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Amline (Amitriptyline)

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Amline is used to treat depression. Compared to other antidepressants, it has a higher risk of side effects, such as weight gain and drowsiness. Amline is a tricyclic antidepressant (TCA). It works on parts of the brain responsible for raising levels of certain chemicals, like serotonin and norepinephrine, to help improve your mood.

Other names for this medication:
Amiclozor, Amicon, Amitar, Amitin, Amitop, Amitrim, Amitrip, Amitrix, Amitryptyline, Amiwel, Amixide, Amline, Amrea, Amtipax, Amtran, Anitryp, Aptric, Arpidox, Axtrip, Bluneel, Chlotrip, Crypton, Eliwel, Eptanol, Estiline, Goldep, Latilin, Libral, Limbival, Maxitrip, Nextrip, Normaline, Raitrip, Ronet, Sereval, Tablin, Teedep, Trixide, Tryline, Typlin, Zodep

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Also known as: Amitriptyline


{name} (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

{name} is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amline dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline can be fatal.

Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amline are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Amline if you are allergic to amitriptyline, or:

if you have recently had a heart attack.

Do not use Amline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

To make sure Amline is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic-depression) or schizophrenia; mental illness or psychosis; liver disease; heart disease; a heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Amline is not approved for use by anyone younger than 12 years old.

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Distribution of tributyltin, dibutyltin and monobutyltin in the liver, brain and fat of rats: two-generation toxicity study of tributyltin chloride. A model is presented that deals with two problems not previously solved: it handles the random arrival of requests for admission and permits continuous updating of scheduling decisions in a dynamic process, and it provides global long-term optimization of patient census rather than a series of suboptimal short-term solutions. Acute cardiac tamponade associated with pericardial extramedullary hematopoiesis in agnogenic myeloid metaplasia. On the power for linkage detection using a test based on scan statistics. Twenty-eight patient records (14 from each hospital) were investigated to assess the impact of skeletal-related events (SREs), including fractures, spinal cord compression, and radiotherapy, on total direct medical costs and cost of hospitalization. Hence, trehalose and glycogen accumulated to much higher levels in cells lacking neutral trehalose or glycogen phosphorylase exposed to stress conditions, which suggested that one of the major effects of stress in yeast is to induce a wasteful expenditure of energy by increasing the recycling of these molecules. Value of the correlation and regression in the evaluation of post-exercise changes in left ventricular contraction in healthy subjects. Figures relating to the document delivery service of NERMLS are given. This hypothesis is currently of unknown pathogenetic, but of potential future therapeutic relevance. Clinical assessment of functional stenosis severity: use of coronary pressure measurements for the decision to bypass a lesion.

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Phosphodiester amidates of unsaturated nucleoside analogues: synthesis and anti-HIV activity. The United States Supreme Court and the chronic drunkenness offender. In two patients, intra-bile duct tumor growth (IBDTG) was observed on imaging. Use of this method permits the physician to have simultaneous information about two aspects of metabolism in the cells and cuts down the time needed for measuring the activities of two enzymes in the leukocytes. Anterior tumour location and renal sinus involvement proved to be the best predictors of loss of healthy renal parenchyma. We analyzed the outcome of surgical treatment and prognostic factors. However, there is sparse literature on the role of serum and urine amylase, lipase levels, etc to help predict the specific intra-abdominal injury after blunt trauma abdomen (BTA). However, the appropriate implementation of this technology in the science of aging requires serious attention to methodological detail and statistical rigor. It is difficult to determine the position of a preferred retinal locus (PRL) relative to the fovea in scanning laser ophthalmoscope (SLO) images as a result of disease-related retinal morphologic changes that obscure the fovea. However, the pre-treatment interview seems to facilitate change on secondary outcomes such as depression and general distress.

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Role of tumor markers in the diagnosis of cystic and intraductal neoplasms. Engineering the frequency correlations of entangled two-photon states by achromatic phase matching. This study aimed to compare glycemic variations seen among Japanese patients with type 1 diabetes treated with insulin glargine versus insulin detemir using continuous glucose monitoring (CGM) in a crossover design. The methods usually employed for reconstruction of total lower eyelid loss include (1) tarsoconjunctival flaps from the upper eyelid and skin-graft cover and (2) chondromucosal grafts and local skin-flap cover. Current annexin V techniques are almost exclusively restricted to flow cytometric analysis. We report here that the Tre2 (USP6) oncogene is derived from the chimeric fusion of two genes, USP32 (NY-REN-60), and TBC1D3. Current therapeutic options are mostly ineffective and mortality rates remain high. Tocolytic effect of a Rho-kinase inhibitor in a mouse model of lipopolysaccharide-induced preterm delivery. Although garlic is believed to have health-promoting benefits, many of the claimed benefits are not supported by good scientific studies. In spite of a slowing or complete block of elbow extension, and in some cases a replacement of elbow extension by elbow flexion, finger opening always occurred and at the same latency as for normal throws.

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Atypical subtrochanteric femur fracture in patient with metastatic breast cancer treated with zoledronic Acid. Enamel and dentin samples were irradiated with Er, Cr: YSGG laser at 6 W or 4 W for 6 second, respectively. Rat and guinea pig hepatocytes were depleted of GSH with 1-bromoheptane and subsequently treated with the oxidative stressor cumene hydroperoxide (CHP) in the presence or absence of the ascorbate synthesis inhibitor sorbinil. Low grade squamous intraepithelial lesion, epithelial cell abnormality-adjusted workload, and the ThinPrep imaging system. Mice were transplanted with OVA-specific TCR-transgenic T cells and either fed OVA or immunized s.c. Formation of spheroid structures in a human colon carcinoma cell line involves a complex series of intercellular rearrangements. The goal of this article is to illustrate the normal maturation and development of the EEG using the age-specific waveforms and patterns seen in neonates, infants, children, and adolescence. The dominant source of the Lyman-alpha emission is atomic hydrogen from the interstellar medium.

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Adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channels allow coupling of membrane potential to cellular metabolic status. Chinese minimally invasive percutaneous nephrolithotomy for intrarenal stones in patients with solitary kidney: a single-center experience. The evolution processes of type IV collagen(CN), fibronectin(FN), and laminin(LN) in carcinogenesis were studied by the use of diethylnitrosamine induced rat hepatocarinogensis model so as to clarify the action of chemical carcinogens on the mechanisms of the occurrence and development of hepatocellular carcinoma. Basilic vein transpositions (BVTs) provide autologous hemodialysis access in the upper extremity. Reposition sense of lumbar curvature was assessed as a function of trunk flexion, trunk asymmetry, and target lumbar curvature using a repeated-measures design and an active-active proprioception paradigm. It was found that the average doses to the body, neck and hands were 0.05, 0.89 and 2.45 microSv/(Gy cm2), respectively for those radiologists with no significant involvement in hepatobiliary procedures. The relationship between demographic, clinical, laboratory, and surgical parameters and survival was assessed using univariate Kaplan-Meier survival and multivariate Cox proportional hazards model. The interaction of Imp4p to telomeres in vivo was also demonstrated by chromatin immunoprecipitation experiments.

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