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Acupain (Tramadol)

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Acupain is an opioid (narcotic) pain reliever. It works by binding to mu-opiate receptors in the brain and changes how you feel and respond to pain. Acupain is usually started at 25 mg per day. After slowly raising the dose over several days, a typical dose would be 50 to 100 mg by mouth every 4 to 6 hours as needed for pain.

Other names for this medication:
Acupain, Admadol, Bestodol, Decotram, Dolocet, Dolstar, Domadol, Ivydol, Leedol, Madol, Moludol, Neutram, Nobligan, Nomadol, Nopidol, Omodol, Opidol, Opiran, Oshdol, Ramax, Rimol, Rybix, Ryzolt, Servodol, Spasteez, Takol, Tradol, Tramache, Tramacip, Tramafen, Tramaflam, Tramasol, Tramatas, Tramazol, Tramed, Tramest, Tramot, Tranat, Trandol, Trapain, Trapidol, Trasic, Trazac, Ultracon, Urgendol, Veeradol, Vegadol, Zamadol, Zytram

Similar Products:
Paxil, Deltasone, Robaxin, Cordarone, Levlen, Avodart, Micardis, Albenza, Acticin, Zithromax

Also known as: Tramadol


{name} ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Acupain ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Acupain ER.

Never share Acupain ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Acupain ER.

Acupain ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Acupain ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Acupain ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Acupain ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Acupain ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep out of the reach of children.

Side effects

The most common side effects associated with Acupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how Acupain ER will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Four patients with four anterior IOLs had one CT and eight MR studies. This study examined the extent to which organizational context predicted use of consensus-based elements of effective substance abuse treatment practices with juvenile offenders. Lethally irradiated mice received BM cells from untreated or 5-fluorouracil-treated mice, and then were administered G-CSF or carrier buffer (control) for 5 days from immediately after BMT. Several phylogenetic clusters of Alphaproteobacteria revealed a CtrA binding site in the promoters of QS genes, including Roseobacters and Rhizobia. To this end, the female prawns were daily fed (controls) or unfed (starvation condition) for up to 12 days, and the ovary tissue was analyzed at different time-points. The dendrites of the layer III non-pyramidal neuron also tended to be restricted to layer III while deep pyramidal cells had long apical dendrites that spanned layers I and II. Surges in the size of adult populations of the flood-water mosquito Aedes albifasciatus can produce important economical losses because of the way this species irritates livestock. It also tries to identify some major gaps of knowledge and raises some questions resulting from the recent advances.

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Activities of colistin- and minocycline-based combinations against extensive drug resistant Acinetobacter baumannii isolates from intensive care unit patients. Selenoprotein expression and brain development in preweanling selenium- and iodine-deficient rats. Delay in treating schizophrenia may narrow therapeutic window of opportunity. Testis sections incubated with an antibody to caveolin-1 showed, by immunohistochemistry, a moderate number of Leydig cells with different degrees of immunoreaction and a strong reaction in endothelial cells and in the lamina propia of seminiferous tubules. This function in amino acid homeostasis is conserved amongst the Actinobacteria and provides an example of the close relationship between metabolism and virulence. The mesothelial cell layers and peritoneal membranes remained viable in culture medium for several weeks. Four key considerations can affect the size of an anesthesia subsidy: Staffing models. More importantly, the goals of intraoperative management are to avoid myocardial ischemia, which include preventing tachycardia, and maintaining normothermia and adequate hematocrit.

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Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes. Histopathological study on the amyloidosis of the tongue and salivary gland. Twenty two outpatients with multiple sclerosis received consecutively a specific training comprising 12 sessions in each of the two most impaired attention functions. Anal endosonography is a useful method for evaluating the anatomic effectiveness of closed lateral subcutaneous sphincterotomy. However, methods for synthesizing SWCNTs produce a mixture of metallic and semiconducting materials, which require additional processing to separate by electronic type. They were found to increase slowly until the ewe was six years old (43.4 g/l) and then fall rapidly (11.2 g/l between eight to ten years of age). Evaluation of magnetic resonance imaging signal changes in vertebral depressed fractures to determine the fracture time. We had a limited number of patients and have no long-term outcome data yet.

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Developmental neuroimaging studies offer a unique opportunity to gain insight into the underpinnings of various cognitive functions by examining age-related changes in brain structure and function. Anabolic hormone profiles in elite military men: Robust associations with age, stress, and fatigue. Upon investigation of protein-DNA binding, we detected an activity in brain extracts which was not detected in kidney or liver extracts. Quinolone alkaloids from Fructus Euodiae show activity against methicillin-resistant Staphylococcus aureus. In this article, we studied the role of actin in the regulation of human CSF1 gene transcription. To analyze the prognostic value of microsatellite instability (MSI) in a population-based study of FIGO stage 1-4 endometrial endometrioid adenocarcinomas. In a prospective study by B-mode ultrasound we assessed the intima-media thickness of the distal common carotid arterial (CCA) far wall at baseline and after 4 years. The model suggested here provides a good match with experimental data such as the spacing between gag protein rings, the number and disposition of glycoprotein (gp41-gp120) knobs and the number of copies of MA in a virus particle. But there were no difference between the both groups, concerning the proportion of those spending irregular life or living alone.

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Factor VIII (FVIII) is activated by thrombin to the labile FVIIIa, a heterotrimer of A1, A2 and A3C1C2 subunits, which serves as a cofactor for FIXa. Novel propeptide function in 20 S proteasome assembly influences beta subunit composition. MiECC provides circulatory support that is equally safe and feasible as conventional extracorporeal circuits. Lysosomal hydrolases, such as cathepsin B, are secreted from the apices of pancreatic acinar cells via a hormone-regulated pathway, as in the secretion of pancreatic digestive enzymes. Recombinant propeptides containing mutations of one of the three tryptophan residues were three orders of magnitude less effective as inhibitors of mature cathepsin S than the wild-type propeptide. Previously, in a cadaveric study, we proposed a modification of the EMLP, termed the modified subtotal-Lothrop procedure (MSLP), to access the ASB and to address complex frontal sinus disease, for which access to the bilateral frontal sinus posterior table is required. General health examinations (GHE) have become an increasingly common measure for preventive medicine in Vietnam. The endoskeleton of the erythrocyte associating with the membranous cytoskeleton may serve to keep its unique biconcave disc shape deformable, pliable, and restorable against external circumstances. The method addresses a critical question that arises during the course of the development and validation of encoding models: is a given model near optimal in terms of its accuracy in predicting the stimulus-elicited responses of a neural system, or can the predictive accuracy be improved significantly by further model development?.

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Fast simulation of Strehl loss due to phase aberration for the sizing of adaptive optics in laser communications system design. In order to gain an understanding of the contributions of caspases 8 and 3 during granule-induced apoptosis in intact cells, we have used target cells that either stably express the rabbitpox virus-encoded caspase inhibitor SPI-2 or are devoid of caspase 3. Research suggests that the effects of inflammatory cytokines and hormones such as leptin and ghrelin play a role in the development of malnutrition in CKD. Clonal diversity of basic protein specific T cells in Lewis rats recovered from experimental autoimmune encephalomyelitis. 2D-DIGE (difference gel electrophoresis) was developed to perform quantitative proteomics of two or more samples. The spindle checkpoint is mostly activated from kinetochores that are not attached to microtubules or not under tension that is normally generated from bipolar attachment. The plant cell wall is a major barrier that many plant pathogens must surmount for successful invasion of their plant hosts. Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity. MPTP-treated young mice but not aging mice show partial recovery of the nigrostriatal dopaminergic system by stereotaxic injection of acidic fibroblast growth factor (aFGF). Crystallographic and molecular dynamics analysis of loop motions unmasking the peptidoglycan-binding site in stator protein MotB of flagellar motor.

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We present the case of a 49 year old, non-hypertensive man who presented with sudden onset of bilateral up and down gaze palsy. This study investigated interactions between penicillin and clindamycin. In hypothyroid subjects atherosclerosis seem to associate with particularly low HDL plasma levels. Generating equations to estimate body mass of Korean skeletal remains. An important problem for therapy is the behavior of inhomogeneities in the pion beam, and experimental methods are described which illuminate this problem. Surface CD4 density remains constant on lymphocytes of HIV-infected patients in the progression of disease. Protein complexes of enterococci: antigenic spectrum and taxonomy. Correlation between CA-125 serum level and response by RECIST in a phase III recurrent ovarian cancer study.

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(b) Inhibition of augmenting expiratory (E-Aug) neurones by decrementing inspiratory (I-Dec) neurones. Since we showed previously that oestradiol stimulates progesterone release under in vitro and in vivo conditions, it can be concluded that the steroid is an important intraluteally acting luteotrophic signal. The A 431 antigen recognized by A 01 and B 11 had an apparent molecular weight of approximately 170,000 and was able to specifically link to EGF. Five individuals aged 17 to 37 years participated in an alternating treatment, single-subject design. Ones who had been hospitalized with discharge diagnoses related to burns were categorized as inpatients and others who had only ambulatory visits and emergency room visits were classified as outpatients. The effect of the introduction of a pigmented lesion clinic on the interval between referral by family practitioner and attendance at hospital. Another methodical approach to exclude the variability of the gravidity length depending on seasonal influences was based on the use of correction factors which were determined for individual months of foaling, on the basis of the sinusoid form of the curve of the gravidity length in the course of the calendar year. Extrinsic and intrinsic ligaments of the wrist: normal and pathologic anatomy at MR arthrography with three-compartment enhancement.

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The 2nd and 4th harmonic components of bEP behave independently of each other suggesting they may be generated by different subsystems. Thyroid gland function and pituitary TSH reserve in patients with cystic fibrosis. The xenoantibody response and immunoglobulin gene expression profile of cynomolgus monkeys transplanted with hDAF-transgenic porcine hearts. Our study shows the importance of minimizing AAV cap gene impurities and indicates that this improvement in AAV vector production may benefit human applications. Odontogenic subperiostal and submucous abscess in dental practice.

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Downregulation of AURKB sensitized cells to both cisplatin and oxaliplatin, but not to paclitaxel, 5-FU or hydrogen peroxide. Population morbidity in a community with nitrate contamination of drinking water. Accuracy of the denaturing gradient gel electrophoresis (DGGE) component of this system strongly depends on the design of the PCR primers and the melting characteristics of the fragments they encompass. The fine structure of the cells that perceive gravity in the root tip of maize. The exposable branches of the MA at the level of the infratemporal and sphenopalatine fossae were the anterior deep temporal, posterior superior alveolar, and infraorbital arteries.

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The prevalence of blindness for 2003, 2007, 2009 and the 3-year incidence of blindness were calculated. On Mycobacterium tuberculosis in the tissue of tuberculosis cutis luposa. Since the advent of strategies capable of manipulating the germline of mice, there has been a rapid expansion in the number of murine models of intestinal cancer. These findings suggest that S100A9 is a useful marker for discriminating ITET/CASTLE from SCC or UC-SCC. A robust nuclear magnetic resonance-based activity assay was developed using robotically controlled reaction initiation and quenching. Operative time, complications, postoperative pain (visual analog scale), postoperative downgrading of hemorrhoids, resolution of symptoms, and quality of life were evaluated. The complex formed between cytochrome c oxidase from Paracoccus denitrificans and its electron-transfer partner cytochrome c has been studied by multi-frequency pulse electron paramagnetic resonance spectroscopy. Spontaneously productive C-type retrovirus infection of fish cell lines. At 28 days, the parameters of bone minerals and strength of the lumbar body in the arthritic rats, both with and without correction for body weight, were significantly reduced compared with can you take prilosec 20 mg twice a day the baseline controls.

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Effects of stress, acute alcohol treatment, or both on pre-pulse inhibition in high- and low-alcohol preferring mice. Our experiments revealed that both synthetic (resiquimod and loxoribine) and natural (ssRNA40) TLR7 ligands abrogate CpG-A- and CpG-C-oligodeoxynucleotide (ODN)-induced IFN-alpha production by human leukocytes. The study of precancerous states at the level of the face and of the buccal cavity in workers from local industrial plants. 80 patients with presumed keratoconjunctivitis sicca (KCS) were examined with break-up time, Schirmer 1 test, and staining with fluorescein sodium and rose bengal. The results demonstrated that although there was a significant increase in paced heart rate per minute throughout exercise (P less than 0.01) with VVIR pacing, maximum watts, VO2, and VAT remained unchanged. MDGF1 binds to putative cell-surface receptors of 120-140 kDa and stimulates proliferation of normal and malignant human mammary epithelial cells. Rats housed with a cocaine partner self-administered more cocaine than isolated rats and rats housed with an abstinent partner. In PC12 cells, Ha-Ras modulates multiple effector proteins that induce neuronal differentiation.

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The present study examined the effects of a 6-week supplementation with two trans-18 : 1 isomers (trans-11 and trans-12) in human subjects on immune cells, several inflammatory and immunological biomarkers (for example, IL, TNFalpha, C-reactive protein, adiponectin, intercellular adhesion molecule-1, prostacyclin, phagocytic process). The GABAergic fraction demonstrated a highly disproportionate survival in culture in relation to other VM neurons resulting in a drastic change in the neuronal composition of the dissociated VM grafts. In addition, segment function may not always reflect changes in myocardial blood flow. The proposed physical growth curves are used to track the physical growth and nutritional status diagnosis of male Wistar rats. Preliminary report of the Cardiovascular Diseases and Alimentary Comparison Study: the Israeli experience. Effects of high pressure treatment on changes in pectic substances in guava juice were investigated and compared with those of heat treated samples. Using an agent-based model, grounded on the present day landscape, we show that groundwater availability would have been critical to supporting isolated networks of hydro-refugia during dry periods when potable surface water was scarce.

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Hypertonic aldehyde solutions resulted in cellular shrinkage during fixation not found with isotonic solutions. This review gives a brief but comprehensive overview of new developments in diagnosis and treatment of localized as well as advanced prostate, bladder and kidney cancer which have been presented on the occasion of the annual meetings of the European and American urologic and oncological associations in 2013. The K71 mutation also abolished the effect of ATP on substrate binding, but ADP, which still bound tightly, had its normal effect on substrate binding. Differential effects on D2 dopamine receptor and prolactin gene expression by haloperidol and aripiprazole in the rat pituitary. Five of the inhibitory IgG fractions blocked binding of factor V to phosphatidylserine. We examined the respiratory behaviours and swimming kinematics of Xenopus laevis tadpoles hatched in microgravity (Space Shuttle), simulated microgravity (clinostat) and hypergravity (3 g centrifuge).

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Reasons that lead to this burnout were among other things doing more than nine hours of overtime per week, the feeling of psychic and physical burdenings during operations as well as disappointed anticipation and unsuitable strategies to assimilate burdenings. The overall goal of this observational study was to determine whether modifiable vascular risk factors contribute to the prevalence of pressure ulcers (PrU) in veterans with traumatic spinal cord injury (SCI). Our data indicate a possible role of the c-erbB-2 gene in the development of aggressive behavior in bladder tumors. Healthy habits taken from home or socioeconomic situation are factors which might influence on regular physical activity. Intracellular origin and ultrastructure of platelet-derived microparticles. Twenty-three endometrial specimens from gynecological surgery for benign conditions were studied by means of immunohistochemistry, in situ hybridization and computer quantitative image analysis. In 96 cases, confrontation between the surgical terms and pathological items was made. The proposed method uses a technique called digital holographic interferometry (DHI), which comprises an optical laser interferometer setup and consecutive physical reconstruction of the recorded wave fronts by means of the Fresnel transform. We expose the obtained responses, the morphology, amplitude and latencies of the (a) and (b) waves in scotopic and photopic conditions with ganzfeld or flash stimulator.

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Meningioma embolization with the pressure cooker technique using Squid 12. Despite successful technical developments these methods remain investigational approaches and refinement of indications as well as further development of instrumentation levaquin antibiotic class action lawsuits are expected to define its area of future application. Previous work in our laboratory suggested that DNA topology could be implicated in the regulation of the division gene ftsZ. Frequency-dependent properties of a fluid jet stimulus: calibration, modeling, and application to cochlear hair cell bundles. The aim of this study was to compare the bone response around titanium implants loaded with fixed bridges in dog mandibles irradiated with total doses of 40, 50 or 60 Gy. This class of cellulose derivatives is a very important intermediate for the design of structures based on cellulose by nucleophilc attack on the carbonyl group. Left ventricular assist device-induced mechanical unloading increases myocardial collagen and stiffness and may contribute to the low rate of recovery. Accumulation of heavy metals in soil and their transfer to leafy vegetables in the region of Dhaka Aricha Highway, Savar, Bangladesh.

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Rationalization of a nanoparticle-based nicotine nanovaccine as an effective next-generation nicotine vaccine: A focus on hapten localization. Comparison of Ecological Momentary Assessment Versus Direct Measurement of E-Cigarette Use With a Bluetooth-Enabled E-Cigarette: A Pilot Study. The role of lipoic acid residues in the pyruvate dehydrogenase multienzyme complex of Escherichia coli. For the defined scan parameters in this study there were no differences in image quality between postprocessing methods (e. Local application of paclitaxcel by DCB has clinical benefits in various galantamine dosage nootropic settings including coronary bifurcations. Deletion of the DNA-binding domain of the transcription factor Ikaros generates dominant-negative isoforms that interfere with its activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemia (B-ALL). Clinical studies on kidney function with radioactive sodium diatrizoate (Hypaque).

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