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To circumvent the life-span limitations of primary fibroblast cultures, we developed a procedure for immortalizing feline primary fibroblast cells by transfection with a molecular clone of simian virus 40 (SV40). The depletion of thiol levels in the cells was thus thought to induce lipid peroxidation and DNA fragmentation. The authors report a case of a 14 years old girl with a bilateral optic neuropathy especially an optic atrophy on the left eye. Cognitive behavioural therapy does not reduce overall episode recurrence in people with recurrent bipolar disorder. While health problems are increasing and becoming more complex and while policy leaders, business groups, and the public recognize that action is necessary, no response has been forthcoming.
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