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Capecitabine

Capecitabine is used in the treatment of cancer of breast, colon, and rectum. It may be also used to treat other conditions, as determined by the doctor. It is used alone or in combination with some other medicine as a part of chemotherapy.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Valium, Nexium, Silagra, Alprostadil, Ceclor

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Capecitabine for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Capecitabine for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Capecitabine dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Capecitabine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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Vitamin C and B1 allowance in various diseases of the gastrointestinal tract. A lipase gene (lip3) from the psychotrophic strain Moraxella TA144 has been cloned and sequenced. Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray. Here, the combinatorial optimization method, simulated annealing, is shown to reduce substantially the computing effort involved and also to permit computations that are beyond the reach of current algorithms. The two resin-based composite materials are effective in Class II clinical situations when placed with either the OIT or MIT. Nonspecific bronchial reactivity in children with bronchial asthma and chronic and recurrent bronchopulmonary pathology. Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes. Reconstructions of the lower lid, the upper lid, the medial canthus, the infraorbital area, and the eyebrow area are reviewed. The ferret may be a suitable animal model for vasculogenic mechanisms of persistent fetal intraocular vasculature and for evaluating vasoinhibitory growth factors and angiostatic test compounds.

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The effect of hypnotic training programs on the academic performance of students. Trilocus disequilibrium analysis of multiallelic markers in outcrossing populations. In this review, I discuss the current state of murine trans-operons, and suggest ways this lac-based system might be used to build more advanced models of human diseases in the mouse. During stress, there were prominent left ventricular apical and anteroseptal defects, which normalised at rest. North Carolina day care center illness policies: a time for change.

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Main stem stenosis, three vessel and severe two vessel involvement, particularly with reduced ventricular function, remain the domain of bypass surgery. Newly identified forms of electron transfer flavoprotein (ETF) deficiency in two patients with glutaric aciduria type II (GA II) were described. This commentary summarizes some of the ethical issues involved in neonatal drug development. Nucleic acids are quantitated by UV absorbance measurement, fluorimetry, or hybridization. The glucoincretin hormone glucagon-like peptide-1 and the chemokine stromal cell-derived factor-1 modulate canonical Wnt signaling in beta-cells which is obligatory for their mitogenic and cytoprotective actions.

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The fact that deprivation of one eye can affect the refractive development of the contralateral eye has implications related to the question of central vs. Final GAS scores were significantly correlated with other outcome measures. The cells contained a single eccentrically located nucleus with evenly distributed, fine chromatin. A complete response (CR) was confirmed by endoscopy in December 2003. We present a case of cholangiocarcinoma which made debut with cholestasis and sepsis in a cholecystectomiced patient, who had a long standing lithiasic cholecystitis. It was established that diastolic function of the left ventricle is realized as the process of filling, so any damage to it can be detected at the early stage not by any changes of systolic characteristics of the ventricle but from its diastolic ones. The School Breakfast provides more calcium, phosphorus, protein, and magnesium than a non-US Department of Agriculture breakfast, but less vitamin A, vitamin B6, niacin, thiamin, and iron. Investigation of the mechanism of the synthesis of oligonucleotides. The external surface of facets of representatives of 19 families of Lepidoptera is discussed and illustrated.

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Furthermore, we show evidence for the presence of mature LOX in the cytoplasm and establish these cell lines as models for epithelial LOX studies. Higher ER variant truncated after sequences encoding exon 2 of the wild-type ER-alpha (ERC-4) messenger RNA and a lower exon 3 deleted er-alpha variant (ERD3) messenger RNA relative expression in the tumor compartment were observed in the ER-positive/PR-positive and the ER-positive subsets, respectively. New Platinum and Ruthenium complexes display antitumour and antimetastatic potentials and lower host toxicities. Using reporter gene assays in conjunction with chromatin immunoprecipitation assays, we show that TRAIL induction by TNFalpha is regulated via both nuclear factor-kappaB and Sp1 binding sites. Antihypertensive and antioxidant effects of Allanblackia floribunda Oliv. Social sciences in the face of AIDS: between silence and too much talk?. We assessed the frequency of transduction of sequences flanking the retroviral vectors from both integration sites.

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Colonoscopy during an attack of severe ulcerative colitis is a safe procedure and of great value in clinical decision making. Letter: Malignant syndrome induced by neuroleptic with anuria and favorable course. Translocation of colicin across the membrane of sensitive cells has been studied extensively. Concentration of interleukin-1 beta in serum and synovial fluid in patients with rheumatoid arthritis and those with osteoarthritis. Odd lips: the prevalence of common lip lesions in 23,616 white Americans over 35 years of age. Acute hypertension has been produced in rats by the intravenous infusion of angiotensin amide for 4 hours. Subjects deprived of REM sleep showed significant MHPG increases on night 4 of sleep deprivation. The concept of self-management of oral anticoagulation has been shown to entail better quality of treatment than conventional management when assessed in selected adults. A case of successful surgical removal of giant bulla with mediastinal herniation.

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Transcriptional analyses suggested that the I-3 and O-1 genes were constitutive genes, being expressed both before and after viral DNA synthesis. Optical interference method for the approximate determination of refractive index and thickness of a transparent layer. The significance of the furosemide test for predicting ascites control by diuretics in cirrhotics: a comparison with volume expansion and octreotide infusion. Small differences in primary structure generally do not result in such a large increase in catalytic efficiency and such a large shift in substrate specificity as was found in the present study. Exons 1 and 4 coded for hydrophobic domains, while, importantly, exons 2 and 3 coded for fibronectin homologous domains. PAR bZIP proteins are able to transactivate the promoter of bcl-gS.

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A complete association of Ba-2 specificities with MLR phenotype was observed. Three cases are presented which will serve to highlight the main features of the disease and its management. Intravenous infusions of UK14304 (0.3-10 micrograms/kg per min) in pithed rat produced dose-dependent pressor responses which were not affected by prazosin (10 micrograms/kg) but were reduced by yohimbine (0.3 mg/kg). Since 1980, nine patients have been treated and six of these remain alive and free of disease. Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation. We concluded that the monomeric peptide with an increased helical content, complexed with the lipids, perturbs the lipid organization and induces the increased permeability. Intestinal perforation due to Macracanthorhynchus hirudinaceus infection in Thailand. 55 patients, aged 18-40, for whom functional dysmenorrhea had been diagnosed, were inserted with the Progestasert, a progesterone-releasing IUD, on the 4th day of cycle.

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Transposition of MINE, a composite retrotransposon, in the avirulence gene ACE1 of the rice blast fungus Magnaporthe grisea. In 1993, one confirmed case and one possible case of endosulfan poisoning in agricultural workers occurred in two southeastern states. Effect of spironolactone on renal prostaglandin excretion in patients with liver cirrhosis and ascites. When incubation was terminated, samples of the lumen and blood side solutions and of the intestinal tissue were analyzed for parent drug and metabolites by HPLC using a multidetector system. Concentrations of PCDD/PCDFs and PCBs in fish and seafood from the Catalan (Spain) market: estimated human intake. Gel filtration on a calibrated column of Sephadex G-75 gives an estimate of the molecular weight of 10,000. Effect of change of habitat (sea and fresh water) on in vivo thyroglobulin synthesis in Atlantic glassed eels (Anguilla anguilla L.). We describe our experience with endoscopic ligation of the sphenopalatine artery in the treatment of severe posterior epistaxis in 2 patients with coagulopathy. The objective of our study was to establish optimal perfusion conditions for high-resolution postmortem angiography that would permit dynamic visualization of the arterial and venous systems.

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Deterministic, Markov birth-death, diffusion and stochastic differential equation models are studied, with a view to assessing their advantages and limitations. Morphological study of capsules formed around various breast endoprostheses. This method is not appropriate for syndactyly of the fingers but is an ideal method for syndactyly of the toes. A study of 29 children and adolescents with cystic fibrosis over 2 years showed some evidence of benefit from the twice daily inhalation of 20 mg nebulized gentamicin when compared to the inhalation of a nebulized saline mixture. 9-Anilino-10-methylacridinium salts result from reaction of substituted anilines and 9-chloro-10-methylacridinium salts in turn prepared from the 10-methyl-9(10H)-acridones and SOCl2 or POCl3. Acute effect of the dual angiotensin-converting enzyme and neutral endopeptidase 24-11 inhibitor mixanpril on insulin sensitivity in obese Zucker rat. Assessing the difficulty of inhibiting a specific protein by a small molecule can be highly valuable in risk-assessment and prioritization of a new target. A review of the top 12 candidates revealed well known thyroid cancer markers such as MET, TFF3, SERPINA1, TIMP1, FN1, and TPO as well as relatively novel or uncharacterized genes such as TGFA, QPCT, CRABP1, FCGBP, EPS8 and PROS1.

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Incidence of otorhinolaryngologic diseases among middle-aged and old persons. In total, these steps should take 6-8 weeks of experimentation and should result in the evolution of a receptor to be activated by the chosen ligand. Bromadiolone in aqueous solution was observed to be in an aggregated state, thereby showing weak emission due to self-quenching. Finally, no side-effects or alterations of heart rate or blood pressure were reported. Our initial analysis indicates that badger urine potentially contains olfactory cues relating to sex and season. Each soybean nonseed protein mRNA is present in tobacco leaves, roots, stems, and seeds at levels similar to that found in soybean plants. The achievement of brain-damaged patients, corrected for these factors, was impaired significantly in all tests with respect to both recognition and speed of performance. Molar uprighting with the piggyback buccal sectional arch wire technique. The model of Prokhorov (Radiokhimiya (Radiochemistry) 11 (1969) 317) was modified to describe the effects of bottom sediment bioturbation, surface runoff from the catchment and suspended solids formation and sedimentation. Loose seeds versus stranded seeds in I-125 prostate brachytherapy: differences in clinical outcome.

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A single gene error of noradrenergic axon growth synchronizes central neurones. Renal failure and thyroid function tests: the effects of commencing haemodialysis. Dermatan sulfate isomers in human articular cartilage characterized by high-performance liquid chromatography. The lesion was extradural and highly vascular with extension into the petrous bone. In the twentieth century, Canadian psychologists have prilosec dosage mg been involved with the educational system and the community at several points in time. An additive effect of cold exposure and hypoxia on pulmonary artery pressure in sheep.

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Thus, the mRNA species for both m2- and m3-mAChR subtypes are differentially expressed in culture and down-regulated by agonist stimulation. We noroxin 400 mg para que sirve suggest that Fasciola hepatica, which synthesizes and releases large amounts of proline, induces enlargement of the bile duct by a similar mechanism. The development of volumetric imaging systems integrated with the medical linear accelerator for the specific purpose of guiding therapy will permit localization and targeting of soft-tissue structures at the time of treatment. The role of different dietary components in mediating this effect was investigated by varying the composition of the semisynthetic diet and of the commerical feed. CT scanning was done liberally to confirm the suspicion and the patients with hematoma were treated aggressively by surgical evacuation with good recovery in most of them. Pulmonary artery perforation repair during thrombectomy using microcoil embolization. SV40-transformed Chinese hamster embryo cells were exposed to 60Co gamma-irradiation and the fate of the integrated SV40 sequences was pursued over a period of 20 days following radiation exposure. The antidepressants enhance ethanol-induced hypothermia and prolong the ethanol sleeping time.

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To find the physiological substrate of this task, we compared increment thresholds of different cell types in the macaque lateral geniculate nucleus with human psychophysical thresholds to the same stimuli, using two spot sizes, 4 and 0.4 deg. The Splotch mutant mouse shows defects in neural crest-derived cell populations. Neurons segregate clusters of membrane-bound acetylcholinesterase along their neurites. Serum magnesium as well alfuzosin uroxatral 10 mg as urine magnesium and calcium should be measured for confirmation of diagnosis. An analysis of variance demonstrated significantly greater activity (p less than .05) of the vastus medialis, biceps femoris, and gluteus medius muscles during QS exercises than during SLR exercises. About half of the subjects with high functioning pervasive developmental disorders (PDDs) are currently reported to be on psychotropics (anti-depressants, stimulants and antipsychotics), with many of them being on anti-epileptic medication simultaneously. Chromogranin A-containing cells are polymorphic and constitute the more numerous NE subpopulation. Mortality was elevated due to specific cancers and among workers more likely to be exposed to solvents and other chemical exposures in manufacturing operations. The aim of this study was to evaluate the diagnostic utility of endobronchial ultrasound (EBUS)-guided transbronchial biopsy (TBB) using a novel 3.4-mm thin bronchoscope and a 1.4-mm ultrasonic probe for peripheral pulmonary lesions.

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The adaptor protein p130Cas (Cas) has been shown to be involved in different cellular processes including cell adhesion, migration and transformation. Patients may be anxious about receiving inappropriate shocks in tricor drug covid 19 case of device or lead system malfunction, or about failing to receive needed therapy for the same reason. Moreover, mitochondria in brain hippocampus cells were observed under electronic microscope. Removal of the involved wires and the fibrous tissue surrounding this anodic point relieved the symptoms of pain and tenderness resulting from entrapped sensory nerves. To review the relevant psychological aspects about affective aspects in epilepsy. Rats fed a non-absorbable bile acid binding resin (cholestyramine) throughout gestation had decreased activities of adipose tissue lipoprotein lipase (LPL), hepatic triacylglycerol lipase and a heparin-releasable placental lipase distinct from LPL, when assayed at near-term gestation. Health care channels for new cases of respiratory tuberculosis in Seine Saint-Denis in 1984-1986. Tumoral calcinosis is an extreme form of peri-articular calcification, and its occurrence in patients with chronic renal failure is unusual. Mid-gestation canine fetuses were injected with 1-3 x 10(7) human cord blood cells and 1 x 10(7) murine fibroblasts engineered to express human cytokines.

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Biosorption of Cr (VI) from aqueous solution by Rhizopus nigricans. We propose that PARP1-dependent PARylation of EBNA1 and adjacently bound TRF2 induces structural changes at the DS element that reduce EBNA1 DNA binding affinity and functional recruitment of ORC. UC diagnosis and monitoring would greatly benefit from supplementing conventional cytology with LOH urinalysis, using a panel of 8 microsatellite markers with specific threshold levels. In September 1986, she noticed the swelling of lymph no does in the right inguinal region and low grade fever. Generalizing from in care populations may not be warranted, while addressing heavy alcohol use may be effective at improving utilization of care for hard-to-reach HIV-positive populations. p27(kip1) and Other Cell-Cycle Protein Expression in Normal and Neoplastic Endocrine Tissues. This essay suggests ways in which spiritual resources--healing stories, psalms of lament and reassurance, rituals, and meditative practices--can be used to foster emotional and spiritual healing for people, such as the adult children of missionaries, who have experienced disrupted relationships with parents during childhood.

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Daclizumab was efficacious as prophylaxis against acute cellular rejection after cardiac transplantation. Atrial natriuretic peptide attenuates ANG II-induced hypertrophy of renal tubular cells. Jewel in a murky firmament: the Diamond Jubilee History of Occupational Health at the University of Manchester. This is the first detailed study to demonstrate a pilot-scale production of CoQ(10) using a mutant strain of R. To determine the plasma concentration of cortisol that is needed for maximal suppression of the systemic inflammatory response to cardiac surgery with cardiopulmonary bypass. The placenta is a highly differentiated organ essential for embryonic growth and development. Thirty-five patients with adult-onset idiopathic torticollis were treated by local injections of botulinum A toxin into dystonic cervical muscles. Ictal episodes often developed focally and then spread as a slowly moving wavefront traveling at less than 0.3 mm/sec into adjacent, uninvolved cortex. Subjects also participated in a separate counterbalanced baseline session. Measurement of the novel antitumor agent 17-(allylamino)-17-demethoxygeldanamycin in human plasma by high-performance liquid chromatography.

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Changes in corneal curvature at different excimer laser ablative depths. Because the focus of the current health care system is on using an interdisciplinary team approach, it is crucial that social workers make a place for themselves on treatment teams and continue to use their skills to provide comprehensive treatment. Patients with chronic hepatic encephalopathy (HE) may present affective symptoms and antidepressant drug treatment in this condition is not uncommon. However, irrespective of concomitant Na supplement, more prolonged treatment with the high-Ca diet completely abolished the further increase in BP between the 9th and 12th weeks of age, which was noted in the rats fed the normal or high-Na diets. Spirometric changes 20 minutes after a single dose of albuterol (2.5 mg by nebulizer) were then recorded. Cold-acclimated larvae required much higher concentration times time (CxT) product for control at 4.4 and 10.0 degrees C compared with nonacclimated larvae.

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To evaluate whether PON1 protects against atherosclerosis and lipid oxidation in a dose-dependent manner, we generated and studied human PON1 transgenic mice. Polyclonal increase of HTLV-I provirus-carrying lymphocytes in HTLV-I-carrier rabbits transplanted with Shope carcinoma cells. As a result physicians were convinced of the applicability of a modelling process to describe health care delivery and recommended that the project be continued. The differences between individual viruses in this respect are very marked and from them also differences in the circulation of these viruses follow. In the human malaria parasite Plasmodium falciparum (Pf), polyamines are synthesized by a bifunctional enzyme that possesses both ornithine decarboxylase (ODC) and S-adenosyl-l-methionine decarboxylase (AdoMetDC) activities. Detailed clarification of the coronary state before the elective operation, a possible aortocoronary bypass operation appear to prevent most effectively the pathological picture. --It is stated that CEA-negative metastases are most likely to be found in patients who fail to respond to hormonal therapy. In each of the centres studied the proportion of admissions due to enteritis necroticans dropped significantly after immunisation was introduced (p less than 0.001) and hospital admissions for pigbel in 1984-86, when immunisation was well established, were less than one fifth of previous figures. The variety of the involved systems may explain the versatile clinical picture of CRPS.

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