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Afeditab (Nifedipine)
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Afeditab

Afeditab is a dihydropyridine calcium channel blocker. Afeditab is used to: treat high blood pressure (hypertension), prevent chronic stable angina (chest pain). Afeditab was the first calcium channel blocker to be shown to significantly reduce the development of new overt heart failure in patients with coronary artery disease. Excellent blood-pressure control in recent clinical trials has been shown to result in significant protection against stroke. Afeditab works by opening up blood vessels in the body to lower blood pressure and improve the supply of blood and oxygen to the heart. Calcium channel blockers do not change the amount of calcium in your blood or bones.

Other names for this medication:
Adalate, Adefin, Afeditab, Amarkor, Anpect, Atenerate, Buconif, Cardalin, Cardules, Casanmil, Citilat, Cobalat, Coracten, Coral, Cordafen, Cordaflex, Corotrend, Depin, Duranifin, Fenamon, Fenidina, Herlat, Jutadilat, Lemar, Macorel, Menoprizin, Milfadin, Myogard, Nefelid, Nidilat, Nidipine, Nifatenol, Nifecard, Nifedalat, Nifedipino, Nifedipinum, Nifedipress, Nifezzard, Nipin, Nirena, Nycopin, Tenif, Tredalat

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Also known as: Nifedipine

Description

Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Afeditab XL. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Afeditab and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Afeditab are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Type-specific serological tests have allowed for a better understanding of the epidemiology of herpes simplex virus type 2 (HSV-2) infection in Africa. The results of studies 1 and 2 showed that AME can be predicted from the chemical composition. There is insufficient evidence to make a definitive statement regarding the effects of iron supplementation on growth, neurodevelopment, or the occurrence of adverse effects in low birth weight/premature infants. These findings suggest that hearing loss in these two cases involved primarily the sensory hair cells. Leptospirosis remains underreported in Taiwan because of ignorance and the broad spectrum of clinical manifestations. Endovascular repair of abdominal aortic aneurysm causes less trauma in patients with AAAs in the short term, and patients treated with EVAR have similar survival rate with open repair in the long term, but have postoperative complications requiring further interventional treatment.

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Farnesyl transferase inhibitors (FTIs) exhibit limited cytotoxic effects against human cancer cells, perhaps explaining the limited efficacy of FTIs in clinical trials. Rubella virus genome diagnosis during pregnancy and mechanism of congenital rubella. Finally, we have shown that the fusion protein can cross the placenta and was detectable in the fetus and newborn pups. Under the experimental conditions employed the rate of oxygen production was controlled by the diffusion of hydrogen peroxide, allowing for the estimation of the diffusion coefficient of hydrogen peroxide across the liposome bilayer. Participating members were examined and genetic linkage and genotyping performed. The role of bcl-2 in the progression of the colorectal adenoma-carcinoma sequence. We described a case of ADPV in a female patient who presented with ascites. Five hundred and nine PAD-patients were randomised to receive either a 3-day course of azithromycin (500 mg daily) or placebo, with 2 years of follow-up.

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Expression of vascular endothelial growth factor and its receptors, flt-1 and kinase insert domain-containing receptor in normal human endometrium during menstrual cycle. Immunohistochemically, most tumor cells were positive for cytokeratin 7, were partially positive for CD5, and were negative for TTF-1, Sp-A, CDX-2, MUC2, napsin A, and cytokeratin 20. We investigated the ability of COOH-terminal heparin-binding fibronectin fragment (COOH-HBFN-f) containing IIICS to induce matrix metalloproteinase (MMP) production and the role of mitogen-activated protein kinase (MAPK) pathway and CS-1 sequence that can bind alpha4beta1 integrin in MMP induction by COOH-HBFN-f in rheumatoid synovial fibroblasts (RSF). Tanshinone II A has an inhibitive effect on the proliferation of K562 cells and an inductive effect on the differentiation of erythrocyte series. Recent studies have provided new insights into the molecular mechanisms that drive NK cell development, control the NK cell receptor repertoire and the cytokines that define the NK cell niche.

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The significance of superimposed hysterography in intrauterine contraception. Two specialised complexes in epithelial cells: the desmosome and the hemidesmosome, serve as attachment sites for keratin filaments. We describe a patient with microcephaly, developmental delay, and nephrotic syndrome who had normal renal function and normal brain imaging studies. Inhibitors of adenosine diphosphate receptor and glycoprotein IIb/IIIa antagonists are more effective than aspirin and are used in the clinic. This study was undertaken to ask mothers who had children with Down syndrome after receiving a prenatal diagnosis: How was the process and what, if anything, could be improved?. It was found that weight of placenta correlated with the weight of lambs at birth in both groups. The hydrodynamic coefficients and solution properties can be combined to give universal, shape-dependent functions, which were initially intended for ellipsoidal particles, and are extended here for the most general case. Psychosocial correlates of nocturnal enuresis among poor boys at a summer camp. Cyprinid herpesvirus 3 (CyHV-3), the causative agent of koi herpesvirus disease, is a major threat for carp populations in many countries worldwide, including Indonesia. A synthetic peptide containing this sequence and constrained through a disulfide linkage reacted strongly with the A6.2.1 MAb, whereas the linear sequence did not.

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To create an antibiotic-modified vascular prosthesis with a prolonged bactericidal activity, susceptible to endothelialisation. All photosynthetic organisms control expression of photosynthesis genes in response to alterations in light intensity as well as to changes in cellular redox potential. Investigations of reasons for the avirulence of the A7 strain of Semliki Forest virus in adult mice. Effects of riboflavin on 6,7-dimethyl-8-ribityllumazine formation in growing cells of a riboflavin-adenine-deficient mutant, Bacillus subtilis. A group of 100 subjects who had smoked for at least 2 years were compared with 100 age- and sex-matched never smokers. Increased serum level of stem cell factor in association with disease progression of hyperpigmented mycosis fungoides. The aim of the present study was to determine the incidence, clinicopathological characteristics, and outcome of patients with gallbladder cancer presenting with acute cholecystitis. Neuropsychologic outcome of children whose mothers had proteinuria during pregnancy.

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Telemetry-controlled drug infusion and blood pressure monitoring in unrestrained pigs. The key is to stop taking the Central Dogma as the only direction in which genome research can scale the semantics of genomes. The U46619-bound enzyme is detected as a 6c/ls heme too, which is in contradiction with a previous conclusion based on absorption difference spectroscopy. The potential toxicity of nicotine, apart from cigarette smoking, is an important variable in assessing the benefits and risks of such therapeutic applications. Older adults show deficits in retrieving and decoding associative mediators generated at study. Diminution of the cell nuclei volumes after simultaneous administration of oxytocin and estradiol was observed.

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Febrile gastroenteritis after eating on-farm manufactured fresh cheese--an outbreak of listeriosis?. The objective of this study was to describe a technique for uterine-sparing hysteropexy. Trichomonosis, caused by Trichomonas vaginalis, is the number one, nonviral sexually transmitted infection that has adverse consequences for the health of women and children. To analyse the fate of a visceral aortic patch (VAP) in patients that underwent thoracoabdominal aortic aneurysm (TAAA) repair. A retrospective study has been carried out on 124 consecutive patients with abdominal aortic aneurysms admitted during the period 1960-74. The risk of psychiatric disorders was estimated to be higher when comorbidity among different types of disorders was present. The development of functional brain asymmetry during childhood is confirmed by changes in cerebral blood flow measured at rest using dynamic single photon emission computed tomography.

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Further, we identified other small non-coding RNAs differentially expressed in response to diet. One protein, Pso2p, was shown to participate in the repair of DSBs induced by DNA inter-strand cross-linking (ICL) agents such as cisplatin, nitrogen mustard or photo-activated bi-functional psoralens. Dynamic response criteria for fluid-filled esophageal manometers. Other neurotrophins (brain-derived neurotrophic factor, neurotrophin-3), genes encoding neuropeptides (preproenkephalin, preprotachykinin) and amyloid protein precursor were also studied, but no significant change was observed. The aim of this paper is to examine whether the use of spatial representations in arithmetic can shed light on this debate. To gain insight into the structure-function relationships of Vpr, the (1-96)Vpr protein was synthesized with 22 labeled amino acids. In addition to the ability of cathepsins G and L to degrade major extracellular matrix components of intervertebral discs, cathepsin G is capable of activating latent pro-MMPs. We report a new case of MED and microcephaly, without other additional features, suggesting a mild form of LWS.

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Stability analysis for postural control in a two-joint limb system. We localized genes associated with CPE by using TnphoA insertion mutagenesis in strain B10. Long-term results of a prospective randomized trial comparing tacrolimus versus cyclosporine in African-American recipients of primary cadaver renal transplant. ACh (1 microgram-1 mg) increased the frequency of action potentials recorded from the CSN in a dose-dependent manner. Eye-hand coordination: spatial localization after saccadic and pursuit eye movements.

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Enzymatic determination and other single-component analytical techniques are often used for the determination of these metabolites. A monitoring study was conducted in 2001 to determine the organochlorine pesticides and their metabolite residues in milk taken from supermarkets in Beijing, P. Bone marrow stromal cells enhance the osteogenic properties of hydroxyapatite scaffolds by modulating the foreign body reaction. Molecular epidemiology of methicillin-resistant Staphylococcus aureus in a Tokyo hospital in 2002. Regional anesthesia has many advantages as intraoperative and more important as postoperative analgesia in pediatric anesthesia. This study examined proteolytic enzymes and serine proteinase inhibitors in turkey seminal plasma with relation to their distribution within the reproductive tract and to yellow semen syndrome (YSS). Development and validation of an RP-HPLC method for CB13 evaluation in several PLGA nanoparticle systems. RESULTS: The relationship between corrected blood pressure and random-zero values measured with the electronic device was similar to that observed when the R-Z machine was used correctly. Role of surgery and radiotherapy in the treatment of cancer of the cervix uteri. The significance of stature as a clinical measurement of ageing.

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Both the phosphonate and carboxylate peptidomimetics fit into the active site adopting a retrobinding mode and provide the structural base for a new class of metalloproteinases inhibitors. Parallel upstream signaling pathways and cross talk between the two kinases suggest that the regulation of signaling in RPE cell death is complex. In anticipation of lower analgesic effects than are to be expected from solely consensus-based guidelines, they recommended a more thorough control of individual therapeutic opioid trials than before. Using a metallothionein-inducible c-mos(mu) expression system, we show that c-mos(mu) induction in quiescent NIH3T3 cells causes elevated expression of p34cdc2. alpha-ZAL, E2, and ICI182780 had no effect on NO/ET-1 release, NOS activity, or expression of NOS and ET-1. We studied 10 healthy women with normal pregnancies and two pregnant women with heart disease undergoing elective CS. Helicobacter pylori(Hp) infection and a high salt diet are considered important enhancing factors in gastric carcinogenesis.

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Benign glandular inclusion cysts occurring within lymph nodes have been well described in the literature. Etching masks comprising long and straight nanoribbon array structures with linewidths as narrow as 10 nm were fabricated, and the patterns were transferred to graphene. These observations are consistent with derivation of fat globule membrane from plasma membrane accompanied by structural rearrangement of membrane constituents. Induction of rabbit antibody with molecular uniformity after immunization with group C streptococci. However, de novo protein expression was required for the induction of CD44DL, suggesting that activated NK cells contain proteins not present in fresh NK cells that couple CD44 to the lytic machinery. Duodenal adenocarcinoma arising from a pyloric gland adenoma with a brief review of the literature. These findings favor the hypothesis that vascular calcification appears spontaneously in the absence of an inhibitory protein.

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We conclude that in cells which respond to AcMNPV infection by initiating programmed cell death, the p35 gene product alone is sufficient to inhibit apoptosis. Immunological studies in peripheral vascular diseases and in ischaemic heart disease. was unable to judge whether the colours of two lights comprising an apparent motion sequence were the same or different when the two lights were presented bilaterally although he was able to do so when both lights were in the same visual field. Mental disorders and mental health problems, active component, U.S. In a similar manner, the synthesis of 21-fluoroprogesterone labeled with prilosec omeprazole dose fluorine-18 has been accomplished, producing approximately 800 muCi of product from 6 mCi of K18F in one hour. The co-distribution of TLN with this lipid raft marker also persists during its endosomal targeting to CD63-positive late endosomes. The results are impressive for refractive error correction and stability and for improvement of both uncorrected and corrected distance visual acuity.

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After inoculation of a stationary-phase culture of Nitrosomonas europaea into fresh growth solution, the cell-associated orthophosphate increased rapidly to 800 mumoles/g (wet weight), whereas the acid-insoluble long-chain polyphosphate content decreased rapidly to 22 mumoles/g. This report presents pooled data from two multicenter studies conducted to assess the efficacy, safety, and tolerance of lower-dose intravenous immune globulin (IVIG) regimens of 250 mg/kg/day, 400 mg/kg/day, and 500 mg/kg/day for 2 days, compared to an established higher-dose regimen of 1 g/kg/day for 2 days, in children with immune thrombocytopenic purpura (ITP). The latent phenotype underlying parental and observational measures of behavioral inhibition was moderately to substantially heritable. Monoclonal antibodies to a high molecular weight isoform of porcine CD45: biochemical and tissue distribution analyses. Metastability of superconducting compounds in the y-ba-cu-o system. The relative extent of bioavailability as assessed by the measurement of the total area under the plasma concentration time curves showed no difference between the products (P greater than 0.05). Diazepam effect was significantly reduced in and 3.5 mM calcium medium and KCl vas deferens response was inhibited by diazepam 1.3 x 10(-5) and 1.3 x 10(-4) M. The purpose of this study was to determine the pattern and distribution of acute DVT as well as the different types of thrombi. Primary malignant fibrous histiocytoma of bone (PBMFH) is a rare tumor.

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recurrentis infection and that endotoxin may play a role in both the acute illness and in the development of the Jarisch-Herxheimer-like reaction after treatment. Sleep and daytime functioning: a short-term longitudinal study of three preschool-age comparison groups. The role of platelet factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury. Alterations in lung mechanics and gas exchange following training in chronic obstructive lung disease. The blood concentration of FK506 at the onset of encephalopathy was 21.7 ng/mL. To gain better insight into the possible basis of these functional differences, the physical properties of LBP-LPS and BPI-LPS complexes have been compared in this study by sedimentation, light scattering, and fluorescence analyses. The efficiency of the medical dispensary care of school children in Szczecin.

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Nearly all programs have overnight in-house radiology resident coverage, but there has been a slight decline in the percentage of programs that provide in-house attending coverage at night. Virilizing adrenocortical adenoma: in vitro steroidogenesis, immunohistochemical studies of steroidogenic enzymes, and gene expression of corticotropin receptor. Persistent chlorinated pesticides and intra-uterine foetal growth retardation: a possible association. The 2,5-dimethyl pyrrole derivative is much more effective than glutathione as a protective agent against phototoxic reactions induced by protoporphyrin IX. Surface-enhanced Raman scattering assay combined with autonomous DNA machine for detection of specific DNA and cancer cells. We suggest that chronic B19 infection should be considered in immunocompromised patients with suspected CNS vasculitis. Despite these discouraging facts, recent research efforts have led to important findings, which have shown that a better understanding of the disease may contribute to the improvement of control strategies. Both AtBphPs contain an N-terminal chromophore-binding domain that covalently attaches a biliverdin chromophore.

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The expectations of the amounts of nucleotide variation within and between two genes and linkage disequilibrium are obtained, and a coalescent-based method for simulating patterns of polymorphism in a small multigene family is developed. We introduced TIR signalling pathway components into both types of vectors. In 1981 and 1992, identical questionnaires measuring lineal and lateral wealth flows and emotional nucleation were administered to comparable samples of male household heads in rural Kenya. To determine the pathways mediating this connectivity, the lateral part of the spinal cord containing the ipsilateral lateral vestibulospinal tract (i-LVST) or the central part of the spinal cord containing the medial vestibulospinal tracts (MVSTs) and possibly reticulospinal fibers (RSTs) were transected at the caudal end of the C1 segment. TRAIL gene with an IL-2 signal peptide was constructed by PCR and cloned into vector pGL3-181hTERT downstream of hTERT promoter to form an eukaryotic expressing vector. Recently, some studies have emphasized the role of plasma 25-(OH)vitamin D (25OHD) levels in mineral metabolism dysregulation in chronic kidney diseases (CKDs). The CT scan showed the existence of a vascular anomaly as well as of a significant tracheal compression in all cases, and was considered conclusively diagnostic by the cardiac surgeons. Histological and ploidy analysis of POC results in underdiagnosis of complete moles.

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We report a patient what does maxolon tablets do undergoing awake fibreoptic intubation in whom the use of topical local anaesthetic precipitated acute loss of the airway so that urgent surgical intervention was required. Chromosome 11 aneuploidy detected by fluorescent in situ hybridization (FISH) in breast cancer: relation with progesterone receptor expression. Initial recognition of such bleeding disorders and their possible systemic causes, as well as knowing when to refer those cases to secondary care, plays a crucial and important role in reducing potential complications and negative side-effects. The high number of diagnoses and the frequency of infections as a primary complaint in this patient sample reconfirm the primacy of the physician in prioritizing patients and assigning treatment pathways. The use of ventricular electrograms in operation for coronary artery disease and its complications. Future studies should focus on the development of therapies specifically tailored towards the treatment of asthma in obesity. Toxic effect is generally attributed to peri-vascular deposition of calcium oxalate crystals in various tissues.

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