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Capxcel (Capecitabine)
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Capxcel

Capxcel is used in the treatment of cancer of breast, colon, and rectum. It may be also used to treat other conditions, as determined by the doctor. It is used alone or in combination with some other medicine as a part of chemotherapy.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Motrin, Coreg, Zanaflex, Antivert, Aygestin, Noroxin, Omnicef, Risperdal

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Capxcel for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Capxcel for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Capxcel dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capxcel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Capxcel if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Capxcel is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Capxcel .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Capxcel and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Capxcel, and for at least 2 weeks after your last dose.

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Overhead and opportunity costs were calculated using historical norms and actual costs. Distribution of pancreatic trypsin among the fractions of duodenal contents in an in-vitro system. PPARs function as regulators of lipid and lipoprotein metabolism and glucose homeostasis and influence cellular proliferation, differentiation and apoptosis. Sonography showed the presence of multiple bladder nodules in a background of diffuse bladder wall thickening. Effect of oxidants, hydrazines, and aminoquinolines on the filterability of erythrocytes from vitamin E-deficient lead-poisoned rats. We compared complication rates, intensive care unit (ICU) and hospital stays, nutritional intake, number of tracheoesophageal punctures (TEPs) performed, TE speech fluency, and functional use. We linked 2005-2006 pharmacy, outpatient, and inpatient claims to enrollment and Census data.

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These results suggest a possible molecular mechanism for the elasticity of spider silk fibers. This enables one to estimate: (a) a rate of elongation curve for each segment level, (b) the intrinsic rate of change of elongation of the cartilage, (c) a definitive extrapolation back to classical presumptive fate maps, (d) the normal range of variation in the proportion of the limb occupied by the three main segmental levels (stylopod, autopod, zeugopod). All these changes restored to normal levels at 21 d post hypoxic-ischemia. The immunosuppressants used included mainly cyclosporine A as well as mycophenolate mofetil or azathioprine, steroid and ALG, or basiliximab. However, increasing model complexity means that more powerful global optimisation techniques are required for model fitting. Quantitative microsatellite analysis further confirmed DNA copy number gain at the Jab1 locus. Diffusion tensor imaging was used to examine white matter integrity at four levels of the visual system in 17 patients with schizophrenia and 21 comparison subjects. Phacoemulsification in filtered chronic angle closure glaucoma eyes.

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Detection of chronic lead exposure in children living in public housing. Melting of the ribosomal RNA gene reveals bacterial species identity: a step toward a new rapid test in clinical microbiology. 11 has had limited effect on international medical education programs, at home and abroad. Examination of the anti-anginous effect of Sensit in angina pectoris. This suggests that the asymmetry of the zygote that is established at fertilisation and early cleavage has a lasting impact on the delineation of body axes during embryogenesis. Decreased activities of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), total thiol, glutathione peroxidase (GPx), glutathione reductase(GR) and glutathione-S-transferase (GST) were also observed in pesticide-treated as compared to control mice. Internal reconstruction of the pelvic floor for recurrent groin hernia. We found that higher-order interaction-induced effects were essentially negligible for both liquids. Soluble erbB-2 protein was demonstrated in culture supernatants of cell lines that expressed high levels of erbB-2 protein as shown by western blot analysis of cell lysates.

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Traumatic occipitocervical disruption: a new technique for stabilisation. The protection of Factor VIII and Factor V activities were monitored in a lyophilized plasma preparation following formulation with either no additional excipient, 40 mM Hepes (4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid), 10 mg/mL glycine or a combination of 40 mM Hepes and 10 mg/mL glycine. Current methods of research in early diagnosis of cor pulmonale in children with diffuse connective tissue diseases. Different cytokines and growth factors has been used to expand stem cells, but no combination of these factors was identified that could effectively expand the most primitive stem cells. Golimumab: A novel anti-TNF-alpha human monoclonal antibody for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. The influx of neutrophils into cutaneous lesions induced with the chemotaxins formylmethionyl-leucyl-phenylalanine (FMLP), platelet-activating factor (PAF), and alpha-casein, and the chemotaxinigens endotoxin and zymosan peaked at 2 to 4 hr and then rapidly declined. Kirschner wire migration in the contralateral lung after osteosynthesis of a clavicular fracture. We analyzed the survival rate of patient/kidney at 1-, 3-, 5 years. We report a randomized study on an attempt to simplify monitoring of COH. There is insufficient evidence to definitely conclude that GORD treatment with PPI is universally beneficial for cough associated with GORD in adults.

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Impaired gastrocolonic response and peristaltic reflex in slow-transit constipation: role of 5-HT(3) pathways. To examine the clinical and genetic heterogeneity of autosomal dominant optic atrophy among two unrelated central Illinois families. Automated external defibrillation by very young, untrained children. The augmented activity of NK cells induced by alpha-IFN was variable, but remained at lower levels than the endogenous activity of NK cells in normal controls. The adductor division was grafted with one of the following nerves: proximal recurrent laryngeal, external branch of superior laryngeal, or ansa hypoglossi.

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Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates. The average increase of the BMC values relative to the mean for the vertebrae L2 to L4 for aortae with severe complicated lesions, i.e., those containing larger amounts of calcium, was 0.03 g/cm2, with a maximum deviation of 0.09 g/cm2. Hemophilia A and B are hereditary coagulation disorders that result from functional deficiencies of factor VIII (FVIII) or factor IX (FIX), respectively. Signal transducer and activator of transcription 3 (Stat3) is the main mediator of interleukin-6-type cytokine signaling required for hepatocyte proliferation and hepatoprotection, but its role in sclerosing cholangitis and other cholestatic liver diseases remains unresolved. Ischemic mitral regurgitation: impact of the left ventricle and mitral valve in patients with left ventricular systolic dysfunction. EHDP, and especially Cl2MDP, are promising agents for treating hypercalcemia and inhibiting bone resorption in malignant disorders. Use of the different neuromonitoring techniques permits optimum use of the treatment available.

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Hypertension pharmacogenomics: current status and future directions. (188)Re-Herceptin can effectively inhibit the growth of in vitro cultured breast cancer cells overexpressing HER-2/neu, and shows much potential for clinical use in beast cancer radioimmunotherapy. In particular, IL-6 did not stimulate detectable LGL IL-2 production or IL-2R modulation, and mAb to the p75 IL-2R had no effect on IL-6 induction of LGL NK activity. Interstitial fibrosis and infiltration with lymphocytes and plasma cells with formation of follicles were observed in the lung biopsy. Adjustment of sarcomere length to sustained stretch was studied in situ by the light diffraction method applied to the extensor digitorum longus muscle of the mouse. A preliminary study of applying chemical biliary duct embolization to chemical hepatectomy in rats. Haversian cortical bone model with many radial microcracks: an elastic analytic solution. As in our case, the initial symptoms may be the result of progressive cervical cord compression. In contrast to the predicted properties of M135R as an inhibitor of type I interferon, all binding and inhibition assays designed to demonstrate whether M135R can interact with IFN-alpha/beta have been negative.

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Larval growth in postlarvae of Penaeus indicus on exposure to lead. Measurements of right coronary artery blood flow, aortic and right ventricular (RV) pressures and heart rate were radiotelemetered during strenuous, spontaneous exercise in normal dogs and dogs with severe RV hypertrophy induced by chronic (5-6 mo) pulmonary artery stenosis. Although the approach has yielded positive results, typically the trait-associated loci explain only a small fraction of the heritable fraction of trait variance. Utility of echocardiography in assessment of pulmonary hypertension secondary to COPD. Effects of acetylcholine, propranolol, and verapamil on sinus node refractoriness of the rabbit. Advances in molecular biology have allowed for the identification of potential vaccine candidates against several parasitic diseases. Since mucins are glycoproteins mainly produced in the digestive organs, our results suggest that pp-GalNAc-T12 plays an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. We have taken advantage of the high yield provided by an affinity chromatography method for partial purification and after the incorporation of additional steps, we obtained purified progesterone receptor devoid of detectable contaminants and suitable for chemical analysis. Hypoparathyroidism, a rare endocrinopathy in thalassaemia major.

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