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Biger (Atorvastatin)

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Biger is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Biger is indicated for the treatment of several types of dyslipidemias, including primary hyperlipidemia and mixed dyslipidemia in adults, hypertriglyceridemia, primary dysbetalipoproteinemia, homozygous familial hypercholesterolemia, and heterozygous familial hypercholesterolemia in adolescent patients with failed dietary modifications.

Other names for this medication:
Alvastin, Anvistat, Atacor, Atasin, Atenfar, Ateroz, Atorva, Atorvin, Atova, Atovarol, Atovin, Atroact, Avastatin, Caduet, Cardyn, Colostat, Danelip, Delipost, Dislipat, Divastin, Finlipol, Hypolip, Lipicon, Lipidra, Lipinor, Lipitaksin, Lipizem, Lipobi, Lipofin, Liprimar, Lorvaten, Saphire, Stacor, Stator, Tarden, Tarimyl, Torid, Torvazin, Totalip, Trova, Vastina, Xelpid, Zoamco

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Also known as: Atorvastatin


{name} (atorvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins."

{name} is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

{name} is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors such as genetically high cholesterol.

{name} is for use in adults and children who are at least 10 years old.


Generic Biger can be taken in tablets. You should take it by mouth. It is better to take Generic Biger once a day at the same time with meals or without it. If you want to achieve most effective results do not stop taking Generic Biger suddenly.


If you overdose Generic Biger and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 20 to 25 degrees C (68 to 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Biger are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Biger if you are allergic to atorvastatin, or if you have:

liver disease; or if you are pregnant or breastfeeding.

Atorvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant. Stop taking Biger and tell your doctor right away if you become pregnant. Use effective birth control to prevent pregnancy while you are taking this medicine.

Atorvastatin may pass into breast milk and could harm a nursing baby. Do not breastfeed while you are taking Biger.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

liver problems; muscle pain or weakness; kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily.

Biger can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

Atorvastatin is not approved for use by anyone younger than 10 years old.

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Loss-of-function mutations in PTPN11 cause metachondromatosis, but not Ollier disease or Maffucci syndrome. Such cutaneous appendage tumors are uncommon, and surgeons may be unfamiliar with them. Like pharmaceuticals, implementation interventions need to go through several stages of development before they are evaluated in designed experiments. The addition of each polyamine to the suspensions of the mast cells caused a histamine release in a dose-dependent manner. Light chain distribution in the nephron was confirmed with immunoelectron microscopy and was not associated with deposition of other serum proteins such as immunoglobulin heavy chains, complement, transferrin, alpha 2 macroglobulin and albumin. In the second stage, the process of the autolysis is enhanced and the system of intercellular lacunae functioning as an excretory system is formed. A fast reaction, e.g., scavenging by a nitro derivative or beta-fragmentation, is necessary in order to trap the final imidoyl radical, since addition of vinyl radicals to isonitriles seems to be a reversible process. We have found evidence that NUSAP1 plays a role in these processes through regulation of BRCA1 protein levels, and BRCA1 overexpression from a plasmid mitigates the defective phenotypes seen upon NUSAP1 depletion. During the Fifth International Workshop on Peritoneal Surface Malignancy in Milan in 2008, a consensus was reached that contrast-enhanced CT (ceCT) was the principal imaging modality for patients being evaluated for treatment of peritoneal metastases. Investigation of mercury-containing proteins by enriched stable isotopic tracer and size-exclusion chromatography hyphenated to inductively coupled plasma-isotope dilution mass spectrometry.

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Postoperative lung injury is a common, although decreasing, complication of cardiac surgery. If an endoleak was identified at 30-day postoperative computed tomography, conventional arteriography was performed to identify and eliminate its source. Multiple state transport deduced by weak antilocalization and electron-electron interaction effects in Sb(x)Te(1-x) layers. Low household income was a predictor for RTW in workers without comorbidity only. The management of patients presenting with metastases of unknown primary origin remains a clinical challenge despite a large variety of imaging modalities.

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Each produces its own homogenous endothelial culture, namely, MV-EC and RV-EC. These results suggest that the ligand-activated Valpha14 NKT cells kill tumor cells directly through a CD1d/Valpha14 T cell receptor-independent, NK-like mechanism. This study suggests that the production of recombinant HSA fragments will be useful for the study of HSA ligand interactions. A postoperative manometric study was performed in 12 patients, including measurement of resting and squeeze pressures, opening characteristics and pressure during straining. The X-ray crystal structures of synthetic Z-Dml and TFA-Dpv have also been completed. Incorporation of L-methionine-S35 into casein by the isolated mammary gland of the sheep.

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Characterization of a high mechanical-Q fiber laser Lorentz force dc magnetometer. We compared the accuracy of a new method for measuring LVEF that allows for machine interpretation and uses contrast-enhanced intermittent harmonic color Doppler ultrasonography (CHCD). Essential fatty acids (EFAs) and their long-chain polyenes (LCPs) are indispensable for human development and health. Mitochondria were found localized in the spine neck as well as the spine head and often extended between the two compartments. Significant relationships between mortality and annual volume were noted for both groups. Here we study the molecular interactions of both this region and the N-terminal region of HMG-14 with nucleosome cores. Primary rat hepatocytes were cultured as liver spheroids and the expression of Hsp25 and Hsp72/3 measured along with the levels of ATP, GSH and albumin secretion. High-Efficiency Perovskite Solar Cell Based on Poly(3-Hexylthiophene): Influence of Molecular Weight and Mesoscopic Scaffold Layer. Australian and New Zealand Clinical Trials Register ACTRN12616000575437 , registered May 2016.

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Insights into the evolution of vitamin B12 auxotrophy from sequenced algal genomes. Pinealectomy impeded formation of time-conditioned reflex in the mode of fixed intervals. Effects of prostaglandin E1 and hydralazine on the longitudinal distribution of pulmonary vascular resistance during vasoconstrictor pulmonary hypertension in sheep. Conditions found to preserve RE activity during thermocyling were then tested for their compatibility with DNA polymerase-mediated PCR. The authors realized a retrospective clinical-statistical study about 121 cases of acute myocardial infarction (AMI), treated in the Department of general medicine with a pharmacological association of Lysine acetylsalicylate--Erythrityl tetranitrate--Papaverine hydrochloride, with the purpose of obtaining a vasodilatation on coronary arteries and a platelet antiaggregation, in the light of the new etiopathogenetic views about the prolonged coronary spasm and the platelet aggregation, in some cases of myocardial infarction with or without thrombosis. The most significant change seen in RA was decreased levels of mono-galactosyl bi-antennary N-glycans, in agreement with the previous reports regarding IgG.

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Bateson proposed that the change in the number of cervical vertebrae in sloths is due to homeotic transformations. Cell cycle analysis revealed that C2C12 cells underwent G2/M cell cycle arrest when incubated with BTZ for 24h. Veratridine (0.3 microM) produced a time-dependent blockade of synaptic transmission as indicated by inhibition of the evoked population spike in the region CA1 of the hippocampus. Hepatic microcirculation was studied on a experimental model of obstructive jaundice and obstructive purulent cholangitis in rats by polarographic measurement of hydrogen clearance. Nine of these were children and adolescents aged 11 to 18 years, while six were adults aged 21 to 44 years. Our mechanism is supported by kinetic, XPS, voltammetry studies, and high-resolution ESI-MS data. UV caused a lesser frequency of morphological mutations than mitomycin C did. The interaction of WGA-LPNs with mucin improved enterocyte endocytosis in Caco-2 cells. Other bacteria produced similar results, except mean peak levels ranged from 5 to 30 pg/ml.

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Incidental findings during routine bariatric surgery are a common occurance, and therefore prompt and effective intra-op management is key to the prognosis of the patient. Thermodynamic analysis of hepatitis C virus vitality in syringes. Physiological aspects of human milk lipids and implications for infant feeding: a workshop report. These are the kinetics, the number of receptors on the cell wall and the character of these receptors. Secondly, toxin A produced cataract of the ocular lens, whereas infection with the viable organisms did not. The biphasic effect was not modified by the SP antagonist Spantide in a concentration that blocks tachykinin response (3.10(-6) M), nor by removal of the endothelium. The neuroligins and their ligands: from structure to function at the synapse. Alterations on polyamine content and glutathione metabolism induced by different concentrations of paraquat in CHO-K1 cells. For each of the recorded plant species the use value (UV) and fidelity level (FL) was calculated.

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Gado-6Si-NP were imaged following intravenous injection in control Wistar rats and mice using MRI (7 T), optical fluorescent imaging, and SPECT. Number of psychomotor symptoms was correlated with degree of violence in the members of this group. Hamster polyomavirus (HaPV) is associated with lymphoid and hair follicle tumors in Syrian hamsters. Angiotensin II (Ang-II) was found to be associated with reduced TINCR expression and increased hypertrophy in cultured neonatal cardiomyocytes. Specifically, on challenge with imidazole, Mg(II) protected the enolases of yeast and rabbit muscle but not of P. Bactericidal activity of human, swine and cattle serum against pseudomonas aeruginosa strains. Rayon flock: a new cause of respiratory morbidity in a card processing plant. Site-specific mutagenesis within the recognition pocket identified several residues essential for enzyme activity. The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents. Corticospinal neurons exhibit a novel pattern of cytoskeletal gene expression after injury.

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Clostridium difficile expresses a number of cell wall proteins, including the abundant high-molecular-weight and low-molecular-weight S-layer proteins (SLPs). The MPS criteria for treatment of subfoveal neovascular lesions require the following conditions: (1) the presence of classic CNV, (2) well-demarcated lesion boundaries, and (3) size less than or equal to 3.5 disc areas (if no previous treatment of CNV in the macula was performed). These data disclose an impairment of the neuronal functions in the biological clock in African trypanosomiasis, and may serve to unravel functional and molecular mechanisms behind endogenous rhythm disturbances. Transient disturbances to one limb produce coordinated, bilateral responses during infant stepping. Here, we identify Artichoke (ATK), an evolutionarily conserved leucine-rich repeat ECM protein that is required for normal morphogenesis and function of ciliated sensilla in Drosophila. The evaluation of the left ventricular (LV) function is one of the most important elements of diagnosis in patients with cardiovascular (CV) diseases. In addition to being prevalent and bothersome, urologic and sexual symptoms may be related to chronic medical illnesses. (1) The reduction in PCr concentration and increase in Pi and Cr concentration which are characteristic of fatigued muscle, reduce the free energy of PCr splitting. Suggested methods to close the utilization gap between HC and PC services among rural patients appear feasible, but universal effectiveness cannot be determined. Brain MRI with Gd-DTPA enhancement demonstrated two mass lesions with ring-enhancement in the left temporal lobe and the right frontal lobe.

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In this case series study, 11 patients with unexplained RPL who had anti-P antibody in their serum were treated by plasma exchange during their next pregnancies. Hyaluronan (HA), an unbranched polysaccharide consisting of repeated glucuronic acid/N-acetylglucosamine disaccharide units, is ubiquitously present in the extracellular matrix of many tissues (for a more comprehensive review see: Fraser et al., 1997). In hippocampi of trained animals phosphopeptide levels representing signalling, neuronal, synaptosomal, cytoskeletal and metabolism proteins were at least twofold reduced or increased. Descriptive demographic data, risk factors, surgical details, length of stay, deaths, and complications were recorded. The implications of these findings for the relationship between number of vaccine doses and cervical cancer risk require further investigation. In the context of an NIAAA/Fetzer Institute-funded study designed to look at the impact of spirituality in an inpatient alcohol treatment, this retrospective case control study investigated whether spiritual growth occurred during an inpatient phase of treatment for alcohol dependence, the degree to which spiritual gains (if noted) would be maintained at follow-up, and whether spiritual growth would be associated with follow-up sobriety. Recently, electron microscopic studies reported that the ganglion cells of human vestibular ganglion were mostly unmyelinated unlike in other mammals. A total of 384 specimens were analyzed, primarily to determine if the emerging human bocavirus (HBoV) infections exist in Kenya as coinfections with other respiratory viruses and to describe the genotype of the virus in circulation. We assessed usability requirements, general acceptance of eHealth, and the impact of eHealth and mHealth pregnancy applications on the doctor-patient interaction and daily clinical routine. The Cochrane Pregnancy and Childbirth Group trials register was searched.

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Enhancement of hexobarbital-induced sleep by lysine and its metabolites. To evaluate the safety and refractive stability following LASIK retreatment over a four-year follow-up period. The overall results for the scales in terms of feasibility and reliability were satisfactory. Both the kinase activity and the biological effects of Cdk5 are absolutely dependent on association with an activating subunit, called p35. A recent cluster-randomized controlled study showed that the VIPS practice model (VPM) for person-centred care had a significant effect on neuropsychiatric symptoms in nursing home residents with dementia. Clinical and Biochemical Characteristics in PCOS Women With Menstrual Abnormalities. Although cardiac beta-adrenoceptor density and affinity and membrane fluidity were adversely affected by bile acids, the relevance of these findings to our understanding of the etiological basis of hepatic cardiomyopathy is questionable, since such concentrations exceeded the highest concentrations seen in the plasma and/or tissues of patients with cholestatic liver disease.

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The complete microspeciation of ovothiol A, the smallest octafarious antioxidant biomolecule. All studies used a controlled trial design, with four using random allocation of schools or communities. Six lifestyle clusters emerged delineated by smoking, screening and physical activity levels. mutans in the modified AS was very similar to the growth in HS, both in the absence and presence of different carbon sources. About 83 percent and 52 percent of dentists wore a mask and eyewear or glasses respectively when carrying out dental procedures. By contrast, a comparison of tetrapod proenkephalin sequences with the partial sequence of a sturgeon proenkephalin cDNA indicates minocin acne dose that the position occupied by the penultimate opioid sequence in vertebrate proenkephalins may be a highly variable locus in this gene. Utilizing o-iodoaniline with isocyanates, carbodiimides, and ketenimines for the reaction, 2,4-(1H,3H)-quinazolinediones, 2-amino-4(3H)-quinazolinones and 2-alkyl-4(3H)-quinazolinones were obtained, respectively. The influence of metoclopramide and nitrendipine on the antitumor action of mitoxantrone (MX) in murine leukemias L1210 and P388 was investigated. Metal reinforcement for implant-supported mandibular overdentures. If the athlete has clinical evidence of shoulder instability and arthroscopic evidence of capsular stretch, an open stabilization procedure is performed.

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It also includes a Flash-based simulator that can be rulide dose child played on a web-browser. The appropriate use of vaccines in patients with inflammatory bowel disease. Evaluation of the detoxification efficiencies of coking wastewater treated by combined anaerobic-anoxic-oxic (A2O) and advanced oxidation process. The filter function is analyzed to define the structure of filter roots for one-dimensional (1-D) and two-dimensional (2-D) window filters as data patterns that are invariant of the filter. Effects of botulinum toxin type a in the bladder wall of children with neurogenic bladder dysfunction: a comparison of histological features before and after injections.

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Functional aspects of primate pelvic structure: a multivariate approach. Quantification of Clara cell protein in rat and mouse biological fluids using a sensitive immunoassay. The efficiency of this integration method has been verified via strong cascaded Raman scattering in both toluene (high index) core capillaries and ethanol (low index) core HCPCFs, for power thresholds up to six orders of magnitude lower than previous results. The properties of DNA were selected for review because a substantial amount of remarkable work has been performed during the past few years but has received less notice than other works, although DNA properties appear to be critical for boosting electroporation delivery. An investigation of strangulation tools often reveals DNA of the victim. According to current theories of NPH, altered mechanical properties of brain tissue seem to play an important role. Molecular phylogenetic tree based on the sequences of these vSPs and their orthologs revealed six major clusters, one of them covered four lineages of plasminogen activator like vSPs. Case report with dermatohistological, endocrinologic, immunologic and cytogenetic studies. The purpose of this study was to improve the data available for this variant of MF thus enabling clinicians to apply the appropriate treatment and follow-up.

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High-flow nasal cannulae for respiratory support in adult intensive care patients. Expression of reactive oxygen-species related enzymes in endothelial cells stimulated with glycated lipoproteins. To determine the hepatic changes in patients with human immunodeficiency virus (HIV) infection in Dublin and to assess the usefulness of liver biopsy in this condition. This mutation results in an unstable phenylalanine hydroxylase (PAH) protein completely devoid of enzymatic activity well correlated with the severe form of the disease exhibited by the homozygous patients. The patient underwent a microvascular free tissue transfer using an osteocutaneous free fibula flap to reconstruct a right/left infrastructure maxillectomy defect, a soft tissue modification of the skin component using an implant retained stent, and placement of maxillary dental implants to retain a fixed prosthesis. The plasma level maxima and minima of the unchanged drug were measured on the 10th, 15th, 20th and 25th day of the four-week treatment (steady-state equilibrium). Immunostained serotonergic fibers are decreased in selected brain regions of alcohol-preferring rats. Quantum dot (QD) solar cells have emerged as promising low-cost alternatives to existing photovoltaic technologies.

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Isolation of a new broad spectrum antifungal polyene from Streptomyces sp. Rapid changes in policies and laws in different countries are attempts to find effective policy mechanisms, but also reflect the difficulties of choosing a realistic policy objective. Under-explored areas for which these fish may also provide unique research opportunities include their use as platforms for disease modeling, norfloxacin and tinidazole tablets side effects drug discovery, and regenerative medicine. Malignant glioma tumors are characterized by cytoplasmic bundles of glial fibrillary acidic protein (GFAP), a protein normally expressed in mature astrocytes. Lever press responding as a measure of ethanol preference in rats.

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