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Benformin (Glibenclamide)

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Benformin is an oral diabetes medicine that helps control blood sugar levels. Benformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Other names for this medication:
Benclamet, Betanase, Bionil, Codica, Daocon, Diabetrol, Diabnil, Diolin, Euglucon, Eumet, Glibenclamide, Glibet, Glibson, Glifil, Glime, Glimsug, Glitrac, Glucored, Glucosafe, Glucosil, Glucotrac, Glybovin, Glybovine, Glycurb, Glycurub, Glymep, Metclam, Pionorm, Sugnl, Symet

Similar Products:
Micardis, Bystolic, Microzide, Epivir, Temovate, Zyvox

Also known as: Glibenclamide


{name} and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

{name} and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. {name} and metformin is not for treating type 1 diabetes.


Usual Adult Dose for Diabetes Type 2:

Doses provided as Benformin-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Benformin (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Benformin and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Benformin (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Benformin-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Benformin component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Benformin/metformin dosage information


In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Benformin dosage information

Side effects

The most common side effects associated with Benformin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before taking Benformin,

  • tell your doctor and pharmacist if you are allergic to Benformin, any other medications, or any of the ingredients in Benformin. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you are taking bosentan (Tracleer). Your doctor may tell you not to take Benformin if you are taking this medication.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan); chloramphenicol; clarithromycin (Biaxin); cyclosporine (Neoral, Sandimmune); disopyramide (Norpace); diuretics ('water pills'); fluconazole (Diflucan), fluoxetine (Prozac, Sarafem); gemfibrozil (Lopid), hormone replacement therapy and hormonal contraceptives (birth control pills, patches, rings, implants, and injections); insulin or other medications to treat high blood sugar or diabetes; isoniazid (INH); MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); medications for asthma and colds; medications for mental illness and nausea; miconazole (Monistat); niacin; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); phenytoin (Dilantin); probenecid (Benemid); quinolone and fluoroquinolone antibiotics such as cinoxacin (Cinobac), ciprofloxacin (Cipro), enoxacin (Penetrex), gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), nalidixic acid (NegGram), norfloxacin (Noroxin), ofloxacin (Floxin), sparfloxacin (Zagam), trovafloxacin and alatrofloxacin combination (Trovan); rifampin; salicylate pain relievers such as choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan's, others), and salsalate (Argesic, Disalcid, Salgesic); sulfa antibiotics such as co-trimoxazole (Bactrim, Septra); sulfasalazine (Azulfidine); and thyroid medications. Also be sure to tell your doctor or pharmacist if you stop taking any medications while taking Benformin. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had G6PD deficiency (an inherited condition causing premature destruction of red blood cells or hemolytic anemia); if you have hormone disorders involving the adrenal, pituitary, or thyroid gland; or if you have heart, kidney, or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Benformin, call your doctor.
  • talk to your doctor about the risks and benefits of taking Benformin if you are 65 years of age or older. Older adults should not usually take Benformin because it is not as safe or effective as other medications that can be used to treat the same condition.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Benformin.
  • ask your doctor about the safe use of alcoholic beverages while you are taking Benformin. Alcohol can make the side effects from Benformin worse. Consuming alcohol while taking Benformin also rarely may cause symptoms such as flushing (reddening of the face), headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety.
  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Benformin may make your skin sensitive to sunlight.
  • ask your doctor what to do if you get sick, develop an infection or fever, experience unusual stress, or are injured. These conditions can affect your blood sugar and the amount of Benformin you may need.

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Three sequence motifs have been identified in both proteins: an N-terminal alanine, proline, and lysine rich domain, one and a half internal consensus RNA binding domains, and a C-terminal KKDX repeat region. We then conducted three rounds of modified Delphi rating by 12 national eHealth experts via Web-based surveys to prioritize the measures. These are the first such markers to be developed for this flatfish species. An overview of medical education at both the undergraduate and postgraduate levels in Canadian faculties of medicine is provided. Several studies have examined the relationships between diffusion tensor imaging (DTI)-measured fractional anisotropy (FA) and the symptoms of schizophrenia, but results vary across the studies. Headache and visual disturbances are common symptoms of sphenoidal sinus tumors. Effect of isoprinosine on IL-2, IFN-gamma and IL-4 production in vivo and in vitro. Psychophysical performance with artificial stimulus frequencies was almost identical to that measured with the natural stimulus frequencies.

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Immunological evidence for the identity of three proteinases from rat skeletal muscle. The results of the current study show that neoadjuvant tamoxifen was effective in the treatment of elderly or frail patients with locally advanced breast carcinoma with estrogen receptor positive tumors, and resulted in a reasonable response rate, including complete responses and good overall survival. Although most MRCs lack morphological features of photoreceptors, they contain some but not all, elements of the phototransduction cascade, indicating that they are most probably misplaced rods that failed to complete differentiation and integrate into the photoreceptor mosaic. The aim of this study was to evaluate the effect of niacin on LXRalpha and PPARgamma expression and HDL-induced cholesterol efflux in adipocytes from hypercholesterolemic rabbits. Properties of catapres, a new hypotensive drug: a preliminary report. This tendency to late recurrence clearly limits the reliability of short-term survival data. This Review describes the application of nitroxides to synthesis and polymer chemistry. In our present study, we discovered that nuclear domain 10 (ND10) of human cells was not disrupted by murine CMV (MCMV) and that the ND10 of mouse cells was not disrupted by HCMV, although the ND10-disrupting protein, immediate-early protein 1 (IE1), also colocalized with ND10 in cross-species infections.

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Leptospira Immunoglobulin-Like Protein B Interacts with the 20th Exon of Human Tropoelastin Contributing to Leptospiral Adhesion to Human Lung Cells. Magnesium may act as a neuroprotective agent through vascular effects (increasing regional cerebral blood flow to ischaemic tissue, anticonstrictor effects against vascular mediators, vasodilatation of the cerebral circulation) or neuronal effects. The pathologies-causing CRI were, in particular, congenital anomalies and hereditary nephropathies. Color vision was examined with Standard Pseudoisochromatic Plates 2 (SPP2) screening test, Farnsworth-Munsell 100 (FM 100) hue test, and Color Vision Meter 712 anomaloscope. The efficiency of attenuation of these organic micropollutants during MAR was difficult to determine due to variations in the source water concentrations. Collectively, the results suggest that exogenous PGEs or AA may inhibit A II-induced drinking by elevating body temperature or some other pharmacological action and that endogenously synthesized PGEs of cerebral origin do not play an important role in the normal termination of drinking induced by centrally administered A II. Separately dealing with these three steps has been adopted in many existing assignment programs, and it works well on protein NMR data that is close to ideal quality, while only moderately or even poorly on most real protein datasets, where noises as well as data degeneracy occur frequently. Immunoglobulin did not change the history of the illness as far as the time of ventilatory support in AMAN and AIDP groups is concerned and the time to reach state III on the GBS disability scale. However, data security issue arises when a CAD application is integrated with a PACS.

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This study demonstrated that group climate plays a significant role in determining treatment success in group voice therapy. There were no cases of infection, prosthetic failure, or dislocation. In addition, we stratified cases and controls by menopausal status and cancer histologic subtype and grade. During negative-pressure breathing onset latencies were shortened, and durations of firing were lengthened, sufficiently in some cases to fill the expiratory pause. Assessing the likelihood of injury depends to a great extent on preoperative radiographic examination, to determine the proximity of the tooth to the nerve. Taken together, these results define a set of evolutionarily conserved mechanisms by which FOG proteins repress GATA-dependent transcription and thereby form the foundation for genetic studies designed to elucidate the role of FOG-2 in cardiac development. Limited proteolysis by venoms was analysed by the cleaved peptide band(s) in SDS-polyacrylamide gel electrophoresis. In this study, acute and subchronic oral toxicity studies of aqueous extract of R.

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Echocardiography showed abnormal vessel inserting into pulmonary artery (PA), continuous shunt into PA and intercoronary collateral signals within the ventricular septum in all cases and bifurcate structure of the abnormal vessel with retrograde filling in 4 cases. These miRNAs may serve as novel and non-invasive prognostic markers for early detection zithromax suspension strength of CHB-infected patients who are at risk of progression to cirrhosis and/or HCC. To prove that perfused liver can be preserved at room temperature (22 degrees C), we made the experiment, in which HTK was basic solution, perfluorocarbon acted as oxygen carrier and lipid acted as energy substrate in the homoiothermy condition, pig liver organs were perfused extracorporeally through the V. A slow up-titration of clozapine is recommended in order to reach the optimal dosage of clozapine and diminish the risk of dose-dependent side-effects. Modulation of growth and differentiation of human colon carcinoma cells by histone deacetylase inhibitory trichostatins. For the 115,374 births in our sample, we estimated logistic multilevel models of retention in skilled birth attendance (SBA) among clients that received skilled antenatal care (ANC). Glial cells may facilitate and amplify immune effector mechanisms within the CNS.

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Both pertussis and cholera toxins also inhibited IL-1-induced IL-2 secretion, although probably by acting at different levels. To examine geographic variation in motor vehicle crash (MVC)-related pediatric mortality and identify state-level predictors of mortality. Specifically, recent progress in the recognition of the association of lymphoproliferative disorders and autoimmunity against mature blood cells, and common pathogenetic background of aplastic anemia, paroxysmal nocturnal hemoglobinuria, and myelodysplastic syndrome are discussed. Bed net coverage was also examined temporally and spatially, and its relationships with vector abundance and species composition were examined. If proved accurate, it should lead to less discomfort and anxiety, fewer complications, less cosmetic disfigurement, and a significant decrease in cost when compared with conventional surgical biopsy. The examined primary neurons innervating the facial structures were those comprising the frontal and zygomaticofacial nerves and those innervating the cornea, while the primary neurons innervating the intraoral structures included those innervating the mandibular incisor and molar tooth pulps and those comprising the palatine nerve.

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Intracardiac dendritic cells and expression of co-stimulatory molecules after heart transplantation. Severe cervical spinal cord injuries related to rugby union and league football in New South Wales, 1984-1996. Recent evidence, however, based on analysis of mitochondrial DNA homologies, suggests that the guinea pig is not a member of the order Rodentia and may be more closely allied with lagomorphs. The multilamellar bodies were varied considerably in size and shape, but often showed a fingerprint-like appearance. Nutritional evaluation in cotton-top tamarins (Saguinus oedipus). Stabilization and functional studies of high-molecular-weight murine lymphotoxins. To study the prevalence and patterns of contrecoup injury in traumatic temporal bone fracture cases. Differential effect of cyclic GMP on the release of endothelin-1 from cultured endothelial cells and intact porcine aorta. Effect of heptabarbital on the response to bishydroxycoumarin in man.

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Helices 7, 8 and portions of helix 5 contribute to the formation of a functional site. Two boys with classical NDI have been treated with prostaglandin synthetase inhibitors. Work distribution and cooperation in surgery--horizontal and vertical decision and responsibility fields. OH and H2O2 formed within the cell during light exposure are agents that directly or indirectly cause chromatid damage. The EC(50) values have been derived for some selected parameters on the generations of D. Dual-channel dispersionless slow light based on plasmon-induced transparency. In these patients, reflux is associated with a hypotensive lower esophageal sphincter and abnormal esophageal peristalsis, and often extends into the proximal esophagus. pCramoll and rCramoll lectins induce cell death in human prostate adenocarcinoma (PC-3) cells by impairment of mitochondrial homeostasis.

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