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Biortan (Losartan)

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Biortan belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Biortan prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Biortan slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Other names for this medication:
Angioten, Arapres, Asart, Biortan, Cardoplus, Cartan, Covance, Eklips, Fensartan, Fortzaar, Lifezar, Lopernal, Loplac, Losacar, Losacor, Losamet, Losan, Losap, Losaprex, Losardil, Losartanum, Losavik, Lospre, Lostankal, Lostat, Lotar, Lozap, Lozatan, Lyosan, Medzar, Nefrotal, Niten, Ostan, Portiron, Prelow, Prosan, Rasoltan, Repace, Resilo, Sarvastan, Satoren, Tacardia, Tacicul, Temisartan, Tensartan, Tozaar, Xartan, Zartan

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Also known as: Losartan


Biortan (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Biortan is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Biortan is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Biortan 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Biortan 25 mg, Biortan 50 mg, and Biortan 100 mg may also contain carnauba wax.


Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Biortan dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Biortan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Biortan if you are allergic to Biortan components. Do not take Biortan if you're pregnant or you plan to have a baby, or you are a nursing mother. Biortan can harm your baby. Do not use Biortan if you are taking salt substitutes or potassium supplements, other blood pressure medicine, diuretic (water pill). It can be dangerous to use Biortan if you suffer from or have a history of liver disease, kidney disease, heart failure. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid machine driving. Do not stop taking Biortan suddenly.

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Enhanced detection of Schistosoma circulating antigens by testing 1 ml urine samples using immunomagnetic beads. When patients are infected by viral isolates presenting a substitution of the serine at position 250 by a proline, no antibodies recognizing the 244-257 region could be found. The possibility of the mutation fixation via selection is discussed and their relative neutrality is suggested. what drug is allegra We present an integrative mining approach to uncover the functional gene relationships from MEDLINE and TCM bibliographic literature. A new approach for the detection of type III hyperlipoproteinemia by RLP-cholesterol assay. The effect on embryos and young of rainbow trout from exposing the parent fish to X-rays. Homologous recombination (HR) and nonhomologous end joining (NHEJ) are two distinct DNA double-stranded break (DSB) repair pathways. There is conflict in the literature about the extent of alterations of resting energy expenditure (REE) in persons with HIV. We conclude that kinetics of ileal overgrowth with enterobacteria and enterococci in hfa mice can be used as an indicator for compromized intestinal functionality and for more precisely defining the time point of death under defined ambient conditions. SOME PECULIARITIES IN THE THERMOELECTRIC PROPERTIES OF MONEL METAL.

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P wave morphology during spontaneous and paced pulmonary vein activity: differences between patients with atrial fibrillation and normal controls. Multiple infant anthropometric measurements, including skinfold thicknesses, were obtained at birth and age 1 year. The present study investigated the differentiative capacity of satellite cells and their involvement in the compensatory regenerative process in long-term denervated rat muscle. Several questions relating to the dose, duration of treatment, long-term side-effects, quality of life changes and health economic implications of treatment still need to be assessed. In the testis of normal adult mice, the abundance of Hsp25 mRNA differed among the seminiferous tubules in different stages of spermatogenesis. Underachievement among preadolescent boys considered in relationship to passive aggression. This methodology was imuran medication demonstrated to be an effective tool for identifying lead displacer candidates for a particular protein/stationary-phase system.

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Patients were randomly selected, contacted by telephone, and surveyed using three measures of global satisfaction, 23 perceived quality-of-care indicators, and six perceived wait times. The acute hemorrhagic leukoencephalitis affects mainly young adults and is the most fulminant from of demyelinating disease. Heinz body formation test in the peripheral blood of normal, favic and beta thalassemic children. Bone marrow smears showed erythroblastopenia with giant proerythroblasts. Subsequently developed necrotizing fascitis of the anorectum, perianal region, and scrotum necessitated emergency debridement and defunctioning colostomy. Mouse inflammatory giant cells formed after subcutaneous implantation of coverslips were exposed to sheep red blood cells opsonized with isologous antibodies. Additionally, post-receptoral sensitivity to both UV and long wavelengths decreased with age, probably reflecting changes in photoreceptor sensitivity and retinal circuitry. Urinary lead and determination of tetraethyl lead (PbEt 4) poisoning. The level of Kyn exogenously added into the cell-free culture supernatant of BMDC stimulated with CpG was severely decreased by deproteinization with TCA but not methanol, and the decrease was prevented when BMDC was stimulated with CpG in the presence of a NOS inhibitor.

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Twenty-two volunteers consumed five cups of coffee per day for 1 week and maintained their usual diet. Here we consider the use of the coxibs in acute pain syndromes such as primary dysmenorrhea and the pain associated with dental extraction, as well as considering their application in chronic low back pain and cancer pain. Aspartate/glutamate-enriched blood does not improve myocardial energy metabolism during ischemia-reperfusion: a 31P magnetic resonance spectroscopic study in isolated pig hearts. Fifteen patients (10 men and five women, mean (SD) age 49 (10.3) years) with asymmetric hypertrophic cardiomyopathy underwent high frequency (5 MHz) transthoracic Doppler echocardiographic assessment of the left anterior descending coronary artery. tuberculosis isolates with increased susceptibility to antituberculous antibiotics. A less potent steroid may be considered first to decrease the risk of the potential adverse effects. Then, cells were co-cultivated with endothelial cells for different periods of time. This intrinsic resistance to EGFR TKIs in breast cancer does not correlate with Met amplification.

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Several studies have reported a high prevalence of hypopituitarism after traumatic brain injury (TBI). Breathing and heart rate during experimental solvent exposure of young adults with self-reported multiple chemical sensitivity (sMCS). Complexation with ADP increases the thermal unfolding temperature of dihydroxyacetone L from 40 (apo-form) to 65 degrees C (holoenzyme). The adipocyte hormone leptin binds to its receptors in hypothalamic neurons and decreases appetite and food consumption. Diagnostic criteria for 70- tricor online login mm radiophotofluorography in mass screening for heart disease. Cbfa1, a transcriptional activator of osteoblast differentiation during embryonic development, is also expressed in differentiated osteoblasts postnatally.

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All patients received levamisole 50 mg tid for 3 days every other week. A potential drawback to vaccination with autologous monocyte-derived DCs (MoDCs catapres review ) could be that MoDCs from patients are functionally impaired. This review considers the advantages of the antisense RNA approach over the use of antisense oligodeoxynucleotides, the different means by which one may deliver and produce antisense RNA inside cells, and the experimental criteria one should use to ascertain whether the antisense RNA is acting through a true antisense mechanism. Large-scale transcriptome analyses reveal new genetic marker candidates of head, neck, and thyroid cancer. This study indicates that serum leptin does not play a role in the regulation of eating in obese women, at least not in the short term. As regards mental health nursing the author concludes that there should be an end to the quest for professionalism personified by notions such as individualized care. Extensive demographic and medical information was prospectively recorded. So these parameters allow us to predict the chance of obtaining embryos during an IVF trial and to choose for each couple the most appropriate technique: IVF or ICSI.

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