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Amicure (Amitriptyline)

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Amicure is a type of drug called a tricyclic antidepressant. These drugs were originally developed to treat anxiety and depression, but when taken at a low dose they can reduce or stop pain. Amicure works by increasing the amount of serotonin your brain makes.

Other names for this medication:
Amicon, Amicure, Amitar, Amitone, Amity, Amiwel, Amixide, Amize, Amoten, Amtran, Aptric, Chlotrip, Cotrip, Crypton, Emotrip, Endep, Goldep, Latiln, Libotryp, Limbitrol, Limbival, Lodep, Nextrip, Normaline, Psycomer, Raitrip, Relidep, Ristryl, Sarotena, Tridep, Trixide, Tryptomec, Typteez, Vanatrip, Zodep

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Also known as: Amitriptyline


{name} (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

{name} is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amicure dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline can be fatal.

Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amicure are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Amicure if you are allergic to amitriptyline, or:

if you have recently had a heart attack.

Do not use Amicure if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

To make sure Amicure is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic-depression) or schizophrenia; mental illness or psychosis; liver disease; heart disease; a heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Amicure is not approved for use by anyone younger than 12 years old.

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We conducted a case-control study using the Washington State Birth Events Record Database linked to statewide hospitalization data. To identify differentially expressed lumican in scleral tissue of eyes with primary open-angle glaucoma (POAG) and high myopia (HM). Here we show that Vav and c-Cbl form inducible molecular complexes in TCR-activated murine thymocytes and peripheral T cells as well as pervanadate-treated T cells. Neither KMP-11 protein nor K1 peptide elicited the expression of the maturation marker CD83 on dendritic cells of patients or healthy control individuals. Dantrolene was also tested in combined application in caffeine neurotoxicity. The managerial duties of the nurse in charge of a unit in combating the spreading of HIV/AIDS. The findings are compared with similar cases in the literature and a tentative diagnosis of a lysosomal storage disease is proposed. Despite its extensive industrial applications, the genetic inventory of this fungus is only partially understood.

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Methods for the simultaneous measurement of pressure differentials and flow in single unbranched vessels of the microcirculation for rheological studies. Social interaction with conspecifics can influence the developing brain and behaviour of the exposed animal. Undetected dyslexia, a frequent cause of social and mental school maladjustment. Bacillus megaterium strain NK84-0218 produces a potent antiviral antibiotic, oxetanocin A, which has an oxetanosyl-N-glycoside linkage to an adenine moiety. However, since PR3 was not found in malignant tissues from the WG patients, the immunopathologic mechanisms leading to autoimmunity and vasculitis remain unclear. In 1994, the favorable experience with composite cartilage shield tympanoplasty was reported to the American Otological Society. In addition, conductors levitate in strong radio-frequency fields, charged particles in alternating electric fields, and magnets above superconductors or vice versa.

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A combination of automated and manually extracted data was used to identify HMO members with diagnoses of allergic rhinitis or asthma who were treated with immunotherapy. Eleven different bacterial strains were obtained from patients attending the Sultan Qaboos University Hospital, Muscat, Sultanate of Oman. To investigate the role of astroglia in intracerebral immune response to Toxoplasma gondii, astrocytes cultured from mouse brain were inoculated with mouse-virulent or -avirulent toxoplasma strains. We also demonstrate that immunoaffinity purified plant peptide induces stomatal opening in a concentration dependent manner. We also found that this ongoing activity exhibited high synchronization over many millimeters of cortex. The objective was to examine the assumption that suicide is inevitably preventable.

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Umbilical metastasis from malignant neoplasms of pelvic and abdominal cavity with 3 cases analysis. As NCK controls actin dynamics, this pathway may connect DNA damage responses and cellular morphology in metazoans. The SUVmax of the biopsy site, the tumorous lesion sites, and 3 different bone marrow sites (right iliac crest, sternum, and L1) were measured. Proposal of a uniform fiber Bragg grating as an ultrafast all-optical integrator. High-resolution definition of vaccine-elicited B cell responses against the HIV primary receptor binding site. Collection of urine in rabbits by conventional methods such as catheterization of ureters or bladder with polyethylene tubing or Foley cannulas is hampered by the occurrence of hematuria or obstruction of urine flow, or both.

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Adrenergic and cholinergic responses of the isolated saline-perfused heart of the elasmobranch fish Squalus acanthias. Individual components of the kallikrein-kinin system as well as their origin, structure and biodegeneration were described. Both IGF-I and hydrocortisone treatments, however, significantly increased lactase, maltase and sucrase activities and hydrocortisone significantly increased aminopeptidase activity at the proximal small intestine when compared with the control. In this review, CT features of malignant hepatic masses are discussed in conjunction with a demonstration of the role for 3D vascular mapping. This multi-center, double-blind, randomized trial enrolled patients with endoscopically documented reflux esophagitis. These changes correlated with a rearrangement of the actin cytoskeleton, which strongly colocalized with syndecan-2. The creation of this specialty may be judged to have been a successful venture that has led to a better treatment of the concerned patients. While in-hospital CPR is most often performed on patients lying on a bed or stretcher, CPR training uses primarily nolvadex dose manikins placed on the floor. Pain and anxiety management in the postoperative gastro-surgical setting.

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Acute interstitial lung disease is a rare but potentially fatal complication of therapy. Bone reactions to titanium screw implants in ovariectomized animals. One visit should take place after the autumn kill of animals for winter consumption, and this is a good time to vaccinate animals born in the summer, and also all other animals while they are healthy and immunologically responsive. CVD risk factors were measured, IR was quantified using the homeostasis model assessment (HOMA), and MS as defined by the National Cholesterol Education Program Adult Treatment Panel (ATP III) was assessed for each participant. Although we find that S-nitrosation of caspases can occur in vitro, our study questions whether this post-translational modification is solely responsible for NO-mediated inhibition of apoptosis.

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The effects of the non-fumigant nematicide imicyafos on soil nematode community structure and damage to radish caused by Pratylenchus penetrans were evaluated in two field experiments in consecutive years (2007 and 2008). Kidney biopsies and in appropriate cases liver biopsies were examined by LM and electron microscopy (EM). Recently, an acellular matrix (Alloderm) has been advocated to decrease complications at the radial forearm donor site, as well as obviate taking a split-thickness skin graft from the thigh. To investigate the validity of the Trendelenburg test (TT) using an ultrasound-guided nerve block (UNB) of the superior gluteal nerve and determine whether the reduction in hip abductor muscle (HABD) strength would result in the theorized mechanical compensatory strategies measured during the TT. Sertoli cells in culture and mRNA differential display provide a sensitive early warning assay system to detect changes induced by xenobiotics. These data are of varying quality, reflecting in part the methods used to collect them. Finishing an IM requires less training than has been previously reported in studies that have primarily focused on elite competitors.

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This intraamniotic pressure threshold was 20 mm Hg in group I (saline), but only 15 mm Hg in group II (air). Of the nitroxides, 3-carbamoyl-proxyl (3-CP) is especially promising for clinical use, because it does not cause hypotension in animals. Studies have also indicated that the peroperative depth of anaesthesia may affect the postoperative course. Polycyclic aromatic hydrocarbons have a low water solubility and tend to adsorb on soil particles, which both result in slow bioremediation processes. Three tumours (mammary carcinoma, osteosarcoma and squamous cell carcinoma) were used. These data norvasc 5 mg dose elderly patients provide a fundamental basis that should be taken into account for low temperature preservation of bovine oocytes in the presence of Me2SO. Here, we report that in H-NS mutants that are unable to silence genes, are unable to form a rigid H-NS nucleoprotein filament.

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To better understand its target protein in A549 cell, two-dimensional electrophoresis and liquid chromatography-tandem mass spectrometry were applied. Autologous cultured mucosal graft to cover large intraoral mucosal defects: a clinical study. Haemodynamic effects of pneumoperitoneum in elderly patients with an vantin generic name increased cardiac risk. The difficulties of diagnosis and the advantages of laparoscopic management are discussed. We found strong relationships between aerobic capacities and cognitive functioning.

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The results showed that the apparent constant of Michaelis-Menten, K(m(app)), increases from 4.3 to 79.3 mM, for experiments realised without and with 0.5 mM sodium tetraborate, respectively. The patients were randomized to either fenofibrate 100 mg tid or gemfibrozil 600 mg bid for three months, then shifted to alternate drug for another three months after a two-month washout period. Knowledge is scarce about movement disorders that follow neurosurgical operations other than functional stereotactic surgery. Unhealthy lifestyles should be monitored during the management of when can you drink alcohol after stopping flagyl CKD patients with proteinuria. Although these alterations returned to normal on full recovery, NK cells in patients with DIHS displayed a defective ability to express CD122 (IL-2/15R beta) even long after recovery. Preclinical studies have shown that modulating cellular/tissue redox state by different gene therapy (GT) approaches was able to control tumor growth.

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Concurrent increases in MTX uptake and MTX cytotoxicity in these treated SqCHN cells were found. To study the effect on subjective refraction of artificial divergence surgery in congenital nystagmus with blocking convergence. Transgenic expression of a novel thymic epithelial cell antigen stimulates abberant development of thymocytes. Children may be exposed to low-level environmental tobacco smoke (ETS) or thirdhand smoke, even if parents avoid smoking in the presence of their children. Two cases of scalp wound colonization and respiratory tract by mycelial fungi. Among adiposity indexes, SST was the best predictor of IGFBP-1 levels. Approximately 10(6) colony forming units of each test spore were individually inoculated into 22 replicate containers of each sample volume.

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Male B6C3F1 mice were exposed to 6.25, 62.5, 200, or 625 ppm butadiene alone, 50 ppm styrene alone, or mixtures of 6.25, 62.5, 200, or 625 ppm butadiene and 50 ppm styrene. The guinea pig is highly developed at birth and requires little active maternal care. It is thought that as a person becomes more musically adept, increasing use is made of a left hemisphere sequential analytic mechanism. 5-(2-Chloro-phen-oxy)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde oxime. By simple regression analysis, the serum sialic acid level was found to correlate significantly with these parameters. Hepatic involvement is linked with systemic lupus erythematosus after exclusion of hepatotoxic drugs, viral hepatitis and absence of anti mitochondrial and anti muscle antibodies. To take an important first step toward dissecting the effects of HER2 overexpression on cell responses in terms of the various specific underlying mechanisms, we have developed and validated a quantitative model of the relevant trafficking processes. The observation in twins and the opportunity of histologic examination of optic nerve, permitted some considerations in order to help in understanding this syndrome. A number of studies have shown variations in the occurrence of alcoholism between different socioeconomic groups and occupations, but it has not been clear to what extent this is related to the average alcohol consumption in the same socioeconomic groups or occupations. The reverse transcriptase-polymerase chain reaction was employed to determine the mRNA expression of these chains because of the relatively small amount of RNA extracted from rat embryonic hearts.

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