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Actapin (Amlodipine)
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Actapin

Actapin is used with or without other medications to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Actapin belongs to a class of drugs known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily. Actapin is also used to prevent certain types of chest pain (angina).

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Also known as: Amlodipine

Description

{name} (amlodipine) is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.

{name} is used to treat chest pain (angina) and other conditions caused by coronary artery disease.

{name} is also used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.

Amlodipine is for use in adults and children who are at least 6 years old.

Dosage

Take Actapin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

You may take Actapin with or without food. Take the medicine at the same time each day.

Your blood pressure will need to be checked often.

Your chest pain may become worse when you first start taking Actapin or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.

If you are being treated for high blood pressure, keep using Actapin even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Your hypertension or heart condition may be treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or stop taking any of your medications without your doctor's advice. This is especially important if you also take nitroglycerin.

Actapin is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

Detailed Actapin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include rapid heartbeats, redness or warmth in your arms or legs, or fainting.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Actapin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Actapin if you are allergic to Actapin components. Do not take Actapin if you're pregnant or you plan to have a baby. Do not use it if you are a nursing mother. Do not use Actapin in case of suffering from significant aortic stenosis, cardiogenic shock, and unstable angina. Try to be careful with Actapin usage in case of having liver disease, heart failure or hepatic impairment. Do not use potassium supplements or salt substitutes. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Be very careful when you are driving machine. Do not stop taking Actapin suddenly.

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Ketone bodies metabolism during ischemic and reperfusion brain injuries following bilateral occlusion of common carotid arteries in rats. The MAP strategy with nine IMRT plans to accommodate the prostate motions in two major directions achieved good dose coverage to the prostate and PLNs. Bone lengthening was effective (from 5 to 26 mm, mean lengthening 13 mm) almost without stepping out from the metatarsal formula. Newborn feeding practices are important to neonatal health and survival, but understudied in sub-Saharan Africa. However, the findings demonstrate that a postoperative cardiorespiratory recording is needed in order to identify the patients with persistent moderate to severe OSA after the operation. In late pregnancy, IFN-gamma treatment significantly decreased placental IL-1beta protein levels.

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The role of routine coagulation studies in the management of patients suffering from epistaxis is unclear. Zinc Finger E-Box Binding Protein 2 (ZEB2) Suppress Apoptosis of Vascular Endothelial Cells Induced by High Glucose Through Mitogen-Activated Protein Kinases (MAPK) Pathway Activation. We enrolled 1 000 men aged 40 - 80 years with regular sex partners, evaluated their erectile function using IIEF-5, and investigated LUTS among them by International Prostate Symptom Score (IPSS). Mergers and acquisitions in professional organizations: a complex adaptive systems approach. Molecular characterization of cryptic and sympatric lymnaeid species from the Galba/Fossaria group in Mendoza Province, Northern Patagonia, Argentina. Solitary hemangioma located in the skeleton of the hand is a rare tumor, very different from diffuse angiomatosis or benign, hemangioma, located in the two distal phalanges of the right fourth finger.

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Participants performed a lexical decision task for words varying in affective valence (but equated in terms of arousal) that were presented briefly to the right or left visual field. All were submitted to traditional anthropometry (weight, height, BMI, arm circumference, triceps skinfold thickness and mid-arm muscle circumference), subjective global assessment, serum albumin and lymphocyte count. Effect of conditioned medium on recovery of circulating blood cells in irradiated mice. Focal mineralization defect during disodium etidronate treatment of calcinosis. Evidence points to activation of pro-inflammatory and pro-thrombotic stimuli during the haemodialysis process in end-stage renal disease (ESRD) with potential to predispose to cardiovascular events. To investigate the value of diffusion-weighted imaging (DWI) in evaluating parametrial invasion (PMI) in stage IA2-IIA cervical cancer. This case is important in that it represents a potential minimally invasive treatment strategy.

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It was suggested that the S1P-induced PGE2 was at least in part involved in the aggrecan-suppressing effect of S1P, seeing as COX inhibitors attenuated the effect. In conclusion, our new device to administer locally the thrombin solution is effective and safe for management of bleeding after TURP. The importance of vascular restoration, stable skeletal fixation, and provision of adequate skin cover are stressed. The morphologic distinction of epithelioid mesothelioma from a reactive mesothelial proliferation can be difficult. Here, we explored differences in the profiles of circulating miRNAs in mice after PFOA exposure.

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Birthweight categories give information which may be distorted when using mean weight alone. The cytoskeleton underlying the plasma membrane of most cells is rich in actin filaments whose assembly and disassembly are regulated by actin binding proteins that are stimulated or inhibited by signals received and transmitted at the membrane/cytoplasm interface. Primary data from surveys of NH administrators and directors of nursing from a nationally representative sample of 1938 freestanding United States NHs in 2009-2010 matched to Online Survey Certification and Reporting, aggregated NH Minimum Data Set assessments, Medicare claims, and county information from the Area Resource File. The ultrasonic velocity of shear waves propagating through radial direction of a wood plate specimen, transversely to the loading direction, was measured. Mesangial cell growth constitutes a key feature of progressive glomerular injury. Genomic and biochemical insights into the specificity of ETS transcription factors. Malignant transformation of ELP to squamous cell carcinoma has been reported.

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The objective of this study was to determine the effects of calcium supplementation on body composition, weight, insulin resistance and blood pressure in the face of calorie restriction in obese adults. These results revealed distinct fiber pathways to the rostral medulla that arise from the dorsal, lateral/ventrolateral, and ventromedial parts of the PAG. Brain magnetic resonance imaging (MRI) revealed a small lesion in the right mesial temporal lobe with radiologic features of a low-grade glioma. This study demonstrated the dependence of skin carcinogenesis on angiogenesis. The risk of Acanthamoeba keratitis as a potential complication of overnight orthokeratology should be considered, especially in patients with over one-year duration of contact lens wearing. A 47-year-old Japanese woman was admitted with complaints of hypermenorrhea and abdominal distention. We report a case in which a fibroepithelial polyp of the renal pelvis showed unusual radiological features. To establish rat models of FSH autoantibody and to investigate the effect of FSH autoantibody on the spermatogenic capability of rat testis. Pre-diabetic and diabetic subjects, compared to normoglycemia, were associated with significantly higher pericardial and peri-aortic adipose tissue burden. The effect of low dose corticosteroids, equivalent to 15 mg prednisolone daily or less, in patients with rheumatoid arthritis has been questioned.

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Growth in bone mass and size--are racial and gender differences in bone mineral density more apparent than real?. Microalbuminuria and tubular reabsorption of minerals in children with type 1 diabetes mellitus. Burn-induced delayed intestinal transit is associated with the p38 MAPK pathway. It is strongly suggested that a survey of ESBL-producing clinical isolates of E. Properties of intraepithelial neoplasia relevant to the development of cancer chemopreventive agents. Patient-centered care is associated with decreased health care utilization. Despite the mandated and moral imperative to advance linguistic competence in all health care contexts, leadership that addresses this area of practice and study in end-of-life and palliative care is not readily obvious. Repression of the HBV enhancer was not detected when the NF-1 site was disrupted, indicating that the NF-1 site was involved in the suppression of the HBV enhancer. Treatment was considered successful if the patient had had two consecutive negative cerebrospinal fluid cultures by the end of the 10-week treatment period.

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Labour management and Obstetric outcomes among pregnant women admitted in latent phase compared to active phase of labour at Bugando Medical Centre in Tanzania. The cytotoxicities of the title compounds were evaluated against HeLa, SMMC 7721 and HL 60 cancer cell lines by a standard MTT assay in vitro. Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome. Two-day collection and pooling of peripheral blood stem cells with semiautomated density gradient cell separation. Capsule expression was assessed in six coagulase-negative staphylococcal strains in serum-soft agar and by india ink and electron microscopy.

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Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. The prevalence of overweight was significantly higher in children with moderate to severe asthma than in their peers, and being overweight was associated with significantly more severe asthma symptoms. Examination of membrane components by isoelectric focussing revealed that blood group components of the A1Bm membranes were distinctively different from that of the usual membranes. The larval ring gland of Drosophila melanogaster: a comparison of Ebony and Oregon strains by use of a qualitative protein stain. Unfortunately, water frequently contains various solutes and suspended particulate matter that can influence its appearance, odor, taste, and physical and chemical properties.

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Health care services provided to detained immigrants are inadequate to provide for the needs of this population. Due to the apparent association with the plasma membrane and plasmodesmata, it was also speculated that chromatubules are involved in nucleus-cell-cell communication. The aim of the present study was to evaluate the usefulness of whole genome sequences as a source of phenotypic information. During December 2003 and March 2004, large scale epidemics of low-pathogenic avian influenza (LPAI) H5N2 occurred in poultry farms in central and southern Taiwan. This method cannot only be used to determine the CRI of the GW optically and provide one of the fundamental parameters for designing graphene-based optic devices for communication and sensing applications, but also is adoptable in graphene-based transformation optics for determination of the CRI of the GW at other wavelengths. Protective effects of a human 18-kilodalton cationic antimicrobial protein (CAP18)-derived peptide against murine endotoxemia. Leptospirosis is one of the most relevant zoonosis worldwide and a potentially life-threatening infectious disease. The model is based on the difference between the number and context of the water molecules in the hydration sphere of a hydrophobic dimer and of two isolated hydrophobic solutes.

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The results showed that there are different ocular shapes in eyes with pathologic myopia, and that the difference in the ocular shape is correlated with the development of vision-threatening conditions in eyes with pathologic myopia. Body weights were recorded and faecal soiling of the breech wool (dags) was assessed. A retrospective analysis of initial radiographs of 18 patients with blunt diaphragmatic rupture treated at bactrim breastfeeding safety two Greek Trauma Centers was performed. The risks and benefits of more stringent glycemic control must be considered in the context of treatment options, priorities, and quality-of-life issues for both the patient and family. FVP can occur in the peripheral retina and in the posterior pole. Thirty-four patients were treated in our department between 1990 and 2006 for EAC and middle ear tumours.

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We report a case of INLV revealed by ventricular fibrillation in a patient with Wolff-Parkinson-White syndrome. Serum-neutralizing activity was highest in the groups protected most effectively. Each enzyme synthesized full-length primer extension products and cleaved the RNA template at least once during DNA synthesis. Here, we explored the role of Nur77 in atherosclerotic plaque progression in apoE(-/-) mice fed a high-fat/high cholesterol diet. The relative role of each factor in the bleeding can be rapidly determined by using routine clinical laboratory tests. Genetic screening, particularly for AIP mutations, should be performed routinely. The authors describe the results of HIFU treatment in a series of preclinical studies performed in a validated porcine model. Upregulation of interleukin-2 may be involved, not only in the pathophysiology of nephrotic syndrome, but also in steroid resistance treatment, by increasing expression of multidrug resistant gene-1 (MDR1) gene on lymphocytes and its product P-glycoprotein effluxing corticosteroid. The bacteriological titre was lower in the resistant than in the susceptible animals in the 48 hours following inoculation, although milk somatic cell concentration was similar. Expression of GABA(A) receptor isoform genes in the cerebral cortex of cirrhotic and alcoholic cases assessed by S1 nuclease protection assays.

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In order to explore the biodegradation behavior of nonylphenolic compounds during wastewater treatment processing, two full-scale wastewater treatment plants were investigated and batch biodegradation experiments were conducted. With increasing number of transport units agreement with the previous theory was obtained. We have developed an effective therapy for experimental brain tumors by systemic intravenous transfer of ex vivo activated T cells derived from tumor-draining lymph nodes. The findings regarding internal locus of control are more unique. The sum of cleocin t gel how supplied the SEPs of left median and ulnar nerves was not equal to that evoked by the simultaneous stimulation of the two nerves even at early latencies. Tissue specimens obtained at autopsy were stained with colloidal iron to demonstrate acid mucopolysaccharides.

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Hypertension as an expression of the lack of the well-balanced life. In addition, the CN of ZNF280BY was positively correlated to that of HSFY on the BTAY. OsBSMT1-overexpressing Arabidopsis showed little induction of PR-1 when treated with SA or G. Remission Induction Therapy with Rituximab for Microscopic Polyangiitis: A Feasibility Study. A coherent pattern of ability, personality, and interest relations is found. Diffusion and the transport of organic nonelectrolytes in cells. The dosage of the steroid, life style factors (such as lack of exercise, alcohol consumption and smoking), menopausal status, low bone mineral density at baseline and previous osteoporotic fractures predispose for the manifestation of steroid-induced osteoporosis. In situ hybridization localized mRNA expression for this serine/threonine kinase receptor. Analyzing data before risk windows fully elapsed improved the timeliness of safety surveillance.

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A potential role for alpha B-crystallin as a target of the p38 branch of the cardiac stress response. In this study, we hypothesize that the in vitro hydrodynamic function of a self-expanding transcatheter heart valve (Medtronic CoreValve) assessed in an oval compartment representing the aortic annulus will differ from the conventionally used circular what is the generic brand of zyrtec compartment. Neonatal hyperglycaemia after prolonged maternal treatment with diazoxide. During tests performed to study the inhibitory effect of the crude bacteriocin CBE V24 (concentration 800, 1600 AU ml-1) against L. A multicentre cohort study assessing day of week effect and outcome from emergency appendicectomy. Race and the treatment of cytomegalovirus retinitis in a cohort of patients with acquired immunodeficiency syndrome. Since then the field has greatly expanded, with 10 therapies currently approved to treat MS. The mean arterial pressure and acid-base status were monitored using a 16-gauge polyurethane catheter inserted into the descending aorta via a femoral artery. In this study, hand-transmitted vibration from the long cane due to tapping the ground was measured because an exposure to repeated shock-type tapping vibration may affect the hand-arm system.

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All techniques resulted in cochlear hypothermia without a concomitant change in rectal temperature. This non invasive technique is mainly advocated for the study of fetus brain. Alpha(1)- and alpha(2)-adrenoceptor mediation in melanosome aggregation in cryptic patterning of Pleuronectes americanus. Characteristic albenza 400 mg temperature dependent mixtures of ring and three-dimensional, voluminous water clusters provide the famous density maximum. The study used data from the Stockholm Public Health Survey, a cross-sectional survey carried out in 2006 for the Stockholm County Council by Statistic Sweden. Plasma concentrations of C-19 steroids, estrogens, FSH, LH and prolactin in post-menopausal women with an without breast cancer. The use of single-cell WGA has enabled the analysis of genomic heterogeneity of individual cells (e.g., somatic genomic variation in tumor cells).

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A sex-linked recessive lethal mutation assay was performed in Drosophila melanogaster using immature spermatocytes and spermatogonia irradiated with X rays at a high or low dose rate. Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage. Nucleosome positioning influences the overall rate of sequence evolution. Cardiopulmonary bypass increases the blood levels of various immune mediators, thereby leading to a systemic inflammatory response syndrome, e.g. In six animals limited resection was performed by means of Nd YAG and CO2 lasers. Loss of basic nuclear protein during fermentative isolation of epidermal cells. The inactivated effector sample for the control prepared by irradiation(50Gy X-ray) or heat treatment(56 degrees C, 20 min), however, showed an enhancement effect on the ALP production in the target cells. Opinions on the strategy of forced diuresis with matched controlled hydration to prevent post procedural acute kidney injury in the catheterization laboratory.

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Implementation of a chest pain management service improves patient care and reduces length of stay. We provide support for timing of parturition as an adaptation in Tasmanian snow skinks (Niveoscincus) by demonstration of (1) ongoing selection against poorly timed parturitions, (2) retention of full-term young through episodes of unfavorable conditions, and (3) phylogenetic shifts from autumn to spring parturition in taxa where costs of autumn parturition are expected to be relatively higher. Nearly all combinations of these three markers were found and the frequency of combinations showed that the markers assorted independently. Supersnowflakes: Stepwise Self-Assembly and Dynamic Exchange of Rhombus Star-Shaped Supramolecules. Our data demonstrate sustained topographic EEG responses during tonic stimulation from hand immersion in painfully cold water. Vibrio cholerae O1 strains are facultative intracellular bacteria, able to survive and multiply symbiotically inside the aquatic free-living amoeba Acanthamoeba castellanii. The parameters screened were chromosomal aberrations, with and without gaps and break per cell. Two reconstituted high-density lipoprotein (rHDL) particles of different sizes (approximately 8.2 nm and 7.6 nm in diameter) were produced by mixing apoA-I and 1-palmitoyl-2-oleoyl phosphatidylcholine (POPC). In contrast, overexpression of plant BI-1 increased autophagic activity and surprisingly caused autophagy-dependent cell death.

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