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Aclene (Adapalene)

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Aclene works well for treating mild-to-moderate acne, but it can cause burning and itching right after using it. The medication has many different formulations, but only the lower strength gel is available over-the-counter.

Other names for this medication:
Acneril, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Risperdal, Aceon, Arimidex, Naprosyn, Uroxatral

Also known as: Adapalene


{name} (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

{name} is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


Follow the directions for using this medicine provided by your doctor. Use Aclene exactly as directed. Aclene is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Aclene. Aclene should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Aclene. Continue using Aclene until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Aclene promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Aclene dosage information

Side effects

The most common side effects associated with Aclene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Expression of human p140trk receptors in p140trk-deficient, PC12/endothelial cells results in nerve growth factor-induced signal transduction and DNA synthesis. These results indicate the importance of S363 phosphorylation in the function of Ebp1. To evaluate the demographic characteristics, clinical course, and outcome in organ transplant recipients with metastatic skin cancer. FVG has one of the highest incidence rates of cervical cancer in Italy. The cases were operated on at the subacute or chronic stages after hemorrhage. Risk for complete humeral fracture may be lower on synthetic surfaces than on dirt surfaces, and, by inference, for horses examined using scintigraphy. Less than 40 percent of patients whose depression was treated with antidepressants made more than two visits during the 8 weeks after the initial prescription. Incorporation of radiosulfate in the tissues of normal rats and rats under restraint. In the bulldog and suture groups, 30 and 31 patients underwent concomitant bilateral extended pelvic lymph node dissection (PLND), respectively.

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When these proportions were noted to be significantly different, we compared them with the 7,731-patient TIMI IIIB Registry, which represents the non-trial, screened population with these syndromes at these centers. Hypersensitivity reactions to oxaliplatin: clinical features and risk factors in Koreans. We conclude that relaparotomy through an existing PL prosthesis previously integrated with the abdominal wall does not affect the tissue integration process or the tensile resistance of the implant. To assess neonatal screening for cystic fibrosis using immunoreactive trypsin, either alone or in conjunction with DNA analysis for the delta F508 mutation. Choice Behavior in Rhesus Monkeys: Effect of Stimulation during the First Month of Life. Here, we analyzed the timing of the maternal-to-zygotic transition during early Zea mays seed development. To address issues about data monitoring committees (DMCs) for randomised controlled trials (RCTs). Data suggest that the EEA stapler has better haemostatic properties than the PPH stapler and allows resection of a larger area of mucosal prolapse with potential benefits over the recurrence rate of haemorrhoid prolapse. Initiation of adjuvant hormone therapy by Medicaid insured women with nonmetastatic breast cancer.

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Early forms of amyotrophic lateral sclerosis with special reference to the initial bulbar-paralytic syndrome. Each of these adverse events, however, declines with medication use. Costs (direct medical and indirect costs) and effectiveness (percent reduction in low-density lipoprotein cholesterol levels) were based on approximately the first 6 months of initial therapy. The cytomorphologic features were reviewed and correlated with immunocytochemical findings and telomerase activity. Previous findings suggest a possible role for free radicals in cold-storage-associated tissue injury. Conversion of a reporter gene for mitochondrial gene expression using iterative mega-prime PCR. To observe the effects of hemoperfusion on oxidative stress status and the levels of matrix metallo proteinase (MMP-2, MMP-9), tissue inhibitor of metalloproteinase (TIMP-1) in lungs, livers and kidneys in paraquat poisoning rabbits, and to explore the mechanism of therapeutic effects induced by HP on acute paraquat poisoning.

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Construction of human phage antibody library and screening and characterization of phage antibodies against N terminal fragment of human lipopolysaccharide binding protein. Relations between sanitary conditions of the environment and acute intestinal infections. Fecal samples were collected at the time of serum collection through day 35 PI. If the seizures last longer than 1 hour, homeostatic mechanisms may start to fail. Forums in gastrointestinal roentgenology: roentgen evaluation of small-bowel obstruction. According to the United States Preventative Task Force, hearing screening promotes early detection, adequate treatment, and improved quality of life. In this brief review, the notion that passive stiffness is exclusively extracellular in origin is challenged. In addition, the influence of DTE on in vitro mediator release from blood eosinophils, basophils and bronchoalveolar lavage (BAL) mast cells was studied. Aggregation is consistently enhanced by dimethyl sulfoxide, which is known to increase the level of phospholipids and membranes in yeast cells. A prospective, randomized, double-blind, multicenter clinical trial.

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MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets. Cofactor specificity of neural NADPH-diaphorase found in the central nervous system of Porcellio scaber. The mesospore, like the exospore, is resistant to the acetolysis reaction and can, thus, provisionally be considered to consist of sporopollenin. Web-based patient-specific decision support has the potential to improve evidence-based parameters of diabetes care. This article describes our progress and reports on lessons learned that might guide future work in this field. Effects of intracerebroventricular injection of histamine on memory deficits induced by hippocampal lesions in rats. The relative pulmonary vascular specificity of oral sildenafil, and its low cost, makes it an attractive therapeutic alternative to inhaled nitric oxide, and warrants further study. In fact, it does not add anything to the quality of the trial and invades the field of competence of the ethics committees and virtually needs a national register of the volunteers to allow a check. Relationships between risk variables and VMS frequency (24 h, day and night) were assessed by univariate and multivariate robust regressions with adjustment for age and WHtR.

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Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Two months after surgery she is asymptomatic with normal renal function. Intraabdominal abscess following open and laparoscopic appendectomy in the pediatric population. The incidence, types, anatomic locations, sites, and activities related to injuries on school premises are presented. Involvement of the cyclin-dependent kinase inhibitor p27Kip1 in negative signaling through the antigen-receptor of B lymphocytes. Among patients treated with GH during childhood, psychological impacts may persist in late adolescence. In rabbits, lightly anesthetized with ether, tetanic stimulation of the superior laryngeal nerve (SLN) displaced the jaw toward opening and reduced the amplitude of cortically evoked rhythmic jaw movements.

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Formation of the early-region-2 transcription-factor-1-retinoblastoma-protein (E2F-1-RB) transrepressor and release of the retinoblastoma protein from nuclear complexes containing cyclin A is induced by interferon alpha in U937V cells but not in interferon-alpha-resistant U937VR cells. To document the activity profile of transcription factors following chondrocyte stimulation with hyaluronan (HA) hexasaccharides (HA(6)) and to determine the expression of genes whose transcriptional activation is tightly associated with the transcription factors. When used to prepare the TiO(2) layer for a photoanode, their photovoltaic performances were much worse than that of a nanocrystal TiO(2) layer. Control of Ascorbate Peroxidase 2 expression by hydrogen peroxide and leaf water status during zantac drug recall list excess light stress reveals a functional organisation of Arabidopsis leaves. Review of observational studies, controlled trials, case reports, institutional experience, and hospital HFOV guidelines for adult patients. A gas chromatographic method for detecting nitrites in the blood and stomach contents. Five osteocalcin assays compared: tracer specificity, fragment interference, and calibration. Human plasma was treated with rt-PA (10 micro g/mL) and/or captopril (1 micro M).

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The potent inhibition of vapiprost, a novel thromboxane A2 receptor antagonist, on the secondary aggregation and ATP release of human platelets. Transient ischemic attack (TIA) is often followed by a stroke episode. The six classes identified in other insect species are all represented and, as in Anopheles gambiae, the majority of the mosquito GSTs belong to the insect-specific Delta and Epsilon classes with eight members each. Our new range of biochemical techniques provides a standardized method to assess the quality of both engineered cartilage produced in vitro and repair tissue biopsies obtained after in vivo implantation. This results in greater local strain adjacent to the upper border of the bone block increasing the risk for patella fracture. Design and synthesis of inhibitors for crystallographic studies on the active site of chymotrypsin. We tested the actions of PTH on the expression of mac25/IGFBP-RP-1 in cultures of osteoblast-enriched cells from 22-day-old fetal rat calvariae (Ob cells). subtilis is substrate inducible, their expression is generally not regulated in response to nitrogen availability by GlnR and TnrA.

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