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Alpam (Alprazolam)

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Alprazolam, available under the trade name Xanax, is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpam, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpam is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Almac, Alpose, Alpra, Alprastan, Alprawin, Alprocontin, Altok, Alzex, Alzoft, Alzomax, Alzot, Anxit, Anzilum, Benzolam, Calmtec, Coolam, Depser, Dexolam, Enxolam, Esteem, Exprex, Imprax, Isorest, Kaprolam, Mebasap, Mebrin, Mentolift, Notence, Plaxid, Poize, Prazil, Pyrex, Rescalm, Richpram, Romipraz, Selamb, Somaspas, Somnia, Tancalm, Tensfree, Trazopin, Unixl, Visram, Wycalm, Zoldac, Zotam

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Depakote, Flonase, Norvasc, Abilify, Glyburide, Floxin, Revia, Calan

Also known as: Alprazolam


{name} (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that alprazolam works by enhancing the activity of certain neurotransmitters in the brain.

{name} is used to treat anxiety disorders and anxiety caused by depression.

{name} is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).

It is dangerous to purchase {name} on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.


Take Alpam exactly as prescribed by your doctor. Follow all directions on your prescription label. Never use Alpam in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in treating your symptoms.

Alpam may be habit-forming. Never share Alpam with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Misuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.

Do not crush, chew, or break a Alpam extended-release tablet. Swallow the tablet whole. Call your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms. Do not stop using Alpam suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alpam XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpam dosage information

Side effects

The most common side effects associated with Alpam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

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Cardiovascular complications have occurred in clinical trials of interferon. The results indicate a direct effect of tetraiodothyronine on jejunal brush border disaccharidases of the rat. Isometric contractions can influence the way that we perceive pain, but conclusions on the dose-response effect of force amplitude on pain perception are limited because previous studies have not held the duration of force contractions constant while varying force amplitude. All RCTs of psychosocial and/or psychopharmacological treatment versus standard or less intensive types of aftercare for patients who shortly before entering a study engaged in any type of deliberately initiated self-poisoning or self-injury, both of which are generally subsumed under the term deliberate self-harm. Using a two-channel recording system, ASSRs were obtained from 15 normal-hearing young adults for an amplitude-modulated carrier of 250 Hz and repeated tone bursts of 10,000-16,000 Hz, gated using a Blackman window. The production of rhBChE in the hemolymph was 23-fold higher than that in BmN cells and about 280-fold that in Chinese hamster overy cells (125 microg x L(-1)).

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Sphincteric incontinence is the most common urodynamic finding in patients with post-radical prostatectomy incontinence, although other findings may coexist. The ability of myelin basic protein-sensitised leukocytes to adoptively transfer experimental allergic encephalomyelitis following coculture with FK 506, cyclosporine, or prednisolone. We conclude that 1) hemodynamic effects produced by microinjection of L-Glu into the NTS of conscious rats involves activation of the sympathetic nervous system and 2) release of preformed nitrosyl factors may mediate vasodilation in the hindquarter vascular bed. TP53 promoter methylation in primary glioblastoma: relationship with TP53 mRNA and protein expression and mutation status. apoptosis choices are made by individual T cells during an infection. There is no evidence that photodynamic therapy is beneficial for people with evidence of occult choroidal neovascularisation. The persistent CH in this patient with DS is likely to be attributable to the diminished PAX8 expression due to a new heterozygous mutation in the PAX8 promoter sequence. Penicillin V is more effective than placebo in the treatment of acute maxillary sinusitis in adults in general practice, but only in patients with pronounced pain. Oocysts from faecal sample collected from each animal were concentrated using sucrose gradient centrifugation and examined by immunofluorescence assay (IFA). RH blood groups and diabetic disorders: is there an effect on glycosylated hemoglobin level?.

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Recent advances in capillary electrophoresis for biomarker discovery. Surveillance for outbreaks of respiratory tract infections in nursing homes. The results favoured the conclusion that SP is an inducer of bilirubin conjugation in the livers as well as in extrahepatic tissues, such as the small intestinal mucosa. In Saccharomyces cerevisiae, gluconeogenic enzymes are in the extracellular fraction/periplasm when cells are grown in media containing low glucose. Relative phytoplankton growth responses to physically and chemically dispersed South Louisiana sweet crude oil. For this reason, we speculated whether the Bunsen-Roscoe law of reciprocity could still be valid in these conditions. Efficacy studies are awaited for meningococcal conjugate vaccines. Genetic analysis of the larval secretion gene Sgs-4 and its regulatory chromosome sites in Drosophila melanogaster. We present three cases of endoscopic sonography of ovarian disease. RET genetic analysis has achieved an early diagnosis and treatment with no development of MTC in our patients, adjusting the time and type of surgery and allowing a genotype-phenotype correlation.

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We have recently reported that adventitial fibroblasts are able to express endothelin-1 (ET-1) in response to angiotensin II (Ang II) stimulation. We aimed to develop standard procedures and protocols for blood transfusions and assess all adverse outcomes while seeking process improvements to decrease the risk of transfusion. The cultured organism Enterobacter is a relatively rare cause for median sternotomy wound infection and was associated with massive postoperative hemorrhage. We focus on clinical features that should raise suspicion for autoimmunity. The trophoblastic villi projecting into the lumen of the glandular chambers are covered by a pseudostratified epithelium consisting of a flat basal layer and a superficial columnar one. Acetone and its major metabolites-acetol, 1,2-propanediol, methylglyoxal, and pyruvic acid-were assessed for anticonvulsant activity in two mouse seizure models.

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Similarly, in obesity, consensus has been reached on the importance of QOL as an independent outcome measure for obesity surgery along with weight loss and comorbidity. Picroliv pretreatment resulted in better hepatocyte glycogen preservation and reduced apoptosis. 15N metabolic labeling of mammalian tissue with slow protein turnover. For the somatostatin receptor targeting of tumours, however, it was recently reported that antagonist tracers were superior to agonist tracers. Macrobrachium rosenbergii is extensively grown in aquaculture and exhibits unique male morphological forms, termed morphotypes. The results obtained from this method correlate well with those obtained by immunoelectrophoresis.

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By contrast, it was shown previously that prostacyclin secretion by cultured human umbilical vein endothelial (HUVE) cells is increased significantly after exposure to blood from preeclamptic women. Serial dilutions of porcine tissue extracts diluted parallel to the porcine standard curve, while the rat and human tissue extracts did not. However, the comparative thermal risk to the pulp between these two sources of light energy requires determination. Prognostic value and development of late potentials after aortocoronary bypass. Unusual thyroid-stimulating activity in the plasma of a man with choriocarcinoma.

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Timed intercourse versus intra-uterine insemination with or without ovarian hyperstimulation for subfertility in men. PTLD remains in remission 47 and 33 months after therapy, respectively. Increasingly internists are involved in primary patient care with over two-thirds being office based practitioners. Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties. We report our experience of the hemicallotasis technique in 36 patients and the early clinical results after a median follow-up of 14 (11-16) months. This method could be used as an alternative to Western blot in certain applications. This coupling requires the C-terminal domain of the RNAPII largest subunit (CTD), although the underlying mechanism is poorly understood. In other experiments on H9c2 myocytes, a fetal cardiomyocytes-derived cell line, specific GHRP binding was found and hexarelin showed an anti-apoptotic activity. The results indicated that the CiOSC gene plays a pivotal role in biosynthesis of limonoids. Utility of Genomic Assessment of Blood-Derived Circulating Tumor DNA (ctDNA) in Patients with Advanced Lung Adenocarcinoma.

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Increased activity of a beta-galactosyltransferase in tissues of rats bearing prostate and mammary adenocarcinomas. Twenty-two clinicopathologic factors were examined in 369 consecutive patients who underwent curative resection for liver metastasis from colorectal cancer (original cohort). II Quantitative relationships of IgG, IgA, and IgM immunoglobulins. At 15 degrees C, the autotrophic and mixotrophic growth of the mutant were both inhibited, paralleled by decreased photosynthetic activity. Given the disability caused by chronic migraine, these should both be available to patients as necessary. Addition of purified catalytic subunit of cAMP-dependent protein kinase (PKA) plus ATP to the recording pipette also activated a similar current, whereas internally applied Walsh inhibitor, the synthetic peptide inhibitor of PKA, blocked the PGE1 effect.

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The formation of and EF2- and GTP-dependent puromycin derivative of phenylalanine was inhibited slightly by the three toxins, indicating that translocation is not influenced significantly by them. Chronic captopril treatment prevented L-NAME hypertension by lowering of sympathetic tone, whereas chronic NAC treatment attenuated L-NAME hypertension by reduction in the vasodilator deficit due to enhanced NO-dependent vasodilation. The specificities of seven monoclonal antibodies to the human B cell differentiation marker CD24 have been investigated with respect to sialic acid containing carbohydrates. To investigate the techniques and effect of extradural approach for the resection of trigeminal schwannomas involving the cavernous sinus. The authors have studied 100 cases of human placental tissue ranging in age from 2 to 40 weeks. The purpose of the present study was to assess the diagnostic usefulness of early diffusion-weighted MRI (DWI) and MR angiography (MRA) in patients with ischemic stroke. First-line leaders should be offered guidance in understanding the consequences of consciously choosing and strengthening the communication component in leadership. I touch on the factors that control the synthesis of the various peptides, which are now numerous and varied, and again are tissue specific. The genetic analysis detected the heterozygous germline p.R260W mutation in the NLRP3 gene in the three women, confirming the diagnosis of CAPS. Mannan-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are two key components of the lectin-pathway of complement-activation.

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The objective here was to develop a semiochemical-baited trapping system to facilitate monitoring of the pest. The structure of biocompatible nanocomposites formed by the action of laser radiation on an aqueous dispersion of albumin with carbon nanotubes has been studied by the high-resolution methods of atomic force and transmitting electron microscopy. The electrochemical behaviour of SNP modified carbon paste electrodes (CPE) was first investigated by using cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) techniques. Here, we describe the detailed procedures for generating knockout and knockin OSC cells. The hazards of wood as a foreign body are discussed and it is stressed that the possibility of a retained foreign body, even unsuspected, must always be borne in mind. Renal tubular cell expression of the C5aR was sparse in normal cortex but markedly upregulated after UUO. As we conclude that valid reasons exist to adopt a duty to return genetic research results, a qualified disclosure policy is proposed. The effect of deuteriation on the germination rate of seeds is studied as a possible screening technique prior to the cultivation of a plant in high concentrations of D2O. The study was conducted on a common phoretic mite--Uropoda orbicularis (Uropodina) and two aphodiid beetles--Aphodius prodromus and Aphodius distinctus. One recombinant clone, designated lambda gt11/L2/RKA10, was selected on the basis of its strong hybridization signal.

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The fundamental unit of chromatin is the nucleosome, which contains 146 base pairs of DNA associated with two each of histones H2A, H2B, H3, and H4. In the lower cervical spine, kyphotic deformities require anterior decompression and posterior stabilization in the case of electrophysiologically confirmed neurological deficits. This pattern is qualitatively similar to that obtained from the mitochondria of cells cultured in vitro (HeLa cells), although differences in the relative amount of some components have been detected. From the present results a biological activity increase was observed in montmorillonite extracts, while no significant differences between immunological activity of FSH were found in either extract. On the other hand, revisions after gastric banding are frequent and may be technically challenging. The behavior of placentae obtained from CBA/J females with two previous pregnancies by BALB/c males was also investigated.

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An antibody raised against aristocort generic name residues 150-172 in the large subunit (anti-L123) bound to intact neutrophils, indicating that this region is exposed to the outside of the cells. Patients with antroponotic cutaneous leishmaniasis (ACL) in the Isfahan province of Iran were enrolled in the study if the examination of a smear from a suspected CL lesion was confirmed positive for Leishmania. Comparison of cognitive functioning among individuals with treated restless legs syndrome (RLS), untreated RLS, and no RLS. To properly interpret scores, there should be evidence for content validity, construct validity, reliability, and responsiveness. There was no indication of double coloured cells either in the trigeminal ganglion or in the adjacent bulbo-reticulo-pontic regions. The degree of staining on the organisms expressing the HS-epitopes was of the same intensity as the positive control organism.

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To evaluate the incidence of renal and seminal vesicle (SV) abnormalities, and the presence or absence of CFTR gene mutations, in a cohort of patients referred for congenital bilateral absence of the vas deferens (CBAVD). As the activity of these genes plays a role in cancer development, their rearrangements may be one of the crucial points in the pathogenesis of some cancer types. Dichotic monitoring as a test of hemispheric dominance in cases of epilepsy. X-ray diffraction showed that the amorphous films recrystallized to a hydroxyapatite crystal structure after annealing. We describe a rare case of hereditary bisalbuminemia in a portuguese family. Rehabilitation in amyotrophic lateral sclerosis: why it matters. There are limited data on the natural history and longitudinal changes of retinal microvascular lesions.

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Problems for the future include the best management of warts in the sexually abused child, the immunocompromised host, and the pregnant patient. Functional comparison of the upstream regulatory DNA sequences of four human epidermal keratin genes. Antibacterial activity of different honeys against pathogenic bacteria. Urine was collected after digital rectal examination (three strokes per lobe) from 233 men with serum PSA levels persistently 2.5 ng/mL or greater and at least one previous negative biopsy. There were no differences in doses of paracetamol and tramadol, or in adverse effects. The potential increase in male genital malformations was norvasc generic brand name small in absolute terms, and should be evaluated further. Both hypothyroidsm and hyperthyroidsm produce a clinical syndrome causing a diagnostic and therapeutic dilemma to the endocrinologist and cardiologist.

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Cancer that might develop as host natural killer (NK) cells fail to detect ligands for their activating NK receptors. Atrial fibrillation increases the probability of an embolic stroke, especially for the elderly population. Gastroesophageal reflux disease: integrating the ventolin drug class barium esophagram before and after antireflux surgery. Northern blot analyses indicate that SA suppresses GA-induced expression of a barley low pI alpha-amylase gene (Amy32b). We conducted a retrospective cohort study with a nested case-control design within the General Practice Research Database (GPRD) in the United Kingdom. Future work aimed at comparisons with other species and modeling of future climatic scenarios will be a fruitful area of investigation.

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Histamine H1- and H2-receptors in canine renal artery in vivo and in vitro. The helical form can be generated by expressing only residues 1-327. This study was a prospective, randomized, monocentre, controlled explorative intervention trial to determine the multidimensional effects of exercises for strengthening the paravertebral muscles. Because of its great genetic potential, the mouse (Mus musculus) has become a popular model species for studies on hearing and sound processing along the auditory pathways. Herein, four representative Ag NMs including spherical Ag nanoparticles (Ag NPs, NM-300), two kinds of silver nanowires (XFJ011) and silver colloids (XFJ04) were selected to study their inhibitory effect on TGEV-induced host cell infection in vitro. Baseline characteristics were compared with the Chi-squared test for categorical variables or the Mann-Whitney U test for ordinal or continuous variables. Two groups of patients were included in the study: (1) women with unexplained infertility and (2) healthy, fertile women with normal menstrual cycles. Prevalence of Vector-Borne Pathogens in Southern California Dogs With Clinical and Laboratory Abnormalities Consistent With Immune-Mediated Disease. A total of 73 patients with primary small cell carcinoma of the esophagus who had been treated by surgery from 1984 to 2003 were analyzed retrospectively.

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An additional factor for Caribbean reefs is the aftereffects of the epizootic that reduced the abundance of the herbivorous sea urchin, Diadema antillarum. Transversal study in medical students in the Saint-Joseph University of Beirut. A positive result, however, should be cautiously interpreted for potential positives among those without active TB in intermediate TB incidence areas. Probes consisting of brief changes in dot motion direction were reported. X-ray diffraction study of the phase transitions of (CH3)4NCdCl3 between 293 and 80 K: a quantitative analysis of the ferroelastic domains distribution below 118 K. Low-level laser and local corticosteroid injection in the treatment of subacromial impingement syndrome: a controlled clinical trial. Unexpectedly high toxicity of MACOP-B in young patients with low grade lymphoma. Presence of appropriately positioned interdental papillae in the anterior dentition is essential. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia.

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Site- and phosphorylation state-specific antibodies are indispensable to analyze spatially and temporally distribution of protein phosphorylation in cells. The multi-criteria decision support system proposed by us, integrated into a more colitis cipro flagyl dosing complex computerized decision support system, could be used as an important aid in oral cancer screening and establish future medical decision in oral potentially malignant disorders. c-Met expression is a marker of poor prognosis in patients with locally advanced head and neck squamous cell carcinoma treated with chemoradiation. This review raises the argument that a global control strategy conceived to address the extraordinary malaria situation in Africa may not be suitable elsewhere. Immunologic, virologic, clinical, mortality, primary caregiver, and psychosocial variables were collected and analyzed. Miniplate fixation for the repair of segmental mandibular defects filled with autogenous bone in cats. Here we explored the molecular mechanisms underlying defective brain development induced by MAO-A knockdown during in vitro embryogenesis. This genome-wide association study sheds light on a genetic mechanism of longitudinal cognitive changes during the transition period from MCI to AD.

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Long-term and short-term survivors after pancreatectomy for pancreatic cancer. The double-blind, split mouth design study involved 10 human subjects randomly assigned to one of three treatments: 1) scaling and root planing alone, 2) dental laser plus scaling and root planing, and 3) control only. Behavioral analysis in preclinical neuropsychopharmacology relies on the accurate measurement of animal behavior. Methylation of H3 at lysine 4 (H3 Lys4) may be correlated with active gene trascription, whereas methylation of H3 at lysine 9 (H3 Lys9) may be linked to gene repression in murine cells and Schizosaccharomyces pombe. A brief review of literature regarding the main characteristics of the lesion is provided. Use of lead -aVR improves the ECG classification of acute inferior or lateral acute myocardial infarction and thus may be useful as part of the routine 12 lead ECG assessment of such patients.

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