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Aptogrel (Clopidogrel)
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Aptogrel

Aptogrel and aspirin are both antiplatelet medications, but they are not always used for the same medical conditions. If you are on Aptogrel and are interested in switching to aspirin, check with your healthcare provider first to make sure it is appropriate for you.

Other names for this medication:
Adplatt, Antiban, Aplatin, Asicom, Blothin, Caplor, Carpigrel, Ceruvin, Clavix, Clobi, Cloflow, Clopact, Clopicure, Clopidogrel, Clopigrel, Clopione, Clopisa, Clopitab, Clotsafe, Deplatt, Neogrel, Noplaq, Nugrel, Oprin, Pidgrel, Platfrin, Platloc, Plodrel, Synplatt, Themigril, Thrombosprin, Torpido, Zoclop, Zogrell

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Nolvadex, Thorazine, Aldara, Nimotop, Imuran, Estrace, Diamox, Mobic

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Also known as: Clopidogrel

Description

{name} (clopidogrel) prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery.

{name} is used to lower your risk of having a stroke, blood clot, or serious heart problem after you've had a heart attack, severe chest pain (angina), or circulation problems.

Dosage

Usual Adult Dose for Acute Coronary Syndrome:

Unstable Angina (UA)/Non-ST-Elevation Myocardial Infarction (NSTEMI): -Loading dose: 300 mg orally once -Maintenance dose: 75 mg orally once a day -Duration of therapy: Optimal duration unknown. ST-Elevation Myocardial Infarction (STEMI): -Loading dose: 300 mg orally once (OPTIONAL) -Maintenance dose: 75 mg orally once a day, with or without thrombolytics -Duration of therapy: Optimal duration unknown. Comments: -Administer this drug in combination with aspirin 75 mg to 325 mg orally once a day. -The benefit of this drug for patients who undergo primary percutaneous coronary intervention is unknown. Uses: Prevention of atherothrombotic events in patients with non-ST-segment elevation acute coronary syndrome (UA, NSTEMI, those who are to be managed medically, those who are to be managed with coronary revascularization) and STEMI.

Usual Adult Dose for Ischemic Stroke:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Myocardial Infarction:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Peripheral Arterial Disease:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Detailed Aptogrel dosage information

Overdose

If you overdose Aptogrel and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Aptogrel overdosage: vomiting, abnormal bleeding or bruising, problems with breathing.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aptogrel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Aptogrel if you are allergic to Aptogrel components. Do not take Aptogrel if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Aptogrel if you suffer from or have a history of stroke, stomach ulcer or ulcerative colitis; liver or kidney disease, hemophilia. Be careful with Aptogrel if you are taking such medicines as aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs such as naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ibuprofen (Motrin, Advil), (Toradol), ketoprofen (Orudis), nabumetone (Relafen), piroxicam (Feldene), ketorolac mefenamic acid (Ponstel), meloxicam (Mobic) and the others), phenytoin (such as Dilantin); torsemide (such as Demadex); medication used to prevent blood clots (alteplase (such as Activase), anistreplase (such as Eminase), dipyridamole (such as Persantine), streptokinase (such as Kabikinase, Streptase), ticlopidine (Ticlid) and urokinase (such as Abbokinase); fluvastatin (such as Lescol); a blood thinner (warfarin (such as Coumadin), heparin, ardeparin (such as Normiflo), dalteparin (such as Fragmin), danaparoid (such as Orgaran), enoxaparin (such as Lovenox), or tinzaparin (such as Innohep); tamoxifen (such as Nolvadex); tolbutamide (such as Orinase). It is not recommended to do sport while taking Aptogrel because it can cause bleeding or bruising injury. If you are going to have a surgery you should stop taking Aptogrel for 5 days before the surgery. Do not use potassium supplements or salt substitutes. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Do not stop taking Aptogrel suddenly.

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Inoculation of Wistar rat bone marrow mesenchymal cells selected by adhesion activity did not reduce tissue calcinosis. Data from these fusions, in combination with information from other studies, provide the basis for two-dimensional models for each of the two subunits, defining the way in which the subunits fold in the inner membrane of E. There are very few reports describing inclusions in spontaneously occurring myopathies in cats, and these reports are limited to nemaline rod myopathy. The classification of early forms of scleroderma identifies patients with different prognostic risk of progression. Here, we investigated a coformer screening system for salts and cocrystals based on binary phase diagrams using thermal analysis and examined the effectiveness of the method. The naive repertoire of human T helper cells specific for gp120, the envelope glycoprotein of HIV.

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The discovery and characterization of thousands of genes involved in human disorders has the potential for great benefit in patient diagnosis and treatment. Exposure to radon and its decay products in drinking water can vary significantly depending on when during the day that the water is consumed. The vesicles were further transported over the microtubules and accumulated at the microtubule organising centre after 10 to 30 min. The majority of reports took no account of diseases (cancer, immune disease, infection) or therapies (radiation, drugs, surgery) known to affect skin test response. Our results suggest that trastuzumab concurrently with WBRT may have a potential clinical impact with low toxicity. The results of the treatment protocol in this patient group is presented and the current classification schemes, prevention of infection, debridement, antibiotics, soft tissue reconstruction, fracture stabilization methods, bone grafting, and exchange nailing are discussed. Cell bodies of neurons at risk of death in Alzheimer disease have increased lipid peroxidation, nitration, free carbonyls, and nucleic acid oxidation. Molecular mechanisms of tumor necrosis factor alpha-stimulated leukocyte recruitment into the murine hepatic circulation. Frequent gains and losses of specific chromosome segments in human ovarian carcinomas shown by comparative genomic hybridization.

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Not all patient tumors respond equally to the same type of therapy. The present study focused on the rest-activity rhythm, as assessed with actigraphy, and WMH in nondemented aging. The bone flap was detached, and remained attached to the periosteum as a free floating osteoperiosteal flap, and the resultant defect was filled with xenograft. Effects of septal and reticular stimulation on cardiac rate and somato-sensory recovery function in the cat. Weak-base amines inhibit the anterograde-to-retrograde conversion of axonally transported vesicles in nerve terminals. Basic fuchsin and five chelating agents-alizarin complexone, calcein, calcein blue, oxytetracycline, and xylenol orange-were randomly assigned to label microcracks in sequential rib sections from 10 donors. This study compared the debonding strengths of 2 types of porcelain, with and without opaque porcelain, to 2 types of dental casting alloys. Reduced body cell mass following severe head injury in children: implications for rehabilitation.

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Homologs of the chromatin-bound yeast silent information regulator 2 (SIR2) protein are found in organisms from all biological kingdoms. The aim of this study is to assess the added risk of ventral hernia repair and panniculectomy (VHR-PAN) using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) data sets. Impact of the ACERTO project in the postoperative morbi-mortality in a university hospital. Evaluation of antiarrhythmic drug effects with simultaneous analysis of single ventricular premature contractions, couplets and salvos. A case of primary clear cell carcinoma of the pelvic and abdominal peritoneum which occurred in a 67-year-old woman and with histological characteristics of Mullerian derivation is presented. At discharge, the magnitude and proportion of positive responses of Brazilian patients against the proteins and phenolic glycolipid (PGL)-I were lower for most of the clinical forms. Transition of pediatric liver transplant recipients to adult care: patient and parent perspectives. Subjects were recruited by an early intervention team in Finland. Vena Cava Responsiveness to Controlled Isovolumetric Respiratory Efforts. Consistent with available literature for all-causes PTSD nightmares, prazosin is an effective off-label option for combat-related PTSD nightmares.

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Magnetic Resonance Imaging in Hematospermia: Does It Increase Unnecessary Prostate Biopsy?. HCV-RNA was not detected in patients who had no antibodies as determined by all six anti-HCV EIAs. Color Doppler regurgitant characteristics of normal mechanical mitral valve prostheses in vitro. Transcriptional termination sequence at the end of the Escherichia coli ribosomal RNA G operon: complex terminators and antitermination. Then, we draw attention to the use of this method in bipolar disorder, revising previous discordant-twin studies. Oestrogen receptor mRNA was detected in cancers and paired normal mucosae in equal amounts. Bipolar disorders benefit from a mix of medication and nonmedication components, with complementary clinical management and patient self management reducing the high morbidity and suicide risk associated with these disorders. These results and studies on the properties of other ECM-immobilized enzymes (i.e. These parameters showed that the adsorption of Cu(II) and Pb(II) ions onto EP was feasible, spontaneous and exothermic at 20-50 degrees C.

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There was minimal variability and high levels of score similarity across the various test administration formats and forms. Since only a small number of RCTs of poor methodological quality are available, well-designed RCTs are needed for further investigation. We hypothesize that cognitive dysfunction occurs due to cortical deafferentation or disconnection arising from subcortical white-matter disease. Using radiolabeled oligonucleotides, it was demonstrated that the bulk of the material stays in the injected region but that a minor part is transported with the projection pathways to regions far away from the site of injection. Polychlorinated biphenyls (PCBs) are persistent environmental contaminants, and exposure to PCBs and their hydroxylated metabolites (OHPCBs) has been associated with various adverse health effects. This paper describes the method used to obtain a virtual mock-up that is useful for preoperative simulation. Lower repositioning errors occurred with active displacement procedures compared with passive, and with the intermediate starting position compared with the extreme. The law has been in effect for six years and a May 2004 decision from the Ninth U.S. The software was then trained on the two separate merged text files categories of positive and negative appendicitis.

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Although all isolates possessing the MrkD adhesin mediate the agglutination, in vitro, of erythrocytes treated with tannic acid, the mrkD gene is not conserved within species. Here we describe a simple spike detection method that reduces approximately two-fold the rate of false detections compared to the single threshold spike detection method. Myocardial perfusion imaging after transient balloon occlusion during percutaneous coronary interventions. Molecular horizons of cancer therapeutics: 11th Pezcoller symposium. Etest and Sensititre YeastOne Susceptibility Testing of Echinocandins against Candida Species from a Single Center in Austria.

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Application of progesterone to Xenopus oocytes expressing a cloned neuronal nicotinic acetylcholine (nAChR) revealed two effects. The analysis reveals that this process has minimal impact on the genetic basis of cell fate specification. It was later confirmed as a deficiency of branched-chain keto acid dehydrogenase (BCKDH), which is the second step in branched-chain amino acid (BCAA) breakdown. Cells lining the tubular gastric proper glands were markedly granulated. There were no significant differences in the staining patterns for active caspase-3 and caspase-8 with only few positive cells for both enzymes. Deficient teamwork and communication should be addressed through specific programmes that have been demonstrated to be effective in the aviation industry: crew resource management (CRM) and simulation. Especially, lobular carcinoma in situ in sclerosing adenosis sometimes can be a potential source of confusion with invasive lobular carcinoma. Learning curves for these two types of motor improvements showed different rates. This may have serious implications if these systems are used for postoperative analysis or contact lens fitting on corneas that have been modified by refractive procedures. In this paper, we demonstrate the effect of heat and chemical stress on glucocorticoid receptor subcellular localization in mouse L929 cells and in a stably transfected Chinese hamster ovary cell line (WCL2) which over-expresses the mouse glucocorticoid receptor.

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Surface knee arthroplasty provides a better opportunity for internal fixation than a knee arthroplasty with a stemmed femoral component. In recent decades, elevated levels of homocysteine (Hcy) have been found to be associated with an increased risk of vascular events. Magnetoencephalographic correlates of brain stem auditory evoked potentials (BAEP) have been identified by applying the model of a current dipole with invariant location and orientation (fixed dipole) to data recorded with a 37-channel first-order gradiometer system. A working pattern was designed accordingly, to sustain therapeutic decisions, which consisted in a detailed anamnesis, complete examination and application of an established diagnostic-therapeutic algorithm. The 80th anniversary of the Novosibirsk Military Clinical Hospital.

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In this review, we discuss the applications of rotor-containing molecules as dyes for luminescent down-shifting layers and luminescent solar concentrators, where their aggregation-induced emission properties and large Stokes shifts are highly desirable. The increase of plasma NO concentrations caused by ERT may contribute to it cardiovascular protective effect in PMW. In our readout, the signals used to calculate the deflections remain as currents, instead of undergoing an immediate conversion to voltages. These findings were supported by our primary culture experiments which demonstrated that both the fibroblast and epithelial cells maintain a capacity to express both isoenzymes in vitro. Four large outbreaks of acute gastroenteritis were investigated aboard US Navy aircraft carriers between 1992 and 1997. Within the thoracic cord, lateral projecting SST axons are distributed throughout much of the VLF but are not found in close proximity to the ventral horn.

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Blood samples for DZP and desmethyldiazepam analysis were obtained before the dose and from 3 min to 240 h after the dose. Impact of vascular disease in predicting stroke and death in patients with atrial fibrillation: the Danish Diet, Cancer and Health cohort study. In comparing open and closed economies, researchers often arrange shorter sessions under the albenza former condition than under the latter. Isolated appearance of single, unifocal PVC in young pilots without any symptoms and in absence of organic changes or functional heart disorder, should be considered as normal medical finding. A nonsense mutation (R335X) in the FRMD7 gene was identified in 4 male patients and an asymptomatic female member. This peptide modified nanofibrous scaffold can be a promising biomaterial for tissue engineering and regenerative medicine with the use of hBMSCs. One should have thought that this is an unusual case of Smith-Lemli-Opitz syndrome associated with features of Joubert syndrome. In 1998, the UK government issued precautionary advice that pregnant or breast-feeding women with a family history of atopy, may wish to avoid eating peanuts during pregnancy and lactation. If chronic erythematous OC is found in patients with SS an oral assessment at every appointment may help provide appropriate treatment.

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Antimicrobial activity of Gel-entrapped catechins toward oral microorganisms. It is demonstrated that the enzymes keep their catalytic activity upon their incorporation into the gels, opening perspectives ranging from biotechnologies (e.g., enzyme manipulation) to nanomedicine (e.g., vectorization). For each selection criterion, hitch-hiking in the vicinity of the QTL appeared more extensive when accuracy of selection was higher and the number of QTL was lower. It is postulated that cells normally impermeable to glucose, when serum insulin levels are low, become permeable in some severely starved patients, for reasons unknown. Among its sublines, UT-7/GM, which remains undifferentiated in the presence of GM-CSF, has a bipotency showing differentiation into erythroid or megakaryocytic cell lineages in the presence of EPO or thrombopoietin (TPO), respectively.

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The purpose of this study was to investigate whether changes in the pH of the gastrointestinal tract can directly affect P-glycoprotein (P-gp) function. Purification of pregnancy-associated alpha-macroglobulin by buffer electrofocusing. Microarray analysis revealed alterations in cardiac expression of several microRNAs with shRNA treatment. Amoxicillin was also determined by ANN/RBL in a series of real urine samples, which allowed one to perform a comparison study with the reference high-performance liquid chromatographic technique. We have developed a design algorithm that overcomes this limitation and can be used to compute binary diffractive elements with arbitrary diffraction angles. Comparison of the radioiodine storage test, determination of protein-bound iodine and binding of triiodothyronine to serum proteins. Substance abuse, violence, HIV, and depression: an underlying syndemic factor among Latinas. Therefore, applied neural network controller prevents the load from destruction by positioning characteristics like pressure, acceleration, and stiffness voltage to absorb the adverse changes of the ground. Growth of Pam LY8 tumors in vivo was inhibited with 14-day continuous administration of SM256 by subcutaneous osmotic diffusion pump, during which a mean serum concentration of 56 nM was detected. The fully protected decapeptide 10 has been synthesized from appropriately protected amino acid building blocks using a fragment condensation strategy.

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As several genomes have been sequenced, post-genomic approaches like transcriptomics and proteomics, identifying gene products differentially expressed in association with a given pathology, have held promise both of understanding the pathways associated with the respective disease and as a fast track to therapy. Matrix-assisted laser desorption/ionization mass spectrometric imaging for the rapid segmental analysis of methamphetamine in a single hair using umbelliferone as a matrix. The effect of lysosome permeability changes on DNA synthesis and mitosis of cells growing in vitro. For this interval we also explore nematode diversity as a proxy for modelling vegetation cover and soil quality, and diets of herbivorous megafaunal mammals, many of which became extinct around 10 kyr bp (before present). A significant increase in agricultural productivity will be required by 2050 to meet the needs of an expanding and rapidly developing world population, without allocating more land and water resources to agriculture, and despite slowing rates of grain yield improvement. The endoscopic endonasal transsphenoidal approach for removing pituitary lesions is a form of minimally invasive surgery offering excellent postoperative results. Apathetic hyperthyroidism was first described in the medical literature by Lahey in 1931. These unexpected activations were due to position-specific deactivations, indicating the importance of investigating absolute activation (relative to a no-stimulus baseline) rather than relative activation (comparing different stimulus conditions).

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Effects of gangliosides on the expression of autoimmune demyelination in the peripheral nervous system. Functional assessment of isolated right heart failure by high resolution in-vivo cardiovascular magnetic resonance in mice. The authors describe a new technique for medial column arthrodesis via tension band mesh plating. Patellofemoral complications are one major concern after total knee arthroplasty (TKA). Characteristics of radiology groups and of diagnostic radiologists and feldene flash tablet radiation oncologists in different types of practices. Stability of Drosophila melanogaster chromosomes replicating for the first time in a repair-deficient cell.

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Cancer stem cells (CSCs) represent a small subset of cancer cell populations that possess characteristics associated with normal stem cells. Spot distributions conformed strongly to predicted power-law suprax syrup uses behaviour. These activities suggest that these growth factors are involved in carcinogenesis. The size and shape of the carbon xerogel pores were also shown to play an important role in the final loading of the manganese(III) salen complex. Radiation sensitization by thiol-binding agents of radio-resistant and radiosensitive Escherichia coli and the oxygen effect. Plaque radiotherapy may be associated with fewer anterior segment complications, but the posterior segment complications appear to be similar using either plaque radiotherapy or charged particle radiotherapy.

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Pairwise sequence comparison between NHERF/EBP50 and PDZK1/CAP70 PDZ domains reveals significant identity among the 83 amino-acid residues (12-92) of EBP50 and CAP70 (241-323), which are involved in the interaction with the carboxyl-terminal peptides (STKL-COOH and phosphomimetics) of apactin. Comparing older and younger adults in an event-based prospective memory paradigm containing an output monitoring component. Analysis of the EXAFS shows three Cu-S bonds at 2.26 A, plus a short Cu-Cu distance of 2.7 A, indicating a binuclear cluster in Cox17. We have collected promising water surface-floating microalgae and characterized their capacity for biomass and lipid production. There was significant statistical difference between two techniques: the biofragmentable ring technique exhibited low oedema fluid, organized myofiber tissue and higher number of alongated cellular nuclei in relation to manual suture technique. Targeting of wolbachia endobacteria in litomosoides sigmodontis: comparison of tetracyclines with chloramphenicol, macrolides and ciprofloxacin. Total and available amount of selenate and selenite were tested in a calcareous loamy chernozem soil. On the 90th day, there was obvious scar staining at the site that reached the cribriform and retina. Reducing length of stay provides key to improvement in Veterans Administration Medical Center. In the Bay of Cadiz the background levels are also high, particularly for Cr.

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Therefore, the objective of the current study was to examine if harsh physical punishment (i.e., being pushed, grabbed, shoved, hit, and/or slapped without causing marks, bruises, or injury) is associated with an increased likelihood of more severe childhood maltreatment (i.e., physical abuse, emotional abuse, sexual abuse, physical neglect, emotional neglect, and exposure to intimate partner violence (IPV)) in childhood and perpetration or victimization of IPV in adulthood. Primidone and derived phenobarbital levels did not change significantly. Outcome variables were 1) the presence of MDS, 2) whether participants needed help with emotional problems, and 3) whether they had received psychological or emotional counseling. A total of 350 patients with Type II diabetes mellitus, referring to the Diabetes Clinic, were selected and data were collected by GOHAI and OHIP-14 questionnaires completed by patients and clinical examinations. Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by notable interpatient heterogeneity. Piperine has been reported to possess effective chemopreventive activity.

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A comparison of different methods of extraction of the M-protein from Streptococcus equi. Four new Amaryllidaceae alkaloids (1-4) possessing a homolycorine-type or a crinine-type skeleton have been isolated from the aerial part of Zephyranthes candida, and their structures were elucidated on the basis of spectroscopic data. The casual determination of blood pressure remains the basis of the diagnosis of arterial hypertension and the criteria for usefulness of drug therapy. Transvenous atrial pacing via an electrode placed in the coronary sinus has become an increasingly frequent procedure during the past 10 years for both diagnosis and therapy of cardiac arrhythmias. In particular, we employ a convolutional neural net (CNN) that exploits context and depth information to jointly regress to 3D bounding box coordinates and object pose. Effect of DRB on the biological characteristics of human laryngeal carcinoma Hep-2 cell line. To gain a better understanding of the role that PR plays in the processing and activation of RT, we performed complementation experiments wherein wild-type or PR mutant gag precursors were separately coexpressed with frame-corrected wild-type or PR mutant gag-pol precursors. Sixty-two patients with transitional cell carcinoma of the bladder cancer and 79 controls were examined with respect to the frequency of GSTM1 and GSTT1 null tenormin 10 mg genotypes. Most patients died and were associated with a hemodialysis unit stay.

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