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Alprostadil

Alprostadil is a medication used to treat erectile dysfunction. Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of Alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora.

Other names for this medication:
Alpostin, Caverject, Edex, Muse, Prostin, Vitaros

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Description

Alprostadil injection is used to treat certain heart, lung, and blood vessel problems in infants. It is used to temporarily keep the ductus arteriosus (blood vessel in the heart) open before having a surgery.

This medicine is to be given only by or under the supervision of your child's doctor.

This product is available in the following dosage forms:

  • Solution

Dosage

Read the Patient Information Leaflet provided by your pharmacist before you start using alprostadil and each time you get a refill. Learn all usage instructions in the product package. If any of the information is unclear, consult your doctor or pharmacist. This medication is used by inserting the suppository into the penis as directed by your doctor. Dosage is based on your medical condition and response to therapy. This medication should usually work within 5-10 minutes to produce an erection that lasts for about 30-60 minutes. The manufacturer recommends that you use no more than 2 doses in a 24-hour period. Inform your doctor if your condition persists or worsens (e. g. , the drug does not produce an erection or it becomes more difficult to get an erection).

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause fainting, or a painful and prolonged erection.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store unopened foil pouches in the refrigerator. Keep the medicine away from heat. It may not work if exposed to temperatures above 30 degrees C. You may also store the suppositories at room temperature for up to 14 days before each use.

Side effects

The most common side effects associated with Alprostadil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Before using alprostadil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: genito-urinary tract disorder (e. g. , urethral stricture/obstruction, urethritis, inflammation/infection of the head of the penis), indwelling urethral catheter. Before using this medication, tell your doctor or pharmacist your medical history, especially of: penis conditions (e. g. , angulation, cavernosal fibrosis, Peyronie's disease), bleeding disorders, blood system cancers (e. g. , leukemia, multiple myeloma), heart disease, low blood pressure, sickle cell anemia. This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. Use of this drug does not protect against sexually transmitted diseases (e. g. , HIV, hepatitis B, gonorrhea, syphilis). To decrease your risk of infection, always use an effective barrier method such as a latex or polyurethane condom during all sexual activity. Consult your doctor or pharmacist for more details. This medication is not for use in women. If this drug is used by a male for sexual intercourse with a pregnant woman, an effective barrier method such as a latex or polyurethane condom should be used. Consult your doctor or pharmacist for more details.

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Synthesis of ribosomal RNA in disaggregated cells of sea urchin embryos. Crystal structures of Sj26GST in complex with glutathione sulfonate (Sj26GSTSLF), what is plavix drug classification S-hexyl glutathione (Sj26GSTHEX), and S-2-iodobenzyl glutathione (Sj26GSTIBZ) allow characterization of the electrophile binding site (H site) of Sj26GST. In Ang II-dependent hypertension, cardiac fibrosis was associated with LV hypertrophy and was hindered by both mixed ET(A)/ET(B) blockade and AT-1 blockade. Here we show that direct intravenous application of SeVV in mice is not only feasible and safe, but it results in the secretion of therapeutic proteins to the circulation, for example, human clotting Factor IX (hFIX). Longitudinal study of subjects in the epidemiological follow up study of the national health and nutrition examination survey I. Reference plane definition and reproducibility in optic nerve head images. The SINEs disappeared quickly within these oocytes or eggs, like those within maturing or mature oocytes, suggesting that the envelopes around the sperm chromatin must be newly formed after SINE breakdown.

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