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Azpax (Clonazepam)
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Azpax

Azpax is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Azpax works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines.

Other names for this medication:
Adnil, Alrest, Anxiset, Azpax, Cloam, Clodep, Clonark, Clonasig, Clonatrac, Clonax, Clonaxyl, Cloneepam, Clonix, Clonoasig, Clonopam, Clonotril, Closis, Clotas, Clotweet, Cloze, Clozorix, Convaclon, Cozil, Easyfeel, Epcon, Epicloz, Epitril, Escitacalm, Escitapax, Escitrac, Esitor, Jasoclam, Lonipax, Melzap, Nexclo, Norep, Onapil, Ozepam, Prasilex, Prasilife, Somnotril, Ubitpam, Zeficar, Zepam, Zepamax

Similar Products:
Keflex, Inderal, Ovral, Dilantin, Viramune, Maxolon, Provera, Precose, Sildigra, Dulcolax

Also known as: Clonazepam

Description

Azpax results in a depression of the activities of the central nervous system. This depression is not meant to designate a feeling of depressed mood, although some people may experience depressed mood as a side effect of Azpax use. It instead relates to a reduction in the rate of activity of the cells in the brain. This reduction in the rate of brain activity affects several cognitive functions, most notably the ability to form new memories. Memories are formed in the brain as a result of increased activity of neurons, and a person using a benzodiazepine like Azpax will experience a dampening of these processes that can interfere with the ability to form new memories while one is taking the drug.

There is some evidence that cognitive abilities, such as memory, attention, visual spatial skills, and even intellect, might be affected as a result of long-term benzodiazepine abuse; however, the research in this area is limited due to many of the subjects in the studies having a history of abusing benzodiazepines and other substances, such as alcohol.

Dosage

Adults. The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding Azpax to an existing anticonvulsant regimen.

Pediatric Patients. Azpax is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

Geriatric Patients. There is no clinical trial experience with Azpax in seizure disorder patients 65 years of age and older. In general, elderly patients should be started on low doses of Azpax and observed closely.

Overdose

Benzodiazepines like Azpax became popular prescription medications, as alternatives to another class of anti-anxiety medications called barbiturates. Barbiturates were once very popular in the treatment of anxiety; however, they were highly addictive, carried a high risk for overdose, and were frequently abused. Benzodiazepines also carry a significant risk for the development of physical dependence and abuse (see below); however, they do not appear to carry the same risk of overdose that is associated with barbiturates (although overdose on benzodiazepines can occur).

Many of the cases of overdose that include benzodiazepines also include the co-occurring use of other drugs, such as alcohol, narcotic pain medications, or antidepressants. Using these drugs and benzodiazepines like Azpax together enhances the effects of all drugs as well as increases the risk for overdose and potential fatalities due to drug interactions and drug overdose.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Side effects

The most common side effects associated with Azpax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Azpax may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuzistra XR) or hydrocodone (in Anexsia, in Norco, in Zyfrel) or for pain such as codeine (in Fiorinal), fentanyl (Actiq, Duragesic, Subsys, others), hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Astramorph, Duramorph PF, Kadian), oxycodone (in Oxycet, in Percocet, in Roxicet, others), and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take Azpax with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

Drinking alcohol or using street drugs during your treatment with Azpax also increases the risk that you will experience these serious, life-threatening side effects. Do not drink alcohol or use street drugs during your treatment.

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Four cases of adenosquamous carcinoma from the oral and pharyngeal cavities were analyzed by light microscopy and immunohistochemistry. Is there a linkage between metabolism and personality in small mammals?. We measured the effects of the lipoproteins on mRNA expression of atherogenic molecules in cultured endothelial cells. A knockout strain of Stagonospora (Septoria) nodorum lacking the single ornithine decarboxylase (ODC) allele has been created by targeted gene replacement. The concentration of cerebrospinal fluid tryptophan metabolites was analyzed using high-performance liquid chromatography and compared to metabolite concentrations in cerebrospinal fluid from 20 age-matched controls (mean age: 5.8 months biaxin antibiotic strep ). Itih-4 encodes a 942 amino acid protein containing two EF-hand (helix-loop-helix) motifs with an unique short loop, with a potential calcium-binding function.

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Sixty-one aphasic patients with TBI who were admitted to a rehabilitation centre in the post-acute phase for a late inpatient rehabilitation programme. Therefore, uncovering regulators of the antioxidant stress responses is important for understanding the course of these diseases. Aging alters gastric mucosal responses to epidermal growth factor and transforming growth factor-alpha. TK1 activity is closely related with DNA synthesis, and thymidine analogs derivatized with bulky carboranylalkyl groups at the N-3 position were reported to be good substrates for TK1. CA-125 concentration shed into supernatant medium was determined using a microparticle enzyme immunoassay. An androgen-dependent human prostate cancer cell line (LNCaP) was stimulated with dihydrotestosterone (DHT) and exposed to propofol.

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Previously we found that migration of melanoma cells is both associated with and dependent on global chromatin condensation. Moreover, the effect of argon laser on dentin was more pronounced when compared with that of enamel irrespective of the energy density used. Although there has been much excellent work done in the area of mitosene chemistry and biochemistry, the present study provides a number of new findings: (1) The major fate of the iminium ion is head-to-tail polymerization, even in dilute solutions. This research aims to investigate the health service use-including complementary and alternative medicine (CAM)-and self-care by women aged 62 to 67 with sleeping problems. The solution and crystal structures of a module pair from the Staphylococcus aureus-binding site of human fibronectin--a tale with a twist. The effect of bacterial lipopolysaccharide (LPS) on the development of plaque-forming cells (PFC) against bromelain-treated syngeneic mouse red blood cells (Br-MRBC) was studied in peritoneal cell (PC) cultures. A reservoir bag was attached to the Y-piece connector to act as an artificial lung, and sevoflurane concentrations in the anesthetic circuit were measured at vaporizer settings of 1, 3, 5, 7, and 10 and oxygen flow rates of 250 and 500 ml/min. IL-1 alpha secreting monocytes were not detected although high numbers of IL-1 alpha secreting cells were found among cells isolated from rheumatoid synovium. Benefits from biphosphonates and tissue plasminogen activator have also been reported. Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B.

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