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Alrest (Clonazepam)

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Alrest is one of the products that belong to the bensodiazepine group and have a strong sedative effect. It is widely used among people with severe panic attacks and anxiety caused by depression treatment. Thanks to its unique features, Alrest helps to stop convulsions and epileptic seizures.

Other names for this medication:
Almac, Alrest, Cloam, Clonapax, Clonark, Clonax, Cloneepam, Clonix, Clonopam, Clonotril, Clotweet, Clozep, Clozipam, Clozorix, Convaclon, Cozil, Deptune, Ection, Eminaz, Epcon, Epicloz, Epitril, Epizam, Escitacalm, Esitor, Estalonix, Ezinite, Meloprax, Melzap, Nazee, Nexclo, Nozim, Petril, Prasilife, Revozip, Rivotril, Ubitpam, Zeficar, Zepamax, Zozep

Similar Products:
Sustiva, Dramamine, Cardizem, Soma, Aygestin, Zyvox, Sporanox

Also known as: Clonazepam


Alrest, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects.

Alrest has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of Alrest. As a result, Alrest is sometimes used for certain rare childhood epilepsies; however, it has been found to be ineffective in the control of infantile spasms. Alrest is mainly prescribed for the acute management of epilepsies. Alrest has been found to be effective in the acute control of non-convulsive status epilepticus; however, the benefits tended to be transient in many of the people, and the addition of phenytoin for lasting control was required in these patients.

It is also approved for treatment of typical and atypical absences, infantile myoclonic, myoclonic and akinetic seizures. A subgroup of people with treatment resistant epilepsy may benefit from long-term use of Alrest; the benzodiazepine clorazepate may be an alternative due to its slow onset of tolerance.


Adults. The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding Alrest to an existing anticonvulsant regimen.

Pediatric Patients. Alrest is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

Geriatric Patients. There is no clinical trial experience with Alrest in seizure disorder patients 65 years of age and older. In general, elderly patients should be started on low doses of Alrest and observed closely.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.


Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Alrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Alrest if you have:

narrow-angle glaucoma; severe liver disease; or a history of allergic reaction to any benzodiazepine (alprazolam, diazepam, lorazepam, Ativan, Restoril, Tranxene, Valium, Versed, Xanax, and others).

To make sure Alrest is safe for you, tell your doctor if you have ever had:

kidney or liver disease; breathing problems; depression, mood problems, or suicidal thoughts or behavior; or porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Some people have thoughts about suicide when taking seizure medication. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

If you use clonazepam while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of clonazepam on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Do not give this medicine to a child without medical advice. Alrest is not approved to treat panic disorder in anyone younger than 18 years old.

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However, neither Escherichia coli ssDNA binding protein nor human RPA can substitute in this reaction, indicating that RPA has a second role in this process, a role that requires specific RPA-Rad52 protein interactions. Inherited prion diseases are caused by over 30 mutations in the prion protein gene (PRNP) and common polymorphisms can have a considerable affect on susceptibility and phenotype. The evidence suggests that simple nail avulsion combined with the use of phenol, compared to surgical excisional techniques without the use of phenol, is more effective at preventing symptomatic recurrence of ingrowing toenails. Convergent inputs from thalamic motor nuclei and frontal cortical areas to the dorsal striatum in the primate. This consists of tyrosinase-oxidized phenolic groups of a heparin derivative (heparin-grafted tyramine, HT) to catechol groups, followed by immobilizing heparin and inducing the in situ Ag NP formation onto poly(urethane) (PU) substrates. These results suggest that the main reason for the CR-associated diarrhea might be disturbance in the normal gut microbiota. An RNA helicase, RHIV -1, induced by porcine reproductive and respiratory syndrome virus (PRRSV) is mapped on porcine chromosome 10q13. In the study reported here, we report the generation and analysis of a number of single amino acid substitutions for seven surface residues predicted to lie within one of these two epitopes. The efficiency of the pre-treatment (NA and MA) was demonstrated by X-ray microanalysis at the transmission electron microscopic level. Secondary analysis of baseline data from a randomised controlled trial of health risk appraisal.

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Morbidity in HIV-1-infected individuals before and after the introduction of antiretroviral therapy: a longitudinal study of a population-based cohort in Uganda. Transvenous management of pulmonary embolism and technical aspects of filters. It is feasible to gauge national levels of primary and secondary infertility from population based surveys including a birth history. A decoction of the leaves, flowers, and barks is used in India for the treatment of cancer including diabetes, malaria, and inflammation etc. Correlation between some discrimination functions and hemoglobin E. This is possible because 14CO2 can label any organic compound without any deteriorations in the nature of the compound.

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In green needles of Pinus mugo the most abundant polyprenols occur as a mixture of prenologues in which the dominant alcohol is built of 16 isoprene units. An association between MAP and T1D was recently observed in an Italian cohort of pediatric T1D individuals, characterized by a different genetic background. Survival from initial chemotherapy treatment was 44.5 months (range, 3-130 mo) in patients with low-grade tumors and 26.5 months (range, 2-67 mo) in patients with high-grade tumors. We developed a new tensor to measure the joint gap throughout knee flexion during total knee arthroplasty (TKA). Biofilm growth: a multi-scale and coupled fluid-structure interaction and mass transport approach. This short-term (2-week) study should be followed by others evaluating the effect over longer periods. Metronidazole and the isolation of temperature-sensitive photosynthetic mutants in cyanobacteria. It will enable doctors to formulate a business case for proposal. H-2k, H-2p, H-2r, and H-2v haplotype mice were intermediate responders to beta-chain. In 2 patients, infection of the wound was responsible for a total graft lysis which occurred immediately in the non-sealed grafts and was delayed in the sealed ones.

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Functional Outcomes Following Anterior Transfer of the Tibialis Posterior Tendon for Foot Drop Secondary to Peroneal Nerve Palsy. To determine the effect of a critical pathway on resource utilization in asthmatic patients. Roles of calcium and annexins in phagocytosis and elimination of an attenuated strain of Mycobacterium tuberculosis in human neutrophils. The low excess loss hybrid device is used in individual and two simultaneous OAM states multiplexing and demultiplexing link experiments with a 20 Gb/s, 1.67 b/s/Hz quadrature phase shift keyed (QPSK) signal, which shows error-free performance for 379,960 tested bits for all OAM states. We observed that three and four MYC signals were the most common alterations in gastric cell lines and tumors. Baicalein Exerts Beneficial Effects in d-Galactose-Induced Aging Rats Through Attenuation of Inflammation and Metabolic Dysfunction. On follow up, MRI findings resolved in all except three patients. Acute posttraumatic fetal anemia treated with fetal intravascular transfusion. However, the link between social environment and PPI i.e., the possible role of social defeat in driving PPI plasticity, is far from clear. Positron emission tomography imaging revealed marked right temporal lobe hypometabolism and magnetic resonance imaging (MRI) detected T2 changes consistent with right mesial temporal sclerosis.

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At this range of peptide lengths, most would appear as self, while nonselfness of the remainders are destined to be quite ambiguous, hence creating responders and nonresponders. Monoolein as helper lipid for non-viral transfection in mammals. This article graphically describes the methodology developed to estimate the direct costs of comprehensive care for DM and HT to the health services of MINSA and regional governments. For centuries, large areas were cultivated to feed the local population, with highly marginal slopes being tilled at times of heavy demographic pressure, using the shifting agriculture system. Nutrients and bioactives may produce different physiological phenotypes among individuals because of genetic variability and not only alter health, but also disease initiation, progression and severity. The results support the idea that interprofessional educational interventions cleocin medication classification must be tailored to specific learning goals to be implemented successfully, and that interprofessional education should be prolonged and widespread to have a real impact.

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The aim of this minireview is to summarise and critically evaluate this evidence and to consider the therapeutic implications of this hypothesis. One half of the patients had one recurrence or less of their papilloma. A single oral administration of chlorpyrifos to Nubian goats at 1200, 600 and 300 mg/kg caused nervous signs and death within 15 minutes to 2 days of treatment. Epithelial papillary hyperplasia of choledocho-pancreatic duct, associated with cellular atypism, was observed in Otsuka Long Evans Tokushima Fatty (OLETF) rats, a strain originally established as an animal model for non-insulin-dependent diabetes mellitus (NIDDM). Endovascular embolization might be a preferred procedure for dealing with patients in this setting. Visuospatial working memory mechanisms have been studied extensively at single cell level in the dorsolateral prefrontal cortex (PFCd) in nonhuman primates. Lung congestion is emerging as a pervasive, insidious problem in end-stage renal disease (ESRD) patients on dialysis.

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Alterations of somatostatin and its modulation by levodopa in MPTP-treated mouse brain. A total of 8044 MCC cases in the National Cancer Data Base were analyzed. The interaction between memorized objects and abrupt onsets in oculomotor capture. Subcutaneous poly(I:C) tramadol lethal dose in dogs protected against DSS-induced colitis equally well in C57BL6 and IL-10KO mice, indicating that this antiinflammatory cytokine is not required for such protection. This induction of apoptosis occurred independent of the p53 status of the cell. There was no complication at left forearm donor site with intact musculoskeletal function.Radial forearm osteocutaneous free flap is a versatile option for its capability of reconstruction in complicated defect of soft and hard plate with alveolar defect. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. Dual AMPA receptor-mediated functions of excitation and disinhibition may ensure transmission of cerebellar CF signals controlling sensorimotor coordination. Number of revisions, bacterial cultures, type of wound closure and recurrence of infection after 3 years and 5 months on average after the last surgery was analysed. The computed tomography (CT) was performed in 10 cases of neurofibromatosis.

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The OCR of IVD cells reported in this study will be valuable for understanding human IVD cellular behavior and tissue nutrition in response to disc degeneration. In both groups, proper overjet and Class I molar relationships were achieved, and the occlusal plane was rotated counterclockwise. Results: At the end of the training, patients in the experimental group showed a higher performance compared to patients in the control task group, in the Hinting Task Test and in the emotion recognition of sadness, anger, fear, and disgust. It was demonstrated that Ga doping improves the n-type conduction of the cubic MgZnO films. Comparative immunogenicity of conjugates composed of the Staphylococcus aureus type 8 capsular polysaccharide bound to carrier proteins by adipic acid dihydrazide or N-succinimidyl-3-(2-pyridyldithio)propionate.

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Two phosphAte taRGets in End-stage renal disease Trial (TARGET): A Randomized Controlled Trial. This hypothesis might be called a nutrient-specific model of peptide-induced food intake. Despite expansion of the therapeutic armamentarium, HSV and VZV continue to cause morbidity and occasional mortality in transplant recipients. Staining for 13 different enzymes revealed parasite-associated bands of glucose phosphate isomerase (GPI) activity, not of any of the other enzymes. The purpose of the present studies was to determine the nature and origin of NPYergic inputs to, and the type of specific NPY receptor subtypes in, the rat pineal gland. Transmyocardial laser revascularization is a new therapy for patients with refractory angina. The value of in vitro tests in the diagnosis of bronchial asthma. Achieving Smoking Cessation in Individuals with Schizophrenia: Special Considerations.

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The effects of irinotecan in vivo on a meningioma model were determined with a subcutaneous murine tumor model using the IOMM-Lee cell line. Peritoneal fluid was analyzed for PA, PAI, MMP, and MMPI activities. Maternal deaths after elective cesarean section for breech presentation in the Netherlands. Complementary Immunoprecipitation/WB analysis shows both forms of Rb aldactone 50 drugs protein in the anti-Sp1 immunoprecipitates. A method for reconstruction of the coracoclavicular ligament in acromioclavicular joint injuries.

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