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Capegard (Capecitabine)

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Capegard is an anticancer medication. Inside the body, this medicine gets converted into 5-fluorouracil (chemical). This chemical hampers the synthesis of genetic materials (RNA and DNA) in the cancer cells, thereby interferes with their growth.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Aldactone, Ditropan, Duricef, Albenza, Motrin

Also known as: Capecitabine


{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).


Usual Adult Dose of Capegard for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Capegard for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Capegard dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capegard are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Capegard if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Capegard is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Capegard .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Capegard and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Capegard, and for at least 2 weeks after your last dose.

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In this chapter we will discuss the role of interregional synchronous activity and its relevance as a mechanism for implementation of successful human complex behavior exemplified within studies of complex finger movements, context-dependent control of complex motor behavior, bimanual motor tasks, visuo-tactile integration, and recovery of motor functions after stroke. Initial experience with surgery for retinal detachment using a balloonprobe. Standardization of reference points for gynecologic radiotherapy. A case of an unreducible radial head dislocation found in a 7-year-old girl illustrates the frequent delay in diagnosis associated with radial head dislocation. It has been speculated in recent years that the different tubulin isotypes may confer functional diversity to microtubules. Temperature-sensitive mutants harbouring alterations in ribosomal proteins L28 and L33 have been isolated and used in mapping the genes coding for the two proteins.

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Little is known about the developmental interplay between neurotrophins and neuropeptides. The kinetics of phagocytosis and microbial killing were similar in the insect hemocytes and human neutrophils. A practical route toward the synthesis of 6-deoxy-L-idose and L-acovenose from 1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose is described. Occupational determinants of bone and blood lead levels in middle aged and elderly men from the general community: the Normative Aging Study. Neuroendocrine cell (carcinoid) tumours have been reported in the acid-secreting part of the stomach of rodents after long-term administration of a range of potent chemically diverse antisecretory agents. To understand how food cues might entrain a mammalian peripheral clock, we examined the responses in the expression of clock genes in rat livers to different feeding stimuli. Glucagon and GLP-1 stimulate IGFBP-1 secretion in Hep G2 cells without effect on IGFBP-1 mRNA. Potential for adverse reaction from rubber degradation products and contamination adsorbed from disinfecting agents does not appear negligible. Quantitative and qualitative determinations of the combined effect of tetracycline and oleandomycin. We report a case of an isolated hyoid bone fracture that resulted in sudden and severe upper airway compromise.

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Macrodontia of a single tooth: review of literature and report of case. Furthermore, we emphasize the impact of new developments in molecular biology and the generation of genetically modified mice, which have generated the concept of behavioural phenotyping. Animal experiments suggest that prenatal hypovitaminosis D may underlie greater limb length. Differential regulation of Tbx5 protein expression and sub-cellular localization during heart development. This treatment resulted in the need for general anesthesia, frequent repeat debridement and frequent loss of structure of the ear with subsequent deformity. Uptake and metabolic rate of liposome-entrapped (U-14C)glutamate in rats. Liquid embolization for arteriovenous malformation with temporary balloon occlusion of another feeders.

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Modal karyotypes and mosaicism in mouse mutant cell lines: LM(tk-), A9, and Rag. Respiratory abdominal muscle recruitment and chest wall motion in myotonic muscular dystrophy. This method has proven highly efficient in transferring, in particular, plasmid DNA to muscles, resulting in long-term expression of the transferred genes. The action of several steroidal and non-steroidal antiinflammatory agents, immunosuppressives, and antirheumatics (levamisole, chloroquine, sodium aurothiopropanol sulphonate, D-penicillamine) was studied in two models of Arthus-passive reaction in the rat: paw oedema induced by an anti-ovalbumin serum, and pleurisy induced by an anti-bovine-albumin serum. By middle school, this reward insensitivity is met with inadequate vagal modulation of cardiac output, suggesting additional deficiencies in emotion regulation. Consideration of thermal compatibility in the selection of ceramic alloys. Part 2: Effect of sec-butanol concentration and initial location.

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Relative phytohemagglutinin and mixed lymphocyte culture responses of the cells decreased, whereas purified protein derivative responses were unchanged. Effects and side effects of depot neuroleptics as perceived by patients. Effect of adenosine on melatonin and norepinephrine release in rat pineal explants. Optimal multi-phase three-dimensional fast imaging with steady-state free precession dynamic MRI and its clinical application to the diagnosis of hepatocellular carcinoma. Next, we used a proteomic approach to compare and identify differentially represented proteins in 2-DE of CAPN3 Tg and non-Tg mice.

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Twenty-seven cases of congenital posterolateral diaphragmatic hernia past infancy are reviewed in tabular form and discussed as to presenting symptoms, physical and radiographic findings, operative treatment, and final outcome. By decreasing the STM tip-cluster separation, it was observed that the capacitance first increases and then decreases at short separation. However, to be truly useful, such systems must be integrated into the overall medical informatics architecture including order entry into the radiology information system, the ability to receive orders from the radiology information system, acceptance and transcription of dictation, and transmission of validated reports to the hospital information system (HIS)for billing capture. Mean serum melatonin levels were significantly higher in patients than in controls. A 30-year-old man underwent LASIK in the right eye and PRK in left eye for refraction of -1.75 -1.50 x 48 degrees and -1.00 -1.75 x 100 degrees, respectively.

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THrough the conception of physis, applied principally to the body, the human body will be demarcated as the physical or material aspect of human nature, as opposed to the monistic view of human nature, which has not drawn a categorical distinction between the material and the non-material. Our experiments demonstrate strikingly specific nuclear and territorial arrangements of active genes as compared with inactive ones: on the periphery of their territories facing to the very central region of the cell nucleus. Temporal lobectomy for the treatment of intractable complex partial seizures of temporal lobe origin in early childhood. Effectiveness of WR 163577 against animal trypanosomes in goats and mice. In this case report, this exclusion bypass technique was safely applied through a transperitoneal approach to manage a very large, tortuous and displaced infrarenal abdominal aortic aneurysm which was densely adherent to the left kidney and ureter. HLA and rheumatoid arthritis: a combined analysis of 440 British patients. Antibodies to 5-HT and the native flatworm neuropeptide GYIRFamide were used.

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Cu, Zn superoxide dismutase dominates the longitudinal relaxation rate of the intracellular F- resonance, while diamagnetic interactions with hemoglobin contribute mainly to the transversal relaxation rate. There is lipid accumulation in the lamina propria and lymphatic vessels. Intrapancreatic and subcutaneous (SC) inoculation of cultured pancreatic cancer cells, derived from an induced primary pancreatic cancer in a Syrian hamster, resulted in tumor take in all recipient hamsters. Electroanatomic study of the left atrial insertion of an epicardial accessory pathway integrating the coronary sinus. The outer hair cells were more extensively affected than the inner hair cells. Intestinal parasitic infections in Thai HIV-infected patients with different immunity status. In mammals, p53 is crucial for inducing the genes that lead to G1 arrest following DNA damage, enabling DNA repair.

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As regards number of PDs having a quasi-linear relationship to disability, there was some indication of this on the SF-12 Mental Summary Subscale and the two role functioning measures, and less so on the other two measures. Health outcome utility assessments generally assume procedural invariance. The female patient, who presented initially with bulbar and extrapyramidal dysfunction, was found to have cerebellar cortical atrophy at necropsy. The exact mechanism causing this disease is not known, but immune-mediated features are prominent is generic zyrtec safe during pregnancy and are probably to play a role in its pathogenesis. Moreover, a number of drugs have been developed that target HIF-responsive gene products, such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), implicated in tumorigenesis. While immunohematologic testing has been used in the legal arena to resolve issues of disputed paternity and to investigate instances of criminal acts, the authors believe this to be the first documented application to this clinical disorder. An analysis of the corrected emission activities shows that the resulting transformation is essentially equivalent to the transmission-based attenuation correction for human tissue.

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Both membrane preparations take up PAH into an osmotically reactive intravesicular space. However, the subsequent MRI findings revealed pachymeningitis of the bilateral tentoria and falx. In active MS plaques, EBV-encoded RNA (EBER)-1 was the only and rarely detected transcript. Serum placental protein 14: a novel marker of selective oestrogen receptor modulator action on the postmenopausal endometrium. High serum uric acid concentration (hyperuricemia) has been studied for its relationship with multiple adverse health outcomes, such as metabolic syndrome. There is some evidence that the use of a daily NaF mouthrinse or a GIC for bonding brackets might reduce the occurrence and severity of WSL during orthodontic treatment. A beneficial effect was noted of higher storage temperature (20-24 degrees C) on the maintenance of chemotactic activity. Sixteen patients with pathologically normal nodes at laparotomy had residual lymphographically abnormal nodes at postoperative roentgenography.

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The work was aimed at finding whether the ratio of delta-aminolevulinic acid (ALA) and creatinine (Cn) concentration (ALA/Cn), presently used in occupational health practice for evaluation of lead exposure gives a better assessment of ALA excretion than uncorrected ALA concentration itself, as well as at finding a better, but not complicated method for adjustment. Philosophical, legal and scientific basis for vocational integration. A combined action of the tested plant extract and H(2)O(2) evoked a significant increase of reduced form of glutathione in platelets compared with cells treated with H(2)O(2) only. RANTES is a C-C (beta)-chemokine family member with strong chemoattractant activity for lymphocytes and monocytes that are implicated in the pathogenesis of MS lesions. The observation group was treated by acupuncture at Sishencong (EX-HN 1), Shenmen (HT 7), and Sanyinjiao (SP 6) with tranquilizing and allaying excitement needling method.

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Involvement of insulin-like growth factor-I for the regulation of prolactin synthesis by estrogen and postnatal proliferation of lactotrophs in the mouse anterior pituitary. The solution to this generally lies in encryption and authentication. Reduced antioxidant capacity in paediatric patients with homozygous sickle cell disease. The aggregate data point toward a rate-determining formation of an activated iron-oxo intermediate, which partitions between amine oxidation and reductive uncoupling in a prometrium 200 mg benefits manner that is dependent on substrate structure. Protective effect of Labisia pumila on stress-induced behavioral, biochemical, and immunological alterations. Oxygen consumption of cell suspension in a poly(dimethylsiloxane) (PDMS) microchannel estimated by scanning electrochemical microscopy. To improve the digestibility of paddy straw to be used as animal feed by means of selective delignification using white rot fungi. Several months after the injury, his function was severely limited.

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