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Acroli (Tacrolimus)
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Acroli

Acroli is used along with other medications to prevent rejection (attack of a transplanted organ by the immune system of a person receiving the organ) in people who have received a kidney transplant.

Other names for this medication:
Acroli, Crolim, Cromus, Mustopic, Olmis, Pangraf, Protopic, Seegraf, Tacloran, Tacrel, Tacrim, Tacroderm, Tacrograf, Tacrokid, Tacrolimus, Tacromus, Tacrotor, Tacrovate, Tacroz, Tacstead, Talimus, Tarcel, Techlomus, Topgraf, Triplibact, Vingraf

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Also known as: Tacrolimus

Description

Tacrolimus injection is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Tacrolimus works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ.

Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is to be given only by or under the direct supervision of a doctor.

Dosage

A nurse or other trained health professional will give you this medicine in a hospital. It is given through a needle placed into one of your veins. Your doctor may let you stay for at least the first 30 minutes after the start of the infusion and at frequent intervals thereafter.

You will only receive this medicine for a few days. Then your doctor will switch you to the oral (by mouth) form of tacrolimus.

This medicine comes with a patient information insert and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

You should not eat grapefruit or drink grapefruit juice while you are receiving this medicine. Grapefruit and grapefruit juice will increase the amount of medicine in the body.

Detailed Acroli dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acroli are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Acroli if you are allergic to tacrolimus or hydrogenated castor oil, or if you have used cyclosporine (Neoral, Sandimmune, Gengraf) within the past 24 hours.

Using Acroli may increase your risk of developing serious infections or certain types of cancer, such as lymphoma or skin cancer. Your risk may be higher if you are treated over long periods of time with drugs that weaken the immune system. Ask your doctor about this risk and about symptoms to watch for.

Some people taking Acroli after a kidney transplant have developed diabetes. This effect has been seen most commonly in people who are Hispanic or African-American.

To make sure Acroli is safe for you, tell your doctor if you have::

problems with your liver, kidney, or heart that are not related to your transplant; long QT syndrome (in you or a family member); or if you are scheduled to receive a vaccine;

Tell your doctor if you plan to get pregnant. Tacrolimus may harm an unborn baby, and can worsen conditions such as diabetes or high blood pressure in the mother. Use effective birth control before and during treatment with Acroli.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of tacrolimus on the baby.

If you are a man, use birth control before and during treatment with Acroli if your sex partner is able to get pregnant.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

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Inability to induce tolerance to bovine gamma globulin in mice infected at birth with lymphocytic choriomeningitis virus. Randomized trial of IV valproate vs metoclopramide vs ketorolac for acute migraine. Localization of neuropeptide receptor mRNA in rat brain: initial observations using probes for neurotensin and substance P receptors. A comparison of the LD50(30) values obtained for the different treatments gave a dose-reduction factor of 3.3 for the combined treatment, which was significantly greater than the factor for hypothermia alone, 2.6, or that for cysteamine alone, 1.4. The prevalence of shoulder osteoarthritis in the elderly Korean population: association with risk factors and function. Batch preparation of rabbit gammaG globulin with deae-cellulose. Influence of novobiocin on the induction kinetics of beta-galactosidase in Escherichia coli.

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