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Alrest (Clonazepam)
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Alrest

Alrest is one of the products that belong to the bensodiazepine group and have a strong sedative effect. It is widely used among people with severe panic attacks and anxiety caused by depression treatment. Thanks to its unique features, Alrest helps to stop convulsions and epileptic seizures.

Other names for this medication:
Almac, Alrest, Cloam, Clonapax, Clonark, Clonax, Cloneepam, Clonix, Clonopam, Clonotril, Clotweet, Clozep, Clozipam, Clozorix, Convaclon, Cozil, Deptune, Ection, Eminaz, Epcon, Epicloz, Epitril, Epizam, Escitacalm, Esitor, Estalonix, Ezinite, Meloprax, Melzap, Nazee, Nexclo, Nozim, Petril, Prasilife, Revozip, Rivotril, Ubitpam, Zeficar, Zepamax, Zozep

Similar Products:
Sustiva, Dramamine, Cardizem, Soma, Aygestin, Zyvox, Sporanox

Also known as: Clonazepam

Description

Alrest, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects.

Alrest has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of Alrest. As a result, Alrest is sometimes used for certain rare childhood epilepsies; however, it has been found to be ineffective in the control of infantile spasms. Alrest is mainly prescribed for the acute management of epilepsies. Alrest has been found to be effective in the acute control of non-convulsive status epilepticus; however, the benefits tended to be transient in many of the people, and the addition of phenytoin for lasting control was required in these patients.

It is also approved for treatment of typical and atypical absences, infantile myoclonic, myoclonic and akinetic seizures. A subgroup of people with treatment resistant epilepsy may benefit from long-term use of Alrest; the benzodiazepine clorazepate may be an alternative due to its slow onset of tolerance.

Dosage

Adults. The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding Alrest to an existing anticonvulsant regimen.

Pediatric Patients. Alrest is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

Geriatric Patients. There is no clinical trial experience with Alrest in seizure disorder patients 65 years of age and older. In general, elderly patients should be started on low doses of Alrest and observed closely.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.

Storage

Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Alrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Alrest if you have:

narrow-angle glaucoma; severe liver disease; or a history of allergic reaction to any benzodiazepine (alprazolam, diazepam, lorazepam, Ativan, Restoril, Tranxene, Valium, Versed, Xanax, and others).

To make sure Alrest is safe for you, tell your doctor if you have ever had:

kidney or liver disease; breathing problems; depression, mood problems, or suicidal thoughts or behavior; or porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Some people have thoughts about suicide when taking seizure medication. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

If you use clonazepam while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of clonazepam on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Do not give this medicine to a child without medical advice. Alrest is not approved to treat panic disorder in anyone younger than 18 years old.

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Functional Outcomes Following Anterior Transfer of the Tibialis Posterior Tendon for Foot Drop Secondary to Peroneal Nerve Palsy. To determine the effect of a critical pathway on resource utilization in asthmatic patients. Roles of calcium and annexins in phagocytosis and elimination of an attenuated strain of Mycobacterium tuberculosis in human neutrophils. The low excess loss hybrid device is used in individual and two simultaneous OAM states multiplexing and demultiplexing link experiments with a 20 Gb/s, 1.67 b/s/Hz quadrature phase shift keyed (QPSK) signal, which shows error-free performance for 379,960 tested bits for all OAM states. We observed that three and four MYC signals were the most common alterations in gastric cell lines and tumors. Baicalein Exerts Beneficial Effects in d-Galactose-Induced Aging Rats Through Attenuation of Inflammation and Metabolic Dysfunction. On follow up, MRI findings resolved in all except three patients. Acute posttraumatic fetal anemia treated with fetal intravascular transfusion. However, the link between social environment and PPI i.e., the possible role of social defeat in driving PPI plasticity, is far from clear. Positron emission tomography imaging revealed marked right temporal lobe hypometabolism and magnetic resonance imaging (MRI) detected T2 changes consistent with right mesial temporal sclerosis.

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Since patients recover spontaneously, watchful waiting is justified. Inhibition of factor-dependent transcription termination in Escherichia coli might relieve xenogene silencing by abrogating H-NS-DNA interactions in vivo. This prospective, double-blind study compared the effects of intradermal chlorpheniramine, midazolam, lidocaine, and saline for pain on injection and degree of local anesthesia in adult volunteers. The recombinant proteins purified by Ni-NTA columns were incorporated into ISCOM and ISCOMATRIX by the lipid film hydration method. In experiments where the stimulating probe was placed more apical, two major properties were observed: first, beads revealed only the spectral components present in the motion of the probe. Development and evaluation of a semi-empirical two-zone dust exposure model for a dusty construction trade.

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The trial was conducted by the International Centre for Diarrhoeal Disease Research (ICDDR,B) and the Shaheed Suhrawardy Medical College (ShSMC), Dhaka, in collaboration with the trial sites and sponsored by the Drugs for Neglected Diseases initiative (DNDi). Surprisingly, we observed significant photoreceptor cell loss in both transgene-expressing and nonexpressing patches in hemizygous female retinas. A key regulatory element that controls the ftz pattern is the ftz proximal enhancer, which mediates positive autoregulation via multiple binding sites for the Ftz protein. Molecular, oncologic, and therapeutic spectrum of von Hippel-Lindau disease. The visible fat of meat contained a significant quantity of AA, ranging from 20 to 180 mg/100 g fat, whereas the AA content of the lean portion of meat was lower, ranging from 30 to 99 mg/100 g lean meat.

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Alterations of somatostatin and its modulation by levodopa in MPTP-treated mouse brain. A total of 8044 MCC cases in the National Cancer Data Base were analyzed. The interaction between memorized objects and abrupt onsets in oculomotor capture. Subcutaneous poly(I:C) tramadol lethal dose in dogs protected against DSS-induced colitis equally well in C57BL6 and IL-10KO mice, indicating that this antiinflammatory cytokine is not required for such protection. This induction of apoptosis occurred independent of the p53 status of the cell. There was no complication at left forearm donor site with intact musculoskeletal function.Radial forearm osteocutaneous free flap is a versatile option for its capability of reconstruction in complicated defect of soft and hard plate with alveolar defect. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. Dual AMPA receptor-mediated functions of excitation and disinhibition may ensure transmission of cerebellar CF signals controlling sensorimotor coordination. Number of revisions, bacterial cultures, type of wound closure and recurrence of infection after 3 years and 5 months on average after the last surgery was analysed. The computed tomography (CT) was performed in 10 cases of neurofibromatosis.

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Two phosphAte taRGets in End-stage renal disease Trial (TARGET): A Randomized Controlled Trial. This hypothesis might be called a nutrient-specific model of peptide-induced food intake. Despite expansion of the therapeutic armamentarium, HSV and VZV continue to cause morbidity and occasional mortality in transplant recipients. Staining for 13 different enzymes revealed parasite-associated bands of glucose phosphate isomerase (GPI) activity, not of any of the other enzymes. The purpose of the present studies was to determine the nature and origin of NPYergic inputs to, and the type of specific NPY receptor subtypes in, the rat pineal gland. Transmyocardial laser revascularization is a new therapy for patients with refractory angina. The value of in vitro tests in the diagnosis of bronchial asthma. Achieving Smoking Cessation in Individuals with Schizophrenia: Special Considerations.

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