pathogen activity. Quercetin is a powerful antioxidant which is widely distributed in edible plants, mainly as glycosides such as rutin. Proliferation of peripheral blood mononuclear cells (PBMC) from cattle and bison was measured following stimulation of PBMC with bovine cytokines. Blood pressure control often requires the use of 3 or more antihypertensive agents in patients with diabetes. The alphaHBDH/LDH ratio of H to M subunits of lactate dehydrogenase, was low in the fetus and continued to rise during the 1st mo after birth. Alendronate enhances the new bone formation by autogenous bone graft in the rat calvarial defect model suggesting that the inhibition of the osteoclastic activity allows an increased rate of bone apposition, which could be applicable to the inflammation-induced destruction of the periodontal tissues during disease. Phosphoenolpyruvate carboxylase protein kinase from soybean root nodules: partial purification, characterization, and up/down-regulation by photosynthate supply from the shoots. In this review we examine, through several examples, areas in which insights have been gained into the basic neurophysiological processes that bring about motoneuron firing in man and illustrate how these processes are affected by central nervous system pathology. Ventricular asystole during vagus nerve stimulation for epilepsy in humans.

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Thrombopoietin (TPO), produced mainly in the liver, is a major regulator of platelet production. Therapeutic efficacy of pirarubicin cyclophosphamide and doxifluridine in advanced and metastatic breast cancer. Okadaic acid (OA), a serine-threonine phosphatase inhibitor, induced PGE2 production and a significant increase in PGHS-2 immunoreactive protein. The elaboration of past and future events recruited a common neural network. The acquisition of Pseudomonas aeruginosa in the airways of patients with cystic fibrosis (CF) is the initial event leading to bronchiectasis and lung disease. In order to prevent the chance finding of the hidden platform, the rigid underwater platform was replaced by a collapsible island, resting at the bottom of the pool. Pressure and gait parameters were measured simultaneously while the subjects were standing and walking. milleri was isolated from other abdominal sites associated with appendicitis. Here we examine how the membrane conductances that generate bursts affect neural computation and encoding. The goal of anesthesia in the ambulatory management of fractures in children is to provide analgesia and relieve anxiety in order to facilitate successful closed treatment of the skeletal injury.

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Thus, because labeling density was increased, the yield of PCR was reduced. Four hundred ninety-one fecal samples were collected from 138 patients who were admitted to the Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Japan. The microscopic differences could verify macroscopic CMS to some extent. Questionnaire study of a cohort of women who experienced a severe obstetric morbidity during pregnancy or labour (cases), compared with a cohort of women who did not (controls). Observation of adaptive evolution in several female reproductive tract proteins indicates they are active players in the evolution of reproductive tract interactions. Management of children subjected to anesthesia - basic information. TorsinA protein and neuropathology in early onset generalized dystonia with GAG deletion. Pancreatic amylase activity from ruminants fed different rations. Biliary tract cancers, broadly described as malignancies that arise from the biliary tract epithelia, are usually divided into two major clinical phenotypes: cholangiocarcinoma and gallbladder cancer, differing in etiopathogenesis, risk factors, and perhaps molecular and genetic signatures. Descriptive study with trends in time in general practice in the Netherlands.

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Spreading of viscous liquids at high temperature: silicate glasses on molybdenum. In many instances the recourse to Fibonacci, Thue-Morse or fractal arrangements of layers results in improved optical properties compared with their periodic counterparts. In this context, pain is often present in the second stage, despite the fact that it is comparatively less aggressive for the patient. After blockade of neuronal noradrenaline release with guanethidine, contractions of the tissues to increasing concentrations of exogenous noradrenaline were significantly reduced by EFS, an effect that was reversible by inhibition of NO synthase. These results raise questions about the ethical acceptability of a prospective study of amblyopia treatment at these ages. In this cat plasma parathyroid hormone (PTH) levels were measured repeatedly zantac 75 mg tabs and these values exceeded the maximum reference value on two occasions. An interactive collagen stability calculator based on this algorithm is available online. No significant difference was obtained between the 3 groups in graft volume or microvascular angiogenesis at any stage of the study. Alleviating fragmented systems of health care: the Regional Medical Programs. The purpose of this study is to analyze how the costs to society vary with different levels of functioning and with the presence of a brain disorder.

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This is the first study to demonstrate that stimuli used for assessing early language development in the RDLS-III are not judged to be typical by children or adults. Some patients have very slow-growing distant metastases with relatively favorable outcomes, so predicting prognosis is not easy. In the follow up, there was no differences in sleep profile between groups. Five with twenty: five air medical services celebrate 20-plus years in business. The 4 patients examined showed circumscribed and painful hyperkeratosis at the weight-bearing plantar skin since infancy, rather mild palmar hyperkeratosis, and continuous leukokeratosis confined to the maxillary and mandibulary attached gingiva. To investigate the relationship between inflammation markers and content of pyridinium crosslinks in hydrolysates of synovial tissue and to specify the significance of urinary excreted pyridinoline, released primarily from collagen I and II of bone and cartilage, and deoxypyridinoline released especially from collagen I of bone and dentin, dependent on disease activity in rheumatoid arthritis (RA). Furthermore, ethnicity, in addition to BMI, influenced the STLESD. DAV remains the most important factor for prediction of SP in patients with rectal cancer.

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Guanamycin, an antibiotic of the quinoxaline group, produced by Streptomyces sp. The compounds were isolated and purified by silic gel column chromatography and preparative HPLC. Contrary to a recent report, the biologically active GA4 was not detected. Our method detects events using adaptive thresholds that adapt to low-frequency variations in the baseline. Expression studies of SCA in lily and confirmation of its role in pollen tube adhesion. In the absence of EGF, a well-differentiated epidermis was generated at 33 degrees C with a morphology showing a higher resemblance to native epidermis than cultures grown at 37 degrees C. We tested the hypothesis that different traumatic experiences will contribute in variable degree to different mental pathologies. Spectrophotometric determination of acidity constants of 4-dedimethylamino sancycline (Col-3), a new antitumor drug.

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None of the existing studies are large enough to determine whether combination treatment reduces fracture risk to a greater extent than use of a single agent. It is difficult to identify characteristics of patients with unstable angina that are predictive of a high likelihood of developing clinical events. Serum calcium and phosphorus levels in hens relative estrace cream side effects reviews to the time of oviposition. The recent bus crash in Switzerland involving many children provides several lessons for the pre-hospital care community. coli O157:H7 were found in the feces, with negative or significantly lower levels detected in lumen contents taken from the gastrointestinal tract. An operon that confers UV resistance by evoking the SOS mutagenic response in streptococcal conjugative transposon Tn5252. There is also a strong evidence, that genes, such as androgen receptor gene (AR), e-cadherin, and PTEN, are involved in the development and progression of prostate cancer.

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The results of psychoacoustic experiments indicate that in most cases the recovered and measured HRTFs are indistinguishable. The mean body weight of mice treated with 125 ppm TBT was significantly lower than that of the control from day 5 to day 16 during the treatment period. Pulmonary plasminogen-activator activity in hyaline membrane disease. Starting from a model for neighbor independent nucleotide substitution we successively added neighbor-dependent substitution processes in the order of their ability to increase the likelihood of the model describing given data. Suppression of nocturnal growth hormone secretion in epilepsy with continuous spike-waves during slow-wave sleep. In 14 mite-sensitive asthmatic patients, house dust mite allergen (Der f 1) contents in bedding were measured monthly. Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma. In this study, short-term improvement in the clinical picture of a patient with sympathetic ophthalmia after intravitreal triamcinolone acetonide injection was described. The influence of various peptides containing the aromatic amino acids phenylalanine and tyrosine on the formation of the enzyme EAC1423 of the complement system from component C3 and enzyme EAC142 was investigated. In summary we have reviewed some of the studies and theories regarding the role of the dentate ligaments in cervical spondylosis and myelopathy and the logic which has been proposed either for or against their transection in the surgical treatment of this disease.

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To assess prospectively the quality of life (QOL) of patients treated by preoperative radiotherapy (RT) and surgery for locally advanced rectal cancer. Results from DMPO spin-trapping electron spin resonance measurements confirm the formation of hydroxyl radicals, which is the origin of the considerable bactericidal activity under visible light irradiation. The immediate early genes are regulated by a variety of extracellular signals, including pleiotropic cytokines. The two major size variants, SCAMP1 (37 kDa) and SCAMP2 (39 kDa), extensively colocalize in membranes of fibroblasts and parotid acinar cells based on immunocytochemistry and velocity centrifugation, although the relative amounts of each variant may differ in selected organelles. Pre-clinical but limited clinical studies indicate that under defined conditions, thrombopoietin may accelerate white blood cell count and platelet recoveries following myelosuppression or radiotherapy. E2 or E2-BSA enhanced DNA binding and transcriptional activity of AP-1 and generated c-Fos/c-Jun heterodimers by inducing c-Fos expression. Morphological, ultrastructural, histochemical, and biochemical peculiarities of the tissue of the formed articular surface are described.

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We recently described threats to the terrestrial biological resources on the Mariana islands of Guam and Tinian resulting from the large-scale buildup of military operations. Twenty-eight patients treated by a standardized clinical protocol from infancy through adolescence were evaluated with respect to the need for orthognathic surgery to correct jaw size discrepancy. Clinical response was only accomplished when linezolid was included in therapy. Cathepsins B and L have been shown to play an important role in matrix degradation and cell invasion. In a poor community in Nepal, consumption of a daily supplement containing a recommended daily allowance of 15 micronutrients in the second and third trimesters of pregnancy was associated with increased birthweight when compared with a standard iron and folic acid preparation. However, still debated was the way of analysing ABPM recordings. Selegiline induces dopamine release through ATP-sensitive potassium channels in the rat caudate-putamen in vitro. To identify attitudes and practices in the Spanish population regarding physical activity, and to compare the situation in Spain with prilosec medication side effects in women that of other member stages of the European Union (EU). However, several times a day she experienced severe rebound phenomena with pronounced concentration disturbances, unrest, and dysphoric mood.

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Here we identify, using an integrated genomics and proteomics strategy (referred to iMASp - identification of Mutated And Secreted proteins), 112 putative mutated tryptic peptides (corresponding to 57 proteins) in the collective secretomes derived from a panel of 18 human colorectal cancer (CRC) cell lines. Physical parameters of chlorphenamine maleate suppositories and its release as a function of particle size, concentration and nature of the base. Abstract and concrete non-phonetic logographic symbols (Kanji) were unilaterally cleocin brand presented in either the left or right visual field. Modelling viral evolution and adaptation: challenges and rewards. Neurolysis and epineurotomy of the median trunk in the brachial and axillary areas were performed. Our results also indicate that prefrontal cortex may be a source of control signals for neuroprosthetic applications. Only two of the samples had positive blood cultures as detected by the routine radiometric assay.

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