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Alprastan (Alprazolam)

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Alprazolam, available under the trade name Xanax, is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alprastan, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alprastan is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aleez, Alfresh, Alpose, Alpramax, Alpron, Alzolite, Alzorix, Anxigo, Anxilam, Anxit, Anzilum, Ateez, Berest, Calmtec, Coolam, Diprex, Emcalm, Flunix, Fultop, Isorest, Mebaspa, Niravam, Nitril, Nokzok, Onapract, Prazolam, Prosanti, Restyl, Sinozol, Somnarest, Somnia, Tenlax, Tenrid, Zallpam, Zocam, Zolark, Zolyde, Zotam

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Eulexin, Avodart, Kamagra, Aurogra, Robaxin, Moduretic, Prilosec, Casodex, Avana

Also known as: Alprazolam


{name} XR (alprazolam) is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Alprazolam affects chemicals in the brain that may become unbalanced and cause anxiety.

{name} XR is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

{name} XR may also be used for other purposes not listed in this medication guide.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alprastan. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Alprastan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: kava, sodium oxybate.Other medications can affect the removal of Alprastan from your body, which may affect how Alprastan works. Examples include azole antifungals (such as itraconazole, ketoconazole), cimetidine, certain anti-depressants (such as fluoxetine, fluvoxamine, nefazodone), drugs to treat HIV (delavirdine, protease inhibitors such as indinavir), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (such as diphenhydramine), medicine for sleep or anxiety (such as diazepam, zolpidem), muscle relaxants, narcotic pain relievers (such as codeine), psychiatric medicines (such as chlorpromazine, risperidone, amitriptyline, trazodone).Check the labels on all your medicines (such as cough-and-cold products) because they may contain ingredients which cause drowsiness. Ask your pharmacist about the safe use of those products.Cigarette smoking decreases blood levels of this medication. Tell your doctor if you smoke or if you have recently stopped smoking.

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Identification of cell-type-specific genes of Volvox carteri and characterization of their expression during the asexual life cycle. The third study observed the transthoracic impedance was not altered during pregnancy. Foix-Chavany-Marie opercular syndrome is a severe form of pseudobulbar palsy occurring due to bilateral anterior opercular lesions. The effect of Vasoactive Intestinal Peptide (VIP) on plasma prolactin has been tested in two human subjects. Determination of the site of tyrosine phosphorylation at the low picomole level by automated solid-phase sequence analysis. However, microscopically, the peritoneal tumors have the architectural and cytologic features of carcinoma, are derived from gastrointestinal mucinous adenocarcinomas, and are associated with a significantly worse prognosis than cases of adenomucinosis. The electroretinogram (ERG) was recorded as a transretinal potential using Ag/AgCl electrodes. In these cells, we reduced ErbB-2 mRNA and protein expression by transfection with ErbB-2-targeted hammerhead ribozymes and generated cell lines expressing different levels of ErbB-2.

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The authors compare the data from the psychological assessment of a cohort of 191 French speaking hypothyroid children detected by neonatal screening: 99 were followed in Quebec and 92 in Lille, according to two independent programs. Because mechanical coupling through adherens junctions provides a route for intercellular communication, we tested the hypothesis that myofibroblasts exert tonic contractile forces on the cardiomyocytes and affect electric propagation via a process of mechanoelectric feedback. Determinative factors of biochemical cure after primary and reoperative surgery for sporadic medullary thyroid carcinoma. Decision limits (CCalpha) smaller than 0.5 ng mL(-1) were obtained for each analyte. The mean score for most items was greater than 3.0, indicating overall satisfaction with the care. FISH analysis has shown that the induced MN resulted mainly from breakage events.

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Another unusual type of citric acid cycle enzyme in Helicobacter pylori: the malate:quinone oxidoreductase. Hence, there are multiple ways (regulation of bacterial load or recombinant antigen dose, class II molecule expression, costimulatory or adjuvant activity, and antigen processing) that Nramp1 might influence responses to recombinant salmonella vaccines. Hybrid clones from each successive subcloning were examined for their human chromosomal content and only those clones which were found to be individually chromosomally distinct, a total of 56 clones in all, were used to analyze the segregation of human chromosomes and human Ig heavy chain synthesis. An improved assay for iduronate 2-sulphate sulphatase in serum and its use in the detection of carriers of the Hunter syndrome. To reduce fatigue-related risk among junior doctors, recent initiatives in Europe and the USA have introduced limits on work hours. Osteodifferentiation of bone marrow mesenchymal stem cells after transfected by lentiviral vector mediated bone morphogenetic protein 2. As a result, a variety of empirical, non-specific treatments have been used in an attempt to improve semen characteristics and fertility.

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Relatively little work has been completed integrating clinical with administrative systems. Uncertainty persists regarding whether patient assessment of New York Heart Association (NYHA) functional classification should be preferred over provider assessment among patients with heart failure (HF). Participants were randomized 6 to 24 months postoperatively to either a 12-week program of combined exercise and dietary advice or standard treatment. A Risk Assessment Framework for Seed Degeneration: Informing an Integrated Seed Health Strategy for Vegetatively Propagated Crops. The negative control group consisted of 12 patients undergoing septoplasty for nasal obstruction without CRS/NP. After 18 months, intraoral radiographs of the implants were obtained and probing levels were recorded with a metal probe using a standardized force of 0.2 N (Vivacare TPS Probe) and again using a moderate, unstandardized pressure. A number of recent findings have highlighted the similarities between neurogenesis during development and neurodegeneration during Alzheimer disease.

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Although the concept of prostate liquefaction had been proposed by Wickham 15 years ago, its clinical application has been delayed by various technical problems. We found that naloxone suppresses the acquisition of mitragynine-induced CPP. Liver volume restoration in each section and changes in the diameter of the portal branch were analyzed after fenestration with CT or MRI. This is the first study to define the function of mitochondrial anion carriers in GSH transport. Cervical facet capsular strains were determined during bending and at failure in the human cadaver.

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The phytoplankton functional groups were classified based on the C-R-S growth strategy and its favored habitat. The Ia antigens recognized by our monoclonal antibody were located almost entirely within the cells of some, probably the proximal, convoluted tubules of the kidney. This was supported by the fact that Poly EYK(EYA)5 is alpha-helical but the peptides used here showed only a slight propensity to adopt this structure and it did not correlate with their functional activity. Influence of groundwater depth on the seasonal sources of water accessed by Banksia tree species on a shallow, sandy coastal aquifer. Although referrals appear unchanged, additional investigation of GH prescribing patterns before and after this new indication is needed. T4-OI96, T4-OI145, and T4-OI165, but not T4-OR26, T4-OI320, or T4-OI320CY, formed lung colonies (metastasis) after intravenous injection as a single-cell suspension. Design and initial implementation of a regional tele-oncology project. The actual percentage failing the written component was less than the percentage failing the oral examinations in both periods.

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Cardiac troponin T is a sensitive and specific marker for the detection of minor myocardial injury. As well as the Internet, reminders such as desk calendar, booklets, e-mails and cell phone messages were used in the study. This study was the first systematic drug and alcohol testing of blood and urine samples of drivers injured in weekend car crashes in Belgium. CDC investigations of noninfectious outbreaks of adverse events in hemodialysis facilities, 1979-1999. Extent of resection in surgical therapy of central bile duct carcinomas. This case report is intended to increase the awareness of this condition while alluding to the need for diligent examination by endosonographers. In addition, technological advances offer new perspectives, particularly in the field of morphofunctional imaging. Considerable evidence exists that some reading-disabled children have disordered visual processing, specifically in the fast processing magnocellular (M) pathway. The differences in expression profile indicated that BIP and 5G8 are not the same molecule.

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In this study, the remission rates of nephrotic syndrome and the incidence of side effects of corticosteroids and low CsA doses are compared with those after treatment with cytotoxic drugs. Here we report that potato carboxypeptidase inhibitor (PCI), a 39-amino acid protease inhibitor with three disulfide bridges, is an antagonist of human EGF. A retrospective study was conducted on 35 patients who underwent voice reconstruction with the free ileocolon flap. The aim of this review is to examine the evidence as to whether or not taking vitamin or mineral supplements prevents the development of age-related macular degeneration. To improve minimally invasive outcomes, we designed a new procedure, lower abdominal laparoscopic cholecystectomy (LALC). in layers kept in alternative husbandry systems associated with frequent species variations from end of rearing to slaughter. Characterization of highly conserved cysteine residues and N-linked glycosylation sites. In this study, a preliminary screening of different congeners of PBDEs has been performed in different old electronic and consumer products with an objective to build capacity in order to analyze PBDEs and BFRs. Coordination of the Department of Education and the Department of Health for effective administration of the school dental health programs in the Philippines. Pharmacological interventions for spasticity following spinal cord injury.

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The MSAS-SF psychological symptom subscale was more closely correlated with elavil class of medication anxiety than depression. To investigate the clinicopathological characteristics of primary testicular mixed germ cell tumor (MGCT). Juxta-articular myxoma of the shoulder presenting as a cyst of the acromioclavicular joint: a case report. Production of dissolved DNA, RNA, and protein by microbial populations in a Florida reservoir. There is an association between diagnostic algorithms and CDI incidence. Alcohol, tobacco, and other drug abuse undermine physical and psychological well-being, contributing to the array of illnesses that necessitate admission to acute care settings. The information-based descriptions include molecular-tree structured fingerprints, based on the methodology outlined by Xing et al., with the addition of 2D substructure flags indicating the presence of other important structural features. These improvements are related to evolving front-line and salvage therapies, particularly the introduction of rituximab in combination with chemotherapy.

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Our study revealed that the docking scores of active compounds are more widely distributed than those of decoy compounds. In the present report, we discuss the case of a 66-year-old woman with isolated unilateral hypoglossal paralysis due to cerebral infarction in the centrum semiovale. Healthful dietary patterns and bioactive compounds supplementation can be adopted as simple and easy intervention to prevent, attenuate or cure clinical disorders, especially when it comes degenerative and chronic diseases. Uterine artery embolization: a treatment option for symptomatic fibroids in postmenopausal women. Purification and characterization of some enzymatic properties of neuraminidase from Corynebacterium ulcerans. Application cleocin acne medication of these formulae showed that the recombination fraction between genes and the magnitude and the types of epistasis have important interactions in their effects on power.

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The screening of oesophageal adenocarcinoma involves obtaining biopsies at different regions along the oesophagus. The vein cuff anastomosis alters the mean WSS distribution within the recipient artery and removes the area of low WSS at the heel. In vivo efficacy of intravenous gammaglobulins in patients with lupus anticoagulant is not mediated by an anti-idiotypic ultram mechanism. Effects of hyperthyroidism, hypothyroidism, and thyroid autoimmunity on female sexual function. The HumD3S1358 allele distributions were in agreement with Hardy-Weinberg expectations and two mutations were found in 780 meiotic events.

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On the structure of human serum high-density lipoprotein: studies by the technique of circular dichroism. This increased risk is not mitigated by favorable biology, endocrine therapy, or a radiation boost. Neurological performance was assessed by the inclined plane technique, and groups of rats were killed at 8 to 24 weeks after surgery. 2,888 registered nurses working in hospitals affiliated with five university schools of nursing in these cities were invited to complete a questionnaire. The nucleosomal structure in the Rsp region is preferentially disrupted by Hoechst 33258, whereas the bulk chromatin appears to be insensitive to the drug. We assessed the risk for acute myocardial infarction and ischemic stroke within 1 year of community-acquired bacteremia. The state of the lymphatic heart perfusion has been studied experimentally on dogs with intact myocardium (control 1), with acute myocardial ischemia (AMI) model (control 2) and during injection of heparin, rheogluman and obsidan in AMI. Both lesions resulted in significant and long-lasting impairment of direction discrimination but had a lesser effect on kinetic orientation discrimination. The authors investigated their hypothesis in a lung cancer case-control study.

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Actively targeted in vivo multiplex detection of intrinsic cancer biomarkers using biocompatible SERS nanotags. In traditional zonal wavefront sensing for adaptive optics, after local wavefront gradients are obtained, the entire wavefront can be calculated by assuming that the wavefront is a continuous surface. Assistive lesion-emphasis system: an assistive system for fundus image readers. However, it is not generally possible to recover the original topology with great accuracy, mainly due to the short time series data in face yellow xanax generic of the high complexity of the networks and the intrinsic noise of the expression measurements. Docetaxel, low-dose estramustine, and doxifluridine in hormone-refractory metastatic prostate cancer. In addition to this, the discovery that several neurotransmitters and neuropeptides can modulate their electrical activity greatly increased our knowledge about the role played by the MNCs in fluid homeostasis. We conducted a hospital-based case-control study in Rajshahi, Bangladesh, to examine the relationship of type of smoking materials (cigarette versus bidi) with TAO on 103 pairs of cases and controls matched by age and sex during the period 1995 to 1996. Vascular calcification is an active, cell-mediated process that can involve either the intima or media of the blood vessels.

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Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) are leading chronic illnesses in many major cities arcoxia etoricoxib msd 90 mg para que sirve worldwide. Salicylic acid and its location in response to biotic and abiotic stress. Modulation of brainstem activity and connectivity by respiratory-gated auricular vagal afferent nerve stimulation in migraine patients. All of the cultures decompose sitosterol, the cells of the M variant being most active and the cells of the R variant having the lowest activity. Shedding of tumor cells into the circulation is not observed until vascularization has occurred. Antiretroviral therapy initiation during acute/recent HIV infection limits HIV reservoirs and improves immune response in HIV infected individuals. Donor risk factors for white blood cell antibodies associated with transfusion-associated acute lung injury: REDS-II leukocyte antibody prevalence study (LAPS). These findings are relevant to both developmental neurobiology and clinical neural transplantation, evidencing the considerable plasticity and functional integrity of mesencephalic cells in the second trimester as well as the influence of environmental factors.

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Evidence exists for three mechanisms for this breakdown that are incompatible at the level of individual cells in the seam. Moreover, our findings add a new example of buffer-induced effects on biomolecular self-assembly to recent findings for a range of proteins and lipids. Attending to the heart is associated with posterior alpha band increase and a reduction in sensitivity to concurrent visual stimuli. In these countries different measures ought to be additionally designated to ensure blood products adequacy and safety such as the development of well-coordinated national blood transfusion centers with the increased government commitment, the establishment of a well-organized system for voluntary non-remunerated blood donor recruitment, the establishment of well-equipped laboratories for screening donor samples for transfusion transmitted infections (TTIs) for at least mandatory tests recommended by WHO, the implementation of an educational/training program for professionals working in the blood transfusion establishments or hospitals, the regular audit on the quality and the integrity of the blood transfusion chain, and the development of a regional network of collaboration to bolster the neighboring nations in the EMR through effective communication tools. Floating mobile mass that is probably thrombus: a life-threatening complication of mitral stenosis.

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In contrast, the apical dendrites of the smaller layer V pyramidal cells come together in a more regular fashion. Northern blot analysis using RNAs derived from 32Dcl3 cells that have been grown in the absence of IL-3 demonstrates that the G1RP message is upregulated in these cells following the removal of IL-3, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. The particles are composed of a rubbery core, partially covered by a plastic shell, and well stabilized by fixed (sulfate) charges in the end group of the polymer chains originating from the initiator. All mutations occurred at the second position of codon 12 as shown by the ARMS assay. Although several cases of intraperitoneal abscess have been reported in the literature, retroperitoneal collection is very uncommon. We compared the performance of the methods and provided recommendations. Previous functional MRI studies of the SST have demonstrated regional responses to conflict anticipation-the likelihood of a stop signal or P(stop) as estimated by a Bayesian model-and reaction time (RT) slowing and how these responses are interrelated. Is the 4 mm height of the vertebral artery groove really a limitation of C1 pedicle screw insertion?. Yellow sac spider (Cheiracanthium punctorium) bites in Slovenia: case series and review. Twenty-four-hour ASPECTS provides better prognostic information compared with baseline ASPECTS.

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A new diagnostic/GPS device helps maintain safety in an uncertain world. A joint test for progression and survival with interval-censored data from a cancer clinical trial. Pediatric surgical specialists need to be aware of the range of surgical complications that can occur in children with acute leukemia and they must work in close co-operation with pediatric medical oncologists to ensure optimal treatment for all patients. This also resulted in objects feeling lighter when lifted by the semi-paralysed thumb, even though the motor command to the motoneurons must have been greater. Wide variability in body weight raises concern whether this dosing scheme results in efficacious dosing for patients of various sizes.

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Animal Health Law-- the National Animal Health Act and the European Animal Health Law. Familial alpha-lipoprotein deficiency (Tangier disease) with neurological abnormalities. The specificity of the reaction between anti-cytochrome c antibodies (IgG) and pin-bound hexapeptides of cytochrome c was tested using a competitive ELISA in which free and pin-bound peptides competed for the antibody. Uridine diphosphogalactose:glycoprotein galactosyltransferases were examined in human lung adenocarcinoma and squamous cell carcinoma. The spleens of the same rats show increased granulopoiesis as well as increased erythropoiesis as compared with the spleens of rats treated with either growth factor alone. We present two algorithms that produce a set of screening appointments that aim to increase anonymity of the resulting dataset. The diagnosis of angina is challenging because it relies on symptom descriptions. On the basis of its potential benefit and minimal toxicity, examination of intravenous ascorbate in combination with standard chemotherapy is justified in larger clinical trials.

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