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Betacycline (Oxytetracycline)
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Betacycline

Betacycline was the second of the broad-spectrum tetracycline group of antibiotics to be discovered. Betacycline works by interfering with the ability of bacteria to produce essential proteins. Without these proteins, the bacteria cannot grow, multiply and increase in numbers.

Other names for this medication:
Betacycline, Cotet, Dynoxytet, Ecomycin, Geomicina, Innolyre, Oxyteracin, Oxytetracycline, Tetracin

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Also known as: Oxytetracycline

Description

Betacycline is primarily bacteriostatic and is thought to exert its antimicrobial effect by the inhibition of protein synthesis. Betacycline is active against a wide range of gram-negative and gram-positive organisms.

The drugs in the Betacycline class have closely similar antimicrobial spectra, and cross resistance among them is common. Microorganisms may be considered susceptible if the M.I.C. (minimum inhibitory concentration) is not more than 4.0 mcg/ml and intermediate if the M.I.C. is 4.0 to 12.5 mcg/ml.

Susceptibility plate testing: A Betacycline disc may be used to determine microbial susceptibility to drugs in the Betacycline class. If the Kirby-Bauer method of disc susceptibility testing is used, a 30 mcg Betacycline disc should give a zone of at least 19 mm when tested against a Betacycline-susceptible bacterial strain.

Betacyclines are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form.

Dosage

Adults: Usual daily dose, 1–2 g divided in four equal doses, depending on the severity of the infection.

For children above eight years of age: Usual daily dose, 10–20 mg per pound (25–50 mg/kg) of body weight divided in four equal doses.

Therapy should be continued for at least 24–48 hours after symptoms and fever have subsided.

For treatment of brucellosis, 500 mg Betacycline four times daily for 3 weeks should be accompanied by streptomycin, 1 gram intramuscularly twice daily the first week, and once daily the second week.

For treatment of uncomplicated gonorrhea, when penicillin is contraindicated, tetracycline may be used for the treatment of both males and females in the following divided dosage schedule: 1.5 grams initially followed by 0.5 gram q.i.d. for a total of 9.0 grams.

For treatment of syphilis, a total of 30–40 grams in equally divided doses over a period of 10–15 days should be given. Close follow-up, including laboratory tests, is recommended.

Administration of adequate amounts of fluid along with capsule and tablet forms of drugs in the tetracycline class is recommended to wash down the drugs and reduce the risk of esophageal irritation and ulceration.

Concomitant therapy: Antacids containing aluminum, calcium, or magnesium impair absorption and should not be given to patients taking oral tetracyclines.

Food and some dairy products also interfere with absorption. Oral forms of tetracyclines should be given 1 hour before or 2 hours after meals. Pediatric oral dosage forms should not be given with milk formulas and should be given at least 1 hour prior to feeding.

In patients with renal impairment. Total dosage should be decreased by reduction of recommended individual doses and/or by extending time intervals between doses.

In the treatment of streptococcal infections, a therapeutic dose of Betacycline should be administered for at least 10 days.

Overdose

If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your healthcare provider immediately. Symptoms of Betacycline overdose: retching, diarrhoea, nausea.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Betacycline are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Generic Tetracycline if you are allergic to Generic Tetracycline components.

Do not take Generic Tetracycline while you are pregnant or have nurseling.

Generic Tetracycline only works against bacteria, it does not treat viral infections.

It is forbidden to take Generic Tetracycline by children under 8 years.

Do not use Generic Tetracycline if you are eating or drink dairy products (cheese, yogurt, milk, ice cream).

Try to be careful with Generic Tetracycline usage in case of having kidney or liver disease, allergies, diabetes, asthma.

Try to be careful with Generic Tetracycline usage in case of taking blood thinner such as isotretinoin (such as Accutane); colestipol (such as Colestid) or cholestyramine (such as Questran, Prevalite); blood thinner (such as warfarin (Coumadin)); tretinoin (such as Vesanoid, Renova, Retin-A); minerals (such as iron, zinc, mineral supplements, calcium, over-the-counter vitamin, magnesium); cholesterol-lowering medications such as antacid (such as Milk of Magnesia, Tums, Maalox, Rolaids); products that contain bismuth subsalicylate (such as Pepto-Bismol); penicillin antibiotics (amoxicillin (such as Trimox, Amoxil), dicloxacillin (such as Dynapen), penicillin (such as Pen-Vee K, Veetids, BeePen-VK), oxacillin (such as Bactocill), carbenicillin (such as Geocillin).

Hormonal birth control (eg, birth control pills) may not work as well while you are using Generic Tetracycline. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Try to be careful with sunbeams. Generic Tetracycline makes skin sensitive to sunlight. Protect skin from the sun. Use Generic Tetracycline with great care in case you want to undergo an operation (dental or any other).

Avoid alcohol.

It can be dangerous to stop Generic Tetracycline taking suddenly.

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Spatial-temporal response characteristics of the ON-OFF direction selective ganglion cells in the rabbit retina. Whether the oral administration of non-CHO tastants also affects exercise performance is not known. The information sources were then assessed for their potential to be included in the surveillance system. These results allowed evaluating the expected active dose in human at 6 mg/kg, used in a Phase II proof-of-concept study currently ongoing. Latent atrial vulnerability can be considered to be present when at least one of the following elements are found: significant inducibility, very short and poorly adapted effective refractory periods, decreased latent atrial vulnerability index. These results suggest that PAR2, although not activatable by thrombin, may nonetheless function as a sensor for coagulation proteases and contribute to endothelial activation in the setting of injury and inflammation. Primary outcomes were a) clinical cure and b) clinical cure or improvement. Revisiting p53 for cancer-specific chemo- and radiotherapy: ten years after.

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A growing body of evidence suggests that the cerebellum is involved in both cognition and language. Unfortunately, the imprecision of the estimates prevents definitive conclusion. Cultures consisting of one genotype only have the longest developmental time, and two-allele cultures in which the two homozygotes and the heterozygote occur in a 1:1:2 ratio show the shortest developmental time. This effect was concomitant with a higher relative water content in AM plants, lower proline content, and expression of Lsp5cs gene (mainly maximum dose oral calcitriol at 50 mM NaCl), lower expression of the stress marker gene Lslea gene, and lower content of abscisic acid in roots of mycorrhizal plants as compared to nonmycorrhizal plants, which suggest that the AM fungus decreased salt stress injury. An approach for increasing the mass recovery of proteins derived from inclusion bodies in biotechnology. Heterogeneity of measurement tools and target outcomes prevented meta-analysis or development of formal recommendations. function), definition of concepts (natural selection) and the position of the concept theory as an explaining factor (neutralists vs selectionist, random variation, determinate selection, etc.). pneumoniae test within a longitudinal mother-infant pneumococcal carriage study in Karen refugees on the Thailand-Myanmar border.

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