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Adefin (Nifedipine)

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Adefin is used to treat high blood pressure or angina (chest pain). For high blood pressure: Adefin works by relaxing and expanding the blood vessels. This makes the blood flow more easily and lowers blood pressure. Lower blood pressure reduces the strain on your heart. For angina: Adefin works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.

Other names for this medication:
Anpect, Antrolin, Atanaal, Calchan, Calcibloc, Cardiosol, Cobalat, Coracten, Coral, Cordalat, Corotrend, Depine, Epilat, Fedip, Hexadilat, Jutadilat, Macorel, Nifangin, Nifcal, Nifecap, Nifediac, Nifedical, Nifedicor, Nifedipress, Nifin, Nilol, Nirena, Pabalat, Pressolat, Valni, Vasdalat, Viscard

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Adalat, Benicar, Seroquel, Pepcid, Eriacta, Famvir

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Also known as: Nifedipine


Adefin is a perfect remedy in struggle against hypertension or high blood pressure, angina or chest pain. Adefin acts by relaxing blood vessels (such as veins and arteries), which makes it easier for the heart to pump and reduces its workload. Adefin is also known as Nifedipine, Nicardia, Nifedical, Procardia. Generic name of Adefin is Nifedipine. Brand names of Adefin are Adefin CC, Procardia, Procardia XL.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adefin OROS. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adefin and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adefin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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The structures of the DNA binding domain-DNA complexes of two other zinc-cluster proteins (GAL4 and PPR1) have been studied by X-ray crystallography. Patients with hypoxemia suffering from more severe disease may require a long-term oxygen therapy. Consistent with this finding, addition of BMP4-specific antisense oligonucleotide to cultures of mouse periotic mesenchyme containing otic epithelium decreases levels of endogenous BMP4 protein and suppresses the chondrogenic response of the cultured periotic mesenchyme, providing evidence of the necessity for BMP4 in mediating otic capsule chondrogenesis. Because of the limited detection sensitivity and selectivity in earlier biosensors, researchers have developed a number of sensing/signal amplification strategies. Metronidazole susceptibility testing of anaerobic bacteria associated with periodontal disease. In 20 patients with mild and moderate blood hypertension (BH) the latter was registered sphygmomanometrically by N. Accurate and timely chromosome segregation is a task performed within meiotic and mitotic cells by a specialized force-generating structure--the spindle. Structures of these compounds have been elucidated on the basis of spectral studies. Reduction of palmoplantar keratoderma Buschke-Fischer-Brauer locus to only 0.967 Mb.

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Contractions of the chicken isolated oesophagus or separated external muscle produced by stimulation of the vagus and descending oesophageal nerves were abolished by hyoscine (1-100 mug/ml.) if the duration of stimulation was less than 5 sec, but prolonged stimulation produced delayed contractions not antagonized by hyoscine.2. Many agents have been known to induce the differentiation of HL-60 cells. The PCBP1 protein expression profile was investigated in 10 complete moles that remained benign, 10 complete moles that underwent malignant transformation, and 10 choriocarcinoma tissues using Western blot analysis. Plasma adrenaline and noradrenaline were increased to 521 pg/ml and 1,341 pg/ml, respectively, and the metoclopramide provocative test was positive. Of all workers exposed globally to synthetic sources of radiation, medical personnel represent the largest group, but receive relatively low doses. Lung transplantation: disease-specific considerations for referral. Open access echocardiography is widely available to General Practitioners (GP).

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Noninvasive coronary flow reserve assessed by transthoracic coronary Doppler ultrasound in patients with left anterior descending coronary artery stents. Influence of calcium and magnesium on eugenol-induced desquamation of mucus epithelium in gastric pouches. We report that detour (dtr) mutations encode loss-of-function alleles of gli1. These results are interpreted in a linear scheme: (formula: see text). These results have relevance on how eating disorders are treated and viewed by TCM practitioners. In contrast clinical decisions are increasingly guided by differences of tolerability, which are clearly documented in the current literature. The authors recommend adopting a transformational style of leadership for staff development and argue that focusing on student needs helps overcome tensions between the institution and individual staff members. The results of this work have broad applications in many areas, including the design of novel drugs and antimicrobial agents, helical polymeric structures, and polynuclear metal complexes. Utilization of evoked potentials from the brain using an electronic compiler for the detection of auditory acuity.

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The German doctors and their almost unanimous participation in the atrocious murderies of psychiatric patients, retarded or handicapped people as well as their medical experiments on prisoners are viewed in a historical context. HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Seventy-five volunteer undergraduate students and 25 volunteer collateral informants of individuals with TBI participated in the item-analysis phase. The major metabolite of arachidonic acid formed in cerebral and renal arteries is 20-HETE. We analysed a large cohort study of patients seen in one of six large HIV clinics in and around London, UK. For osteosynthesis operations the doses for the patient and the staff could be kept low by preparing the operation adequately, by using modern image-intensifer units with grid and automatic regulation in fluoroscopy, and with discipline in using fluoroscopy. Evaluation of humoral and cellular immune responsiveness showed no abnormalities except cutaneous anergy. In addition, ZML2 activated transcription of the yellow fluorescent protein reporter gene driven by the CryR1 cis-element in Arabidopsis leaf protoplasts.

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The possible limits of variation become very narrow in severe organic impairment. Research using MSCs in tendon repair provides information on the effects of physical forces on phenotype and gene expression. Caffeic acid, coumalic acid, and corilagin stimulated the germination of Plasmodiophora spores and prevented the formation of clubroots in Chinese cabbage. In this study, stability in RPE and increase in RPD observed in racewalkers may reflect an attentional focus dissociated from internal sensations and directed toward maintaining the required race walking gait. Fertilization, cleavage, and embryo quality were compared in IVF- and ICSI-inseminated oocytes. At corresponding time points, the effect of these treatments on collagen and elastin protein synthesis and mRNA expression was examined. Study on the morphometric and hemodynamic changes of the pulmonary arteries in pulmonary hypertension autopsies. Metastatic node had significantly lower distribution ratio of PA to lymphoarea than that of tumor-free node.

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Overview: initial and long-term management of gastro-oesophageal reflux disease. To determine the in vitro efficacy of three hydrodynamic thrombectomy devices. Marginal cost-effectiveness ratios (2010 US dollars) with effectiveness measured as quality-adjusted life-years (QALYs). The leaders emphasize the importance of evidence-based order sets in our computerized provider order entry system (CPOE), checklists, and tools. To investigate the effect of extramural support from the pouch and abdominal wall to enhance the continent mechanism of tapered ileum. This calculation was based on dose data obtained from measurements in the phantoms and d(a) estimated from the patient group. Neurological dysfunction is usually present in the patients, but the pathophysiology of brain damage is still obscure. We simulated nanocrystals with a diameter of up to 6 nm and made a direct comparison with experimental measurement for the first time for these systems. Dietary induction of some enzymes of amino acid metaboli during azo dye feeding.

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This disease appears to be more serious than in the general population due to the high incidence of infectious complications. While awaiting group communication treatment, participants in the deferred treatment groups engaged in such activities as support, performance, or movement groups in order to control for the effects of social contact. Integration of radiotherapy planning systems and radiotherapy treatment equipment: 11 years experience. Activity of an antimicrobial peptide mimetic against planktonic and biofilm cultures of oral pathogens amaryl xm 2/850 mg . This was a case-control study of 180 patients from a cohort entering a specialist FEP service between 1/12/2002 and 30/11/2005. These results open for development of alternative tools for influenza diagnostics. The dual functions of gene activation and repression suggest that HNF-1 is a global regulator of the transcriptional network involved in the maintenance of hepatocyte-specific phenotype. A systematic review of cooling for neuroprotection in neonates with hypoxic ischemic encephalopathy - are we there yet?.

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Radioisotope angiography of the kidneys in the diagnosis of vasorenal hypertension. In closed films crystallization proceeds faster at higher concentrations and in thinner films. The wild type and the mutant without the spacer were more active in the presence of plasma, raising the possibility of ADAMTS-13 cofactors in plasma. Oxygen supply to isolated rabbit heart during its perfusion with eryhem and blood. An examination of Moraxella and related genera commonly isolated from the bovine eye. Global medical, social and psychological care of school children. Long-term survival after chemoembolization of metastatic right atrial tumor thrombus as a presenting feature of hepatocellular carcinoma: A case study.

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Spinal shortening within the safe range increases spinal cord blood flow. A brief discussion of the clinical relevance of such lesions is also included. Our results suggest that QOL considerations do not justify sphincter-conserving approaches if locoregional tumor control would be compromised. Serum ACE activity depends on concentration of total cholesterol (TC) and triglycerides. The aim of this study was to evaluate the value of measurement of colloid osmotic can i drink alcohol after taking clomid pressure (COP) directly concerned with cerebral vasospasm following subarachnoid hemorrhage (SAH).

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Although the levels of TBARS and total glutathione were within the same range as controls noroxin medication at 6 weeks, they were significantly increased at 12 weeks. Some layer-specific markers showed distinct expression patterns. In addition, Shc, Vav, Ras, Raf-1, MAPKK, MAPK and Pim-1 are also activated. In addition to the mean, systematic displacement of each featurelet, this analysis yields correlated patterns of anatomical deformations. The effects of mild perioperative hypothermia on blood loss and transfusion requirement. To investigate whether family functioning and cognitions in a group of overweight female adolescents differ significantly from those in a group of normal weight female adolescents. IFN-gamma, GM-CSF and IL-4 were not able to induce CD23 expression, while CD69 expression was induced in some negative healthy donors and patients by IFN-gamma, GM-CSF and IL-4 respectively. Magnetic resonance imaging (0.5 T, Philips Gyroscan) revealed a circumscribed dissection of the right-side internal carotid artery from the carotid bifurcation to the petrosal segment.

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Here it is shown that stimulation of CD81 on human T cells can enhance T cell activation by antigen or superantigen, causing an increase in the early activation marker CD69, and increasing the number of cytokine-producing and proliferating T cells. Remote ischemic conditioning in percutaneous coronary intervention and coronary artery bypass grafting. A recombinant HGF antagonist, NK4 could effectively block these aberrant effects activated by irradiation both in molecular and cellular levels, thus suggesting the deep involvement of the c-Met/HGF pathway in the enhanced malignant potential after irradiation. The majority of inner-city girls in this study notified their partners about chlamydia infection. Patient outcome, in terms of managing work and everyday activities, can be very good for some two-year survivors. Insulin resistance in peripheral tissues and in the brain are fundamental to the development of obesity and its associated type 2 diabetes.

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The ratios in a series of alpine ultramafic rocks and ultramafic inclusions in basals and kimberlite pipes are about 200 to 500-significantly lower than those in oceanic tholeiites. Rising living conditions (high protein diet) accelerate maturation, lower pubertal age, shift body-built toward more weight for height and cerebral excitability toward higher levels. Tracheostomy for management of severe laryngomalacia is associated with significant morbidity and mortality. Eighty-eight patients were randomly divided into ultrasonic scalpel group (group A, 42 cases) and control group (group B, 46 cases). Multi-unit responses to somatosensory stimuli were measured from the contralateral thalamic ventral posterior lateral (VPL) nucleus at different stimulus strengths and periods.

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The chemical composition was investigated in the framework of a program for identification of metabolites associated with disease resistance in grape-vine. In patients with cirrhosis and a renal mass options may be limited by medical disease and the surgical difficulties associated with portal hypertension. Delayed type hypersensitivity (DTH) measured by ear swelling in the DNFB group, and peritoneal bactericidal activity, total free peritoneal cell counts (TPC), and cell types in the non-sensitised group. Retinal findings in systemic sclerosis: a comparison with nailfold capillaroscopic patterns. A 31-year-old woman presented to the hospital with symptoms suggestive of pelvic inflammatory disease.

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Further studies on the differentiation of the amphibian heart rudiment in tissue culture. In vitro, this circuit can spontaneously generate a single (type I) motor program, unlike in vivo in which gastric mill patterns with different phase relationships are found. The interface between an electrolyte solution and a metal electrode coated with an oxidatively adsorbed, redox-active monolayer of long-chain thiols has been examined from a thermodynamic point of view. Euclidean distance matrix analysis (EDMA) was used to quantify and compare pelvic shape using these landmark data. Tumor-to-tumor metastasis is an interesting phenomenon and there are only risperdal consta drug class few cases of MM metastasis to other tumors. The MH1 domain of Smad4 was shown to associate physically with Ubc9, the ubiquitin carrier protein (E2) conjugating enzyme in sumoylation. According to self-reported heights and weights, female nonstudents were more often overweight than female students or graduates. Ancient rocks, rhythms in mud, a tipsy venus: ocean mud pins down a million years of time.

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Using hierarchic logistic regression, we examined the relationship between physician specialty and Pap smear reports, controlling for patient age and socioeconomic position, multiple Pap smears performed by the same clinician, and physician attending status. GGF is produced by neurons and stimulates proliferation of Schwann cells, underlining the close interaction between neuronal and glial cells during peripheral nerve regeneration. The effect of heterogeneity in tumor cell kinetics on radiation dose-response. Histopathological and immunohistochemical studies showed T- zovirax cell type lymphoma in the right inguinal lymph node. Furthermore, non-steady-state (NSS) analysis was performed in which the FCR of LDL apoB was calculated as a function of time. Photosensitizing effects of Cymopterus watsonii and Cymopterus longipes in chickens and turkey poults.

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Stabilization and tracking control of X-Z inverted pendulum with sliding-mode control. An experimental analysis of their role in development and maintenance of cell shape. The prediction of adverse cardiac remodelling following myocardial infarction: defining the need for a dynamic multimarker approach. Clinical chronopharmacology, an experimental basis for chronotherapy. Though MCAT scores and grade point averages were correlated with scores on the USMLE Step 1, only the score on the biological science section of the MCAT was significantly correlated with passing the licensing examination. Thirty foods comprised the list of core foods, led by soda, coffee, and white bread. Evaluation of presidential candidates as a function of time and stage of voting decision.

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