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Admax (Calcitriol)
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Admax

Admax is a hormonally-active, synthetic vitamin D analog prescribed to treat hypocalcemia, osteoporosis, and the prevention of corticosteroid-induced osteoporosis. Systemic Admax is FDA indicated to control hypocalcemia in patients on chronic renal dialysis, secondary hyperparathyroidism in those with chronic kidney disease not yet on dialysis, and hypocalcemia in patients with hypoparathyroidism and pseudohypoparathyroidism.

Other names for this medication:
Actical, Admax, Alfarich, Alphadol, Biocitral, Calasto, Calbec, Calcigra, Calcimet, Caldix, Calsure, Caltop, Calzem, Carcal, Cholical, Fovit, Koncal, Laretol, Lctrol, Ostonex, Primacal, Ritoca, Rolsical, Septriol, Solbiocal, Statbone, Tobalt, Trolec, Vezocal

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Cardizem, Xanax, Persantine, Terramycin, Maxalt, Fasigyn, Klonopin, Levaquin, Desyrel

Also known as: Calcitriol

Description

Generic Admax is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Admax are intestine and bone. Generic Admax receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Admax may also act on the kidney and the parathyroid glands. Generic Admax is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Admax has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Admax, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Admax in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Admax produces other independent beneficial effects. Admax is also known as Calcitriol. Generic Admax treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Admax is Calcitriol. Brand name of Generic Admax is Admax.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Admax. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Admax and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Admax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Problems in older adults have not been reported with intake of normal daily recommended amounts. Studies have shown that older adults may have lower blood levels of vitamin D than younger adults, especially those who have little exposure to sunlight. Your health care professional may recommend that you take a vitamin supplement that contains vitamin D.

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Session B: The role of patient databases in assessing antiretroviral treatment. Short communication: Genomic selection using a multi-breed, across-country reference population. It regulates the sharing of viruses within the WHO Laboratory Global Influenza Surveillance Network (GISN) and the access to vaccines, antiviral drugs, diagnostic kits, and other benefits, in particular with regard to lower-income countries. Rubus stunt is an economically important disease in the production of raspberries, blackberries, and loganberries. Morphological features determined included cell clusters, epithelial-stromal interface, stromal invasion and tumor necrosis. This demonstrates that it is critical to use the lowest concentration of such an inhibitor that will alter the response under investigation, to have confidence that the conclusions derived from the use of such inhibitor are valid. 10 merino cross sheep underwent CMR using a 1.5 Tesla system (Siemens, Sonata, Erlangen, Germany). Movement paths were manipulated by changing the sequential order of body postures. PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis. Conjunctival cyst formation following enucleation may rarely occur in patients receiving orbital implants, especially secondary implants.

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Diagnosis and treatment of conduct disorder related to frontal lobe syndrome in a 16-year-old girl. Diazepam and alprazolam were used in combination to produce a relaxed state, allowing local anesthesia to be instilled. (2) What can be learned about the neurobiology of semantic processing when different regions are identified as a function of response?. Women were also less likely to be referred to urology (two studies), receive imaging (three studies) or have cystoscopy (two studies). DNA content analysis has revealed an imperfect correlation between DNA ploidy and histologic diagnosis. Determination of the monoamine oxidase and the diamine oxidase activity of a single blood sample. Molecularly, we found a surprising hyperactivation of Erk signaling in Hs2st(-/-) (2-fold) and Hs6st1(-/-) (6-fold) embryonic telencephalon that was most striking at the midline, where Erk signaling is lowest in wild-types, and a 2-fold increase in Fgf8 protein levels in Hs6st1(-/-) embryos that could underpin Erk hyperactivation and excessive glial movement to the indusium griseum. 24 IOL SA 40 N (group 1) and 22 IOL P 359 (group 2) were implanted. How the visual projection map instructs the auditory computational map. A major assumption of models of the evolution of plant resistance to disease is that plant resistance involves fitness costs.

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The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Using the yeast structure as a template, we have modeled the homologous domains from elongin A and CRSP70 and identified a conserved positively charged patch on the surface of all three proteins, which may be involved in conserved functional interactions with the transcriptional machinery. The central mechanism of hypothalamic-pituitary-adrenocortical system hyperfunction in depressed patients. Prospective, randomized, clinical trial (Canadian Task Force classification I). The YGALSET vector series includes centromere plasmids for low-copy plasmid maintenance and 2 micron episomal plasmids for multicopy plasmid maintenance and four different selectable markers: TRP1, URA3, LEU2 and HIS3. The cloning of the AmbtV cDNA is important, since the 4.4-kDa AmbtV, one of the allergens in giant ragweed (Ambrosia trifida) pollen, serves as a simple model system to study the basic structural requirements for immune recognition of foreign protein allergens.

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Hereditary resistance to coumarin anticoagulant drugs in man and rat. WNK1 and WNK4 stimulate clathrin-dependent endocytosis of renal outer medullar potassium 1 (ROMK1), and PHA2-causing mutations of WNK4 increase the endocytosis. The results suggested the G-CSF producing tumor to be heterologous and the cells with different functional properties, including G-CSF production, sensitivity to bleomycin, and keratinization, to pre-exist in the parental cell population. Ventricular thrombi and thromboembolism in dilated cardiomyopathy: a prospective follow-up study. Our study indicates that MAO catalytic activity is involved in apoptotic signalling in response to serum vasotec davis drug pdf withdrawal in neuronal cells. Abstracts of the 4th Annual Meeting of the American Psychosocial Oncology Society (APOS), 1-4 March 2007, Austin, Texas, USA. With a cut-off point of 19, the sensitivity was 0.64, and the specificity was 0.88.

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Extracorporeal membrane oxygenation in adult patients with congenital heart disease. Experimental apoptosis provides clues about the role of pioglitazone 15 mg tab mitochondrial changes in neuronal death. However, the limited access to equipment for transforming and preserving alimentary products is decisive to the final result. Effect of alpha thalassaemia, G-6-PD deficiency and Hb F on the nature of sickle cell anaemia in south-western Saudi Arabia. CT established that is a profound lymphangioma with a narrow communication with the superficial planes. The use of microorganisms for biological purpose has become an effective alternative to control pathogens. There appear to be no fundamental limitations to this approach as feasibility of all of the individual components has already been shown.

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It is the main epitope recognised by anti-rheumatoid arthritis nuclear antigen antibodies. This review describes the different parts in the dosimetry chain of radionuclide therapy. Use of multiple reaction monitoring for multiplex analysis of colorectal cancer-associated proteins in human feces. tsangchanensis collected in the Chinese Provinces Yunnan and southwestern Sichuan was studied by chemical and genetic approaches. Inhibition of superovulation in immature female rats by the antiserum to cyclooxygenase. Consequently its deficiency, as seen in osteoarthritis could lead/contribute to cartilage dysfunction. The models of this study were Nicotiana tabacum plants and cells suspension exposed to S. Flow-cytometric DNA analysis was performed retrospectively from paraffin-embedded blocks in 158 consecutive ductal infiltrative breast carcinoma patients grades I-III.

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The addition of amantadine to interferon, in contrast, does not seem to enhance the antiviral effectiveness of interferon in patients who have previously failed to respond. The molecular cloning of a dispersed set of developmentally regulated genes which encode the major larval serum protein of D. In the univariate analyses correlations caused nearly all traits to have significant directional selection coefficients. The baseline characteristics and outcomes of adults with PCV7-serotype CAP in comparison to those with non-PCV7-serotype CAP were established. Dynamic observation of chest computed tomography images revealed a slowly progressing nodule in the lower lobe of the left lung. Dogs were treated for shock and operated immediately after a presumptive diagnosis was based on clinical and radiographic examinations. The incinerator workers had worn dust masks or airline masks during the periodic repair work inside the incinerators.

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Lipid-soluble arsenic compounds were found at relatively high levels in liver and testis. The methods are those classically used in the analysis of case-control studies. The lipid lowering action of 3,5-diiodo-L-thyronine (T2) on an in vitro model of hepatosteatosis was investigated in terms of fatty acid and protein content of LDs, lipid oxidation and secretion. Development rates of Aedes aegypti are known to vary with respect to many abiotic and biotic factors including temperature, resource availability, and intraspecific albendazole competition. The method is simple and rapid to perform, does not require costly instruments, and all the reagents used in the assay are commercially available. A reappraisal of its pharmacology and therapeutic use in rheumatic diseases and pain states. A combined radiologic and endoscopic approach to removal of occluded double-mushroom biliary endoprosthesis: technical note.

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